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Isabella C. Glitza Oliva, MD, PhD, MS
Associate Professor
Department of Melanoma Medical Oncology
Division of Cancer Medicine
MD Anderson Cancer Center
Leptomeningeal disease (also known as LMD, leptomeningeal metastases, or LM) is cancer in your cerebrospinal fluid and in your leptomeninges, the membranes that surround your brain and spinal cord. It happens when an advanced cancer spreads from part of your body to your cerebrospinal fluid and leptomeninges.