Have you considered that the acid sensitivity is as simple as the basicity of hydroxide vs the basicity of fluoride? going from pH 6 to pH 5, you'd see a 10x drop in hydroxide concentration, thus reducing the amount available to remineralize into hydroxapatite. fluoride, however, is a weak base and won't start to protonate until the pH drops below 4ish (given that the pKa of HF is around 3).

I am a dentist and stumbled upon this post. Let me say that you did a wonderful job. Like one of the other correspondence, I too grabbed a toothbrush and brushed my teeth after viewing this post. You did ask for corrections and clarifications which is most commendable and thus I assume you follow scientific principles of getting things right. I ran this by a dental materials PhD. Here is his assessment of your explanation: "Apart from it being somewhat inaccurate, the topic is well presented. Fluoride has an anti-cavity effect, and the epidemiological evidence is good. However nobody knows precisely how or why it works. The solubility differences mentioned in the post is minute (x0.6). Fluoroapatite is not formed - CaF2 is. The solubility ratio is constant over a large pH range, and there is NO switch point: it is an artifact of bad data plotting and analysis. Do it right and the illusion vanishes. Tooth mineral is not Hydroxyapatite, but a biological apatite with many important differences. Remineralization is not actually true. The fact is, it is an embarrassment to the folks that work on fluoride that they cannot explain the exact mechanism. However we do know with great certainty that fluoride does reduce tooth decay and is safe in therapeutic doses." Please note that I offer this as a constructive critique. I highly regard the manner with which you attempt to explain difficult and complex biological concepts in an understandable fashion for the lay public. Keep up the good work.

I am a retired dental hygiene educator. I am working on a presentation for nutrition students on oral health as it relates to cariology, dietary counseling and saliva testing. In preparation I've been viewing a lot of videos lately and THIS is short, to the point, simplified science and awesome for visual learners. Thank you so much!

As a fellow biochemist, I love how you explain this stuff great job cant wait to see you make more!

here before this channel becomes the next kurzgesagt ;)

I’m glad you mention that over-fluoridated water can be toxic; while we know it to strengthen teeth, I‘d like to know more about what happens when it’s ingested.

This was so fascinating and the animation is really beautiful. Amazing video - can't wait to see your next one!

Amazing video, this explanation makes a lot of sense and I like the message in the end. Looking forward to your next video!

Gorgeous video, loved the final message

Your modesty and sense of humor make this already fascinating video even more lovable.

Amazing! Thanks for this video. It’s so easy to understand and learn about the different parts of the body. Can’t wait for your next video!! xx

Coming from a biochem grad student, this channel is awesome!! Keep up the great work!

That was fun to listen to. Thank you for compounding knowledge.

Amazing. Subscribing a minute in, because this is just so good.

so the exact mechanism of fluoride in tooth Health has been kind of an imponderable for me. this morning I finally decided to look on some KZfaq videos for answers. I was very impressed with the angle you take and describing the processes and understanding that the limits of your personal knowledge are not bounded and open to review as well as editing from your peers. good job!

Excellent content! Well done!

This was a great video! I just got my first huge cavity a week ago--dentist appointment is next week--and so I've been on an education binge on what to do to help treat it. You are exactly right that most coverage of the effects of fluoride end at just saying "do it, it makes your teeth stronger". That infuriates me to no end! I wanted to know WHY it works, and your video did an excellent job of clearing it up. I truly appreciate the work you put in, I'll be subscribing for sure!

Briefly about fluorine: the fluorine atom is small enough and has the highest electronegativity. As a result of the formation of bonds, the electron that took the fluorine is very close to the nucleus, and the screening effect is minimal. Therefore, it is much more difficult to expel fluorine from apatite than the hydroxyl group.

Earned a sub, great video.

So good quality!

I have a tooth that needs root canal and periodontal pockets. Every time I use fluoride toothpaste I get severe pain and inflammation, this doesn’t happen when using fluoride free toothpaste ever

Banging video. Made me brush teeth instantly. Subbed

great video!

very good just what I was looking for thankyou

Love this. Thank you!

This channel is finna blow up

Such an amazing show

Are you ever going to continue to make videos? Your content is wonderful!

this video was fucking great! solid information and well spoken!

This is gold

Wow awesome guy awesome script... Great

as a dentist, this is amazing. well done

First of all thank you for this useful presentation I really enjoyed the chemistry part but around fluoride may cause damage or discolored your teeth it may cause that if someones receive excessive fluoride systematically during tooth development stages so excessive fluoride in your mouth do not cause discoloration unless you swallow it at time where tooth are in develop stage before they erupt

thank you i learned alot from ur video .. would like to ask if u have topic related to fluorosis .. could u talk about it why we get the white yellow spot related to fluoride consumtion. thank u

Ive always used sodium flouride toothpaste twice a day, still have teeth problems. Im switching to stannous flouride toothpaste and cutting back on sugar to see if it helps strengthen my teeth

Could you cite any research that indicates or proves that ingesting the specific type of fluoride that we drink in our tap water? Also why did you seem to imply that it's the same kind that's in our toothpaste?

Dental health is power💪

Great Channel! Can see why John Green gave this a recommendation Subscribed for more Awesome Learning 😁 👏🏼✌🏽❤🙏🏽

Привет из Беларуси спасибо за это видео!

It's definitely that fluorine is super electronegative. That what makes Teflon never bond to anything, fluorine bonds more strongly than any other atom to the structure

Hi from Vert Dider!

Thanks for the info ! 👍 your very humble dude it's refreshing ✌

A huge thanks to the person who shared this video on reddit

Thanks for this video. I haven't looked this up, but I do have a PhD in Inorganic Chem. F forms really strong bonds. So, I doubt that F- (ionic) is the correct way to picture the compound. F is ionic in some salts but my guess is that P-F (covalent) is a better representation. These days PFAS (also known as forever chemicals) are big in the news. C-F bonds just don't break; hence, the "forever" nature of these compounds - produced only industrially but now found everywhere from penguins to polar bears and everyone in-between. P-F bonds are more stable than P=O or P-O bonds under mildly acidic conditions. Incidentally, HF was featured in the show Breaking Bad as a way to dissolve human bones although I doubt aqueous HF would dissolve a whole human quickly if at all. Gaseous HF is highly toxic and should be handled with great care.

Could other ions (strontium, chloride, heck- uranium theoretically) be used to replace the OH in apatite for an even more acid-resistant matrix than fluoride? Why don’t we use other ions besides fluoride?

Best biochem channel right now. Perfect animation, informative and just, so sexy. This will blow up soon.

03:35 is posible to make this font smaller? :)

So why not use Hydroxyapatite toothpaste instead of Fluoride?

I use miswak never had toothpain since.

Has this channel finally been blessed by the almighty algorithm? I hope he starts uploading again!

What about streptococcus salivarius m18?

What if you don't eat carbs and eat lets say, meat instead?

Does fluoridated water turn your teeth yellow over time?

It bothers me how the woman is brushing her teeth incorrectly with that electric toothbrush!!

many yt vdo about whitening teeth using vinegar, baking soda, etc.... wonder what damage they would cause to teeth?

I never brushed with toothpaste before, lol i guess i should start doing that

Your website links say Website Expired

I wonder if the fluoride has to be applied topically for fluorapatite formation, or whether there is also some mechanism whereby ingested fluoride is transported from the digestive system back to the mouth. It seems like this is part of the claim of water fluoridation advocates

No more videos :( ?

thnks from Kiev

U could have explained why stannous fluoride works so much better than sodium fluoride.

Are u a researcher?

naaaaaooo so tem 12 videos nesse canal 😭😭😭😭😭😭

I wonder about fluoride in toothpaste, I feel just not eating sugary foods would be better.

6:20 me too I cant find a definitive answer

Got here from a Corporis video : )

Так поддержал канал, осталось выучить английский. Спасибо vert dider за перевод

From Vert Dider.

Iiiiiirons iiiiiirons iiiiiirons ⚒️⚒️⚒️

Btw, if you ever wondered what video would be able to make your type of content blow up. In my experience, it would be something connected with reproducing. It's just a kind of trend I noticed in the most popular KZfaq channels of this thematic. Just an observation.

my real question is not why fluorine is better but more why didnt our body already got fluorine there. Well I guess it doesnt like dealing with fluorine because fluorine is... a bit mean.

A customer cured is a customer lost, just remember that.

skip to 0:45 to get to the actual topic.

_interlinked_ *within cells interlinked within cells interlinked within cells interlinked*

Only Calcium Fluoride strengthens and protects teeth not the industrial version Sodium Fluoride! There is no safe minimum dose of elemental Fluoride! I suggest redoing the video after more research.

Is flouride good for my teeth or not please just someone answer and help me

спасибо за полезную информацию. подача отличная! привет из России))

Hello from Kazakhstan. Good lack to your channel

2024 comeback???

fluorapatite causes differential erosion of teeth which then further quickly erodes the hydroxyapatite sections of your mouth

Drink carbonated things, even water through a straw & chew gum often.

6:21 for someone who supposedly loves learning, please learn how to use “begs the question” correctly. It’s a huge red flag when people who are trying to convey information use this phrase in a completely inapplicable way.

The fluoride will make the dentin in the tooth become brittle and will make it easier to snap the tooth. If you stop consuming sugar and high levels of carbs you won't have to worry about the acid from bacteria decaying the teeth. A good alternative for tooth paste is pure olive oil soap, flossing, hydrogen peroxide, mouthwash, and 40-75% ethanol right after consuming food.