Remember there's no Nociceptors in your brain. That's why you don't feel you're brain cells dying while you watch reality shows.

gets foot stuck in bear trap carries on walking what a legend

currently 4am, took one, 200mg ibuprofen for a headache. got curious and searched up on how painkillers even work. was not dissapointed, 10/10.

Nothing is worse than a bad toothache..

I like this guy's animation.

0:40 that animation was so innocent and dumb I couldn't stop laughing at it

Is anyone feeling pain at the moment? Like that is the reason why you found this video? I got a twisted ankle :( while practicing parkour yesterday :/

who else cringed when the dude pricked his finger

Nature made pain to tell Man: "Hey, don't do that!" Man made painkillers to tell Nature: "Oh, believe me, I CAN do that."

my dad has tried to explain this to me a while back but he just went into too much detail and i never really understood it. these animations make it so much easier to comprehend. thanks!

This animation is fantastic as it is simple enough for anyone to understand what happens regardless of age or educations level. Well done again!

I learned more in 4 minutes than I did in 3 weeks of biology.

I have a pharmacology exam in 3 days. This was very helpful thank you !

I'm a grown man but when I stub my toe on a wall corner I curl up in the fetal position for 5 mins due to the pain.

No pain, no gain.

Really appreciated this, all knowledge should be this simple and comprehensive

that brain driving the car is one of the best things ive seen all day

If pain is meant as a warning system to protect ourselves and so we take care of the problems in our body, then how come women suffer pain (sometimes even great pain) when performing a perfectly normal bodily function such as menstruation? What kind of "warning" is that?

This is great! I am making a brochure about ibuprofen for my chemistry class, and I had to write one column on its mechanism. At first, I was reading articles that just made me want to give up. Then, I realized that Ted-Ed is here for a reason, so I clicked on this video!!!! This helped me SO much better than the near-impossible-to-comprehend articles which explain the exact same concept! I'm nearly done with my brochure and I feel pretty proud of it!!! Let's see if my grade thinks the same... 😉😉😉

1. Cox-1 and Cox-2 are always present in the body but they only work when damaged cells release arachidonic acid. 2. Yes, aspirin irreversibly blocks the enzymes that are already present in the body so new enzymes that are synthesized can react with arachidonic acid and cause pain. I hope that helps :)

Pain protects you from the world around you, and from yourself. Why did it hit me emotionally 🙂

Fell on my shoulder and haven’t been able to lift it cause it hurts so much. Had some ibuprofen and it worked so much it interested me. Here I am. Now I know how pain works and how these magic science pills work. So cool man...

At last, I know why do I sleep very well when having painkillers .Thank you ,George Zaidand.

Thanks for explaining in plain english and with nice visuals.

Simple , understandable and deliver the idea perfectly 👏👏👏👏💜💜 outstanding work thank you so much ❤

That guy's going to keep walking with that bear trap clamped to his leg and I don't think there's anything we can do about it!

"All pain comes from the desire of not wanting to feel it" Renato Russo

Awesome presentation , thank you !

This helped me understand my condition of fibromyalgia a little better. Of how it works more or less.

I love this animation! very simple and easy to understand. Good job!

Animations are perfect, huge thanks from Armenia

It's great how a 4 minutes video summarised a lesson of 60 minutes.. Thank you =).

"Through pain i gain strenght"

Who is watching this after taking a pain reliver?

THIS IS INCREDIBLE AND SO SIMPLY PUT!! THANK YOU!!! :D

If you are normal... Aw shit

Anyone else decided to search how pain relievers work, right after taking pain relievers?

I find if I go into a form of meditation and concentrate on the pain and the area it is in, I can reduce the pain. It's hard to explain but I try to imagine the pain, like the images in this video, and imagine calming them down and letting them float away, and it does seem to ease the pain yo some degree! Also I am often in pain as I have Fibromyalgia!

I have to thank you so much for the creation

thank u so much for this video. the animation was so easy to understand. very well done!

BRUV I just got that time of month pain on a whole other level

Can you explain why Ibuprofen works a lot better for a toothache than a stronger painkiller like oxycodone? I have a throbbing toothache and I regularly take oxycodone for another medical problem so I took 1 for my toothache and it did nothing so then I had 2 ibuprofen and the pain went away 20mins later.

Thanks so much for sharing ! Have a good night , good health and safety holidays ! 🤙

words of thank are not even enough to thank you !!

Adorei a explicação!

0:40 apparently that person is also deaf

This is such an entertaining and educative video. I effin love it.

i love videos like this, it makes me realize our human bodies are so awsome!!!

One thing that always was a mystery to me is when you have a minor injury such as a cut or scrape, you don't feel it until you consciously know you did it or physically looked at it. It has briefly covered at the end but not explained. Do we know why this happens?

Who else cringed at about 1:23?

Well explained. Thank you

awesome video, thank you very much

I was looking for 3:21 Thanks dude, I know this but just need a confirmation

Here because I went to a metal concert last night and I head banged my heart out, so now my neck is sore lol No regrets tho🤘🏽🤘🏽

Thank you for the explanation

Thank you so much, it's such a great video

So if aspirin permanently blocks COX-n, like for how long?

Cox entered the chat. I: lost.

Thanks for the lesson

Thanks a lot

I think this Talk could have had quite a bit more information

Is there some advantage to ibuprofen’s approach of not permanently deactivating the enzyme as opposed to aspirin?

Great explanation & visualisation

Wow such a deep research

This reminds me of when I was like 10 and I crushed a bunch of chalky ibuprofen, lined it up with the home phone and snorted it with a straw.

If we can understand pain, we can build artificial nociceptors which receive input from a simulated body, essentially emulating nervous stimulation in the simulated world.

Very very informative and excellently animated video......... Animations make knowledge more attractive.... I just love to watch Ted videos again and again........

Placed crown on my tooth ..next day chopped off half of my nail by a sickle and deep cut in finger. Took pain killer and was curious to know how they work. This was such an amazing video.

As a wise man once said, "Feel PAIN, Accept PAIN and Know PAIN...Those who do not know PAIN will never understand true peace." Guess he had a point.

Him: let's say your at the beach and you get sand in your eyes, how do you know it's there? Me: because you told us there was sand in out eyes.

thanks ted

Awesome lesson

“Doktor, turn off my pain inhibitors.”

Thanks for this video I was wondering how the medication knows where the pain is so it can fix it. Turns out it doesn’t and goes all around the body which is interesting.

i was always so interested and confused about this!!

Thank you for this very interesting video. I belive I now have a better understanding of how pain works.

As useful as pain is it would be nice to be able to stop it on cue in the event of a false alarm or such a time when damage cannot be prevented. Like how you can hold your breath up to a point but eventually you'll start breathing automatically again.

Anybody else here pacing before bed, waiting for it to kick in?

thank you so much :D i always wondered about that

Thanks. That was informative

When he started pushing his finger to the needle i screamed so loud...

Why is this video age restricted

Much love man!

thank you

I'm watching this sort of videos just for learning other languages using subtitles in the settings. Try this next time you're bored.

how does Paracetamol work ? what's the difference between Aspirin and Paracetamol

Thanks for the very informative video!!

oh great video, thanks!

1:37 nerve receptors telling body stops doing whatever you doing. 😂

Okay, now tell me why I felt pain when I watched the animation push their finger into the needle.

I just had an essay assignment on this subject due a few hours ago today This would've been so useful at that time

I love this animation!

Damn science, you're interesting!

How about stepping a lego?

Thank you, very interesting video.

Thank you for the info

Imagine laughing while being tortured.

1:04 I can't stop laughing

Sooo well described

Great video!! Thank you