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KETO & APOE4!
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5 жыл бұрынALL THINGS APOE4! Concerned about the ApoE4 gene? Wondering if it's safe for you to follow a keto/LCHF diet if you're ApoE4+? What's the deal with saturated fat for this genotype? FIND OUT HERE!
Learn more at this site -- the best resource for all things ApoE4: www.apoe4.info...
Have questions? Ask the experts on their forum: www.apoe4.info...
Awesome papers I referenced: (Email me if you'd like to read the full texts and can't find them online.)
1. Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease: www.jlr.org/con...
2. High carbohydrate diets and Alzheimer's disease: www.researchga...
3. Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet: people.csail.m...
(Note: clicking on the link for this one often does not work. You will need to copy the link & paste it into your browser and then try to view it. That should work.)
Enjoy my videos? Please consider supporting my work by making a contribution via PayPal: www.paypal.com -- send to my email address: tuitnutrition@gmail.com
No amount is too small! All support is welcome and appreciated. (All my time spent making videos and writing blog posts is unpaid time, so thank you for your support!)
@amyberger-ketowithoutthecrazy 5 жыл бұрын
PART 2 COMING LATER THIS WEEK! (With just a bit more detail on the dietary recommendations.)
@nicolelaurentLMHC 5 жыл бұрын
Yay! I see it! Thank you
@valentinoelias2736 3 жыл бұрын
i realize Im pretty off topic but do anybody know a good place to watch newly released movies online?
@walterwyatt7522 3 жыл бұрын
@Valentino Elias I use FlixZone. Just google for it =)
@jeffreyzakai6164 3 жыл бұрын
@Walter Wyatt Yup, have been watching on FlixZone for months myself =)
@tylercaden9267 3 жыл бұрын
@Walter Wyatt Yea, have been watching on flixzone for since april myself :)
@MNDanno 5 жыл бұрын
Awesome Awesome Awesome. Good Stuff Amy! For what its worth - Keto is VERY limited and tough if saturated fats are eliminated from food options. We eliminated SF from my Mom's diet for 7 months or so after we learned she was an Apoe3-4 and one of her small LDL numbers was slightly elevated. Surprisingly after 7 months of impossibly hard to to saturated fatless Keto - we re-tested and the lipids numbers were pretty much what they were before eliminating SF. Lucky in our case. So we eliminated the SF elimination. Keto got a lot easier. Just one person. Just one case.
@amyberger6169 5 жыл бұрын
Honestly, I don't think saturated fat needs to be limited. I was just telling people they *can*, if they want to hedge that bet just in case. If it were me, personally, I wouldn't sweat it. I wouldn't overload on butter & cheese, cream, etc., but I wouldn't make it a priority to avoid it.
@barbaramarzette9951 5 жыл бұрын
Glad your "just not making shit up"....you crack me up. But I love the way you break it down
@amyberger6169 5 жыл бұрын
=D
@sadrien 5 жыл бұрын
ApoE4 is associated with increased fat metabolism, AKA you are better at burning fat. You get higher cholesterol because you are metabolizing the fat faster. It seems to be more common in lean mass hyper responders. I also have increased sensitivity to omega 6, If I eat something high in omega 6 I can tell within an hour. My skin feels different afterwards like it's puffy. And I have Apoe4 and Apoe2. So I think you are spot on with that.
@night4142 4 жыл бұрын
You've just described me. My grandma has AD and I have one copy of APOE4. I've never been overweight in my life but I have so many issues when I eat high carb. Also omega six sensitive , when I eat nuts or seeds I will have acne within hours.
@4u2consider50 5 жыл бұрын
💕💕💕💕💕💕 Thank you, Amy! How generous you are with your resources to share such valuable information🤗 I look forward to sharing with others!
@amyberger6169 5 жыл бұрын
:D
@charlottedickson9203 5 жыл бұрын
You're very good at this, explained with clarity, holds my attenuation
@TreehuggerCashMoney 5 жыл бұрын
I just got my genetic test results back and was freaking out about my one copy of Apoe4. This video helped so much with my concerns. I have been on a keto diet for most of my life so hopefully that has mitigated any damage that may have been done.
@tammybaldasaro424 5 жыл бұрын
No clue about this subject, but always support your channel. You were so approachable and really helped me when i needed help, so I appreciate all your effort and will be here watching ♥
@amyberger6169 5 жыл бұрын
Thanks, Tammy!
@10squonkey 4 жыл бұрын
I'm happy about my higher LDL and TC being ApoE4 with my carnivorish-ish diet. Because as you said, my TG:HDL is spot on, Inflammation markers are optimal, have insulin sensitivity, etc. About to check my Lp(a) to round out the picture.
@annav7538 5 жыл бұрын
Excellent information, Amy! Also love your book. This additional clarification is so helpful and I will be passing it on and buying you more coffee 😉. Eliminating or reducing the cheese and having the low carb diet seems to be the most important for APOE4 carriers. I also appreciated the tidbit on the nutrients- omega 3:6 ratio, B12, vitamin D, etc. Thanks for simplifying!
@amyberger6169 5 жыл бұрын
Thanks, Anna! Part 2 coming later in the week with a bit of clarification on the diet. :)
@ediehermes6379 2 жыл бұрын
Appreciate the insight around Bredesen’s work, who we do adore but have had a hard time lowering insulin and eating “keto-light” with lean chicken breasts. Now for a “dairy-light” experiment, to include bacon. Thanks Amy!
@joshlanders9585 5 жыл бұрын
Considering APOE4s are less efficient at metabolizing fat, wouldn’t Paleo be a better way to keep carbs low or at least a modified Keto to keep the fat levels manageable?
@amys5503 5 жыл бұрын
Thank you so much for this video. After finding out through 23&Me that my daughter and I are both heterozygous for this gene, I wanted to use the information to improve our odds of not getting AD. I had already started the Keto-Green diet (a diet designed by Dr. Anna Cabeca to balance hormones and emphasizing lots of vegetables in the context of keto) and am concerned that my cholesterol will be sky high by the time I have my next physical. Based on the information in your video as well as additional research I have done, I think I am on the right track with my current diet even if my cholesterol is high. I also know now that high cholesterol in the context of a keto diet may not even be medically significant, although my doctor is going to have a cow if is because she will likely not know that. If it IS high, I will probably further modify my diet to make it more of a Mediterranean-style keto diet emphasizing olive oil, avocado oil and fish. Thank you for the information and the confirmation that I am on the right path. I know that we do not know all the answers yet, and that some of this information is still speculation, but it seems that we are getting closer to the answers all the time.
@mapleleaves2289 4 жыл бұрын
Thanks for the knowledge. Im buying your book!!
@doctorj7112 3 жыл бұрын
Excellent Video thanks!
@samtorres6352 5 жыл бұрын
Great information. Please keep it coming.
@prodigaleve4580 5 жыл бұрын
Amy, great video again. Lots and Lots of interesting stuff. You always give us lots to think and ponder about. Thanks for your time and resurch. Keep up the good work. 👏
@zeek4749 5 жыл бұрын
So good to see you again . So much great information as always thank you ❤️❤️❤️ first one to comment yaayyyy 😀😀😀
@amyberger6169 5 жыл бұрын
Thank you! :)
@albertouribe435 5 жыл бұрын
Thank you
@amyberger6169 5 жыл бұрын
And thank you so much for your generous contribution Received it a few days ago. :D
@mgrzesia 4 жыл бұрын
Very well explained and your speculations are very logical . Another evident reason to lower carb intake.
@colleenhall44 4 жыл бұрын
Excellent information.....thank you, Amy!
@nicolelaurentLMHC 5 жыл бұрын
Thank you so much for doing a video on this!
@lombardihomes 5 жыл бұрын
Fantastic, so glad I found you. You explain it very well and I found this all very interesting and helpful!
@petercyr3508 4 жыл бұрын
If ApoE4 your liver sucks up too much dietary fat from cholomicron remnants and thus has less ability to suck up (clear) LDL particles from the bloodstream before they get oxidized. So you wind up with too many small dense LDLs. For myself I am trying to modify my ketogenic diet to eliminate dairy. Substitute olive oil for butter and lard. Eat less fatty meat and more fatty fish. Can't wait to dive into the sardines (not). We will see if my LDL-P improves.
@newyorker4113 3 жыл бұрын
Apparently if you cook olive oil, it turns to trans fats in the body. Butter may be a better option. Check out Ginger’s Keto channel for this subject on saturated fat
@orcuttcat 5 жыл бұрын
Wow , I love this content
@dattatreyatelharkar5895 5 жыл бұрын
Great lecture.
@russellgallman7566 3 жыл бұрын
That was interesting.
@karibgold5394 4 жыл бұрын
Wow!! I just started watching you on another channel on YT, forgetting, (lol) that I had bought your book previously. I have experienced some slight memory changes and I'm choosing to be proactive and with the help of the Lord too, I am optimistic!! Thank you!!
@PV-free123world 5 жыл бұрын
Really amazing info Amy. Thank you so much for your hard work and dedication
@KetOMAD 5 жыл бұрын
27:16 "If you are chronically marinating yourself in insulin all day, you are at higher risk for Alzheimer's--period." Maybe so, Amy. But I'm sure that's only true for people who aren't following a high-carb food plan from a conventional RD. If the insulin bath is a consequence of following expert advice, I'm sure the insulin degrading enzyme takes that into account and has pity on us...
@bnakamura6014 5 жыл бұрын
CarnOMAD 😂
@amyberger6169 5 жыл бұрын
Yes, *of course.* If the insulin comes from consuming whole grains, apples, grapes, and oatmeal, it's the "good insulin." Not like the BAD insulin that comes from...I dunno...TMAO, heme iron, and all those other terrible compounds. ;-)
@KetOMAD 5 жыл бұрын
@@amyberger6169 Lulz!
@kellyclover5953 4 жыл бұрын
I have never been tested for that gene, but experience shows that saturated fats cause Lp-PLA2 to skyrocket, indicating serious arterial inflammation. Another website says saturated fats are bad if you have Apo E 4 while monounsaturated fats are good.
@WestieKatie 5 жыл бұрын
Thanks for discussing this!!!
@arthurfremminger1680 5 жыл бұрын
At 23:29 "There are tribes in Nigeria that have a very very high frequency of this APOE4 gene, and you know what they don't have...Alzheimer's disease! They have lots and lots of E4 among them - they don't get Alzheimer's disease because they live, and they eat very very differently to the way that we live and eat in the rest of the industrialized world." I have heard Vegan doctors claim this as a victory for their side, but I have always dismissed this notion due to the fact that (as of 2016) the average life expectancy in Nigeria is fifty-four years old. How many people in any population that are dying in their late 50's to early 60's are already showing symptoms of late-onset Alzheimer's disease (LOAD)? What kind of medical observation are these "tribes" getting that would assure clinicians good stats on this? Therefore, I have always been skeptical of this claim.
@ndusfca2012 5 жыл бұрын
Arthur life expectancy is calculated on population level. Generally all of Africa has low life expectancy because of child death not that people die in their 50es. There are more older and functioning people in Africa if they survive childhood and other killings. I hope this helps.
@arthurfremminger1680 5 жыл бұрын
@@ndusfca2012 When statistics become available that tell me what percentage people who did live 63 years or older show signs of Alzheimer's/Dementia, and how that percentage compares to other nations - then I'll be more open to believe it. Despite your clear explanation, it won't stop some individuals from using per capita stats to support an agenda (i.e. vegans), when in fact a large portion of the population never lived long enough to show symptoms of Late Onset Alzheimer's Disease in the first place.
@LeeAnnSwanson 4 жыл бұрын
Enjoyed this!! I do wonder what your thoughts are on the CHC22 Clathrin? I am APOE3/4 (heterozygous), but my CHC22 is homozygous CC (farmer type). I do Intermittent Fasting (16/8 with some 24hr), eat few refined carbs, but not limiting them much. Never been a huge meat eater, but I do eat it a couple/times/week. Labs are good and insulin was 3.51 a few weeks ago... so wonder if the CHC22 variant I have contributes to this. Thanks again for all you do. Keep it up!!
@karinamorford3949 5 жыл бұрын
So helpful - Thank you!!
@SchmittsPeter 5 жыл бұрын
Nice video ! But in my opinion, the thesis regarding larger plant-nutrient-intake does not hold, as there are also hunter-gatherer societies like the Inuit, which have a great amount of people carrying the gene but eat mostly seafood / sea-marmals.
@sabincioflec8413 Жыл бұрын
I think omega 3 is extremely important for apoe 4 from what I've read. Beef/pork brain has around 0.7g of omega 3 per 100g and it's in line with hunter gatherer the most.
@lukef829 3 жыл бұрын
Just watch your video on apoe4, first love your energy and insight. I do have a couple of questions: you mentioned to limit your glucose, and saturated fat. Question, what percent of saturated is good and what is the best glucose level you suggest. Also, if apoe4 individuals have a difficult time already transported fat wouldn’t consuming saturated fat be not so advised for someone is has cardiovascular issues or another? Thx
@Bio2Balance 5 жыл бұрын
Amy, great video!!! Thanks so much for your dedication. Question, is there any connection with the APOE4 gene and blood type O? I am referring to D’Adamo’s theory of the blood type diet. I still question the validity of that research. Any input would be appreciated. The diet for blood type O is very similar to what you are suggesting.
@MN-wg8qd Жыл бұрын
What if your apob goes up on a ketogenic or low carb diet? Seems like an independent risk factor for CVD until proven otherwise. Should someone eat like 70% protein, 10% carb, 20% fat in that case or something along those lines? Maybe increase carb/fat by a bit as long as numbers are good?
@lowcarbkitchen 4 жыл бұрын
My hubby has the apoe4 gene and he does have Alzheimer's. His mother did also. I'm concerned about my 3 sons. Can't convince them to go keto. :(
@whatta1501 5 жыл бұрын
I'm going to buy your book, thx. I have the worst brain fog
@chrismyers9951 2 жыл бұрын
Check out Stephen Gundry. Has the most direct experience with apoe 3/4 and 4/4 patients. Recommends less saturated fat and lots of real virgin olive oil.
@wendyfried4589 5 жыл бұрын
Is the doctor Dave you mentioned Dave Feldman?
@amyberger6169 5 жыл бұрын
No. Dave Feldman is not a doctor. He's a "citizen scientist." Not an MD or PhD. Doesn't take away from the brilliance of what he's uncovering and sharing with us, but to clarify, no. he is not a doctor.
@Shadow_Warri0r 4 жыл бұрын
Interesting I wonder if Polynesian peoples are higher in this, because the diet you speak seem to fit what Maori (New Zealand) traditionally ate.... just a thought
@steveanston4906 5 жыл бұрын
Very good video - thx. How do I find out about my personal APOE gene? I no idea. 23 and me?
@amyberger6169 5 жыл бұрын
Yes, 23 and Me can tell you, but you can also just ask your doctor to order the test to get your ApoE genotype.
@annav7538 5 жыл бұрын
Steve Anston yes
@jeranjed 5 жыл бұрын
I thought e4/e4 is a 35-65% chance of getting alzheiner's. where did you get 50-90?
@tomlodge1329 5 жыл бұрын
Does Nicotine improve Cognition in E4/E4 users?
@jorgeluisgarcia1006 5 жыл бұрын
✋
@amyberger6169 5 жыл бұрын
Hola!
@DanScottChannel 5 жыл бұрын
I wonder if this is why I responded as I did with going keto then strict carnivore? My liver functions are all good and I'm a low BMI of under 23. I also work out with weights 5 days per week but I responded as follows with high animal fat intake. The numeric order of the numbers = Total....Triglycerides.....HDL….LDL. Has anyone had numbers like this? *Pre-carnivore (vegetarian)* 04/03/18 156 70 63 79 *Post Keto/Carnivore* 12/13/18 770 160 87 651 01/15/19 758 230 53 659 02/20/19 648 103 95 532/ApoB 291 03/21/19 677 126 68 584
@ndusfca2012 5 жыл бұрын
Do you know if you have Apoe4?
@DanScottChannel 5 жыл бұрын
@@ndusfca2012 No, I don't know but will get the test done to find out. Somebody else I was talking to on YT said they had ApoE4 gene and went high fat but their lipids never exceed 300? I have adjusted my macros and increased protein and as of May 19 I am down to 478 where HDL and Tri's are good. I may also have a unique situation seeing I had a kidney/pancreas transplant in 1995 and a second kidney in 2012. It may be something to do with the immunosuppressant drugs I take? I also considered I may not have been metabolizing fats very well for deficiency in L Carnitine. I researched carnatine and started taking 2g of the Acetyl L Carnitine along with Acetyl L Carnosine. As for fat metabolism, although I'm low BMI already, after a week on the carnitine, I dropped more fat around the lower belly and the abs started showing. What they say about this supplement in relationship to mitochondria and fat transport/metabolism seems to work.... BTW, love your channel!
@bettywhill Жыл бұрын
My numbers are similar to yours except lower triglycerides, higher HDL. Maybe I’ll try increase protein, reduce saturated fat and see what happens
@DanScottChannel Жыл бұрын
@@bettywhill I ditched keto a long time ago and now have not total cholesterol numbers in the mid 100's.
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