Excellent overview of an imp yet complex disease. The revised BCLC ( 2020 ) includes upto 5 cm single lesion in A stage and following liver directed therapy stage B disease may be eligible for curative therapy. Whereas BCLC is followed in the west, it’s considered restrictive as regards surgery / curative therapy in Asia. Several Asian centers have given their own staging & management algorithms ie Korea, Japan, China, Hong Kong. In the developing countries with limited facilities for transplant liver resection of operable intermediate stage hcc would be highly desirable. Finally an HPB surgeon to highlight the role of Surg, the only curative option would have been appropriate.

🎯 Key Takeaways for quick navigation: 00:11 🎙️ *The 11th ISC Masterclass focuses on managing hepatocellular carcinoma (HCC).* 01:16 🗣️ *Dr. Anil Arora, a renowned speaker from Sir Ganga Ram Hospital, discusses HCC management, emphasizing prevention.* 08:29 🕵️ *Surveillance for HCC is essential, with criteria including commonality, affordability, acceptability, and effectiveness.* 11:26 🌐 *Ultrasonography is a key surveillance modality, offering high sensitivity in detecting early HCC, especially in countries like Japan.* 13:03 📸 *Radiological diagnosis of HCC, using criteria like arterial phase hyperenhancement, can often eliminate the need for a tissue biopsy.* 15:47 ⚖️ *Biopsy is indicated for indeterminate lesions, and staging considers tumor size, performance status, and liver function.* 19:15 🚑 *Curative therapies for early HCC include ablation, surgery, and liver transplantation, with options like percutaneous ethanol injection and radiofrequency ablation.* 21:10 ❓ *Radiological diagnosis of HCC includes arterial hyperenhancement, total venous washout, and underlying cirrhosis, but not a size less than one centimeter.* 24:57 🩺 *Early diagnosis of HCC involves recognizing well-differentiated carcinoma and assessing fat positivity. PET has no role in early HCC diagnosis.* 25:41 🔄 *Surveillance for HCC in non-cirrhotic patients with portal hypertension depends on thrombosis presence; hypercoagulable state may be a focus.* 26:09 🌐 *BCLC staging system, particularly BCLC, is widely used in India for HCC, validated and considered best. The speaker suggests an easier algorithm as an alternative.* 27:17 🩸 *Larger HCCs, preserving liver function, may not exhibit elevated alpha-fetoprotein. Surgery is the primary curative option, with no significant difference in radiological features based on cirrhosis presence.* 28:13 📉 *AFP of 170 in a