Normal Skin Histology - Explained by a Dermatopathologist

Рет қаралды 290,058

8 жыл бұрын

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Topics discussed:
Epidermis:
Layers of epidermis: 0:10
Melanocytes vs Keratinocytes: 5:16
Langerhans cells: 10:10 & 33:30 & 57:30
Dermis:
Papillary and reticular dermis: 11:50
Three types of white empty spaces on a slide: vessels, glands/ducts/cysts, or artifact: 15:25
Blood vessels & nerves: 18:24 & 48:50 & 58:59
Arrector pili & other dermal smooth muscle: 20:00
Adnexal:
Sebaceous gland: 21:10
Hair follicle 23:14
Eccrine sweat glands and ducts 24:45 & 50:00
Gland/duct vs blood vessel 27:20 & 48:50
Apocrine glands: this video kikoxp.com/posts/7837 (at 12:30)
Acrosyringium: this video kikoxp.com/posts/7837 (at 10:00)
Three types of pink bundles: smooth muscle, nerve, dense connective tissue: 27:50
Acral skin (palm sole) with contact dermatitis 29:37
Parakeratosis 30:00
Perivascular lymphocytes 30:40
Eosinophils vs neutrophils 31:20
Spongiosis with desmosome keratinocyte spines 32:10
Spongiotic vesicles with Langerhans cells 33:30
Normal acral skin (palm & sole) with stratum lucidum 34:20
Normal glomus body/apparatus (canal of Sucquet-Hoyer) 35:40
Nerve 36:46 & 51:50
Adipose tissue (white fat cells) in subcutis with Lochkern 37:55
Normal scalp skin with large anagen hair follicles: 39:30
Hair follicle anatomy (bulb/matrix, inner root sheath, outer root sheath, hair shaft, isthmus, infundibulum): 40:55 (labeled images):
kikoxp.com/posts/3661 & kikoxp.com/posts/7899
Pacinian corpuscle 50:40
Meissner corpuscle 1:02:28
Dense regular connective tissue (Fascia/Tendon/Ligament) vs Smooth Muscle 53:00
Basic Normal Skin Immunohistochemistry:
-cytokeratin in epidermis: 55:33
-S100 in melanocytes and Langerhans cells and adipocytes: 57:30
-Desmin in smooth muscle (arrector pili and blood vessels): 58:59
-CD31 in endothelial cells of blood vessels: 59:33
-SOX-10 in melanocytes: 1:00:40
Digit/Finger/Toe histology (amputation for subungual acral melanoma) 1:04:10 & 1:08:30
-bone 1:05:40
-glomus body 1:05:15
-tendon/ligament 1:06:10
-artery 1:06:58
-fingernail/toenail 1:08:54
-acrosyringium 1:10:45
Solar elastosis (what wrinkles look like microscopically!) 1:11:50
Other videos you might like:
Tendon vs Nerve Histology Made Simple with the Ramen Noodle Sign (of Fulton) video: kikoxp.com/posts/4466
Melanocytes vs Keratinocytes made easy video: kikoxp.com/posts/3802
Blood Vessel vs Gland vs Artifact Made Easy video: kikoxp.com/posts/4808
The basic normal structures of the skin discussed and described by a dermatopathologist. This material is intended for use by medical students, junior pathology or dermatology residents, or for anyone else studying normal human histology. Special thanks to two of my medical students at UAMS for helping make this video possible. Miki Lindsey convinced me that I really needed to sit down and record this video. Akash Patel took time to edit the video and make it ready for KZfaq. My sincere thanks to both of them for helping me overcome procrastination.
Huge thanks to Abigail Cline, a medical student at Medical College of Georgia, for volunteering to type a transcript of this ENTIRE video (over 14,000 words!) so that I could provide closed caption subtitles for those with hearing impairments and for those who may need assistance in understanding spoken English (particularly given how quickly I speak!). You can access a text version of her transcript of my video here: kikoxp.com/posts/5390
Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions.
Also, in the past I used "keratinocyte" and "squamous cell" interchangeably (this is because in dermatopathology, we see and talk about squamous cell carcinomas all the time, and those tumors are composed of keratinocytes). But technically, in normal skin histology, "squamous cell" refers only to the flattened keratinocytes in the superficial epidermis. Thankfully, a histology PhD colleague pointed this out to me and corrected my lazy nomenclature!
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: bit.ly/2Te2haB ‬
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Facebook: / jmgardnermd

Пікірлер: 272

@JMGardnerMD 6 жыл бұрын

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Also, Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions. Sorry about that!

@kanvalImran 5 жыл бұрын

Jerad Gardner, MD yes I thought so too thanks for correcting.. u usually keep the arrow to point out minor structures plz keep arrows pointing on each structure to make it more clear.sometimes the arrow is lost..thanks so much for wonderful videos

@Vlad_Kowach 4 жыл бұрын

Спасибо за ваш труд (Thank you for your work.)

@stephanieys9349 4 жыл бұрын

Thank you so much!!

@System9down 4 жыл бұрын

Hey, Doctor Jerad. How are you? I'm from Brasil and I have a channel on youtube. Could I use this video, without the audio, to explain the skin? I mean, I just want the images of the tissues, I will take off your voice and I will explain this all in my voice. I'll put the creditis down bellow the video and a link for your channel and this video. What do you say?

@GregorMortis420 3 жыл бұрын

Dude, you displayed a shit ton of notions/informations, how are we supposed to judge you from this small mistake? XD

@fernandovet 3 жыл бұрын

I am a professor of pathology in Brazil. I always watch your videos, because it is a mirror where I can try to level myself. You have a didactic talent, showing in a simple and direct way how it works and how our body is attacked. Congratulations.

@JMGardnerMD 3 жыл бұрын

🙏🏻🙏🏻🙏🏻

@mariajoao5261 4 жыл бұрын

I'm a medical student in Portugal and I could not be more grateful for your effort. It enabled me not just to learn some concepts that will be essential for my studies, but also allowed me to start liking this. It is amazing to learn all this material by listening to your explanations rather than reading a book and finding all this boring, when it is great fun. Thanks, Sir. 😊

@MCX-rz9zz 6 жыл бұрын

Dermatology Resident here, OMG I want to thank you so much for recording and uploading these videos. Better than my teachers, for sure :P

@JMGardnerMD 6 жыл бұрын

So glad you enjoy them!

@izhakbar 7 жыл бұрын

is there any chance you will make more videos like this? you are a natural gifted teacher. we would definitely appreciate videos in pathology ... thanks for this one!

@JMGardnerMD 7 жыл бұрын

Thanks for the kind words. More videos in the works soon.

@JMGardnerMD 3 жыл бұрын

@grigonius 6 жыл бұрын

I am a pathology resident and your videos really helped me. Thank you for the great lessons!

@SajithSatheesh1729 8 жыл бұрын

Excellent video! Laying the foundations right. Can't wait for more from dermpath.

@myrtextonwang9052 3 жыл бұрын

Thank you so much for making these videos. I appreciate it so much!!!!! I am a dermatology resident in Germany and this is so much better than most clinics teach their residents. I love these videos and will hopefully get through all of them step by step. Greetings from Germany

@marie-luisebrunner5526 4 жыл бұрын

This is so good! THANK YOU SO MUCH for your effort! This is awesome. Very highly appreciated. Thank you!!

@saurabhmoond 7 жыл бұрын

great video o dermal histology, laying the foundation right. waiting for more........

@lajoswinkler 6 жыл бұрын

Thank you for making this video. It's what a proper histology lesson should look like.

@AndreaDArino 7 жыл бұрын

Top notch lesson, really what I was looking for. Thank you!!

@NigerianArchitect 4 жыл бұрын

wish i had the ability to spot a monocyte amidst all that mess, it's a talent

@lifeonmars1044 4 жыл бұрын

Same 😄👍

@jskim7161 3 жыл бұрын

Reviewing and rethinking of normal histology always make me fresh !!

@missknowall 3 жыл бұрын

Went through the whole video once again. It is so packed with "pearls of wisdom" that every time I see it, I get something new out of it. So thanks once again Dr Jerad Gardner.

@JMGardnerMD 3 жыл бұрын

Thank you! Also you might find this helpful...A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

@ChapmanHistology 8 жыл бұрын

Great job Jerad! You don't see glass slides being used for creating videos nowadays! This is old-school histology teaching and it's great to see.

@juliemontgomery9452 7 жыл бұрын

This is absolutely wonderful. I wish there were great videos like this for every organ and their major diseases. Thank you so much!!!

@JMGardnerMD 7 жыл бұрын

Thank you! Check out WashingtonDeceipt channel. He has tons of great pathology and histology videos. He's an excellent educator.

@marcomazzotta1921 7 жыл бұрын

Hello from Argentina. Great video! It helps understand skin histology clearly! Thank you !

@TH94persia 2 жыл бұрын

I just started my pathology residency in germany, and your videos are helping me a lot to understand the fundamentals, thank you for your clear and good explanations

@purusottammishra7468 2 жыл бұрын

Dear Professor Gardner, I have learned numerous things from this video. Thanks for sharing your experiences.

@angelasaradian6649 5 жыл бұрын

I’ve never seen better histology video and explanation than this one . Thank you very much ... I will wait for some new videos )

@emmadenis2543 5 жыл бұрын

Excellent videos, so educative indeed, your effort is highly appreciated and please keep it up

@carnol10 7 жыл бұрын

you are such an amazing educator. i love these. residents, please look at these!!

@JMGardnerMD 7 жыл бұрын

Thank you for the kind compliment, carnol10!

@priyankakale7741 4 жыл бұрын

You channel is awesome for any pathologist esp in derm and bone soft tissue pathology. I no more find it difficult as it used to be for me. You way of showing no.of cases gives a lot more confidence about the tumors. Your way of teaching the aproach to see any slide is soo good. Thank you so much.

@user-pj7uf9xs8k 4 жыл бұрын

That's a real amazing video to start learning dermatopathology. Thank you!

@rebeccavaughn9659 3 жыл бұрын

EXCELLENT! You are such a wonderful teacher. Thank you so much!

@jaydenwongyisheng4288 5 жыл бұрын

Thank you Jerad! Really helpful for a dermatology resident starting out :)

@user-gt8iq2rf9l 2 жыл бұрын

I'm very keen on skin pathology and I am going to train to become a pathologist, so I find this extremely helpful! Thank you!

@sakshigupta8433 6 жыл бұрын

Blessed to see these videos. Heartful thanks to awesome teacher

@rayaswinasari2825 5 жыл бұрын

I am so grateful to find your video. You did amazing job. You have natural yalent to make people understand. Hope you stay healthy and well. Cheers😊

@kusumikakanak4116 5 жыл бұрын

Amazing video,you are a gifted teacher. Very helpful and a very simple language,so we understand very easily. Thanks indeed

@nicolekraipowich6110 4 жыл бұрын

I love this video. I hope that in the future you might make a video on the normal hair follicle anatomy, stages, how to differentiate different types of alopecia... I love your book too!Thanks for all you do

@JMGardnerMD 4 жыл бұрын

Thank you! And I’m so glad you like the book. Hair follicle Histology I could do, but alopecia is still so complicated for me. Maybe once I get a better grasp of it can make a video! What I should do is partner up with Len Sperling or one of the other alopecia gurus to make a video. That would be pretty awesome. If I get a chance to make that happen, I will go for it.

@adrianaprieto7673 4 жыл бұрын

Extremely clear!! Keep on doing this!

@hanyamid5327 Жыл бұрын

Thank you for the video! It was incredibly informative and helpful. I appreciate your expertise and the effort you put into explaining concepts.

@davebrodhead6315 6 ай бұрын

Thank you for publishing these! I am a beginning A&P student. Histology is brand new to me and I was struggling to find it relevant to put in the time to figure it out. I found your videos on synovial sarcoma. My cousin (same age) passed over 10 years ago from synovial sarcoma so that video anchored my learning to something that I care about, but many concepts went over my head (which is great since you made me curious). Then I found this video which is really bringing alive the concepts I am learning in class. THANK YOU!

@chrysastamou5528 7 жыл бұрын

Mr. Gardner, I am really excited that I can finally attend your video! So happy to find that there are closed subtitles, it was very difficult for me to attend the video without subtitles because of my hearing impairment. Thus, I would like to thank you and the volunteer medical student Abigail Cline for the amazing work. Thank you very much!

@JMGardnerMD 7 жыл бұрын

My pleasure. More subtitles are in the works currently.

@lalanto341 2 жыл бұрын

Holy smokes, Doc. Do you have podcast? You will make an exceptional podcast speaker for sure! Thank you for this, Doc. I'm a first year medical student and our exams this dec 17. Understanding the concepts will surely boost my memory retention.

@dr.dibbyajyotidutta8304 5 жыл бұрын

just Amazing ! A BIG THANK YOU SIR ..

@graceguan9155 3 жыл бұрын

YOU ARE THE CUTEST PATHOLOGIST I'VE EVER SEEN!!! So well explained presentation and it really helped me a lot w understanding the content!!!

@robertmontgomery3892 10 ай бұрын

I'm a layman with nerdy hobbies like Microscopy. I have a Lomo Research Microscope circa 1960 that I've used to examine many tissue slides over the years and I loved your video. I'm 76 years old and I just subscribed to your channel and watch more of your videos in an effort to continue my education. Thank you.

@JMGardnerMD 10 ай бұрын

Nerdy hobbies are the best! Glad you enjoy the videos!

@veronicaking1534 8 жыл бұрын

More more more! Great for veterinary pathologists too!

@Dr.WinAye 4 жыл бұрын

Sir actually I had a lot of doubts in histology spotters, but most of doubts got clarified to me after watching this video. Please continue to make more videos like this. Thank u soooooooo much sir.

@shirleywu4639 6 жыл бұрын

Thank you very much dear Dr Gardner!I am now a faithful fans of you.Your teaching is so excellent and you try your best to share what you know,to help people who want to learn dermpath and those lovely petients.Your English is so beautiful and perfect for us non-English-speaking doctors to learn professional English.Wait for your subsequent update.May god bless you.Take care!

@fahmeedatasnim2175 2 жыл бұрын

Thank you so much for your lessons. I am a pathology resident and i think i would not have known the subject as i do now had not seen your videos. Honestly, cannot thank you enough. May Allah bless you. Love your work.

@sakhumzimalinga1162 2 жыл бұрын

im a first year dentistry student at wits university and this is my first time encountering this content and i already feel like i mastered it. that you Dr Gardner.

@fatm4403 Ай бұрын

Just spectacular! Thank you a million times sir

@RobFraser 2 жыл бұрын

Thanks for the walk through. Really interesting and made me wish I had some slides of my own to explore.

@odeszarules5125 6 жыл бұрын

You’re an amazing teacher. Please make more!

@sara1363sara 3 жыл бұрын

really great talk. I I wish every teacher was like that. Thank you.

@corinneaggabao3718 Жыл бұрын

thank you so much doctor! keep uploading videos!

@andhikahardaniputra5039 4 жыл бұрын

Amazing video. I believe this video will be also very useful for veterinary dermatology residents. Thank you so much!

@alicebrown1815 5 жыл бұрын

Thank you so so much for this incredible video. I am a Derm Resident in South Africa and this is so so helpful!

@JMGardnerMD 5 жыл бұрын

Glad you like it! Have you seen this one too? kzfaq.info/get/bejne/h55orKeGkrbdmac.html

@anetagandrabur2741 5 жыл бұрын

Thank you a lot for your great video. It' s very helpful for young dermatopathologist.

@roshannasimudeen4528 8 жыл бұрын

Excellent!...waiting for more

@riccardorondinone1581 2 жыл бұрын

Thank you very much for your excellent videos. I am a senior dermatologist living in Italy and recently happened to read your book “survival guide to dermatopathology” that is in my opinion the very best introduction to this subject I had ever seen out there. I appreciate your teaching skill. You make a difficult subject easy to understand. Sincerely yours, Riccardo

@JMGardnerMD 2 жыл бұрын

Thank you! Can I ask a small favor? Since you liked my #dermpath survival guide book, could you please rate it & write a short honest review on Amazon? Thank you! 🙏🏻 buff.ly/366R7va

@gizemyilmaz3832 3 жыл бұрын

Very helpful, thank you Dr. Gardner for your efforts.

@anupambrahma1005 7 жыл бұрын

Really very helpful. Please continue the teaching

@nana-yaaab8142 9 ай бұрын

Thank you for this. I am a first year pathology trainee and I so appreciate you taking the time to go through what normal looks like. I find a lot of people skip what normal looks like and go straight to the pathology of whatever organ they are teaching on, which makes it difficult to recognise normal down the microscope

@Annpau Жыл бұрын

Thank you so much for the explanation!! You´re the best. This help me a lot.

@blackf.5242 Жыл бұрын

Thanks prof. Such a comprehensive video

@davidyoung3687 3 жыл бұрын

Appreciate the informal chatting style very much

@archanamalik848 7 жыл бұрын

thank you ! this was a great video, extremely helpful.

@hadira.shakshouk5355 4 жыл бұрын

This video is really GREAT! I'm a dermatology resident and really learnt a lot from this video. Thank you!

@JMGardnerMD 4 жыл бұрын

Awesome thanks! Be sure to check out this one also. 100 classic Dermpath entities are covered. kzfaq.info/get/bejne/h55orKeGkrbdmac.html

@elhamgamal5992 5 жыл бұрын

Thank you professor for this highly informative lecture

@doctorsanakanasskinandbeau3655 Жыл бұрын

Great thanks doctor. I watched the video with my eyes open wide Wonderful presentation Bless you !! 💐💐💐💐🙏🙏🙏🙏

@rimtannous1044 4 жыл бұрын

Thank you! Much appreciation for this perfect explanation!!

@renatalp 11 ай бұрын

WHAT A LECTURE! WOW! I've studied histology in biology school, for 2 years now in medical school, and never have i ever seen the skin explained so thoroughly and so well. I'm currently studying the histology of skin carcinomas and i thought I'd go back a little and refresh my memory on what normal looks like and found your video. man, it's the basics! and i didn't know that i didn't know shit about the basics. NOW I know the basics, thanks to you! so grateful! and so wowed! thank you!

@JMGardnerMD 11 ай бұрын

So glad you found it helpful. Thanks for the kind words! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

@alaanaasani5859 2 ай бұрын

Really very helpful, thanx a lot for ur effort and time explaining this in a simply way

@cristinavelezarroyave1197 4 жыл бұрын

thank you so much Jerad. Thanks to you I could understand thing that were impossible to me onky by reading

@madina-be3lf 15 күн бұрын

Thank you SO MUCH for the video sir. I have never understood histology and pathology so well! 🎉 Now I like this science. Immediately subscribed to your channel ☑️

@burhanemregurdal2502 5 ай бұрын

I am a Turkish medical student and i want to thank you for bringing this amazing video. Its really better than other videos, showing us whole content in a video directly from microscopic view is truely educational.

@bhushanmadke5695 7 жыл бұрын

Such a lucid and excellent video

@abdulazizalnami7792 7 жыл бұрын

Excellent video, I really enjoyed watching the whole videos at once, you have an amazing teaching skills Thank you for the great video.

@akanksham1920 6 жыл бұрын

Great video, thank you so much! This helped me clear the concepts of normal skin histology Can you please do a video on skin reaction patterns

@minatsukinana2761 Жыл бұрын

You r making me fall in love with pathology

@junesun2865 6 жыл бұрын

thanks a lot! You are an inspiring and passionate teacher !

@RandiF2002 6 жыл бұрын

Hi Dr. Gardner! I am a sophomore in High School where I was selected to be in the Advanced Science Research Program. Over this course of this upcoming summer I will be conducting my own graduate-level dermatology research which will transpire to the next 3 years of my high school career. Your videos have taught me so much and vastly increased my background knowledge on dermatology which will surely help assist me through my research path. I have such a passion for dermatology and hope you keep making these videos!

@JMGardnerMD 6 жыл бұрын

That is awesome! Bravo on being selected for such an ambitious research program at such a young age. You are way ahead of where I was at your age! I’m so glad my videos helped you. Thanks so much for giving me that feedback. Knowing that I can help even a few high school students as they pursue a STEM career is so meaningful to me. If you need any other help along the way, just let me know and I’ll do my best. Best of luck!

@stewiegriffin6724 3 жыл бұрын

It’s been 2 yrs how’s the research going

@jordaniasantos2058 Жыл бұрын

Thank you so much for this video! It helps a lot! You are pretty didactic! Please, don't stop doing these videos

@JMGardnerMD Жыл бұрын

Glad you enjoyed it! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

@DrArsilahErum 28 күн бұрын

I am a dermatology attending in my country and now aspiring to be a pathologist in US. Your videos have taught me alot about dermpath. So thanks for such great teaching🙏

@birgitjamz 5 жыл бұрын

This is awesome thank you so much for this!!

@saraanis4069 7 жыл бұрын

This is very helpful, Thank you!

@douglas8051 2 жыл бұрын

Thank you for your videos. I really enjoy pathology

@lubnasuaiti1334 7 жыл бұрын

No words can describe my gratitude! I'm sure those lectures will help not only students but dermatologists all over the world. Thanks a million!

@lizmartorres3138 2 жыл бұрын

Im in my 2dn year of Dermatology and you have really helped me a lot, thank you

@ThisMichaelBrown 2 жыл бұрын

Fantastic! Learned a bunch

@77cprv Жыл бұрын

Thank you !!! Your lectures are awesome

@johnfazio2892 6 жыл бұрын

Excellent review of normal histology.

@kvill1115 6 жыл бұрын

Great lecture! Very helpful! Thank you

@missknowall 6 жыл бұрын

Great lecture. Learnt many things in spite of having been in Pathology for over 25 years.

@JMGardnerMD 6 жыл бұрын

Thank you! I'm so happy to know it is useful to learners at all experience levels!

@missknowall 6 жыл бұрын

Lo and behold! Now our entire department is hooked to your videos. Stay blessed and keep posting please.

@reemgamal6170 4 жыл бұрын

What a great way of explanation! Thank you so much.. Please please make more explanatory videos like this about normal histology. Thanks again

@JMGardnerMD 4 жыл бұрын

Thank you! Check out this bone histology video w Andrew Rosenberg: kzfaq.info/get/bejne/b5ajq5aq192YpGg.html

@giacomomariapini5146 5 жыл бұрын

Such a great video! thank you

@kumarravish561 7 жыл бұрын

just a great video really helpful for pathology resident

@oskarwinters1873 3 жыл бұрын

This video was amazing ! thank you !

@dracarolinalamounier 6 жыл бұрын

Perfect video! Congrats!!

@juliosalamanca1 7 ай бұрын

Thanks Jerad. I really appreciate your work a lot. I am a pathologist in Nicaragua. I have seen many of your videos and for me they are truly invaluable for colleagues, Pathology residents and Medical students.

@JMGardnerMD 7 ай бұрын

Gracias, amigo!

@juliosalamanca1 7 ай бұрын

Gracias a ti. Un día quizás logremos conectar para un evento de Patología en Nicaragua. Tienes un don maravilloso. Sigue brillando