Dr. Jen - how about an in depth focus on WHAT women can do IF hormone replacement was not an option. I am 62. I was advised NOT TO explore hormone replacement because I was in that window15 years ago where CANCER was always associated with replace. So here I am - here WE are - a boatload of us who are just doing our best not to fall apart. I am terrified most about cognitive decline and dementia. Pretty sure I have very little hormones left and my help window, so I am told, is closed. I power walk every day. I eat well. I sleep well. I work in live TV so my mind must be sharp (as you know). I supplement - magnesium glycinate, vitamin D, K2, MK7, ALA, super B, Co Q10, Omega 3, collagen powder in coffee and more. Like many of us, we are dry. WE are crepey, muscle loss, sagging - I mean, it's truly that we are becoming our grandmothers. What can we do??? What is science learning? I also take Repatha for high cholesterol. MEN-O-PAUSE - ya, men PAUSE - look at us - and go younger. Perhaps not in my lifetime will there be options. Thanks!!!!