How to conduct forced degradation study?

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How to conduct forced degradation study?

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Күн бұрын

ICH guidelines emphasize the importance of conducting forced degradation studies, but provided only very general and limited information on the experimental stress conditions. This video will help you to understand forced degradation to much deeper level.

Пікірлер: 33

@hanumantgare1891 2 жыл бұрын

Very nice presentation and explain in very easy language. Thanku so much sir for your efforts.

@rohinikumar7065 3 жыл бұрын

Nice presentation sir and make video on what are facts effecting mass balance failure and solutions

@prashantpandit7806 2 жыл бұрын

Superbly Explained...👍🏻

@mitalipereira446 3 жыл бұрын

Sir, Please make video on finding LOD and LOQ of method

@rajeshpudi8795 2 жыл бұрын

Linearity and sample concentration chapter available

@PG12333 3 жыл бұрын

What is mass balance in FD study and how it is calculate

@LearnValue Жыл бұрын

Plus or minus 5% is acceptable

@rahulgunjal663 3 жыл бұрын

Sir kindly make video on mass balance calculation in fd

@mrinmoysarkar4133 2 жыл бұрын

Thanks a lot sir...it's really informative ♥️♥️🙏🙏

@manishkharkwal6106 2 жыл бұрын

Ur presentation was good. Please check as for evaluating purity / spectra in FD, PDA detectors required not UV. But overall content was good. Thanks for sharing

@krish_krish354 2 жыл бұрын

While conducting acid hydrolysis sample with hcl added. With this diluent added and kept in oven for degradation. Diluent added means how much should add before keeping in oven for hydrolysis. Can anyone reply please

@pharmagrowthhub3083 2 жыл бұрын

The volume of diluent should be sufficient to solubalize your analyte before you proceed degradation

@krish_krish354 2 жыл бұрын

@@pharmagrowthhub3083 if suppose sample and HCl only added no other diluent added before keeping in oven. after taken out from oven neutralize with NaOH and make up with diluent. This way of doing foreced degradation right or wrong.

@krish_krish354 2 жыл бұрын

If the compound melting point or boiling point near 45 degree can we conduct acid or base hydrolysis at 80 c

@verans7152 10 ай бұрын

Thanks sir

@sameer_shindeshinde3674 Жыл бұрын

Ur content is good so don't show advertising in between video, it disturb during learning.....

@krish_krish354 2 жыл бұрын

For themal degradation dry method sample alone heated. For wet method with sampl wt will be added

@pankajshah1084 3 жыл бұрын

Nice video sir, very useful

@kishordangat684 2 жыл бұрын

Good presentation

@modernmogli5155 2 жыл бұрын

Sir what software is this you are using , its very nice way to explain

@madhavikatta2150 2 жыл бұрын

Well explained sir thank you 😊

@jnaniashok Жыл бұрын

Excellent..

@PG12333 3 жыл бұрын

Sir please make videos on process validation

@sanketdalvi2942 2 жыл бұрын

Thanks sir....,❤️

@rohitkhade4060 2 жыл бұрын

How to perform normal phase force degradation study

@supriyabhamare06 Жыл бұрын

How to select drugs for FDS study

@rahulchadha6795 Жыл бұрын

Is it possible to do FD on UV methods?

@ShikshanAcademy Жыл бұрын

Pls put pdf

@mohdazeemuddin8353 Жыл бұрын

Hi sir This is Azeem My Question is We have controlled Nitrite content in water NMT 0.03ppm Secondary amine is there Nitrosamine is possible pls suggest Provide the guideline

@krish_krish354 2 жыл бұрын

Degradation 5_20 or 5_30 in other video of yours I saw 5_30 which is correct

@pharmagrowthhub3083 2 жыл бұрын

5-20% is more relevant and accurate, though there is no as such regulatory reference available.

@krish_krish354 2 жыл бұрын

@@pharmagrowthhub3083 thank you

@krish_krish354 2 жыл бұрын

@@pharmagrowthhub3083 what are regulatory guidelines using for a method validation. Not only ICHQ2R1 and R2. Other than