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An issue with his frontal lobe causes a patient to uncontrollably keep speaking his mind and it gets him in some sticky situations.
From House M.D. Season 5 Episode 17 'The Social Contract' - House and the team take on the case of Nick, a book editor who loses his inhibition and starts insulting co-workers at a dinner party one night before falling ill. The team realises Nick has frontal lobe inhibition, which has caused him to lose his filter and vocalise all of his innermost thoughts, resulting in extremely insulting outbursts.
House (2004) Dr House, an ingenious and unsociable physician who flouts hospital rules, clashes with fellow doctors and his assistants as he comes up with controversial hypotheses about his patients' illnesses.
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