Heme Catabolism and Degradation Pathway

Heme Catabolism and Degradation Pathway - Biochemistry Lesson

Рет қаралды 136,881

7 жыл бұрын

Video lesson on catabolism and degradation of heme from hemoglobin during red blood cell (erythrocyte) hemolysis in a powerpoint, university-styled lecture!
Hey guys! In this video I (attempt to) simplify and explain the heme catabolism pathway in a (hopefully easy) step-by-step lesson! I first start by explaining basics of the physiology and function of a red blood cell (aka erythrocyte) and that hemoglobin is released from red blood cells during degradation or hemolysis. I next explain hemoglobin is taken up by the reticuloendothelial system (white blood cells like macrophages) and converted to heme. Heme is then converted to biliverdin and then bilirubin, and the iron moiety of heme is stored in ferritin and hemosiderin in white blood cells. From here I explain step-by-step bilirubin metabolism in liver hepatocytes, conjugation and incorporation into bile in the gallbladder, conversion to urobilinogen and stercobilin and urobilin in the urine.
I also discuss the enzymes required for each step of the heme catabolism pathway.
At the end of the video, I also provide quick facts regarding erythrocytes, hemoglobin, and bilirubin and the clinical "standard" lab values of blood serum bilirubin.
If you find this video helpful, please like and subscribe for more lessons like this one!
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

Пікірлер: 74

@marihanbadr1271 5 жыл бұрын

this seamlessly summarized an hour long lecture. God bless you sir

@Soujyam 4 ай бұрын

Ah. Such a relief. Learning biochemistry can't be more clearer than this.

@raphaelmalpica401 6 жыл бұрын

If you go to First Aid USMLE Step 1 and get to this section all I read was blah, blah, blah. But with you WOW!!! Thank you!!! You made it so much easier to understand. After 12 years practicing as a general surgeon in Mexico and now having to take my steps its not easy going back to basics. Gracias!

@sofiaaa3346 5 жыл бұрын

haha!!! ur "blabla" made my day

@laurenwright6640 5 жыл бұрын

I'm a 1st year medical student and I REALLY ENJOYED this video! you did a great job! Thanks so much!

@LolLol-dj4uk 4 жыл бұрын

I'm a second year med student i found very useful to understand the basic mechanism and to get familiar with the terminology thanksss

@hasnainbangash4832 3 жыл бұрын

i m not a person who usually visit comment box but your effort made me do so. doin gr8. stay blessed sir

@savannamoody4870 3 жыл бұрын

Dang finally someone who can explain this in a way that makes sense!! You're a lifesaver bro. Great vid

@ASHCASH499 3 жыл бұрын

This was by far the most easiest video made on bilirubin metabolism.......loved how simply sir explained it❤❤❤

@theboutique1 Ай бұрын

I am studying a+p and this is a little more in-depth than we need to know but actually super interesting

@bushrai.n401 4 жыл бұрын

i love the extra info that you added sir. thankyou it was very helpfull

@nikhitakumar 29 күн бұрын

Excellent guide and video !!!

@_6q.171 5 жыл бұрын

Thank you so much .. that helped me alot!

@mesangialcells6635 4 жыл бұрын

This is really helpful. Thank You ☺️

@admorgz 6 жыл бұрын

Great video, thanks for that 😀 👍

@f2slide21 6 жыл бұрын

Thank you for this video, sir.

@drswetaruparel 4 жыл бұрын

Very very very helpful videos !!! 👍

@wahmfarad2719 2 жыл бұрын

Thanks sir from your video my confusion is clear now.

@BrookeAshleyTaylor Жыл бұрын

Awesome! Thank you!

@Medicwordoftheday Жыл бұрын

I really appreciate the class

@shaimakhalid6178 2 жыл бұрын

this is awesome !🤩👏

@ramchandrasuthar2848 2 жыл бұрын

GREAT ANALYSIS SIR 👍 👏

@miriamespinogonzalez6688 3 жыл бұрын

Thank you it was awesome!

@Roger-hu4tk 3 жыл бұрын

Thank you so much, much appreciated

@westwoodoralsurgerydentalgroup 4 ай бұрын

Amazing!

@saeedqasem2877 Жыл бұрын

perfet ,keep it up man

@ismailali6346 4 жыл бұрын

You're the best!

@atmdiary9940 2 жыл бұрын

Thanks for this video!!

@david_greatx 2 жыл бұрын

Thank you , a summary of 3 hour class

@circlez3762 5 жыл бұрын

the discoloration of the bruise was questionable to me ! thank you for your simple explanation and the interesting information

@habibmohsin01 Ай бұрын

Thanks sir that's was really awesome

@teambunny8382 4 жыл бұрын

Tons Of Thanks 😍

@sct.temitopeo.a8713 Жыл бұрын

Helpful, thanks.

@prasannagnanasekaran9596 Жыл бұрын

Thank you so much❤️

@Mati_bm 2 жыл бұрын

Very helpful thank you 😊

@andrefranciscocoutodias3663 3 жыл бұрын

Thank you for the nice lecture! I love your videos and really learn a lot from them. Maybe you could answer these questions I got regarding this topic. From what I've gathered, bilirubin is metabolized in the intestine bacteria who unconjugate bilirubin and it goes back to its original structure. Then they metabolize bilirrubin down to urobilinogen and then it is either excreted as stercobilin or reabsorbed and only some of this reabsorbed part is excreted in the urine as urobilin. So I have 3 questions: 1 - Why is only urobilinogen reabsorbed? (i.e. in the absence of obstructive jaundice, there is never conjugated bilirubin in the blood unless there is backflow of bilirubin from the bilicanaliculus down to the common bile duct; and to the best of my knowledge we can't reabsorb unconjugated bilirubin and its metabolites except urobilinogen). Presumably, unconjugated bilirubin is not able to diffuse tissues despite being unpolar because it's too big but do we have a specific receptor for urobilinogen? 2 - Why don't we excrete stercobilin in the urine and urobilin in the stool? Is there different enzymes for both that are differentially expressed by bacteria and human tissues? It is also interesting that we seem to be able to metabolize urobilinogen into urobilin but only bacteria can metabolize conjugated bilirrubin down into urobilinogen. 3 - What pathways do we use to transport and metabolize urobilinogen back into conjugated bilirubin in hepatocytes? (Because although human cells cannot produce urobilinogen, it is well recognized that through enterohepatic circulation, the majority of urobilinogen reabsorbed via the portal system is reconverted into conjugated bilirubin.)

@lwazishabalala730 5 жыл бұрын

i feel like you should have specified when and how bilirubin becomes unconjugated to being conjugated instead of just using bilirubin throughout the video, but thanks the video was helpful

@ananya5536 Жыл бұрын

Very helpful♥️

@kikibear12146 Жыл бұрын

Great video!!!!:))))

@shahabuddin6149 3 жыл бұрын

Great information thanks

@nutritionandlifestyle890 Жыл бұрын

Good presentation

@user-rr7yo6zh6c Жыл бұрын

Perfect,thank you

@aliyahjownally6460 3 жыл бұрын

Thank you so much!

@reema3496 2 жыл бұрын

Cool!!! Thank you so much

@cavanz7397 2 жыл бұрын

woooow.... thank you very much

@shahedelnadjar3144 3 жыл бұрын

Really good video

@aminhamoodizadeh4055 2 жыл бұрын

great.god bless you

@Staytruebeing 6 жыл бұрын

Thnx for ur hlp...

@komaldiptianandmaisuriya4301 3 жыл бұрын

thanks , it was great

@athiram2572 6 жыл бұрын

Amazing

@yoe91 4 ай бұрын

Your videos remove the imposing/intimidating dimension of biochem and just go straight to the point where it's easy to follow each step without forgetting all over what each moment was about.

@Mahdi-xk7ib 2 ай бұрын

it helped thX❤

@noha1878 5 жыл бұрын

Thank you.

@veronikadolgushina165 3 жыл бұрын

This video is a very informative and easy to understand. Thank you very much.

@jjmedicine 3 жыл бұрын

Glad it was helpful!

@laylaalghizzi1391 4 жыл бұрын

that was great

@olamohamed5811 4 жыл бұрын

thanks a lot

@nada-bp2is 3 жыл бұрын

Thankkk youuuu

@user-fc3it9sg4x 5 жыл бұрын

In 6:15 you mention that bilirubin is oxidize to urobilinogen but its reduced and not oxidize.

@ruthe6017 8 ай бұрын

Thanks

@wahmfarad2719 2 жыл бұрын

Dear JJ Medicine Your way of explaining is marvelous, from your video my confusion is cleared now , but kindly please tell me that from where you read this text that ( when RBCs/Erythrocytes disintegrates/ ruptures / splits then hemoglobins hemoglobins will be comes out from Erythrocytes) I mean say that please sheer book name / website address because I want reference because from your video my half work is done but half will be done after attain reference . Regards wahm farad

@aburaihansarkar2105 2 жыл бұрын

I try to deliver hemin through nanoparticles form to kill cancer cell....but it does not induce toxicity. Why it does not induce toxicity in the form of nanoparticles form????.. Please reply