Layne, you have such a talent for breaking something really complicated down to make it as easy to understand as possible. Thank you for this series.. such great information!

Only thing I might suggest is a higher volume on mic, it’s a bit lower than usual. Other than that, keep em coming this fuels my cardio sessions.

Can't wait till we get the episodes with practical recommendations. Totally appreciate all these videos.

I wanted to express my appreciation for this video series. You do an exceptional job at explaining complex/ technical subject matter at a level that can be understood by anyone with a high school level education in chemistry and biology. Thank you!

better at teaching then my biochem professor 😂

Brilliant work! Your channel needs more appreciation !

Great info in this series. This guy knows his stuff. (Source: I'm a bioengineer) Thanks for putting it out on the internet! Needed a refresher to get that last 10 lbs off. Down 20 so far!

It's insane to me how our bodies have so much crazy chemistry I never even knew about. Our bodies really are pretty fucking cool.

Just catching this series! Absolutely love your stuff bro. I found you while listening to Joe Rogan's podcast with the Keto King Dom D'Agostino. I love the way you challenge everything and want facts. This series is great because fat lose is fat lose. Regardless of how you do it. I personally have gone from 400lbs to 220lbs all on keto and have sustained it. Videos like this and this series fuel me!

So scientific🙌🏼so good at breaking it down,I’m really wishing I picked a science subject now cause I love Learning the science behind nutrition&training.Cant wait for the next episode

Wish I had this series back in my Uni Ex Phys days

Bro your the man. Wish you was my brother. I would learn sooo much from you. Watching this is like learning through 8 years of college.

Holy batman... that was quite the mouthful. Loving this Layne. Keep them coming!

Well..... I think I have found a field I want to go into..... Layne your videos are awesome! Super Interesting!

I like that Eckerd College shirt Layne, almost forgot you live in Tampa...I partied many a night out at Eckerd as a young buck.

Love this series. Get excited when I see the next one uploaded. 🤣👍👍

Hi, Biolayne...thanks for sharing this videos. I read twice the book, Carb backloading...followed the instruction exactly as the book mentioned and the results didn't appear like it was suppose to be. Following another protocol now with much better results..one more time, thanks for all the videos. Keep it up!

For anyone who hasn't purchased the contest prep book... Go. Pick. That. Up. It's awesome. I'm using some of the knowledge for myself and clients. I gotta say the part on %s of lbm vs. fat lost when in a deficit I did not know....

I love this series. Please keep the videos coming.

My sound volume is all the way up and still can't hear this well.

Good information Layne, Can you balance your audio levels with the intro. It is significantly higher gain/volume and then when it cuts to your white board stuff its much quieter. My ears would appreciate it for your future videos. :)

Layne these videos are great man. Thanks so much.

Layne can you please illustrate where the fit tea comes in and burns all the body fat? Lol

You're series are awesome!

the volume is a bit small...

Another great video! Im about to star my degree on nutrition and this is very helpful

Hi Layne, I love your science. I am dinahimg your book on fat loss. You mention prefering fat calipers. How do I use fat callipers for muller calculations? . do u I take average of all the msmt? . will you pls guide me.

Waiting for the Conclusion part of this series. Everyone knows you start reading scientific papers frim Conclusions and Summary.

Woooo! We getting complex! Or as you like to say (Science as F***). Lovin' it! Thanks for another awesome vid.

Would creatine help with fat loss? Since it produces ATP?

oh your Videos are getting quite amazing!!!

So basically all the supplements such as L carnitine or CLA,which are sold as supplements that enhance the fat oxidation process, are not as effective as they are marketed😲😲😲😧😧😧. I wish I had watched this video before I bought L carnitine this week! Thanks for the videos!!

Hi Layne,i think your video is amazing.It helped me a lot about how to get fit in a scientific way.I wonder if i can translate some of your videos into chinese and upload them on a chinese website called 'bilibili' to help more people.

Amazing explanation, thanks alot.

Can you do de nova lipogenisis next?? Got to learn it for nutrition exam in May and it quite complicated lol

Love the series. I'm confused where ketones fit into all this, though. Are ketones represented by one of the terms in this diagram or is ketone metabolism a whole different/parallel/downstream process separate from regular fat metabolism?

Wouldn't UCP be an example of how CICO is more nuanced? I know that some bodybuilders also take a drug that makes ATP generation extremely inefficient (and increases body heat), thus forcing increased calorie burning. Forgot the name. EDIT: Drug name is DNP

13:38 This is the only time I wish to be more efficient about being inefficient!!

Smarts guy ever

I couldn't hear your voice clearly....very frustrating cause I like the content. Hopefully better audio in the future.

Thank you!

Thanks you are the best man 👍🏻 So you mean I can't change the place of the fat , I mean after the fat goes to the liver can I turn them to muscle or change their please?

13:29 So a maintenance phase after a deficit phase could be beneficial? (Although you don’t take the MATADOR study to the highest regards in the mean time?)

Good visual aids use more color to depict the various interactions

Deep. That’s why i’m here... 😏

why is this episode hidden? its super interesting!

So then what can we use or supplement with to create more ATP?

Volume is too low man

Why isnt this guy president.

So drink water and breathe. Understood

All cool and nice except for the foods that don't count ... :-) Since you're describing energy systems - UCP - you could also describe DNP. You can also describe why keto - done properly - may be the WORST diet for fat loss. It causes your UCP to come closer, which makes energy production more efficient. Throwing some numbers - even change of 1 Angstrem distance between inner and outer mitochondria membrane can affect the effectiveness of electron transport chain by ~10-fold. That's huge. This means you can do more on a less energy, thus you'll burn less energy doing the same stuff. Exactly the opposite of what you want to get. The only real benefit of keto for fat loss is that it messes with hunger signalling and getting you off sugar addiction. Dopamine, delta FosB, et caetera. If I got something wrong - please throw an actual science at me. Everyone will benefit from that :-)

Check your volume levels of your intro. Super high

🤯🤯

You just bored me!