Loved your tutorial! I totally understood the concept! I had a hard time getting it right in my head, but now it makes sense! Thank you!!

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thank you so much, I finally understood what is meant by "serum-iron" it was so confusing before I found your video

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Transferrin carries iron molecules around the body body so let's say Each transferrin molecule has two seats or two spots where iron can be carried total iron binding capacity would be the maximum amount of iron that can bind to the transferrin molecules in this is then usually expressed as a value in micrograms micrograms per deciliter or can be all right so in a normaltotaliron binding capacity would be somewhere binding capacity would be somewhere between 250 to 450 micrograms so this is the maximum amount of iron that can be bound then serum iron is simply the total amount of iron that is then somewhere between 50 to 150 mlcrograms Serum iron is total iron that is actually bound to transferrin Total iron binding capacity is that let's say the potential for iron binding for iron binding so the total amount of iron that can be bound if all the seats were taken up on all the transferrin molecules of as I've drawn in this picture as well that about one-third of the seats that about one-third of the seats are taken under normal circumstances and we Serum iron that is divided by the totaliron binding capacity capacity will tell us what number of seats are taken and if we turn this into a percentage so we have to multiply this with 100 then unsaturated iron binding capacity or so called you I *total iron binding capacity equals the serum iron plus the unsaturated iron binding capacity

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I keep thinking of the TIBC and iron sat like a see saw, where the high TIBC has to offset the iron sat at exactly the opposite of the tibc. Am I wrong in this?

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What would it mean then if your transferrin and TIBC are both low, but your iron, iron saturation and your ferritin are in normal range? It’s hard to find anything on the web regarding that particular scenario. Anyone else see this before?

Thank u soo much🙏

How can I increase my transferrin? I see that no where online.

If Ferrintin decrease TIBC also decrease, for someone with iron overload if treated ferrintin goes down, and TIBC also goes down then he will not reach a normal TIBC value I'm confused...

Then I don't understand why TIBC is high in iron def anemic. It seems based on this explanation, TIBC should be more or less constant while UIBC will be high in Fe def anemia. Unless there is a stimulation of increased production of Transferrin in Fe def anemia.

whats the purpose of saturating the sample prior to the test?

My total iron is 349 and my saturation is 90 super hight what does its mean

How can we staminate (Si)

So if serum fe ion increase then ticb decrease??

I am in the health care field and have always had a problem understanding this concept. And I think I do not understand because of not knowing the mechanism of the test. In the blood there is apotransferrin and transferrin, transferrin being the one that is loaded with Fe, two Fe each transferrin. So maybe I assume wrong the TIBC would be the sum of apotransferrin and transferrin. Apotransferrin is without the iron, is it not? So would apotransferrin + transferrin not be the TIBC. We already know the serum transferrin or iron level right? So when you draw the 100 cc and draw the theoretical twelve yellow transferrins, what does the lab do to strip all the iron off the transferrin that was originally in this 100 ml of blood. There must be some as it is not zero. And then how do they "put it back" to measure this serum transferrin. Why don't they just measure the apotransferrin and the transferrin levels separately and add them. When they give the number of serum transferrin as 1.8 mmol/dl then since there are two Fe on each transferrin, wouldn't the actual serum iron be doubled?

OK so I didn't find this helpful in the least bit. Thanks anyway?

Thank you