Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update

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3 жыл бұрын

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Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital
Greg Fahy, Intervene Immune
Thymus Rejuvenation Progress Update
- Designed and led the TRIIM trial; Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration.
- Fellow of the American Aging Association.
(since 2005), Former Director of the American Aging Association (16 years)
- Editor-in-Chief, The Future of Aging: Pathways to Human Life Extension.
- Awarded the Society for Cryobiology’s Luyet Medal in 2016.
- In 2009, showed indefinite survival of rabbit kidney transplanted after cooling to -130°Celsius; Led 21CM team as co-winner of Small Mammal Brain Preservation Prize, 2018 winner of Large Mammal Brain Preservation Prize.
Greg finishes with call to action: • Greg Fahy, Intervene I...
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Zoom Transcription: otter.ai/u/X-tRZMXK_4IiLxw9d7...
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Пікірлер: 120

@rizzobitz 2 жыл бұрын

Wonderful presentation. My sons thymus was removed as a 6.5 pound newborn during heart surgery. He now suffers with severe immunodeficiency, is unable to build immunity to vaccines, has chronic infections, has increased risk of cancer, autoimmune disease, infections. Thymectomy during heart surger has been proven to lead to severe covid in some patients. It is likely to cause early death. They have known since the 1930s how vital the thymus is in children when they studied what happens after they irradiate it, but they still remove it to this day. In the 1980s they placed these heart surgery babies thymuses into AIDS patients. They said the babies don't need it but I guess AIDS patients do. Makes no sense. What if my son gets AIDS or gets cancer and needs chemo? It's nice to see someone promoting the thymus. Thank you again.

@Courtney85 Жыл бұрын

I’m so sorry your son is struggling! That must be so hard for your family. Is he taking a thymus glandular to replace what he doesn’t have? It’s just basically freeze-dried bovine or ovine thymus gland in a capsule, available over-the-counter, and would contain all the hormones and peptides that he needs for immune modulation.

@vince1229 2 жыл бұрын

Colostrum restores thymus function. It also contains lactoferrin which promotes new bone and spinal disk growth.

@SteveRichfield Жыл бұрын

Thanks Vince. Sounds believable. Do you have any references?

@altargull 3 жыл бұрын

So it works! Ok, roll it out to the public ASAP!

@peoplespeace Жыл бұрын

Yes. isn't it wierd that there is is zero mention let alone use of this by official institutions?! And this video only has a few thousand views!

@bobbyjunelive1993 3 жыл бұрын

I love seeing Greg active at the hopeful/global level.

@saulsavelis575 Жыл бұрын

Greg is a prime scientist in Cryopreservation and Cryonics fields

@peterz53 3 жыл бұрын

Thanks. Good talk. There was a recent study (2020 JAMA) of older people who were longer term cyclists, so had a higher level of exercise than their cohort. The had preserved immune function and thymus function. Of course, the impetus for intervention by pill is because most people won't get enough physical activity and there's money in it.

@felicisimomalinao698 2 жыл бұрын

You said it very well.

@peoplespeace Жыл бұрын

Plus, as far as I know, cycling does not reverse ageing!

@cacogenicist Жыл бұрын

They may be able to reverse thymus involution far beyond thymus preservation from being physically active. There is _potential_ here for life extension well beyond what's gained from regular exercise.

@CalumnMcAulay 3 жыл бұрын

This is very promising - hopefully it will soon be available as a treatment! :-)

@newsmansuper2925 2 жыл бұрын

Dr. Fhay looks younger in this video vs the 2019 video .....

@donaldponder6462 Жыл бұрын

Just read in a NY Times article that supplementation with Metformin (for purposes of anti-aging) is self-defeating in a study showing that Metformin greatly neutralizes the anti-aging benefits of exercise (which greatly enhances mitochondrial vigor).. In light of this I'd say that exercise is the natural alternative substitute for Metformin in this cocktail...

@Galaxia53 11 ай бұрын

Hmm an article or a scientific study, The New York Times or Standford University. I sure wonder which one has more credibility

@altargull 3 жыл бұрын

Mentions Steve Horvath, and wow there he is on the call! Caught me off guard!

@rogerbritus9378 Жыл бұрын

He and his twin brother were in the trial pool, according to a documentary by Deutsche Welle.

@ScottChristensenabc 2 жыл бұрын

Great video...only suggestion is to hold questions to the end n fairness to Dr. Fahy and the rest of the audience.

@JohnnyMagorish 3 жыл бұрын

Amazing work! If it’s reversing aging you would expect people to look younger, but Greg points out this hasn’t been noticed, so it seems it’s only reversing some aspects of aging.

@drzavahercegbosnaponosna5974 2 жыл бұрын

do you know how old he is?

@viky2002 2 жыл бұрын

@@drzavahercegbosnaponosna5974 71

@capri2673 2 жыл бұрын

He's 71 here!!!

@capri2673 2 жыл бұрын

@@drzavahercegbosnaponosna5974 I don't think he realises he's 71 here...

@tomo1168 2 жыл бұрын

@@capri2673 WTF :D

@rustybolts8953 3 жыл бұрын

Finally something that agrees with my intuition and life experiences. Having experimented with fasting back in the 1970s with very damaging effects. Makes far more sense to build the thymus and body up, rather than down. Thank you Dr. Fahy and all others involved.

@romaniamyland6191 2 жыл бұрын

what do you mean "Having experimented with fasting back in the 1970s with very damaging effects". What damaging effect? Thank you

@raffaelecorrente1123 2 жыл бұрын

@@romaniamyland6191 no answer!

@maxyazhbin826 3 жыл бұрын

wow, wow, wow!

@MichelleTyner Жыл бұрын

I am an active healthy 53 year old with zero comorbidities. I recently had a ct scan that revealed a thymus. I am asymptomatic.

@JesusSesteagaCORENUTRITION Жыл бұрын

Excellent presentation, question, Dr Fahy, do you think that GABA and other ILGF-1 precursors/stimulators, can have symilar effects on the Thymus gland as HGH?

@MichaelMerritt 2 жыл бұрын

Anyone know the preliminary data he hinted at but didn’t reveal? Has he since spoke to better dosing schedules of each compound?

@Toddcinca 3 жыл бұрын

I am going to try the castration method thanks for your informations

@tomo1168 2 жыл бұрын

will you try this method on yourself or on your patients? :D

@ConfirmedCynic 2 жыл бұрын

Has anyone done a comparison of epigenetic ages of senescent cells vs. other cells in a tissue? If the senescent cells have a higher average epigenetic age, and an invigorated immune system acts to remove them, then wouldn't there be an apparent decrease in average epigenetic age for the tissue without the other cells experiencing any epigenetic rejuvenation?

@dlbdlb3919 2 жыл бұрын

How does this data compare with equivalent data results found in fasting for the same period of time ? Thank you.

@partypao Жыл бұрын

DHEA does increase the risk of cancer. What inhibited this? The HGH and metformin?

@stellarblur 3 жыл бұрын

Just wondering if you doctor's have noticed that fasting does everything your giving people in the trimm study 600times hgh Super low insulin

@sokaiya1 2 жыл бұрын

that's unproven bullshit

@stellarblur 2 жыл бұрын

@@sokaiya1 kzfaq.info/get/bejne/q8mArNCXl9G7f3U.html

@bookzdotmedia 2 жыл бұрын

Fasting helped me big time! Intermittant fasting,, lost 22 pounds in 2 months

@brandonbergeron7617 2 жыл бұрын

@@bookzdotmedia what was your intermittent fasting time frame?

@bookzdotmedia 2 жыл бұрын

@@brandonbergeron7617 14 hours a day 6pm to 8am

@royzlatanestevez9843 Жыл бұрын

Interesting... so the PROGRAMMED AGING (genetical program for aging, selected by evolution) works by making cells listen to whether the thymus is present... when it is not present, the cells "know" that it is time for them to age, thanks to genetic program. But they can be spoofed by adding the thymus.

@antonioalfaro5868 Жыл бұрын

Wishing you all good. May i know if there's a cure now for Myasthenia Gravis? Thank you much for your favorable response.

@lpngolfer Жыл бұрын

I can’t take Metformin after a bad allergic reaction to it when I tried it. I was a borderline diabetic and subsequently treated and controlled it with changing my diet.

@YomeLang4466 3 жыл бұрын

You looking much younger. It's not only the hair(which I assume is dyed), but face looks 10-15 yrs younger from previous videos... Is it possible to naturally restore thymus. Fasting 3 days increase growth hormone by 300%, if we do this once a month will it have the same impact. Also, Berberine can be used as a natural alternative to Metformin. I think this research is the most likely to succeed. It would be interesting to combine this treatment with plasma replacement therapy... I think it could accelerate results exponentially

@simsammalinao1823 2 жыл бұрын

Combining metformin and berberine has synergy - according to a recent research (re: NCBI - Pubmed)

@alwayslearning8365 2 жыл бұрын

Wow you had me looking up the website to sign up, and then came the price of $18000. It took two years off my life. Since I am a senior on a fixed income that $18 grand price tag is out of reach for me. I wish you good luck finding investors and bringing the price down. Great information thank you.

@nikos4641 2 жыл бұрын

He uses botox

@vibhaspalding6457 Жыл бұрын

@@simsammalinao1823 we cannot get metformin in UK over the counter so I just take berberine.

@freedominsteadof1984 Жыл бұрын

@@vibhaspalding6457there are legal European online clinics that prescribe it…

@robertleger4986 2 жыл бұрын

Where to get someone to prescribe somatropin though? Probably have to go to a holistic dr...or someone who works with life extension..

@Heyokasireniei468sxso Жыл бұрын

oxytocin and vasopressin is key .

@capri2673 2 жыл бұрын

He's 71 here!

@Krunch2020 Жыл бұрын

I thought you were joking! Born in 1950. I’ll have whatever he’s taking.

@marilombardi7120 2 жыл бұрын

Hi I would love to be in one of your studies is that possible?? Also what are the best GH and Dhea products to use ?? I already use metformin 1000mg on my non exercise days

@marcalan1198 Жыл бұрын

how can I purchase metformin? I need it very badly.

@stellarblur 3 жыл бұрын

Maybe one of the reasons fasting heals

@sokaiya1 2 жыл бұрын

wrong

@bookzdotmedia 2 жыл бұрын

Yes fasting creates growth hormones at 18 hours

@raffaelecorrente1123 2 жыл бұрын

@@bookzdotmedia too little to have a significative effect

@DC-pk5np Жыл бұрын

Dhea costs like $10 online.

@annoyingmouse1101 2 жыл бұрын

Well can we combine treatments and see what happens. Let's remove senescent cells from the body while adding stem cells and rejuvenating the Thymus and see what happens.

@sokaiya1 2 жыл бұрын

Adding Stem cells such as those live MSC's from wharton's jelly or derived from the endometrium would work well with HGH.

@h20no63 2 жыл бұрын

The u.s should let the right candidates with life in prison/ death sentence opt into this stuff to speed it up .let them give something back to society.

@JohnEnergy2012 2 жыл бұрын

How do you join the trial?

@sokaiya1 2 жыл бұрын

just do it yourself. no need to be on a trial. furthermore it's more beneficial to take HGH daily NOT 4 days/week

@tomo1168 2 жыл бұрын

@@sokaiya1 OK, and how do you suppose to buy HGH?

@galtbarber2328 3 жыл бұрын

Currently the high cost of human growth hormone at $18,000 per year is holding things back. He has a plan that might produce it at just 20% of the cost.

@sokaiya1 2 жыл бұрын

That's nonsense. 10k at most. Half that if you legally import.

@jamespartin3562 2 жыл бұрын

191aa peptide. They are affordable. Insulin is a peptide. The dosing is the trick. You can use to much the just a waste. I am poor.

@SheikhN-bible-syndrome 2 жыл бұрын

Umm you have a bad plug . HGH can be had at 200 to 250 for 100IU

@henryquenin6580 2 жыл бұрын

I used to buy humatrope in Mexico back in 2000 for about $60 a vial. I can't believe how expensive it's become.

@freedominsteadof1984 Жыл бұрын

It can already be produced at a fraction of the costs…Chinese companies are selling their non-FDA approved HGH for 1/10th of the price.

@alwayslearning8365 3 жыл бұрын

Could Berberine be substituted for metformin in the TRIIM study?

@sokaiya1 2 жыл бұрын

nope

@MichaelMerritt 2 жыл бұрын

They’re synergistic according to a new study

@ytacct007 3 жыл бұрын

Looks like HGH is the primary driver for thymus regeneration. Given that pro-bodybuilders have been using HGH, testosterone and some other anabolic; is the data not available already on effects of aging?

@galtbarber2328 3 жыл бұрын

Testosterone is bad for thymus.

@ytacct007 3 жыл бұрын

@@galtbarber2328 did not know that. In the presentation Greg referred to “anabolic” effect. So would HGH on its own be anabolic? The other life extension methods I’ve heard David Sinclair talk involve Intermittent Fasting. But IF is not conducive to adding muscle. And muscle is the best way to ensure better quality of life (maybe not length) which makes me pause jumping into IF 🥲

@tangan6228 3 жыл бұрын

Bodybuilders abuse HGH, taking 10 times normal physiological levels, at those doses it is unhealthy and shortens life. I would expect that dose is super important in what is optimal in achieving thymus regeneration. At specific dose HGH is well tolerated with an acceptable safety profile.

@redberries8039 3 жыл бұрын

@@ytacct007 try a feast/fast weekly/5day cycle pivoting on a training day ...train then eat as much as u can 2 days, then progressively IF fast over the week until training day again. Build muscle and stay lean incorporating IF

@sokaiya1 2 жыл бұрын

@@galtbarber2328 wrong

@CRYPTERIUM4 3 жыл бұрын

Can't you just grow a new thymus in the lab using your own cells.

@markn6941 2 жыл бұрын

yes! in 100 years!

@partypao Жыл бұрын

Using HGH is not uncommon. So wouldn't this simply mean that all people who inject HGH for about a year without the combination of DHEA and metformin, ALSO have regenerated their thymus, with the only difference being that they may have been more at risk of developing type II diabetes?

@sylviablack4935 2 жыл бұрын

I wish I had the 18k or anything near it.

@sokaiya1 2 жыл бұрын

for what?

@sylviablack4935 2 жыл бұрын

@@sokaiya1 for the thymus regeneration treatment.

@christopherellis2663 2 жыл бұрын

Why do Americans say 'a fourth' instead of a quarter? Or ' two times less" for a half? Very obscure

@leeyost9917 Жыл бұрын

Depends on where in US and how old and where parents are from etc. I would say half but I’m not a scientist but I would also say one fourth because a quarter makes me think more of a coin in my thinking

@Montie-Adkins 3 жыл бұрын

So one patient went from their mid 50's to their early 40's but they still looked old in the face. What does this mean?

@sokaiya1 2 жыл бұрын

get off the drugs, smoking, alcohol.

@ritteradam 2 жыл бұрын

Probably one type of damage caused by aging is reversed, but not another. I would also love to hear more on those details.

@josepho5055 2 жыл бұрын

*How many here have $18,000 to be part of this trial?*

@tomo1168 2 жыл бұрын

If it works and w/o side effects and longer lasting, I would pay for it. Better spent than to buy a new SUV instead of my old cheap car.

@rustybolts8953 3 жыл бұрын

Sorry but I don't see the need for controls here. Nor do I consider controls where the outcome is already well known, to be ethical. Steering wheels prevent car crashes, Do we need a control to prove that steering wheels prevent car crashes?

@tomo1168 2 жыл бұрын

lol

@drzavahercegbosnaponosna5974 2 жыл бұрын

dr. fahy you look younger and younger... please, don't overdose!

@iblisthemage 3 жыл бұрын

Metformin in itself reverse age... And increase insulin sensitivity...

@JohnnyMagorish 3 жыл бұрын

I believe I’ve heard Horvath state that Metformin does not seem to reverse the epigenetic clock, even though the data shows benefits for reducing disease risk

@MichaelMerritt 2 жыл бұрын

It appears Metform does not increase lifespan in non diabetics unfortunately based on recent results of a long term human studies. Many links in video description here kzfaq.info/get/bejne/n6iplNSX0r3KeIU.html

@iblisthemage 2 жыл бұрын

@@MichaelMerritt false falsification. I do follow Dr. Brad, and while my initial statement was way too bold, I think the answer still is “we don’t know”. I am drifting towards Attia, simply because he has dialogues with the people who writes the articles, and have lifetimes invested in research, rather than concluding on a few studies.

@MichaelMerritt 2 жыл бұрын

@@iblisthemage That's fair and I also think Dr Attia is probably the better follow if I had to choose. Been a long time subscriber of his. Rapa is the only thing that is starting to convince me it may have life extension benefits in humans, but we'll see where the cards land in the coming years.

@iblisthemage 2 жыл бұрын

@@MichaelMerritt did Rapa for 3 weeks, preparing a 3 month “run”