Grignard to Alcohol Synthesis Shortcuts

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Grignard to Alcohol Synthesis Shortcuts - Aldehyde, Ketone, Ester

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Leah4sci.com/G... presents: Grignard to Alcohol Synthesis Shortcuts when reacting with formaldehyde, aldehyde, ketone and ester
📺Watch Next: Organometallic Reagents and Reactions • Organometallic Reagent...
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: leah4sci.com/o...
Grignard reagents are useful for chain elongation of carbonyl compounds in organic synthesis and retrosynthesis questions.
This video will give you tips, tricks, and shortcuts for predicting the specific alcohol products of Grignard reactions with aldehydes, ketones, and carboxylic acid derivatives such as an ester.
You’ll see a quick overview of the mechanism for each of these reactions, with an emphasis on the similarities and differences between the alcohol products, including degree of substitution and symmetry.
Finally, you’ll learn a shortcut for predicting which Grignard reagent was used, when given the product, in a retrosynthesis.
↪ Links & Resources Mentioned In This Video ↩
▸Grignard Series + Cheat Sheet Leah4sci.com/G...
▸How to Tackle Organic Chemistry Synthesis Questions Leah4sci.com/s...
▸A Simple Approach to Retrosynthesis Leah4sci.com/r...
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⏱ In this video:
[0:32] Formaldehyde + Grignard Mechanism
[1:41] Aldehyde + Grignard Mechanism
[1:57] Ketone + Grignard Mechanism
[2:20] Ester + Grignard Mechanism
[3:57] Overview of Alcohol Products
[4:42] Retrosynthesis Examples
[6:16] Shortcuts for Grignard Retrosynthesis
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Пікірлер: 69

@ianchiwo3536 2 жыл бұрын

Thanks so much for making these videos. They helped me pass both orgo 1 and 2. The only way I was able to score a hundred percent on one of my orgo 2 exams was because of you and your videos. God bless you!

@Leah4sci 2 жыл бұрын

Oh wow, thanks for letting me know how much my resources helped you! I love hearing that I've helped someone to understand orgo. Makes my day!

@nadluxury 2 жыл бұрын

Leah thank you very much 😍😍 I’m a chemical engineer student and this spring semester I took organic chemistry and I watched all your videos about naming ,isomers , stereochemistry, reaction. ect…. you made me understand the subject so any question that came on a test or a quiz I could slove it easily thanks to you and I end up getting an A on in Organic chemistry 😍😍 you are the best orgo teacher ever… all my other friends just memorize or memorize the answers of previous exam because our professors repeats the exam but in this semester he changed everything thing and brought new questions but I was just doing fine because I understand and no matter what he brings i can solve it😍

@Leah4sci 2 жыл бұрын

Oh wow, thanks so much for sharing this! I'm thrilled to hear that my resources helped you to understand the concepts and put them to use!

@SergeantTeabag Жыл бұрын

I just started the second semester of organic chemistry at a different institution from the first, and there was a large gap in information between my previous semester and my current one. This was not covered in the first but is expected to be known at my current school. Thank you so much for what you do. This made learning about the purpose of Grignard reagents much easier.

@Leah4sci Жыл бұрын

So glad to hear it! You're welcome. For even more help with topics like this, I recommend joining my organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

@emilyh3644 2 жыл бұрын

Thanks Leah! I have on a quiz on this topic this week, perfect timing.

@Leah4sci 2 жыл бұрын

Perfect timing Emily! glad to help

@anishuuku. 7 ай бұрын

You helped me so much through out my semesters, Thank you!!!😊

@Leah4sci 6 ай бұрын

You're so welcome, I'm glad I could help!

@priscillaowusu7681 2 ай бұрын

God bless you and grants you more wisdom

@Leah4sci 2 ай бұрын

Thank you!

@siladolcevita Ай бұрын

Thank you soooo much for your video ❤

@Leah4sci Ай бұрын

You're so welcome!

@amdigousfish 2 жыл бұрын

I just took my exam on this hahaha I was looking all over your channel for this oh well coming up though are carboxylic acids and their derivatives, alpha carbonyl, conversations, lastly amines I always tell me friend to go watch leah4sci

@amdigousfish 2 жыл бұрын

Condensations

@Leah4sci 2 жыл бұрын

At least you'll have it for finals? ;) I have quite a few of the other topics mentioned on my website/channel and even more in the orgo study hall here: leah4sci.com/join

@Grace_moon_ 2 жыл бұрын

Mam you are the queen of organic 😘😘🥰 thanks

@Leah4sci 2 жыл бұрын

Awww thanks! You're very welcome!

@Cursed.alpha97 2 жыл бұрын

Amazing 😃🤩....thanks..Cheers from India!

@Leah4sci 2 жыл бұрын

You're very welcome

@arunvenkit5373 6 ай бұрын

super helpful!

@Leah4sci 6 ай бұрын

Glad to help!

@strugglingcollegestudent Жыл бұрын

Thank you!

@Leah4sci Жыл бұрын

you are welcome

@niloofarkh4779 Жыл бұрын

a thousand times thank u

@Leah4sci Жыл бұрын

you're very welcome

@zainabarora9389 2 жыл бұрын

A compound when treated with Zn in methanol , the alkene is formed.when alkene is formed acetaldehyde is formed as major product .Explain reactions ,give name and structure of the compound?

@zainabarora9389 2 жыл бұрын

Sister plx answer this question..

@Leah4sci 2 жыл бұрын

I'm sorry, but I don't offer tutoring over social media. For help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

@ayayaayaya1845 2 жыл бұрын

I was watching your aldol condensation video and this video popped up XD

@Leah4sci 2 жыл бұрын

perfect timing?

@ayayaayaya1845 2 жыл бұрын

@@Leah4sci yupp!!

@Leah4sci 2 жыл бұрын

@niloofarkh4779 2 жыл бұрын

U RE THE BEST

@Leah4sci 2 жыл бұрын

Aww thanks!

@tinimeshack2242 2 жыл бұрын

What is the product formed when i carry out oxymercuration-demercuration hydration of a benzyl methyl ketone like 1-phenyl-3-butanone?

@Leah4sci 2 жыл бұрын

@svnspell6709 3 ай бұрын

Can i know why OCH3 is a potential leaving group?

@Leah4sci 3 ай бұрын

O- can exist in a negative solution and so the grignard can kick it out in a base

@svnspell6709 3 ай бұрын

@@Leah4sci thankyou!

@varunvarmanadimpalli7968 2 жыл бұрын

How do we decide if something is a potential leaving group or not??

@Leah4sci 2 жыл бұрын

Great leaving groups are stable and usually neutral when alone in solution. For more on what makes a good leaving group, you'll want to visit my Substitution-Elimination series at Leah4sci.com/Elimination Or, you can join us in the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

@varunvarmanadimpalli7968 2 жыл бұрын

@@Leah4sci Thanks a lot.

@nguyenhoangphuc9782 Жыл бұрын

Please help me !! Why grignard only tent to 1,2 addition ? When it also can 2nd attack both carbonyl and double bond ?

@Leah4sci Жыл бұрын

For more on the Grignard reaction, visit my complete Grignard tutorial at Leah4sci.com/Grignard For additional help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

@SMM-xg7dn 2 жыл бұрын

Can an R group denote a hydrogen atom? If I see R1 and R2 etc does this mean two different functional groups or could they be the same? What about R groups attached to rings? Thanks Leah I use your videos a lot for gamsat prep

@Leah4sci 2 жыл бұрын

I have a video on functional groups that talks all about the 'R' group, see it here: leah4sci.com/functional-groups-guide-organic-chemistry-drawing-naming/

@selmasamir1867 2 жыл бұрын

Hi there! İ've a q, i hope you could reply me! H3C-C(triple b.)C-CH=C-CH2-CH3 | CH3 What' s the name of this structure? Btw. thank you for every info.♥️

@Leah4sci 2 жыл бұрын

That question is outside of the scope of this video. Since I don't offer tutoring over social media, I recommend joining the organic chemistry study hall for help with this question and more. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/ You may also find my complete Nomenclature Tutorial Series at leah4sci.com/naming

@phanikumarm697 2 жыл бұрын

pls make video on suzuki coupling..

@Leah4sci 2 жыл бұрын

Thanks for the recommendation. I post free videos as I have time and am always looking for suggestions. For more help with this topic in the meantime, contact me through my website: leah4sci.com/contact

@phanikumarm697 2 жыл бұрын

@@Leah4sci Thanks for your reply...

@amanagarwal3327 2 жыл бұрын

can you make videos on inorganic chemsitry???? please suggest me any good channel with great explaining like you.... metallurgy salt oxides mechanism.... are very difficult.... I don't want rote learning.... proper explanation......🙏🙏

@amanagarwal3327 2 жыл бұрын

I am preparing for jee advanced exam.....

@Leah4sci 2 жыл бұрын

I'm currently focusing on MCAT videos including some inorganic on my other channel

@layankassas4877 2 жыл бұрын

you're amazing

@Leah4sci 2 жыл бұрын

Thank you!

@princedavid5067 Жыл бұрын

Thanks for making chemistry feel less devilish 🙏🏾😅

@Leah4sci Жыл бұрын

you're welcome! :)

@amanagarwal3327 2 жыл бұрын

Why sodium thiosulphate good reducing agent?????

@Leah4sci 2 жыл бұрын

I don't believe this video covers sodium thiosulphate. At which specific point in this video do you have a question?

@amanagarwal3327 2 жыл бұрын

@@Leah4sci I have question related to my book... Not this video.... Please answer that... It will help me a lot...

@MrGerdbrecht 2 жыл бұрын

Dear beautiful: I like your videos, but there are so many of them, and topics that i kinda loose oversight in the information ocean. Would you add some index, toc, some index numbers to the video titles or so? Thx in advance. Have a great time.

@Leah4sci 2 жыл бұрын

Do you mean in the individual video, or for all my videos? An index of each video is in the description, and for a list of all of my orgo resources, check here: leah4sci.com/syllabus

@MrGerdbrecht 2 жыл бұрын

@@Leah4sci Hi, the sylla bus page helps i think. Need some time to work it through. Thanks cutiful.

@phanikumarm697 2 жыл бұрын

nice madam...

@Leah4sci 2 жыл бұрын

Thanks a lot!

@phanikumarm697 2 жыл бұрын

madam, pls requesting u.make videos on C-C bond formation reactions...like suzuk coupling.etc..