Intro to Orgo Mechanisms Nucleophilic Attack and Loss of Leaving Group

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Intro to Orgo Mechanisms Nucleophilic Attack and Loss of Leaving Group

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leah4sci.com/me... presents: Introduction to Orgo Reaction Mechanisms + Nucleophilic Attack and Loss of Leaving Group explained.
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: leah4sci.com/or...
Organic Chemistry is all about the reaction mechanisms. This video breaks down the mechanism concept and moving arrows followed by an in-depth look at the first 2 common mechanism types: nucleophilic attack and the loss of a leaving group.
Links & Resources Mentioned In This Video:
Understand Arrow Pushing in this Tutorial:
• Electron Pushing Arrow...
Review your resonance skills in this Resonance Tutorial Video Series: leah4sci.com/re...
Solidify your formal charge calculations through this Formal Charge Series: leah4sci.com/fo...
Catch the entire Mechanism Video list in Organic Chemistry Series, on my website at leah4sci.com/me...
For more in-depth review including practice problems and explanations, check out my online membership site: leah4sci.com/join
For private online tutoring visit my website: leah4sci.com/or...
Finally, for questions and comments, find me on social media here:
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Пікірлер: 169

@nanako1298 4 жыл бұрын

so far in my life, I have not seen any body have mad any clear explanation than you are. God bless! my HEEEEERO!!!

@Leah4sci 4 жыл бұрын

Aww, thanks! I'm happy to help!

@GabrielCarvv 4 жыл бұрын

Amazing video! The "don't get confused" parts are super helpful, no one else seems to clarify them! Very clear.

@Leah4sci 4 жыл бұрын

Glad it was helpful!

@BidyadharSahoo 3 жыл бұрын

Madam, I have no words to thank you for this lucid explanation. You are one of the best lecturers in the US and the world !

@Leah4sci 3 жыл бұрын

Wow, thank you! I'm glad my videos help you!

@mohubeduabram3896 5 жыл бұрын

you do everything step by step.i cant say much about you,what i can say is that ''i was blind now i see'' i love you so much God bless!

@Leah4sci 5 жыл бұрын

I'm glad you are able to understand the topic. All the best! :)

@user-th7jb1qb4s 2 жыл бұрын

Hey even-though you might not see this , i just wanted to appreciate your teaching. It has helped me a lot through my college. I have never done chemistry before trying to study university level chemistry , if it wasn't your detailed and well explained videos , i would have not made it. You are the best.

@Leah4sci 2 жыл бұрын

Aww thanks so much for sharing this, I really appreciate it! I'm so happy I helped you in your university journey!

@nicolerieux8593 6 жыл бұрын

You have no idea how helpful this is! I am a chemical engineering major and have been struggling orgo and my professor never knows how to help me. Your videos are truly the best, most helpful and broken-down examples on YT! please don't stop making videos! Thank you so so so much!

@Leah4sci 5 жыл бұрын

Thank you for your wonderful feedback! You're welcome.

@AliMohamed-bm3mr 5 жыл бұрын

You are the best teacher for organic chemistry in KZfaq

@Leah4sci 5 жыл бұрын

Thank you! Please don't forget to subscribe! :)

@DivyaDrewBiebs 7 жыл бұрын

I literally was about to start reading about Substitution and Elimination reactions and you uploaded this video :) Thanks a lot, Leah !

@Leah4sci 7 жыл бұрын

That's awesome! perfect timing. You should also watch my substitution elimination series leah4sci.com/nucleophilic-substitution-and-beta-elimination-sn1-sn2-e1-e2-reactions/

@DivyaDrewBiebs 7 жыл бұрын

Leah4sci Thankyou very much ♡

@lindam1663 5 жыл бұрын

Leah4sci alkene mechanism

@apoorvshri5376 5 жыл бұрын

Leah, I am an Ivy league graduate and starting a 3rd career. I love your videos. You are simply marvelous! I love it more than Khan Academy ones!

@Leah4sci 5 жыл бұрын

Thank you so much for the kind words :) . I'm glad you love the videos :)

@Moshito_m 6 ай бұрын

First 5 minutes brilliantly explained so many things I had failed to previously understand and grasp.

@Leah4sci 6 ай бұрын

oh wow, I'm sorry to hear that your professor wasn't able to explain this for you, but I'm happy to hear that in just 5 minutes everything turned around

@HotSauce-mn1mp 6 ай бұрын

This is a great vid. First vid I watched that broke done exactly what a nucleophile and electrophile were clearly. I hope future organic chemistry students come across this great vid

@Leah4sci 6 ай бұрын

I'm so glad you found this video helpful. I find that understanding the foundations make the more advanced concepts so much more graspable

@HotSauce-mn1mp 6 ай бұрын

@@Leah4sci keep up the good work

@chahevartanian2066 7 жыл бұрын

Hi Leah! I don't know if you remember me but I commented on one of your videos in late 2016 saying you were one of the reasons I aced both my organic I and II courses with 90+/100 in my chemistry undergrad degree. Well now i'm about to enter my senior (and final) year as an undergrad and I have organic III in my first semester and that means i'll be needing your help once again! I searched your website and youtube channel and I don't think I found videos related to organic III. My university's chem department teaches a lot of courses that many universities do not provide in their chemistry undergrad degree (organic III I think being one of them). Maybe that's the reason? Anyway this is the course outline for orgo III: pKa in organic chemsitry Enols and enolates Radical substitutions Pericyclic reactions and cycloaddtitions Molecular Transpositions Chemistry of aromatic heterocycles Oxidation and reduction reactions in organic synthesis I hope in future you'd do videos on at least one of these topics. You really are a gifted teacher and I deeply appreciate and thank you for everything you've done for me and others (needless to say).

@Leah4sci 7 жыл бұрын

firstly, congrats again on acing orgo 1 and 2. It's always an honor to join students on this journey. Regarding Orgo 3 I cover those topics in the study hall. Details: leah4sci.com/join

@gimunsuk 3 жыл бұрын

Very comprehensive explanation. Thanks for the great lecture.

@Leah4sci 3 жыл бұрын

You are welcome!

@triple_gem_shining 9 ай бұрын

Love your work and explanations. You leave no stone unturned!

@Leah4sci 9 ай бұрын

Thank you! That is my goal and I'm glad you're finding it to be that way

@Bribrandyn489 6 жыл бұрын

Your explanations are so straightforward. Thank you so much for this. I will be sure to check out your other videos... it's been a long time since I did organic so I'm using these to help me catch up for an online graduate class....

@Leah4sci 6 жыл бұрын

You're very welcome! I'm glad it helped! I wish you the best of luck in your class

@AbuguBenardineOdinaka 9 ай бұрын

The explanation is just too good.. I wish I can have you as my personal tutor☺️

@Leah4sci 9 ай бұрын

I'm happy to help! Are you in orgo now? Check out leah4sci.com/syllabus to match up my resources to what you're studying!

@buhlehlongwane2197 2 жыл бұрын

You saved my life. Thank you 🥺🙏

@Leah4sci 2 жыл бұрын

Happy to help!

@SachinSingh-se2xe Жыл бұрын

You teaching to much good your video very useful for my 12th examination (thankyou)

@Leah4sci Жыл бұрын

Glad you found the video helpful!

@MrKoni83 3 жыл бұрын

Great presentation! Breaking down complex ideas is the hardest thing to do! Only one comment, "philos" doesn't mean "loving", it means "friend". So electrophile, for example, is the one being friends with electrons.

@Leah4sci Жыл бұрын

Thank you!

@raeesadhorat2170 Ай бұрын

God bless you!!Thank you so so so much for thee best and articulated videos

@Leah4sci Ай бұрын

You're very welcome, I'm so happy to help!

@m.a8641 Жыл бұрын

Glad I found your channel, greetings from the Netherlands!

@Leah4sci Жыл бұрын

Hello there! Thanks for watching. :)

@HighFidelityFox 7 жыл бұрын

Thank you so much for the tutorials! You have no idea how much they've helped!

@Leah4sci 7 жыл бұрын

you are very welcome! Are you in orgo this semester?

@sophiamacking 3 жыл бұрын

I wish I found your channel sooner! You make ochem so easy to understand :)

@Leah4sci 3 жыл бұрын

I'm so glad it helped!

@dlaminisenanelo6762 4 жыл бұрын

your videos are so helpful, your explanation are so clear.. Thank you

@Leah4sci 4 жыл бұрын

You're very welcome!

@superemepwr 6 жыл бұрын

better at teaching O-chem than my own professor... thank you so much!

@Leah4sci 5 жыл бұрын

You're welcome! Glad to help! :)

@BarakaYves-pw3zb 2 ай бұрын

This video was helpful. Thank u

@Leah4sci 2 ай бұрын

You’re welcome 😊

@emlynn4070 3 жыл бұрын

Thank you, this was an excellent in-depth explanation of reaction mechanisms.

@Leah4sci 3 жыл бұрын

You're very welcome!

@yuinelisha5388 Жыл бұрын

Wow that's nice please can you make a video for all organic chemistry

@Leah4sci Жыл бұрын

For help with organic chemistry, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

@thatguy431 Жыл бұрын

This is so well done, thank you so much!

@Leah4sci Жыл бұрын

You're so welcome, I'm glad you liked it!

@youthhood9547 3 жыл бұрын

better and clear explanation thank you

@Leah4sci 3 жыл бұрын

Glad it helped!

@howardfriedman4527 Жыл бұрын

I took organic chemistry 35 years ago to become a pharmacist. I have always loved organic, bio and medicinal chemistry . I'm a geek I guess, I still watch videos and try to understand a little deeper. Your videos are awesome . Thanks. Howard

@Leah4sci Жыл бұрын

So happy to have you here; thanks so much for watching and commenting!

@militaryenthusiast1929 Жыл бұрын

Breathtaking 😅

@Leah4sci Жыл бұрын

Wow, thank you!

@mpotsengmasetla947 7 жыл бұрын

Thanks I was waiting 4 this. It has been long

@Leah4sci 7 жыл бұрын

awesome! Are you studying this now?

@katefuglestad5894 Жыл бұрын

At 8:23, I don't understand why that particular bond was chosen as the nucleophile. Why that one and not the bond between Mg and Br?

@Leah4sci Жыл бұрын

That's a great question! The Mg has low electronegativity. Therefore, any negative charge will gravitate towards the neighboring atoms of Bromine and Carbon. However, the difference in these two atoms is that Bromine can actually hold a negative charge and be stable. While a Carbon holding a negative charge is highly UNstable and, therefore, very reactive. In the case of a Grignard, the carbon acts as a carbanion, and this explains why the electrons between C and Mg are the ones acting as the nucleophile here. For more, please visit my tutorial on the Grignard reaction and mechanism at Leah4sci.com/Grignard

@katefuglestad5894 Жыл бұрын

@@Leah4sci Thank you!

@khayyam3000 2 жыл бұрын

Great Job!!

@Leah4sci 2 жыл бұрын

Thank you!

@pattemthanuja5846 3 жыл бұрын

Nice explanation

@Leah4sci 3 жыл бұрын

Thanks!

@sinajafarzadeh9577 3 жыл бұрын

Sorry if it dumb but why you didn't attach MgBr instead of CH3 to form the new molecule?

@Leah4sci 2 жыл бұрын

It is actually the carbon that acts as the nucleophile in a Grignard reagent. If you want to learn more, visit my tutorial on this reaction at Leah4sci.com/Grignard

@vasanthakumarg4538 3 жыл бұрын

Good work!

@Leah4sci 3 жыл бұрын

Thanks!

@IIT24Aspirant Жыл бұрын

11:20 why did O moved it's lone pair in the first place?? It's electronegative and can easily hold -ve charge so why did it shift it's lone pair towards less electronegative N??

@Leah4sci 11 ай бұрын

Of course, oxygen is electronegative. It can hold negative charge, but it can also be happy and stable when neutral. Notice that the new molecule that we form in this reaction has lower total formal charges and is arguably MORE stable than our starting molecule because of this.

@jiayuchen2952 4 жыл бұрын

so precise!

@Leah4sci 4 жыл бұрын

Thanks!

@belinda8153 3 жыл бұрын

So helpful. !

@Leah4sci 3 жыл бұрын

Glad it was helpful!

@SachinKumar-rf3lh 6 жыл бұрын

Love from India....

@Leah4sci 8 ай бұрын

Thank you

@shivasankari1277 6 жыл бұрын

Thank you very much

@Leah4sci 8 ай бұрын

You're welcome!

@purple9441 5 жыл бұрын

your voice is so peacefull and relaxing and it just down my stress

@Leah4sci 5 жыл бұрын

:) thanks!

@ramyaahmad6654 6 жыл бұрын

its helpfull thank you......

@Leah4sci 6 жыл бұрын

you're welcome!

@tenzoemury1714 11 ай бұрын

So at the beginning. Why is hydronium and not water drawn as one of the products?

@Leah4sci 10 ай бұрын

Oh wow you're so right! Without taking the solvent into consideration, conservation of atoms should give us just 2 H in addition to what's on carbon! Great catch!

@stoneklef 7 жыл бұрын

your voice melts my brain

@Leah4sci 7 жыл бұрын

I'd say sorry but... nah

@stoneklef 7 жыл бұрын

Leah4sci i would want to hear you talk 24/7😀

@Leah4sci 7 жыл бұрын

I'm confused, melt is a good thing? are you taking orgo?

@rabz-jsh7829 Жыл бұрын

hello may I ask why CH3 was the one that shifted from CH3 +MgBr and not Mg or Br

@Leah4sci Жыл бұрын

That's a great question! For an explanation of the Grignard reaction, visit my tutorial at Leah4sci.com/Grignard.

@user-lh1jb2xm3z 6 жыл бұрын

7:46 you said it is an electrophile due to the partial positive but why ignore the partial negative charge and only focus on the partial positive charge which concluded to be an electrophile?

@Leah4sci 6 жыл бұрын

we look at the specific area on the molecule that gets attacked. In this case it's the carbonyl carbon while the oxygen does not get attacked or do an attack.

@user-lh1jb2xm3z 6 жыл бұрын

12:46 why the Cl is separated not the OH ? :)

@Leah4sci 6 жыл бұрын

OH is a strong attacker and bad leaving group. Cl is the opposite. The better leaving group is the one that gets kicked out

@shainemaine1268 4 жыл бұрын

Where would be a good starting point for learning about organic chemistry in general?

@Leah4sci 3 жыл бұрын

Head over to leah4sci.com/syllabus :)

@user-lh1jb2xm3z 6 жыл бұрын

10:50 The formal charge makes C, negative and Cl neutral and partial charge makes C, positive and Cl, negative. Why does the electron moves from C to Cl not Cl to C?

@Leah4sci 6 жыл бұрын

I'm confused, C is not negative. Cl is electronegative and pulls on the electrons so much till they break off and collapse onto the Cl pulling them.

@InnovativeScience22 7 жыл бұрын

Thank...you.......

@Leah4sci 8 ай бұрын

You're welcome!

@pervindersingh9889 5 жыл бұрын

Nice

@Leah4sci 8 ай бұрын

Glad you like it!

@jjkasij2408 6 жыл бұрын

Hey Leah, I was wondering at 8:30 in your video, how would we know the CH3 would be the Nucleophile rather than the MgBr. I thought it was always CH3 would be the positive end and MgBr would be the negative. Thanks!

@Leah4sci 6 жыл бұрын

Have you learned organometallics yet? This is a grignard reagent characteristic for a carbonion-like carbon atom.

@aa63aa 7 жыл бұрын

Can I have Reactivity of Organic compound video ? I am facing the trouble in comparing the reactivity of haloalkane, halobenzene and acyl chloride

@Leah4sci 6 жыл бұрын

Reactivity depends on the specific reaction conditions.

@adiran2016 6 жыл бұрын

@leah4sci I'm just familiarizing myself with organic chem and have a question -- the full headed arrow indicates that 2 electrons are moving but in the examples im seeing it seems that only one electron is really moving to be shared (or are both being moved to be shared?) so i'm confused on why the half headed arrow isnt being used to instead indicate that one electron is being moved to be shared (because doesn't the middle atom have at least one valence electron to share? Hope this makes sense.

@Leah4sci 5 жыл бұрын

I'm sorry, but I don't offer tutoring through KZfaq comments. For help with this and more, I recommend joining the organic chemistry study hall. Full details: leah4sci.com/join

@saffiyahmajid7882 2 жыл бұрын

Would this be okay to use as a revision source for alevels?

@Leah4sci Жыл бұрын

I'm unsure. I'm an organic chemistry tutor. Feel free to contact me through my website at leah4sci.com/contact/

@SaiKiran-ly8vv 7 жыл бұрын

Madam why only Cl is leaving here? Why not OH. O is even more electronegative than Cl

@DivyaDrewBiebs 7 жыл бұрын

Cl is a good leaving group because it can accept electrons better ( 'Cause it needs 1 electron to attain octet) than Oxygen.

@Leah4sci 7 жыл бұрын

See my video on OH as a poor leaving group in the substitution videos

@orcgaming3594 7 жыл бұрын

Hey miss thank a lot

@Leah4sci 8 ай бұрын

You're very welcome!

@lukmanmohammed5387 2 жыл бұрын

Best

@Leah4sci 2 жыл бұрын

Thanks!

@sureshm-ir5ev 5 жыл бұрын

how do we know abt lone pairs

@Leah4sci 5 жыл бұрын

For help with this and more, I recommend joining the organic chemistry study hall. Full details: leah4sci.com/join

@sibisugan5026 4 жыл бұрын

Madam in 1:16 see. I think it is H2O

@Leah4sci 9 ай бұрын

Oh wow you're right, that was a mistake on my end . Thank you for catching it

@back2back135 7 жыл бұрын

Pls more Videos more often 😁😁

@Leah4sci 7 жыл бұрын

that's the goal ;) Which topics are you working on right now?

@back2back135 7 жыл бұрын

Leah4sci I study Biotechnology. So i have organic chemistry, Biochemistry (yes i already subscribed to your mcat Channel), physical chemistry and General chemistry. Your Videos in orgo helped me alot

@back2back135 7 жыл бұрын

I would really Love if U would do Carbonyl reactions

@Leah4sci 7 жыл бұрын

oh wow you're covering a lot at the same time. Carbonyl reactions are on my long term list but probably not for a few months. too much to cover, too little time

@back2back135 7 жыл бұрын

Ok 😢

@najeebullahkakar8555 5 жыл бұрын

👌

@Leah4sci 8 ай бұрын

👍

@robintherubefan709 7 жыл бұрын

If I've done a chapter how can I remember the same concepts after some weeks??

@Leah4sci 7 жыл бұрын

review!

@robintherubefan709 7 жыл бұрын

Leah4sci how to review? Everyone says review, but how to review it properly?

@Leah4sci 7 жыл бұрын

practice and repetition. Read the chapter again, do practice and more practice. Get help if you get stuck. do more practice

@VeritasEtAequitas 4 жыл бұрын

Do many practice problems and pay attention to the electrons. The problem with all of these KZfaqrs videos and Khan academy is a lack of practice problems

@marathimixdjs8671 Жыл бұрын

Hello mam I want to contact with you?

@Leah4sci Жыл бұрын

You can contact me through my website at Leah4sci.com/contact

@marathimixdjs8671 Жыл бұрын

H²0 or H³O+

@Leah4sci Жыл бұрын

I don't understand if you're asking a question. For help with topics like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/