Kratom with Dr. Christopher McCurdy

Рет қаралды 7,473

Күн бұрын

An estimated 3 million Americans use kratom products for recreational purposes, in self-treatment of opiate addiction, and to manage pain. Yet, our scientific understanding of its safety, efficacy, and potential for addiction is still poorly understood. With new data emerging each year, scientists are starting to gain a better picture of the full spectrum of risks and benefits of this SE Asian medicinal herb. Our guest this week, Dr. Christopher McCurdy, is an internationally recognized expert on kratom. Chris is a Professor of Medicinal Chemistry and Pharmaceutics at the University of Florida College of Pharmacy, where he also directs the UF Translational Drug Development Core. We address questions like:
1) What is kratom? Where does it come from and how does its traditional use differ from the ways it is consumed in the USA?
2) What are the major active compounds found in kratom and how much variation is there in different products?
3) What are the side effects of chronic versus acute use of kratom?
4) Are there any drugs you should avoid taking in combination with kratom?
#kratom #MedicinalPlants #Pain #Addiction #tea #Herbs #HerbalSafety #Stimulant #Science
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Kratom: Uses, Risks, and Research Insights with Dr. Christopher McCurdy
00:00 Welcome to Foodie Pharmacology: Exploring Kratom
00:38 Meet Dr. Christopher McCurdy: A Kratom Research Expert
02:35 Kratom's Traditional Uses vs. Modern Applications
07:03 Investigating Kratom's Chemical Complexity and Potential Uses
29:46 Exploring the Safety and Interactions of Kratom
33:50 Exploring the Chronic Effects of Kratom
34:40 The Increasing Tolerance and Dose Escalation in Kratom Users
36:53 Side Effects and Interactions of Kratom
38:10 Kratom's Impact on Pregnancy and Newborns
41:53 Understanding Kratom Usage and Its Scope
44:39 Navigating Resources and Future Research Directions
48:48 Collaborative Opportunities and Closing Remarks

Пікірлер: 85

@gsdlover257 9 ай бұрын

Thank you Dr. McCurdy for all of your research.

@Mysticstone1111 5 ай бұрын

Thank you doctor❤ We apreciate all your hard work. I know theres got to be something in nature to help with opiod withdrawal and pain management

@jimothyj2638 4 ай бұрын

Fantastic interview! We need more research on all these alkaloids. I never knew about the seratonergic effects

@calebliang4984 Ай бұрын

There’s even an alkaloid with nmda antagonism very minor albeit but it’s impressive that it’s there nmda antagonism is responsible for drugs like ketamine and pcp

@Mxxnmuk 3 ай бұрын

I've taken kratom like 3x a day for like 5 years now and I still take the same dose as when I started I take 3 grams at a time and I take green and red separately and they still have the same effect I don't have a tolerance and I haven't had any health issues I haven't been sick or anything for like a decade but I'm really healthy cause I know the fact humans are frugivores so all I eat is fruit and herbs cause that's actually food unlike 99% of most Americans diets which is just toxic chemicals that kill them so yea I'm super healthy and run and skate every day and I'm 33 an most people think I'm 23.

@eddiesland93 9 ай бұрын

Thankyou for that research

@ronnie5329 2 ай бұрын

In the fresh leaf and white strains there is more noradrenaline action. Almost everyone ive seen trying to keep upping their dosages will get tired of the slightly annoying side effects. In that sense it has a self regulating mechanism for abuse potential.

@AmandaBellefeuille-pq8oz 3 ай бұрын

I have been on 100mg of sertraline (generic zoloft) for years and started taking kratom a couple of years ago and have not noticed any side effects from use.

@hellokittycutie2003 3 ай бұрын

good to know!!! thx

@user-qh9st9xn9f 6 ай бұрын

This is really awsome and much more interesting than other videos I have seen where it is just an argument over kratom..Thanks for researching the potential danger of benzo. and ssri use with this kratom. For me I have consumed kratom for pain I have secondary to Primary Aldosteronism--Veins and circulation-super high bp led to venous insufficiency,neuropathy. Plus DjD arthritis...It helps me to be more functional and enjoy more activities.Ive never had a Euphoric feeling from it

@dmk7826 4 ай бұрын

What time in video does he talk about mixing with benzo...and ssri....can you tell me the (min)00:00 ?

@user-qh9st9xn9f 4 ай бұрын

23:50@@dmk7826

@discipledesigned 5 ай бұрын

i’m curious how low, stimulant effect inducing doses would affect prolactin levels over time. obviously higher doses would increase the speed at which the endocrine system is deregulated, but how long on how minimal of a dose would serum prolactin be affected?

@thateabishhh 8 ай бұрын

KRATOM SAVES LIVE! Thank you for this interview! 49:29

@OoSwIItchyOo 4 ай бұрын

Kratom is highly addictive. The withdrawal is HORRIBLE. You've been warned.

@thateabishhh 4 ай бұрын

@@OoSwIItchyOo warned by who? Google?

@OoSwIItchyOo 4 ай бұрын

@@thateabishhh Of course not! Warned by MY firsthand experience, and if one just searches KZfaq or Reddit for "kratom" withdrawal one will find TONS of user reports of just how bad it is. It truly is agony, and if you don't think so just try stopping for a week after consuming it regularly for 1 month...you can find out for yourself the hard way like so many of us have.

@OoSwIItchyOo 4 ай бұрын

@@thateabishhh I lost all ambition for everything in my life because I used this plant for too long. KZfaq and Reddit searches will provide anyone with the horrors of "kratom withdrawal"

@OoSwIItchyOo 4 ай бұрын

@@thateabishhh I also became quite violent while on it, but that is because I'm a naturally violent person, I'm sure.... Still, many others report the same. Even a name for it: Opi Rage

@Bob-bm1fk 9 ай бұрын

Always good to see his vids pop up. Kratom on.

@OoSwIItchyOo 4 ай бұрын

Kratom is highly addictive. The withdrawal is HORRIBLE. You've been warned.

@Bob-bm1fk 4 ай бұрын

Google old Mississippi and Kratom and give that a read. Buttercup. A substance so addicting that it stops the addiction. Smh. Thanks for playing. It's about freedom. I use Kratom for chronic back pain. Geez.

@Bob-bm1fk 4 ай бұрын

kzfaq.infocxPf9_pnduQ?si=yKxiT0RL5kMzlMIC

@MikeHunt90731 3 ай бұрын

I ve never had a problem.not everyone is a raging addict like YOU who has no self control 😅@@OoSwIItchyOo

@2nostromo 4 ай бұрын

I make opium every spring and usually run out by autumn. Kratom gets me through the dark days. Funny thing, my Doctor supports my use of Kratom but not of opium. I do not live in the USA btw. He also says I have a "normal amount of arthritis for a 70 year old". I'm 70. So in his view a disease state is normal. We really are still in the middle ages when it comes to doctoring.

@dipper888bp 4 ай бұрын

How do you ingest opium?

@2nostromo 4 ай бұрын

@@dipper888bp I weight it into 00 size capsules. But it is a serious thing. I take the risk because it keeps me in motion. If you are thinking about it there is more to it than just collecting sap which is so vile it will make u sick. probly not wise to discuss here. where jas that "free speech" internet gone? heh

@willthomsen7569 3 ай бұрын

Opium is smoked. And nobody really doing that would say it to the world on the internet lol

@MarioGomez-nd2mx 3 ай бұрын

@@willthomsen7569You'll be surprised.

@Dukiebutt23 29 күн бұрын

I love the Green and Red maeng Da

@banaresali 3 ай бұрын

to get off opiates like suboxone, burenorphine type substances is challenging like nothing some one has ever been challenged to do before for so many people...kratom is great for weening off for good. just dont use more than a teaspoon or 2 a day

@aldon78 3 ай бұрын

Hello, I have a blood rutime blood test on Monday is kraton alter my test results?

@Erinskow Ай бұрын

@iDudditsi0G 8 ай бұрын

Kratom Saves lives!!!

@OoSwIItchyOo 4 ай бұрын

Kratom is highly addictive. The withdrawal is HORRIBLE. You've been warned.

@iDudditsi0G 4 ай бұрын

Why did u abuse it?

@OoSwIItchyOo 4 ай бұрын

@@iDudditsi0G I didn't abuse it, that's the thing. I just used it everyday.

@iDudditsi0G 4 ай бұрын

Have to use it wisely taper use potentiators like turmeric take breaks it’s not for everyone …you good?

@OoSwIItchyOo 4 ай бұрын

@@iDudditsi0G good now that I'm off the dope yezzir 😁

@michaelblankenau6598 8 ай бұрын

Oregon baby ... Lol

@user-us5pv8zw3z 7 ай бұрын

#BostonStrong

@MarioGomez-nd2mx 4 ай бұрын

#LomgbeachCa

@dipper888bp 4 ай бұрын

90 g for one dose? Or per day?

@notmyrealname9059 4 ай бұрын

An average dose is between 2 grams for more stimulating effects, and 6 grams for far more sedating, opiate effects.

@dipper888bp 3 ай бұрын

@@notmyrealname9059I’ve never felt sedated no matter how much I took.

@dipper888bp Ай бұрын

@@notmyrealname9059 6 grams not sedating at all for me, more the opposite

@george.s.8491 7 ай бұрын

We would be absolutely crazy to throw the baby out with the bath water when it comes to kratom. It has it’s potential cons, but waaay more pros.

@OoSwIItchyOo 4 ай бұрын

Kratom is highly addictive. The withdrawal is HORRIBLE. You've been warned.

@notmyrealname9059 4 ай бұрын

Compared to what?

@dipper888bp 4 ай бұрын

True; but it’s not for addicts. Addicts can’t take it as prescribed like every other drug. No addicts can skip days, addicts can’t.

@OoSwIItchyOo 4 ай бұрын

@@dipper888bp If anyone takes this drug every day, they qualify as an addict.

@george.s.8491 4 ай бұрын

@@OoSwIItchyOo that’s why it shouldn’t be taken every day. There are plenty of folks who use it regularly that are very careful. You don’t have to warn me, I totally understand, but that’s my fault, my stupid choices. Everything can be used in moderation as a tool.

@ljh150 5 ай бұрын

How does kratom affect the gut microbiome?

@TeachEthnobotany 5 ай бұрын

Great question! We don't know yet. I have a student working on metabolism of kratom compounds by liver enzymes and we hope to student gut microbiome effects in the future as well.

@youtuberadical9421 5 ай бұрын

No scientific answer yet unfortunately….but if you experience constipation on Kratom it can negatively affect gut biome….constipation allows bad bacteria to grow and multiply on the trapped fecal matter. When I use to consume Kratom daily, I also used 400 mg Magnesium Citrate, and 1-2 grams of triphala and was usually fine

@OoSwIItchyOo 4 ай бұрын

It wrecks it. Massive constipation. Kratom is highly addictive. The withdrawal is HORRIBLE. You've been warned.

@gsdlover257 4 ай бұрын

Have to stay super hydrated with electrolytes

@MarioGomez-nd2mx 4 ай бұрын

I use Kratom and take my usual dumps in the morning. 💪