did they drink alcohol? Were they early diagnosed with AATD ?

unfortunately there is not much to do for the liver except live healthy, not drink alcohol, stay fit and active, don’t take too much pain medication or other liver toxic meds. And if the RNA stuff comes through, it means life long weekly infusions with AAT to protect the lung. Obviously better than liver cirrhosis/failure.

PiMZ is not that bad. Only one allele is affected. Heterozygote form. Be sure to not damage liver with alcohol, pain medication etc. Live healthy. Avoid other diseases. Chances are good that lungs will never be affected and liver most likely not or only little. How high is ur AAT blood serum levels? If it’s normal range (which is possible with PiMZ) the lungs are protected. Don’t smoke obviously or choose a job with dust/smoke.

which genotype? PiMZ, PiMS, Pi00, PiZZ….?

@@StephyGrowsWeed zz

the RNA Stuff stops/reduces production of AAT. That means u d need weekly prolastin infusions. It’s expensive.

why no prolastin? 😧

@@StephyGrowsWeed It is approved but too expensive for the region, it is said. And that the effect is too low from the treatment. Don't know if I totally believe it. I think the research in Sweden wants us zz for themselves to experiment with.

@@susannegidlof9842 yea, i don’t know. I ve read different studies now. Some say it doesn’t have a huge effect. Most likely needs double the dosage to be effective/more effective. And yes, it’s so expensive. Also having a weekly infusion for the rest of the life sounds bad to someone like me with pretty bad veins. They would have to figure out smth like subcutaneous applications but i think A1AT is too huge to be applied subcutaneously or intramuscular 😢 I think they are work on A1AT for inhalation 🤔