UPDATE 6/5/2020: This study was RETRACTED! Here's our followup video: kzfaq.info/get/bejne/oNiKf6yXy9ayp3U.html

The fact that HCQ stops viral replication is the main reason why it should be given early before the cytokine storm resulting from the increased viral load can cause pneumonia and lung damage. The studies in France showed that it worked only in the early onset of symptoms. It was never asserted it would work on very sick patients. Yet we see studies being done on very sick patients with the conclusion that it doesn’t work.

If you’re looking for an unbiased, intelligent, medical opinion, you won’t find it here.

NYU Grossman School of Medicine trial, 932 patients. Group 1: hydroxychloroquine + azithromycin. Group 2: hydroxychloroquine + azithromycin + ZINC. The group receiving zinc was 44% less likely to die than the group that did not receive zinc. This study was also done on an appropriate patient group, unlike the VA study which apparently gave the drugs (without zinc) to patients who were about to die.

You completely missed adding Zinc to the treatment plan. You were a bit quick to tape this one before completely doing the research. Nurse Kitty would be sad.

the Lancet study failed to give the anti-virals EARLY in disease progression. That is key. Anti-virals are TOO LATE to give when they’re admitted to the hospital !!

Don't forget zinc

My wife’s hospital has used it with great results.

Why didnt you mention the zinc? The zinc is the active components so other experts tell us. You are a really skilled presenter, very intelligent and so convicing, and us less clever people want the cleverest to simplify this situation so we can understand it. Why not mention the zinc?

I’m confused. A-fib happens at double the standard dosage. Does the drug not work with the regular dosage??

why they ignored early treatment including Zinc.

HCQ was given much more to those with advanced symptoms in that crappy retrospective study. HCQ benefit is very early in the infection & side effects are minimal. HCQ risks for arrhythmias is obviously very high in very sick patients & should not be used. Many CV patients with advanced disease have cardiac involvement. Show me the data actually quantifying the arrhythmia risks with HCQ......there is none. Don’t give to cardiac pts, or people on other QTc prolonging meds, but there’s no evidence against giving to others early in CV disease course especially when other treatment options are minimal. Ridiculous

As a sixty year old mildly obese diabetic with hypertension, I had a patient cough in my face while not wearing eye protection. A week later I felt like dying and seemed to develop severe CHF... I tested Covid positive and immediately started Zinc, Hydroxychloroquine, and a z-pack. By the third day I felt fine. Whether this was its normal outcome or even a placebo effect doesn't matter to me. Today I'm watching Med cram videos and taking more vitamin supplements than ever (with quercetin and NAC thrown in for good measure). Despite You-tube editing these responses, I'm a firm believer in my own outcome.

The best thing about your dishonest video is that your comments section got bombed with people leaving a lot of links about how well it works when used correctly. The sources cited throughout the comments are way more informative than your video.

Waiting for a chiropractor to chime in on this

I have bad arthritis and my rheumatologist has had me on Plaquenil (aka Hyrodoxychloriquine) for years, I was surprised when I had my latest check up with him via phone 2 weeks ago and he said it's a good thing I'm on that drug, it "might" make surviving Covid-19 less severe for me, God forbid I got it... which, of course I'm trying to be super careful, staying home as much as possible etc, but then he reminded me as he always does, to make sure I'm getting my eyes examined, apparently that's one of the risks I don't hear many people talking about, with this drug, in a small percent of people, it can cause eye issues... I imagine in higher doses, it's even higher risk? but still better than death i suppose, thanks for keeping it real ZDogg, always enjoy your candor :-)

So what about a study that actually introduced the medication before it was well too late?

How’s that Lancet report now ZDogg? Makes you wonder about the sources you get your information from?

Dude I share your videos regardless of cursing. The information is important.

Good review Dr ZDogg. I look forward to these overviews to keep the rapidly accumulating & changing info on this pandemic in perspective. Great public service at an extremely critical time.

Thank you! I've seen other videos which have tried to explain this issue in a factual, unbiased way and yours is up there with the best of them ... video shared immediately!

Z your great at explaining things in layman's terms, definitely a useful video to the public too!

I was thinking about Dimox, can we use that??

Trying to explain as a pharmacist that these are not inherently safe, risk free drugs has been the bane of my existence for the last few months. 🙄

Have a fear of needles. I would prefer Hydroxycoiquine with z pac. Is it available how can I find doctor to support or provide these meds.?

Gotta take it with zinc.

I have seen more good evidence for hcq and zinc than remdesiver. The experience of police in india showed some evidence of preventive use.

Thank-you for helping me understand this issue better.. I'm glad to have more information to be able to think for myself..

Don't forget the zinc.

"(...)Lancet did a study(...)" LOL, that aged well

THANK YOU. Good presentation. How does Zinc Sulfate effect the study?

Is hydroxy currently being administered in the US? How about something on Vit D

Thank you for giving us the full information on this!

The doctors who are saying it works say you need to give it to patients within either 5 or 7 days from start of symptoms. On average people enter the hospitol with covid on day 12 of symptoms. So for this treatment to work they say that you need a different treatment strategy and recomend it be given by doctors in outpatient setting early to patients who still only have mild symptoms. There is data comming out froma US study to this effect and the French data is already available and being published as well.

Thanks for explaining this

The paramedic in me went mmmhmmm R on T.... Out loud... My kids were very confused at my random outburst

My question- unless I’m missing something- if it gives these symptoms at high doses, why were patients given what I’m told is TWICE the normal dose? If I’m misunderstanding something, someone please fill me in.

The parties that advocate HCQ always add zinc to the regimen. Zinc was omitted in this study. Why?

My first thought is, it sure is weird that they showed that chloroquine produces fewer arrhythmias than hydroxychloroquine. Then while reading i found that the antiviral baseline showed a benefit (most common baseline antiviral was kaletra/ribavirin combo..uh oh NEJM lol). I’d also like to point out that clarithromycin prolongs the QT interval more so than azithromycin and azithromycin states in their PI that the combo with hydroxychloroquine prolonges the QT ~10ms more than azithro alone (small potatoes). Now, since people in the treatment group died like twice as much as the control group and were vented way more often, i dare to say that i bet that most of these arrhythmias were probably due to increasing pressor needs prior to expiring or failure to oxygenate. It would have been nice to see QTC measurements, pressor requirements, and if the patient was even on the treatment drug at the time of the arrhythmia ;). Providers prior to COVID19- who needs QTC monitoring with hydroxychloroquine... Providers after COVID19- oh my gosh people, why do you not have continuous QTC monitoring on this patient? Meanwhile another patient on sotolol, levaquin, methadone, diflucan with a crcl of 30 without qtc monitoring, no one bats an eye lol….j/k🤔🤔😉😉🤣😆😅😝

No mention of T cell modulation and reduction of IL6 in early course prior to cytokine storm or did I miss your take on that?

What I don't understand is why there has not been warnings's for Lupus patients and people who take it for malaria?

Thank you! (Pharm.D)

Interesting, because this has been prescribed as a travel medication to prevent malaria for 60 years and for lupus for many years also. It is the 128th most prescribed drug and in all that time no one stopped giving it, because of possible heart issues. I also understand that if you are to the point of being extremely sick, it is too late for Hydroxychloroquine and it should be taken right away from first symptoms to be effective in preventing the more severe symptoms. I would totally take it if I got diagnosed with Covid 19.

Very good info

Thank you for saying what the pharmacists have been saying

Cardiac arrythmias in addition to the increasingly observed cardiac symptoms of younger COVID-19 patients? Please expand on that for the non-medical public.

What about vitamin D deficiency as comorbidity. Do you know of any studies on that?

I love your videos because you try to be as non bias as possible.

There have been numerous doctors who have reported positive outcomes, most recently Dr. Lozano in Texas. Do you have data to discount her results? What have you seen work in your treatment of Covid patients?

You never mention zinc with HCQ. I do appreciate that you pointed out some of the problems with the study, but not all of them. The data looks manipulated.

Thank you so very much for your informative videos! You restore my faith in humanity every time I watch! My all time favorite is the ICU vs ER report Memoji video. As a former ICU of 6 years l can say that comparison is SPOT ON!!! Thank you for that.

+Zinc?

What about giving antibodies to sick patients. Any studies on that?

Sadly even if good RCT's show no benefit there are those that will say it wasn't soon enough or there wasn't zinc and on and on and on we will go because this got overly politicized from the beginning

Anybody remember Seldane? IIRC that was associated with Torsades. No free lunch when it comes to meds.

Thank you for this video! Much love! ❤️

Evidence-based medicine, ftw!

Thanks doc, my patients are requesting this medication and are not accepting that it can cause them more problems.

The question lately is will the randomized studies be taken to completion or stopped. A minimum of three anti-virals are needed to be effective. There never has been even one anti-viral for any type of corona virus. It would be a travesty if this comes up short for covid-19 because one drug was blacklisted.

Hey doc try reading the Yale paper that came out this last week. You might want to revise your video.

Found you on facebook videos some times ago.

Most generic brands are junk. No studies disclose the brand used. Either brand plaquenil or the authorized generic from Prasco are superior. Really difficult to get right now do to short supplies.

The second half of this video is what most people have been missing. It's not that hydroxychloroquine has been disproven as a therapy for COVID-19; it's that the blinded randomized controlled trials have not yet been done. And the value of future trials of that nature will be at least partly dependent on how many variables they can manage to control for, and whether there are any "blind spots" in the data.

The problem is that, if you can get laws passed by presenting supposedly scientific studies to juries or policymakers who might not know any better, then it pays to cherry pick data. That's why people are fighting about chemistry

The results of the Lancet trial are "too good" for the drug companies. In particular the purported increase in heart arrythmias using hcq is too large to be believable. The study reeks of bias. The authors of this study are endangering public health and should be investigated and face criminal charges.

I love the video. And I totally agree more and more studies need to be done to see better data come through as time goes on. Seeing that the majority of studies being done with HCQ are showing patients who are in pneumonia phase take the drug (later stages of the virus) completely show no signs of recovery. It's been proven it does pose a risk and it's an utter fail. Plus the fact they are given a higher dose which is basically a last resort next to a ventilator. Smaller studies from NYU show that a combo of HCQ, z-pack and zinc can decrease the death rate close to 50% which is a marvel to say the least. What's tough with the virus is to catch and administer the HCQ, z-pack and zinc early on, even before symptoms appear. The general study of HCQ used as a Prophylactic will really be a huge eye opener.

This aged well....

Finally, someone who makes sense apart from Zelenko. You're good doctor, I subscribed. We need to explore adding zinc and using quercetin in place of hydroxychloroquine. Quercetin is another ionosphere. If the dose is the problem with hydroxy , then why not just half the dose, the same dosage prescribed to Lupus patients instead of "pausing" studies as the WHO did?

I'd love to see a podcast with you and Joe Rogan.

Right on! Balanced.

Do a song about a patient with Situs inversus totalis, and nobody figured it out after numerous tests

subtitle,please

With Zinc is the key for successful outcome but who knows 100 percent

How do we get you on the Joe Rogan podcast? You would be a perfect guest.

What’s up, doc? Good video! Very much appreciated! 🙂👍🏻

🗣Thank you so so much for your honesty and giving people life saving advice that is coming from a caring and trustworthy person who will not lie like so so many do who are put on all major media platforms to get all the public to believe the bear faced lies they are telling,, so thank you for helping us know the truth..🤕🤧🤮👏👏🤝🩺🧬💊⚕

I can understand people are looking for a cure, what I also understand having taken hydroxychloroquine for Lupus for 10 years is that this drug takes some weeks to build up in your system. Giving it to a person that is already very ill with COVID would probably not be helpful & dangerous at high dosages. Maybe with the studies they are doing on prophylaxis it may be proven to be helpful, having said that it would mean everyone would need to be taking it, so that’s another problem.

Yeah we will need the studies, but there seems anecdotal evidence from multiple places that shows that hCq needs to be coupled eith zinc and administered very early.

Levaquin almost killed me.

I'm glad you made this. I shared it to my Facebook to hopefully keep people from trying to get it to prevent infection

ZDoggMD - the Lancet study didn't explain why it excluded patients receiving remdesivir. Why is that? Do you know why?

I’m very disappointed in you ZDogg. You sound thorough, as usual, except I’m aware of information you’re leaving out. And I’m not talking about wacky stuff from political sources.

Interesting critical review of a Lancet published study which is indeed needed - thank you for this post. I see what Prof Didier Raoult in Marseille France is doing, generally great results with this general class of drugs and the man is still being crucified for his sucessful method of treatment. Politics indeed need to be kept out of science.

Great explanation....given that how is it that the physician for the Commander in Chief would perscribe this med? Isn't that verging on quakerly, or if that is too extreme, at the very least dangerously irresponsible?

I am a doctor. I listen to this guy because he is speaking like a real doctor. You can pretty much trust everything he says. At least what I've seen so far

Reason and rationality simply does not work for a LARGE population subset. Why?

My friends only watch vids with the F Bombs....lol Chubby emu covered what happens when you self medicate with these kind of drugs. Guess what? It was really bad! Thanks for sharing the science and explaining the results of taking them.

Anadotal evidence is very high dogg. I’ve used it in many patients with dramatic results.

The Lancet did a study...that’s hilarious.

That doesn't bode well for your esteemed leader, who doesn't look at all healthy.

Shock paddles dont work in real life? HMM I have tons of ICU nurse friends that have shocked people back into a good rhythm almost daily. This single comment makes me question anything you have ever said.

Like you said, too many will push this aside because it doesn’t fit their political narrative. It’s honestly sad that our politics (right and left) have gotten to the point that we’ll believe or disbelieve a drugs effectiveness based on what a politician says about it.

You’re not nor did the Lancet talk about the protocol involved in using it on covid 19. By the time the trials are done many people will have died.

Thank you - this is a great rational and comprehensive description of this drug - most of the info on this circulating in social media is just opinion and dubious observations, mostly politically motivated.

Please lost your sources, I would have to.

See the channel Peak Prosperity for a factual evaluation of the Lancet study. A very sloppy study. It is eye opening.

Came here looking for unbiased opinion. Wow. You said all trials were in vitro except ONE SMALL STUDY. Didier Raoult, Frances premier microbiologist has successfully treated over 3,000 patients with HCQ. You tell us to look at all data critically and you completely ignored your own advice. In-F-ing-believable.

Let's talk about Dr. Risch from Yale... Look him up... How about Dr. Ford's study that has already been peer reviewed?

THANK YOU!!! The well known Prolonged QT Interval side effect of these medications, alone, is one of the biggest reasons that my Elephant threw me in the dirt, and ran away when this combo got pushed as “the cure all”. I have an arrhythmia, and hx of Long QT. Azithromycin is one of the medications that exacerbates my QT, badly. I’ve shared multiple sources - (down to the drug pamphlets themselves) to inform people about the risks of a Cardiac Event, when I see someone blatantly & ignorantly pushing the combo. Honestly, I am, and have been genuinely concerned for the people who don’t know about these side effects, or that they have an unknown underlying cardiac condition, and are just going to take it because (__________) told them to. I am all for research, and correctly done studies; I’m not for the way the politicians, and media turned this into a circus.

Waiting until someone goes into the hospital is too late give HCQ. That is why those studies failed for late stage. HCQ works in the early stages. CDC's advice for people to stay home until they need to go to the hospital for treatment is lethal advice.