Inositol Triphosphate (IP3) and Calcium Signaling Pathway

Inositol Triphosphate (IP3) and Calcium Signaling Pathway | Second Messenger System

Рет қаралды 166,456

6 жыл бұрын

Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon activation of a G protein-coupled receptor. Inositol triphosphate and DAG are cleavage products of phosphatidyl inositol 4,5 bisphosphate (PIP2), which is cleaved by phospholipase C. Increasing levels of IP3 lead to augmented cytosolic calcium levels that further lead to activation of downstream cellular targets.
Hey everyone. In this lesson you will be introduced to the IP3 and calcium signaling pathway. We will also discuss the purpose of the pathway, enzymes involved in the pathway, and how the pathway is regulated.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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Thanks for watching! If you found this video helpful, please like and subscribe! JJ
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.

Пікірлер: 88

@danielareyes9920 5 жыл бұрын

Thanks so much for this!! I sat through a 2 hr lecture and didnt understand but I got it here after less than 6 mins lol. You’re a lifesaver

@CT--gs1wj 5 жыл бұрын

you should have included the activation of G alpha subunit by GPCR which then activates phospholipase C... regardless, the video is excellent.

@marishenmarindi6046

2023 this was really helpful

@nesmajawahar7926 Жыл бұрын

Can u tell hw its getting degraded ?

@premalmartin3246

Thank you, my physiology book did a terrible explanation along with a figure that didn't seem to go along with the explanation.

@sobialaghari225 4 жыл бұрын

But why is PIP2 no second messenger? It does it work too right?

@jacksilver2884 2 жыл бұрын

Unbelievably useful explanation, so well laid out. Thanks

@user-oq8oq3pf3e

Thank you so much, I watched like 5 different videos on this topic but still didn't get it but I do now

@giomaraustria2371 5 жыл бұрын

What is the specific ligand

@ivypellerin1000 3 жыл бұрын

thank you thank you

@josephandhopelopez8492

Who created this magnificent, elegant, yet simple mechanism? The way PIP2 is disassembled into two useful parts is genius! Calcium is stored and is only released with the key (IP3), genius! This is a very controlled chemical pathway needing several keys (DAg, IP3, and Calcium. It must be responsible for very intricate balances in the cell. Thank you for making this elegant pathway simple to understand and accessible to marvel at. Thank you!

@keurinrin16 2 жыл бұрын

Read my book for a week and I had a hard time understanding this topic. And I just discovered this video and now I understand hahah thankyou very much!Please make more videos like these

@pureispure3184 5 жыл бұрын

Saved my brain cells, thx

@MustafaAhmed-eh1kk

Thank you so much!

@Esraa-mr9ce 3 жыл бұрын

Wow!! It is clear explaination to a complex pathway ...please keep on

@buho3539 6 жыл бұрын

Thank you. You have great videos. Greetings from Colombia

@Veronica-nx3ss 4 жыл бұрын

I think I may have a metabolic disorder, and my doctor keeps telling my symptoms are psychosomatic, I am trying to do some personal research about non epileptic childhood seizures and how that effected my metabolism. I appreciate the video in helping me better understand the concepts in the papers I am reading.