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Innate Immunity | Complement System | Immunology | Dr Najeeb
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
0:00 Mechanism of Action
8:10 Antigen X Antibody Reaction
11:30 Complement Protein-C1 Activation
14:50 C1 C4 Helper T cells
18:40 C1 C4B C2B
20:40 C4B C2B C3B Complex
23:10 C3B CONVERTASE
28:10 C6 C7 C8 C9
34:10 GRAM-POSITIVE VS GRAM-NEGATIVE
42:40 MACROPHAGES / NEUTROPHILS Action
46:10 Opsonin's C3B IgG
50:00 Opsonization Process
1:00:40 Endotoxins’ Action On Protein LPS
1:11:00 Alternate Pathway-Mannan
1:14:00 Lectin Pathway
1:22:00 Mast Cell Response
1:28:00 Anaphylatoxin
1:35:00 B Cell Activation
1:37:24 REVIEW
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The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
The complement system consists of a number of small proteins that are synthesized by the liver, and circulate in the blood as inactive precursors. When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and damaged material, inflammation to attract additional phagocytes, and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, and cell membrane receptors. They account for about 10% of the globulin fraction of blood serum.
The innate immune system is one of the two main immunity strategies found in vertebrates (the other being the adaptive immune system). The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms.
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