See all of Dr. Seheult's COVID-19 updates ad-free as well as videos on many other topics (sleep, asthma, diabetes, heart disease) at our website: www.medcram.com and many videos are accredited for CME / CEUs!

Thank you to the MedCram folks, and especially Dr. Seheult, for making the mechanism of this treatment comprehensible. This is another helpful and welcome video!

What about NAC / L-Glutathion? Anything that messes with mRNA or DNA sounds dangerous in the long-term.

Another excellent video that clearly explains how something works including potential benefits and risk. Your channel is a breath of fresh air in the clouded of loud voices.

Thanks for the straight talk Dr. Seheult and MedCram team. Your honest discussion about the knowns, unknowns, risks and benefits is always appreciated.

This is very interesting. But is this not what Ivermectin does as well?

What time does it take to eliminate molnupiravir completely from the human body after the five day treatment?

How about hydroxychloroquine or ivermectin? I noticed they disappear from your lectures so can you give us a good reason why from a scientific point of view?

$700 per patient? Why so expensive if it's for the use of to stop a pandemic that has hurt humanity? "Merck expects to produce 10 million courses of the drug before the end of 2021, meaning they could earn $7 billion from molnupiravir, making it one of the most lucrative drugs ever"- (source: Newsweek 10-11-21) Lets hope it works and they come to their senses about the cost. Is it all about the money or saving humanity? 🌍💰

Merck's molnupiravir study looks well designed and the outcome positive. However, Merck has refused to run the same study with its other drug that has been indicated as having strong anti-viral and anti-covid behavior (at least in vitro). That study was proposed by a Japanese team. The drug is Ivermectin. It would be great to see Merck run this study. Or better, an independent team, with no conflict of interest. The world needs as many anti-viral treatments in its armamentarium as it can muster. Especially treatments that are inexpensive and available in developing countries which have limited access to vaccines.

Wouldn't molnupiravir indiscriminately cause those mutations to every proteins made in human cells? That sounds terribly bad. How does it solely target infected cells?

Very interesting and well explained video that this laymen had no trouble understanding. But the obvious question is how does it compare with the much cheaper Ivermectin (also a Merck product) which appeared to be at least as good according to the Metadata link provided on Dr John Campbell's channel two weeks ago?

Correct me if I’m wrong but isn’t this the same mechanism of action of ivermectin?

Love how comprehensive this is

I'm a bit frightened by the mutagenic potential of this drug. Personally I would prefer a repurposed drug even if it's a bit less efficient. May be 10 years down the road I would use it.

Hmmmm. Very good presentation as always. Your channel has been a largely unbiased source for real science throughout all of this so thank you. With respect to this drug, if all we are doing is chasing nucleotides and replacing uracil and cytosine with this false dual acting nucleotide, it would seem to me that there would be tremendous opportunity for undesired mutation, corruption, and large colonies of cells getting labeled for apoptosis. What is to stop this from attaching itself to any normal gene expression/transcription in the cells and inhibiting normal body functions, fixes, and responses? A more plausible methodology would be if the false nucleotides were embedded in part of a pseudo-mRNA snippet that is only found in the viral mRNA so that the sequence could only attach itself to the viral mRNA. I’m not sure how many base pairs it would take to be considered unique to the virus and safely only target and inhibit it’s replication, but this would be my thought… If I’m way off base here, please help to explain how this drug wouldn’t corrupt normal transcriptions?

won't this actually affect our own protein synthesis?

Any word on Quantitative antibody level and immunity threshold determination? We are going on 2 years with this pandemic and I'm surprised the medical community has not determined what is the protective antibody level so as to help decide whether or not to vaccinate and/or get the booster shot.

Thank you Dr MedCram and Team Medcram!!

Thank you for your latest update Dr. Seheult. It's always wonderful to learn from you. You are a superb teacher! ❤️🙏

Is there any chance that molnupiravir can enter the nucleus and disrupt normal cell mRNA genesis?

I am a member of Kaiser Permanente in California. I have easy access to several hospital emergency rooms and infusion clinics. Getting monoclonal antibodies treatment would be readily available. As I understand your presentation, MA treatment would be more advantageous in the event I contract the virus.

Excellent explanation The key point is, when RNA is replicating, the pairing to be obstructed by the medicine, the level of concentration should be sufficient. With the efficacy of ca 50%, the reason why the developer cannot increase the efficacy is due to already high dosage (2200-2800mg) without further risking Severe side effects. It has been observed in separate research published on BMJ that it can induce mammalian mutagenic effect. We have observed similar mechanisms In the 1st gen chemotherapies and that is the reason why we no longer use the 1st gen chymo treatments. The truth is, the longer term side effect (cancers and other permanent genetic mutations) are not clearly understood and risk is present. There are safer alternatives like monoclonal antibody treatments which has shown no material side effects. The sole consideration for the Merck medicine appears to be the cost. We are not out of options. Given the risk of genetic mutations, we should also consider future personal and financial cost when assessing the use of this medicine as well.

Thanks for the update on Malnupiravir Doc. I think that in the short term, it's a good stop gap measure. Hopefully, more studies & trials will determine its safety & efficacy going forward.

Thanks for explaining how it works. Does the drug interfere with normal cell DNA/RNA cell replication? If it can interfere with DNA/RNA replication, what stops it from interfering with good replication in the body?

How does ivermectin work?

Could you compare Ivermectin to Molnupiravir? As far as I understood, it works similar but costs only a fraction.

Yeah, I would be concerned that this drug would serve as an antagonist to nucleotide integration for host cell replication. I didn't hear enough information for how, even over a short course, you can avoid this from happening. It's not like the therapeutic is viral specific. While the oral delivery is beneficial, I still think monoclonals present the best intervention for moderate to severe COVID.

An intervention that works best when used early, which will benefit from early detection, which is improved when Rapid Tests are deployed widely. We need to follow the UK example and make them easily available for free to anyone who asks for them.

Thanks, Doc! Once again, you hit it out of the park.

Other than cost, it would be interesting to note how this drug compares with a therapeutic regimen including Ivermectin, which has a well documented safety record. Great presentation.

Thank you for another update, Dr. Seheult. 130 so far... What a roller-coaster 🙆‍♂️

I have been waiting for more information about the Molnupiravir. This is hopeful for the future.

For me there is a bitter fun that people who don't want to be vaccinated usually have no problem with treatment like this one. Personally I'm fascinated with this medicament. It is very advanced treatment and it is a big adventure to see the progress in medicine research.

Affecting cells' own replication mechanisms is certainly a concern but that should be relatively easy to test: take a replicating human cell tissue and add Molnupiravir to the mix. If it interferes with cell replication, there will definitely be signs of it, the replication will stop, there will be dead cells etc. It's even possible to do DNA analysis of resulting cells and check if there are any significant effects. Since it's that (relatively) easy, I'd expect they already did such or similar test before they even started giving it to humans.

Why don’t they allow Ivermectin which is much cheaper & has been used in India, with huge success. In fact the WHO distributed Ivermectin containing kits in India for early treatment. Here we are told to do nothing till we are gasping for breath. Doctor start fighting the good fight.

Thank you Dr. Seheult. I have tremendous respect for you and have relied on your COVID videos for accurate information. Would it be possible for you to discuss, using the data in this video, what the difference is between relative risk reduction (about 50%) and absolute risk reduction (about 7%)? There's a big difference in these 2 numbers.

My graduate school advisor invented this drug!! Congrats Dr. Liotta and DRIVE team at Emory U!!

Excellent as always! I hope this drug gets more research before widespread use.

Would a study comparing efficacy of ivermectin vs molnupiravir (since both are Merck products) be a good thing? I know that there is no incentive for ivermectin money wise, but at least we know that ivermectin long-term is safe, and may even be effective.If Merck will not do the study should the CDC pay for the study?

Thank you for this study. Are there any studies using Ivermectin ? it's currently widely used for early stage. I know ivm is not approved by FDA !!!

If molnupiravir can differentiate between SARS-CoV-2 and the host's cells, the mechanism by which it does so has not been explained here. There is only the catch-all, disclaimeresque phrase, "more study is needed." Doesn't exactly instill confidence in the safety of this unapproved drug, available only because of Emergency Use Authorization.

Thank you Dr Seheult…there’s always something interesting to learn… I appreciate your calm voice when you teach… and your drawings helps to understand…I only was a Registered Nurse.

David, what is the affinity of molnupiravir metabolites for human RNA polymerase I, II, or III? If this molecule interferes with RNA replicases, it could theoretically also inhibit endogenous RNA polymerases.

My initial thoughts as it was being described that Molnupiravir disrupt the covid mRNA replication, what was the long term ramifications of these mutations and mutations to other mRNA. Yes it may be beneficial now for covid, but what happens in 10-30 years. It may not be a perceived problem for over 60's however it could be a risk to the younger population. Being what I would classify as an expensive drug one hopes that this does not become a driving force for approval. This may be a greater sticking point for hesitancy than vaccines.

I am medical student but can understand your explanation.

Could malnuparavir cause a new viable varent? Or are the resulting errors always fatal for the virus?

Were vaccination rates similar between the 2 groups? Would be interesting to see outcome data stratified by age group & comorbidities. Has this been published yet? I can't find it.

The science of these drugs is so fascinating!!

Excellent, and balanced presentation. It is worth emphasizing that this drug's mechanism will work on all variants and will avoid development of resistant variants. Other drugs that target the protease for example could eventually generate resistant variants.

Thank you but I’ll stick with the one I started out with. Having a baseline, to me, means improvements better determined. Breakthroughs occur every day, but tried and true works as well also.

I would like to hear a report from some people who have had all three jabs but no covid infection at all --- who have also taken the T-DETECT TCELL test. I am wondering if ... IF... those who are fully vaccinated --- are they producing TCell immunity or just spike protein immunity???? Thank you.

So glad you make these explainer videos!

Why is it so expensive? How much does it cost to make? Didn’t the public already pay for its development?

Thank you so much doctor, as always.

I'm sorry if this is off topic, but can Covid-19 mutate in a fully vaccinated person?

Tnx for the excellent explanation!! What is puzzling me is that Molnupiravir is develloped in 2014 and was not part of the covid strategy until now. Why? Merck is also producing Ivermectine and their statement that Ivm does not work against Covid has remained one of the main arguments in excluding Ivm from the early treatment strategy. Could you perhaps make a like vid on Ivermectine so we can compare?

What is the latest on Molnupiravir going into 2023?

Thank you so much doctor for your wonderful knowledge that you are educating us in these pandemic. Good job.👍👍👍👍

Question sir! Wouldn’t this drug also mess up proteins that the human body needs? Wouldn’t it outcompete human nucleotides?

Thank you, MedCram!

This drug is planned to be rolled out in the US in the next coming months, we need some real time updates on its side effects and dangers. India and France have rejected / cancelled this drug and more have it under review. Can we have a re-review or update on this topic?

Have you considered the effect of the current approved vaccine entering the bloodstream accidentally? I refer to intramuscular infection catching a vein bower rarely

Hai Professor Seheult, are there any data that explain how long will molnupiravir stay in the host before excreted?

So like what ivermectin has been shown to do in vitro

Super news esp for countries abroad where an oral medicine is much preferred by everyone: easier to buy and take, no need to go to a medical facility (fear of contracting the virus), and at home treatment is preferred in many countries

Great video - as always. Your videos are always so informative for us lay people. If the molnupiravir (?) was used only in at risk, over 65, then pregnancy or birth defects would not be an issue I would think.

Nice to hear from you!

Well!!!?? Hope it works. The VA ER just sent me home with it. I just took my first dose. I have Severe Asthma and Tachycardia. I’ve even been intubated for the Asthma before and the VA ER Nurse Practitioner wouldn’t Admit me even with me begging that I was scared and live alone.

Another great video explanation, thanks!!!

Thank you.

The best video about Molnupiravir for anti sars-cov2. Thank you so much.

It’s very optimistic. Thanks for the update

CLEARLY if you are a doctor or educated in micr-biology; But even a lay person can "get the gist"... so thank you.

Thanks for sharing, very informative and useful.

Well explained simple and concise

An important fact missed in this presentation is that some 30 people need to be treated with the drug to prevent one event. No data is available on adults who dont have cancer, diabetes, and just have COVID (otherwise healthy adults)

I see this as a solution for the people that can't get vaccinated or the ones that didn't develop an immune response to the vaccine. I don't think that something that was tested on that low number of people even with the p value they got is anywhere near tested enough.

I wonder how this compares to Ivermectin. I guess it is not as good and not as safe and costs way more. Ivermectin given for two or three days only.

Mitochondria depletion was the adveres event i had from An HIV drug called Lamivudine. It is a Non-Nucleoside Reverse Transcriptease Inhibitor. I was hospitalized for five days and have never fully recovered. That was twelve years ago. Discuss this with your doctor before taking a NNRTI.

Amazing and informative Dr Seheult's, thankyou for sharing

Thanks Dr S🇨🇦

Thanks for sharing.

Thanks for explaining.

Well explained, thanks

Best Medical lectures in cyberpace

Thank you for continuing to inform us and making this understandable to non-medical/scientific peeps like me. Cell mutation, conspiracy buffoons will have a field day with this information.

Can u please speak to the fact the US approved Molnupiravir based on 1,433 patients trial. And the current status and it's dangerous side effects, and it's now being rejected as form of covid combat in many counties. U claim to be on the side of the people, can u give us some real world truth on this topic...??? please

Excellent review thanks

So how do we know it won't affect our own protein synthesis mechanisms?

You are awesome, very thorough..

I love love your videos and share them with everyone. But one question: won't it do the same when trying to replicate human A and G sequences?

Great for risk groups.

This sounds like a good thing I am 70 and have an upper respiratory problem and have not been vaccinated

How does it compare to ivm?

What makes the drug only messes with covid19 RnA replication, not with the whole function of replication within the cell?

Good for technically skilled or educated. Regular folks will draw a blank.

Thank - you . I want this to be able used as a tool against spread of all/many virus.

As with oseltamivir, I would expect a medication shortage issue if this gets approved. During influenza season, it was difficult to get our hands on certain doses. We had to call around to pharmacies to find the pills.

Hi Dr, would you have any toughts on Zyesami/Aviptadil for treatment of more severe Covid respiratory problems? Thank you for all your great work !