Lipoprotein a? What's that!

Рет қаралды 10,356

Күн бұрын

LDL causes atherosclerosis. That’s a fact. We now have drugs that can wipe LDL out of the blood, but is that the end of history? Probably not. There are other causal lipids (lipoproteins) than cause atherosclerosis. The next target for therapy is probably gonna be Lipoprotein (a). So here is the summary of what we know about Lpa and how to manage it.
0:42 Lipoproteins and heart disease
1:58 Structure of Lpa
3:36 Link of Lpa to CVD
4:52 Risk or cause?
5:37 Lpa and aortic stenosis
6:35 How does it injure valves and vessels?
7:14 Normal blood levels
8:45 How to treat elevated Lpa
10:35 Specific Lpa target therapies
11:10 Summary

Пікірлер: 82

@85jre 11 ай бұрын

Love your question answer format and direct delivery. New subscriber!

@CardioBuzz 11 ай бұрын

Awesome! Thank you! Welcome aboard

@numberthree267 4 ай бұрын

LP(a) is a risk factor, not an inevitable sentence to CVD. Don't smoke, stay active, maintain a normal weight, and eat a healthy diet. Try to achieve an optimal (not "normal") level of LDL if your LP(a) is elevated. Be concerned but not paralyzed!

@JandP_Travels 4 ай бұрын

This is the most excellent lesson on LPa, great data, Thank You

@SatishSharma-uu1lp Жыл бұрын

Good Info

@Notme-tq4xs Жыл бұрын

Are you sure ?

$@arnoldfrackenmeyer8157$

@arnoldfrackenmeyer8157 9 ай бұрын

Without LDL we would cease to exist.

@cyanoko1 10 ай бұрын

Thank you for the infor. My lipids (LDL, HDL, TG, total cholesterol) are all within normal limits without any meds but lipoprotein a is 160 and HS CRP is >10. Should I be worried about the numbers?

@CardioBuzz 10 ай бұрын

It depends on the values of LDL and the cardiovascular risk

@leelajapheth4051 9 ай бұрын

Yes

@Brilliantindians 4 ай бұрын

Hello friend how r u? Now what is ur level of lpa a ? Any treatment r u taking?

@luisflynn991 Жыл бұрын

My wife her lipoprotein A is 402 and her hs-crp is 19.4 all her doctors did was give crestor 10 mg. Trying to get her on lipoprotein apheresis but the doctor dont know because her ldl is 45 on statin. Shes also pre diabetic which adds To the problem

@CardioBuzz Жыл бұрын

Wait for new targeted therapies

@michael-qp9xd 5 ай бұрын

Hello - great update here. Back 10+ yrs ago couple studies showed L-carnitine supplement and flax seeds can lower LPa by ~ 5 to 30%. Please any new studies or just your scientific thinking on any benefits of this two compounds>. Thank you

@CardioBuzz 5 ай бұрын

Yes, L-Carnitine, in small studies, reduced Lp(a) but without effects on cardiovascular outcomes. Besides, animal studies suggested that L-carnitine accelerated atherosclerosis!

@milanpintar 4 ай бұрын

i had a 100% blocked widow maker a few months ago, i got my lp(a) today and only have a value of 7!

@JMK-vo8pv Жыл бұрын

Could you please refer me to ANY RCT's that PROVE a CAUSAL relationship between Lp(a) levels and cardiovascular disease? From what I can find in the literature, the ONLY studies on Lp(a) and CVD are purely associational and, as we know, association/correlation does NOT inform on CAUSATION.

@CardioBuzz Жыл бұрын

Thanks for your question. There is a general consensus that causation can be established through Mendelian randomization studies. Here is an example of one of these randomization studies. Best regards

@CardioBuzz Жыл бұрын

www.atherosclerosis-journal.com/article/S0021-9150(22)00192-7/fulltext

@Notme-tq4xs Жыл бұрын

Firefighters are at fires. They don't start them ! lp(a) is repair. It repairs wounds. Am I wrong ?

@porkpie2884 10 ай бұрын

HI there, epidemiology cannot show causation only association. Consensus isn't truth, but simply multiple people agreeing with one another @@CardioBuzz

@porkpie2884 10 ай бұрын

NO you're not wrong you are correct. @@Notme-tq4xs

@davidbenjamin4798 Жыл бұрын

Sir, My lp (a) is 83. Will my children automatically also have high reading of lp (a)?

@CardioBuzz Жыл бұрын

Hi David! I can't give comments on individual situations but we know that the heritability of Lp(a) is very high, exceeding 90%

@thibaudjacquemaire7076 10 ай бұрын

In my family, we are 2 children out of 3 to get high LPa from our dad. So that is not automatic 100%.

@jillmorton3096 Жыл бұрын

I had a stemi a month ago 100% blockage. Confirmed elevated lpa. I was running with my sons dog at the time. I dont drink , smoke have dairy oils or eggs and am vegan. Had a major heart attack was life flighted from one hospital ro another had 2 stents. Im 54 and am nervous as the surgeon said that my lifestyle is what he prescribes to his patients. I jyst dont want to be on all of these pills a year from now espexially the statin😭

@CardioBuzz Жыл бұрын

Sorry to hear that! I hope you are making a good recovery. We hope that future therapies for LDL and Lp(a) are injectables so that we don't need the daily pills 🤞🤞

@kuuhgle 9 ай бұрын

Eating carbohydrates and being overweight causes atherosclerosis, but doctors don't know that. Keto diet is the only thing that helps.

@tanitasara5919 4 ай бұрын

Estoy probando esta dieta cetogenica

@JMK-vo8pv Жыл бұрын

How come there are some elderly patients who have had a LIFETIME of very high levels of Lp(a) and those same humans have perfectly clean coronary arteries (i.e. ZERO plaque) on their coronary angiograms and pristine aortic valves on their CT scans?

@CardioBuzz Жыл бұрын

Life would have been easier if atherosclerosis had just one direct cause. Unfortunately it is more complex than that. LDL and Lp(a) are causal but lifestyle is, still, responsible for 80% of atherosclerotic disease. Smoking, exercise, diet, diabetes, and blood pressure can significantly modulate the disease process and progression.

@JMK-vo8pv Жыл бұрын

@@CardioBuzz Thank you very much, Dr. Hishmat, for your prompt response. I will continue on my educational journey to learn everything I can about CAD.

@Notme-tq4xs Жыл бұрын

yes. lp(a) isn't the cause.

@SET12DSP 11 ай бұрын

@JMK-vo8pv Let's add on the fact that it can be reversed as my CAC coronary artery calcium score has gone from 660 to 458. This was done with the Linus Pauling Heart Protocol. Pauling uses Lysine and Proline amino acid supplements to bind Lp-a in the blood when this happens the Lp-a is neutralized.

@SET12DSP 11 ай бұрын

@@Notme-tq4xsLp-a is a substitute for vitamin C, it the first responder to a vitamin C deficient artery sticking to exposed Lysine and Proline strands.

@thibaudjacquemaire7076 10 ай бұрын

Very clear and complete. Love it. Started PCSK9 4 months ago, due to stent , high cholesterol and high LPa, which decreased from 85 to 69 mg/dl.

@CardioBuzz 10 ай бұрын

Great to hear that you are taking good caring of your heart💖 Your doctor is also doing a great job ⭐️

@thibaudjacquemaire7076 10 ай бұрын

Just slightly disappointed that Praluent 75 or even 150 ml decreased mbiweekly y LDL only like 25%….!?! 😥

@CardioBuzz 10 ай бұрын

What were the initial values?@@thibaudjacquemaire7076

@thibaudjacquemaire7076 10 ай бұрын

Pre Praluent: LDL 125 mg, now 85 mg.

@CardioBuzz 10 ай бұрын

That's a 32% reduction. When did you move to the 150mg dose?

@jackkauer7022 Жыл бұрын

Is lipoproteinA the same as lipoprotein(a)?

@CardioBuzz Жыл бұрын

The small (a) refers to the protein component of LPa. The capital (A) refers to the protein component of HDL

@jackkauer7022 Жыл бұрын

@@CardioBuzz thank you

@tahanyomar4206 Жыл бұрын

مرحبا استاذنا وحشتنا

@sherrio5629 Жыл бұрын

Thanks for the video. My LP(a) is 250 😭🥹

@sherryyang8487 Жыл бұрын

👍👍👍

@Notme-tq4xs Жыл бұрын

Japanese study says otherwise. French over 100yrs old all have higher lp(a). Check out other studies.

@theroofstore 7 ай бұрын

Raise the volume of your voice and more importantly stop playing the background music (decreases the ability to listen to your content)

@CardioBuzz 7 ай бұрын

Thank you for informing me about the production issues. I think we have fixed them in the videos that followed.

@nessieness5433 6 ай бұрын

Take time when pronouncing words, you seem to eat syllables and that makes it difficult to follow you at times.

@user-gn7md6fq7b 11 ай бұрын

It says very LOW levels of lpa increases the risk of Diabetes. Is it the LOW OR HIGH LEVELS of lp a ,causes diabetes risk and what is the mechanism. Thanks

@CardioBuzz 11 ай бұрын

Inverse relation: low Lp(a) is associated with increased risk of diabetes. The mechanism is unclear.

@CardioBuzz 11 ай бұрын

cardiab.biomedcentral.com/articles/10.1186/s12933-017-0520-z

@porkpie2884 10 ай бұрын

Association is not causation. This is basic stuff @@CardioBuzz