This 5-minute video features the 2019 to 2020 chair of the U.S. Preventive Services Task Force, Dr. Douglas K. Owens, providing an overview of the USPSTF’s 2019 final recommendations on HIV screening and HIV prevention. The video explains who should be screened for HIV and who should be offered preexposure prophylaxis, or PrEP. PrEP is a medication that substantially reduces the risk of acquiring HIV. PrEP is not for everyone, so it’s important that clinicians and patients discuss the important issues related to PrEP use, as outlined in this video.