How cancer therapy has changed over the years | Peter Attia and Andrew Huberman

Рет қаралды 12,116

4 ай бұрын

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This clip is from episode 286 - Journal club with Andrew Huberman: the impact of light exposure on mental health & an immunotherapy breakthrough for cancer treatment
In this clip, Peter and Andrew discuss:
- Has the metastatic cancer survival rate increased over time?
- How have cancer treatments improved?
- Flaws with the relationship between cancer treatments and their costs
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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Пікірлер: 43

@dm_podcast_takeways 4 ай бұрын

Peter Attia emphasizes that overall survival rates for solid epithelial tumors have remained at 0% since 1970, despite improvements in cancer therapy. He critiques the pharmaceutical industry for highlighting modest increases in median survival while charging high prices for treatments. Attia discusses the societal and patient costs, potential compromises in quality of life, and the dignity component in terminal illnesses.

@westfield90 4 ай бұрын

I’ve become very pessimistic about cancer. A decade ago with the over hyped promises of stem cells, check point inhibitors, immunotherapy, crispr I feel like none of them panned out and even worse now the whole industry and media overhype everything. Quality of life and going bankrupt for a few extra months is something never addressed by the field. If you are diagnosed with cancer you will in all likelihood die. I follow 5 young to middle aged people on KZfaq with cancer and within a few years of diagnosis, 2 have died and 1 will shortly despite having received every treatment. Oncology needs to do better. Siddarth mukerjee who wrote the amazing “Emperor of All Maladies” doesn’t think we will actually cure cancer in our lifetimes since we barely have identified 3% of the pathways in the body. We just don’t know enough.

@quantumfx2677 4 ай бұрын

Dostarlimab

@anthonylawrence5842 4 ай бұрын

I think a substantial part of the answer to cancer treatment lies in the realm of biophysics not biochemistry. The work of Prof Peter Gariaev and Prof Michael Levin is significant in this regard.

@jeremyvanced4731 4 ай бұрын

It's not about "will i ever get cancer ?", it is "which cancer and at what age will i get cancer ?" Putting people in placebo group for cancer cure, where does ethics has gone in medical research world ?

@morganaalexander8672 4 ай бұрын

Cancer placebo groups are not one group gets medicine and the other doesn't. They are all getting a combination of medications. One group is getting the drug being tested in their combination. Like, one group is getting what would be traditionally used for that treatment (control group) and the other is getting that plus the new drug (Test group). We need medical trials to see what works and what doesn't. Lots of drugs and methods have been tested, and the WAY testing and treatment happen is much better than the past. Especially when it comes to ethics. We have come a long way in cancer research and treatments - but we still have a hell of a long way to go

@nyguy5370 4 ай бұрын

Exactly - what if your quality of life is significantly compromised? In fact it is the case that the treatment can be worse than the disease.

@tinamccombs5239 4 ай бұрын

Why aren't we talking about those Metastatic patients that are still alive after 20 years? What about those that are no evidence of disease and without conventional treatment or a combo of conventional with alternative.

@Sunlightsam24 4 ай бұрын

@@tinamccombs5239 Good question…who’s going to do that work when almost every entity that might do that work if funded by big pharma?

@Sunlightsam24 4 ай бұрын

Sounds familiar with a certain virus

@nyguy5370 4 ай бұрын

@@tinamccombs5239 It is not a very large percentage of the total.

@my-4th-cancer 4 ай бұрын

we tend to be cancelled.

@lonnieraesmith2482 4 ай бұрын

Societal costs amongst costs to family and friends of cancer patients have paid dearly for decades. I especially despise the proclamations and promises for recovery--"you're cancer free now". Rarely is this the case for long. 😢

@LynneHamer-uv1fx 3 ай бұрын

Dr peter speaks the truth. I have rectral metastasis advanced. i only trust in god to help me in whatever way through this nightmare.

@vickybiagini8623 4 ай бұрын

It seems living past forty is detrimental. All our bodily functions start declining after age forty. Up until that age, we pretty much feel on top of the world. We can live up to seven short, fast decades, which is depressing. Life is unbelievably short, and quick. We are all on the road to death.

@davidgrana1268 4 ай бұрын

Forty? damn i'm 32 and feel like shit already

@vickybiagini8623 4 ай бұрын

@@davidgrana1268 , It starts around 37

@marilyn6905 4 ай бұрын

Quality of Life vs Quantity is uppermost in my mind as I consider the pros/cons of starting a TKI INHIBITOR for progressed RAI Refractory Thyroid Cancer. Yeah or Neah...which path offers BEST quality of life longest...while acknowledging some inherent denial about how things will progress.

@TheBlueClaw 4 ай бұрын

Can someone explain what type of cancer they are talking about?

@meanredspider 4 ай бұрын

I’m not a doctor or an expert in cancer but I’m trying to understand “solid organ epithelial metastatic” cancers. Metastatic suggests that it has already spread from the original organ. I’m slightly sensitised to the suggestion that medicine hasn’t made much progress since two of my kids have had very different cancers (Ewings and AML) and both have survived (13 and 7 years respectively). The AML seems to have been very effectively treated by Gilteritinib (a pathway inhibitor) a very new type of drug. Neither cancer was metastatic. The Ewing’s was treated by some very advanced surgery (at the time).

@jillf4882 4 ай бұрын

Yes they are talking about metastasized cancers ie breast or colon cancer that has spread to other parts of the body.

@ladonnabellavillalobos9627 4 ай бұрын

can you tell me what this medicine is? They got me on makes me feel like I’m going through menopause and still bleeding a lot. They diagnosed me with uterine cancer but first they said I had endometriosis cancer but they put me on medicine. It makes me feel like I’m getting cancer. Can you tell me what this medicine is, MEGESTROL acetate 40 mg four times a day. I feel like I’m in labor I’m still bleeding I was diagnosed at the beginning of November. I believe I told him the problems I’m having with this and asked for by a denticle hormone bad.

@quantumfx2677 4 ай бұрын

Learn about Dostarlimab look into it.

@anthonylawrence5842 4 ай бұрын

But what about the quality of life - pain, misery and suffering!

@my-4th-cancer 4 ай бұрын

👌Curing is bad for business.

@gioponti6359 4 ай бұрын

I would hope it’s not: in our last decades we might have many different serious diseases, or a terminal one that takes our lives after few months, or a year

@morganaalexander8672 4 ай бұрын

A cure isn't bad for business. There are many different types of cancer, so it wouldn't be ONE cure. Plus, then it would be a much larger market - for everyone. And if 2020 taught us anything, it's that there will still be people who will turn down any new medications and want chemo/radiation/surgery. Plus certain chemotherapy drugs are used for other illnesses.

@pschotland 4 ай бұрын

I think you're confused about terminology. There is no such thing as median survival. There is median overall survival (OS), median progression free survival (PFS), median disease free survival. (DFS), etc. Which one does your paper discuss? If OS, then median OS *is* overall survival. They are one and the same. OS is measured as median time to death, typically from date of randomization, in the setting of an RCT.

@leannebryant9962 4 ай бұрын

well that wasn't very uplifting or encouraging. Neither are a lot of the comments. Feeling extra anxious about my mammogram results now. I don't know why I watch this stuff.

@audreymulvey4589 4 ай бұрын

There has been huge advances in breast cancer treatment and survival rates. I don’t know why I watch this stuff either… unsubscribing now

@jillf4882 4 ай бұрын

Breast cancer survivor 13 years this month. They are talking about metastatic cancers.