Immunology | Inflammation: Toll Like Receptors and Interferons: Part 4

Рет қаралды 361,918

7 жыл бұрын

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join Professor Zach Murphy for our final discussion on the physiology of inflammation. During part 4 of this lecture series, we discuss toll like receptors and interferons along with their signaling pathways. We hope you enjoy this lecture and be sure to support us below!
Inflammatory Response Video Series:
Part 1: • Immunology | Inflammat...
Part 2: • Immunology | Inflammat...
Part 3: • Immunology | Inflammat...
Part 4: • Immunology | Inflammat...
References:
● Asa Cusack. The London School of Economics and Political Science. Interferon functions [Digital image] LSE
● Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung, "Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy", Journal of Immunology Research, vol. 2020, Article ID 2045860, 9 pages, 2020. [Digital image] www.hindawi.com/journals/jir/...
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
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#ninjanerd #Inflammation #Immunology

Пікірлер: 120

@aijieli2802 6 жыл бұрын

Your drawing and knowledge goes hand in hand so well, which is much better and easier than reading any books listening to some dry lectures

@imanchere8339 4 жыл бұрын

Dr zachary we need more lectures about immunology I can say somehow it's the beast for all students although we pleased learning it from you still we need a lot of lectures specially from you you have a very specific method of explanation just makes infos drop into our mind THANK YOU A LOT ❤❤❤

@bradcallahan3546 5 ай бұрын

he's not a doctor

@denisdenak 3 ай бұрын

@@bradcallahan3546 he is tho

@than_us 5 ай бұрын

Its incredible how much knowledge can fit into a video

@chinajackson6220 3 жыл бұрын

You have literally, in 2 hours or less, across this series, explained to me what almost 8 hours of lecture attempted to cover!!

@romulobanaag5314 5 жыл бұрын

Thank you so much! This is what missing in NP and PA schools! I learned so much! You are so brilliant!

@sirinesaleh5398 3 жыл бұрын

Hello ninja nerd, first thank you so much for your videos they saved my life. Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse). Thank you deserve so much more recognition.

@cosmictask781 2 жыл бұрын

Finally. I've been looking for a good lecture that will help me understand interferons and toll like receptors. Thank for this.

@KJT3000 4 жыл бұрын

Who else here is a certified expert after watching this?

@ashleelarsen2233 Жыл бұрын

0:45 wow

@jessicabaileyatsml 4 жыл бұрын

Thank you so much. Your explanations are clear, concise, and I can cram an entire semester worth of knowledge into 3 hours. You are awesome!

@nouralshihaby7476 4 жыл бұрын

Iam addicted to your words and to every single word you say Thanks from the bottom of my heart ❤

@AshutoshSingh-lf7cx 5 жыл бұрын

u are absolutely amazing, bro u deserve much much more recognition. u really are a blessing for students like me. thank u...

@kindraoconnor9135 4 жыл бұрын

You are literally saving my life in PA school... thank you so much!

@MG-gf1nw 5 жыл бұрын

Video by video i get more in love with u!! Thank you for this❤️ merry christmas

@Manisha332abcd34 4 жыл бұрын

I have my exam after 2 days and here u r explaining everything so simply, Thankyou so much

@caterpillargirl7284 4 жыл бұрын

thank you so much sir for making this difficult topic so much easier to comprehend and memorize!

@Norscho 2 жыл бұрын

After 5 years, that is still the best!

@KshanalShrivastavaSecretmess 4 жыл бұрын

In the book Essentials of Medical Microbiology, It says that both TLR 7 & 8 respond to ssRNA. . Any which way, I'd like to say : All your videos are precise and extremely informative. Thank you so much!

@user-sy8ei3mi2g 2 жыл бұрын

Just wanted to say, your videos are amazing!!!! They help sooo much to see the general picture

@mahziyar_sttr Жыл бұрын

Your vids are making immunology like a piece of cake for me

@Akash-ru1nm 3 жыл бұрын

What prevents RBCs and platelets from normally undergoing apoptosis by the Natural killer cells? Because these cells do not have nuclei and hence lack MHC-1.

@zeppelinbtd6788 Жыл бұрын

Please release a book about all these videos, they are so helpful!! Love your videos, keep going man!

@xDelga 3 жыл бұрын

Just got a ad about a guy saying he was absorbing the material by just touching the cover of the book. 25 min later I've been holding my hand over the computer screen, and I have absorbed the lecture.. Thanks Ninja ;))

@ahealingplace7350 3 жыл бұрын

🤣🤣🤣🤣🤣🤣

@joellachocco3610 5 жыл бұрын

I think tlr 7 and tlr 8 respond both to ssrna but in different patways. Thank y so muccchhhh.

@diegojobe9318 3 жыл бұрын

Genio . Más simple la explicación no puede ser. Muchas gracias !!

@chiamakaogbuagu5429 Жыл бұрын

thank you for all you do, your videos are always my go-to learning videos except you haven't done a topic on it

@alexanderchaihorsky4605 4 жыл бұрын

Great series!

@wolfie5470 4 жыл бұрын

There is no better way how to celebrate Easter Monday than studying for exams with Zach ❤❤❤ HAPPY EASTER ❤❤❤

@maryodonnell5760 2 жыл бұрын

and New Year's Ever :)

@kajalpandey209 9 ай бұрын

10:40 , 24:02 revision of the lecture

@drswetaruparel 5 жыл бұрын

Very helpful !!! 👍 Gratitude from India 🙏

@lawencekongwa5667 2 жыл бұрын

Hi Nerd Ninja, I'm going over this video to refresh my memory on the innate immune system to better understand the research into the covid virus. I believe that a slow innate sytem response coupled with an agreassive adaptive response is in part responsible for higher mortality...

@stepup5338 2 ай бұрын

Awesome explanation!

@kanikaoy4207 3 жыл бұрын

thank you so much .. it's so helpful

@elinaperi2844 4 жыл бұрын

Thank you, thank you!

@nari1555 5 жыл бұрын

love u and ur lecture

@alexandraandronik7479 Жыл бұрын

🥰🥰🥰 the best teacher!

@dianaridha9057 2 жыл бұрын

You’re a legend literally🔥

@jesica2466 4 жыл бұрын

This makes me cry. God bless you sir

@wakaflockaboi10 3 жыл бұрын

Love what you're doing. Super helpful. Just wanted to point out acyclovir is a guanosine analogue not an interferon. Otherwise great lectures!! Keep it up.

@luciannylima1111 3 жыл бұрын

Thank you so much!

@andiswaluthuli4867 4 жыл бұрын

love all your videos and i'd like to know what textbooks you use to study ?

@tepptomepetto Жыл бұрын

Nice video. I thought- Protein Kinase R is inhibiting the eIF2 by phosphorylation.Therefore, the cell can not doing proteinbiosyntheses of their own and the virus proteins. The enzyme destroying virus DNA or RNA ist RNAse L, which is activated by the 2'5' OASE (also activating by INF alpha and beta).

@TourniquetTwin 5 ай бұрын

The macrophage is fricked, I am not, thanks to you. Thank you so much for putting living visual associations to the knotted bundle of facts and names I had in my head before watching this. As always, immensely helpful. Thank you so much.

@yazsam930 3 жыл бұрын

Ninja .... you are a super hero 🦸‍♂️

@alysidfernandes7936 4 жыл бұрын

Thank you for delivering this lecture so perfectly! Was wondering if you could add to this by talking about NOD like receptors and inflammasomes?

@niyadeo7970 Жыл бұрын

Amazing!

@goldenretriever977 Жыл бұрын

Thank you so much for such an amazing lecture. Are interferons only secreted by infected host cells (like tissue cells) or can immune cells themselves secrete them like monocytes?

@shivanishivani4705 2 жыл бұрын

much much much helpful.🙏

@natureslover7831 2 жыл бұрын

You are a Legend Sir❤

@shivalikatal5839 3 жыл бұрын

Thankew soo much ♥️

@aureliavruzhaj3191 Жыл бұрын

you are a blessing!

@kimderick6806 Жыл бұрын

I long for your pathology lectures. Kind regards, thank you.

@Athena_Behafarin 4 ай бұрын

superb

@aliileleijuniortenari5091 3 жыл бұрын

thank you

@MuhammadAhsan-mp8hq 2 жыл бұрын

Waiting for website launch 🎊

@terew9145 4 жыл бұрын

BLESS YOU & WORK...SUPEME TEACHER & I KNOW W BACKGROUND IN ANATOMY & PHSYOLGY..NOW EXPERIENING SJORGRES & COMPLICATIONS...VASCULAR, EXOCRINE INFECTIONS , ETC...AM DETERMINED TO FIND NATURAL CURE..,GOD BLESS U..HOPEFUL NOW..❤

@shivanishivani4705 2 жыл бұрын

exactly what i need.

@abinashbaniya8497 11 ай бұрын

You are a savior 🙏

@tariqjagmag 4 жыл бұрын

Nice video zach.howd u miss PDC cells when u explained Interferon beta.nice video though,truly inspirational teaching style

@Rasha.Ishtar 2 жыл бұрын

Hi Zack, thank for your amazing videos, I just think there is a mistake here IFN gamma is not secreted by macrophages, it is secreted by TH1 cells and Natural killer cells and work on macrophages, IFN alpha and Beta work on natural killer cells

@amnie 2 жыл бұрын

LIFE SAVING!

@hossnaras6072 Жыл бұрын

perfect

@joycegarrison6871 2 жыл бұрын

thank you thank you thank you thank you

@raheelqureshi7643 5 жыл бұрын

Have any videos on NOD like receptors???

@niloofarkh4779 Жыл бұрын

great

@user-cp1nh4wh3v Жыл бұрын

you lecture is amazing, can we get your note ?

@sangeetchhantyal8259 5 жыл бұрын

Can you plz put subtitles in part 2 3 and 4.. i am little hearing impaired

@maryodonnell5760 2 жыл бұрын

which video is next, IBD is in the top right corner, other vids on adaptive immunity and t cells and antibodies exist...found it, immune review, adaptive, t cells, antibody structure, he has 8 immunology lectures and now notes on his website :)

@saffakhder2693 3 жыл бұрын

so are IFN cytokines only released why a virus infects the cell or it can be released when a bacteria is present as well?

@josiahsunday5981 Жыл бұрын

Where’s the icon where I can double or triple like, u are amazing 🤩

@biplabsinha4746 3 жыл бұрын

Sir Can You make Video on The Cell Repair Mechanism?

@jamesgordon8867 Жыл бұрын

One of these days when it is safe to discuss COVID-19 , maybe they will tell how they tried to find ways to negate these receptors

@meatballs6046 3 ай бұрын

Note: TLR-8 responds to ssRNA, single stranded RNA

@ridah4419 4 жыл бұрын

Is there a video on chronic inflammation?

@pasinduchamod4705 3 жыл бұрын

Can you please write the expanded forms of symbols you use in a side of the board.

@jamesgordon8867 Жыл бұрын

What is part 1 called? Tried to look up

@guilianbirindwa2453 4 жыл бұрын

Is there a micro Playlist anywhere?

@user-vm9lh9yo7o 10 ай бұрын

Are we able to download pictures of your drawing board? Your lectures are amazing.

@GUSTAVOYEHFUZINATO 3 ай бұрын

hey man, what book do you use to study the immunology?

@natureslover7831 2 жыл бұрын

Sir Cover the Whole Micro And Pathology

@daniely2282 2 жыл бұрын

We need a video on B cell development

@Zvonko73 Жыл бұрын

My head hurts 🤕

@palshah3509 3 жыл бұрын

I hope your all wishes come true

@andredharmawanmed9751 Жыл бұрын

10:54 , 20:24 , 24:04

@MakkaP Жыл бұрын

Is TLR4 a homodimer?

@hazalsarird1219 3 жыл бұрын

Where do defensins come in?

@FA-gv2eo 4 жыл бұрын

Just a quick note you mentioned that TLR 8 responds to double-stranded RNA which is incorrect. TLR8 responds to single-stranded ssRNA and not dsRNA.

@sethbueno2934 3 жыл бұрын

agree

@shabihusain3901 3 жыл бұрын

Thank you so much sir😊

@Bourgeoisie-Slayer Жыл бұрын

@MM-pq7uk 4 жыл бұрын

Please can you put english subtitile in many videos that Don't.

@wiktoriahawel9920 9 ай бұрын

Hi, Why subtitles aren't available?

@user-gl7pk4pn7v 3 жыл бұрын

bro，could you add the subtitles？thanks for doing this！！！

@tobiaslarsen7395 5 жыл бұрын

According to basic immunology (6th) by abbas and Lictman TLR-8 respons to ssRNA and not dsRNA.

@nhanquang8884 5 жыл бұрын

ss or ds is either umimportant, the point is to understand and remember basic concepts, not the example

@Vunami 5 жыл бұрын

@@nhanquang8884 Understanding that TLR-8 responds to ssRNA is the basic concept though.

@nhanquang8884 5 жыл бұрын

Nope, basic concepts answer these questions: what is a TLR? and what such things do it do?. You dont need to go into too much detail cause it's impractical. If you wanna be pratical, for your records, TLR8 not only recognizes dsDNA, it also goes for ssDNA, ARN and some proteins in specific conditions. You see how complicated it is ? So do not mention it's basic concept.

@Vunami 5 жыл бұрын

@@nhanquang8884 meh, pretty basic stuff to me. But everyone's different.