Presented By: Melissa J. Caimano, PhD
Speaker Biography: Melissa J. Caimano received her Bachelor of Science degree in Microbiology from the University of Rhode Island and her Ph.D. from University of Alabama at Birmingham, with her thesis focusing on capsule biosynthesis in Streptococcus pneumoniae. She is currently an Associate Professor at UConn Health in the Departments of Medicine, Pediatrics and Molecular Biology and Biophysics....
Webinar: Keynote Presentation: c-di-GMP Signaling in Borrelia Burgdorferi: A Guiding Compass for Navigating the Enzootic Cycle with Live Q&A
Webinar Abstract: Borrelia burgdorferi, the causative agent of Lyme disease, cycles between an Ixodes spp. vector and a vertebrate reservoir host, typically small rodents. Humans become infected when they intrude upon this enzootic cycle, providing a blood meal for an infected tick. To sustain its dual-host lifestyle, B. burgdorferi employs elegant regulatory mechanisms to remodel its transcriptome in response to tick- and mammalian host-derived signals, a process collectively referred to as ‘host-adaptation’. The majority of differentially-expressed genes involved host-adaptation by Lyme disease spirochetes are controlled by two regulatory pathways.
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