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Schistosomiasis expert, Conor Caffrey (University of California, San Francisco, USA) discusses drug discovery efforts towards addressing this life-threatening neglected disease and his perspectives on what the future holds for schistosomiasis treatment and prevention. Conor Caffrey recently guest edited a Future Medicinal Chemistry special focus issue on schistosomiasis. In recognition of the importance of open science in neglected disease drug discovery, the editorial team have made this issue free to access. Check it out here: htp://www.future-science.com/toc/fmc/7/6