Marvel’s Spider-Man 2 has 10 Mysterium locations. These collectibles are needed for 100% District completion and unlock Trophy: Behind the Masks & Suit: Smoke and Mirrors. Getting a bronze rating is enough to get the trophy/suit and 100% district completion (silver/gold rating isn’t mandatory). They are unlocked after Main Quest 13: Hunt to Live, Live to Hunt. These are marked on the map in defogged areas, or when the entire district is defogged at the second district level. The final location becomes available after having collected all other Mysteriums.