Metabolism of Drug (Part 01) | Introduction to Drug Metabolism | Metabolism | ADME | Pharmacokinetic

  Рет қаралды 315,323

Solution- Pharmacy

Solution- Pharmacy

5 жыл бұрын

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Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.
Drugs are metabolized through various reactions including:
(1) Oxidation
(2) Reduction
(3) Hydrolysis
(4) Hydration
(5) Conjugation
(6) Condensation
(7) Isomerization
There are often two phases of drug metabolism.
(1) Phase I: Non-synthetic reactions such as cleavage (e.g. oxidation, reduction, hydrolysis), formation or modification of a function group.
(2) Phase II: Synthetic reactions such as conjugation with an endogenous substance (e.g. sulfate, glycine, glucuronic acid).
The most common and important enzyme group involved in the Phase I metabolism of drugs is the cytochrome P450 (CYP450) superfamily of enzymes. This group of enzymes acts as a catalyst for the oxidation of many drugs. It can, in turn, also be induced or inhibited by many drugs and other substances. As a result, the metabolism of some drugs is affected by the presence of other substances. This is what is known as a drug interaction.
Some of the important enzymes in this family include:
CYP1A2
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A4
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@prasantarana4403
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@40.nidhichauhan46
@40.nidhichauhan46 3 жыл бұрын
Sir , I have just entered in 2nd year & luckily I found your channel & you are making pharmacology much more easier in this lockdown era!!! Thank you so much sir 😊...now already subscribed!
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much for your valuable feedback
@abhinavchauhan4079
@abhinavchauhan4079 3 жыл бұрын
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@Dr.Pranav_Lohiya
@Dr.Pranav_Lohiya 4 жыл бұрын
sir thank you so much for making pharmacy very easy🙏...very much grateful...
@bismaadnan3574
@bismaadnan3574 Жыл бұрын
Very informative and very easy to understand all those tough things...thnx sir for such kind of effort for all of us ❤️
@cricketfans1977
@cricketfans1977 5 жыл бұрын
Your videos are very easy to learning and understanding
@monikatiwari3830
@monikatiwari3830 Жыл бұрын
Sir you are explaining very well,a big big tnq so much..!
@vijaythapa7016
@vijaythapa7016 2 жыл бұрын
Thank you sir for best teaching 🙏
@ayeshadanish1602
@ayeshadanish1602 2 жыл бұрын
Jazakallah ameen thanks a lot ❤👍
@singhmanisha161
@singhmanisha161 3 жыл бұрын
Thank you Sir...
@shrutikabhurse9627
@shrutikabhurse9627 3 жыл бұрын
Sir you are the bestest teacher of pharmacology 👍 and I will see all your pharmacology classes video here thankyou so much sir for your efforts
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much for your valuable feedback. Your satisfaction is my real award. This motivate me to give best. TC
@umapatel4063
@umapatel4063 2 жыл бұрын
Thanku so much sir..😊
@griffinkoshy2990
@griffinkoshy2990 4 ай бұрын
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@solutionpharmacy
@solutionpharmacy 4 ай бұрын
Thank you so much sir Your feedback and support is very vital for us. Thank you
@VBJyoti-qr9iy
@VBJyoti-qr9iy 2 жыл бұрын
Absolutely genius 🙏🙏🙌
@PharmaG264
@PharmaG264 Жыл бұрын
Thanks sir for doing this lecture
@jivamodhwadia5118
@jivamodhwadia5118 Жыл бұрын
Thank you sir🙏
@amitranvir1227
@amitranvir1227 2 жыл бұрын
Sir bohot bdiyaa sir 🙏🙏🙏🙏.. ...sir aise hi video bnate rgeyiga hmara pharmacology subject acchha ho jayega ☺
@akashkushwaha7378
@akashkushwaha7378 4 жыл бұрын
THANKS SIR FOR MAKE MY CONCEPT OF METABOLISM REALLY YOU ARE A GREAT TEACHER OF PHARMA
@Dr.wonder373
@Dr.wonder373 Жыл бұрын
Thank you so much sir 😌😌
@bonggyanpapi2942
@bonggyanpapi2942 4 жыл бұрын
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@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you so much for your valuable reply and feedback sir. It is most imp for me to have feedback from experts like you.
@anushkapaul3934
@anushkapaul3934 4 жыл бұрын
Sir, er kono scope aache bhalo? Jodi bhalo kore kamate hoye?
@shuklavishwas9849
@shuklavishwas9849 2 жыл бұрын
Sir mai koi bhi medicine le raha hu to mujhe side effects ho ja raha hai. Q ho raha hai sir pls help me
@anjalimehra8149
@anjalimehra8149 Жыл бұрын
Thank you sir 🔥🔥💯 good 👍 work
@vidsvarun4391
@vidsvarun4391 5 жыл бұрын
thank you so much sir
@surbhijain212
@surbhijain212 4 жыл бұрын
Thanks
@taruntarun8317
@taruntarun8317 4 жыл бұрын
Wht a fluency !! Super...Aap jaise teacher muze pahle kyu nahi mile
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you
@user-fz9nh4ct4x
@user-fz9nh4ct4x 3 жыл бұрын
spectacular. you made my day by this video . thanks a lot sir.
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much for your valuable feedback
@tasteofindiaeverythingishe5263
@tasteofindiaeverythingishe5263 3 жыл бұрын
Thanks sir for teaching all students for clear the concept of pharmacology,. 🥰🙏🙏👌👌
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Welcome
@shuguftaparveen8695
@shuguftaparveen8695 2 жыл бұрын
Sir thankyou so much for clearing my concepts i am.paying huge amount of money to college equal to mbbs for pharm d which is 6 year course in my college pharmacolgy teacher just reading slides only i am now more interested in pharmacolgy subject because of you thanks a lot sir you are doing a great job your method of teaching is very easy to understand and interesting also
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Happy to know this. Thank you so much for your support and feedback
@RxDharmendra22
@RxDharmendra22 4 жыл бұрын
Thanks Sir
@saqibdeedar5286
@saqibdeedar5286 3 жыл бұрын
thank you sir from Pakistan
@PK-yk9gy
@PK-yk9gy 5 жыл бұрын
Waiting for part 2☺️
@rechaldillu5546
@rechaldillu5546 4 жыл бұрын
Thank you sir God bless you 🙌
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you so much
@SurajKumar-cp3ul
@SurajKumar-cp3ul 4 ай бұрын
Way of learning is fabulous
@solutionpharmacy
@solutionpharmacy 4 ай бұрын
Thank you so much
@potatofamily4661
@potatofamily4661 3 жыл бұрын
Good to learn from you sir, but In this video I heard PCM is Antibiotic, I hope you said Antipyretic. Hats off to you for everything.
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
I said antipyretic but due to simularity its sounds like antibiotic. I have already clarify this in comment box many times.
@hello_mr_imperfect
@hello_mr_imperfect 4 жыл бұрын
Allah aapko mahfooz rkhe Aur aap hm logo ko esehi gyaan dete rhe Thank you sir❤
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Shukriya
@anamikakc2182
@anamikakc2182 5 жыл бұрын
Thank you sir. It was really helpful.
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Most welcome
@vamsumandal3903
@vamsumandal3903 3 жыл бұрын
Thank you sir, Aapka samjhane ka tareeka amezing hai..... Hum jaise backbencher bhi aasani se samajh jaate hai
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much for your feedback. Pata hai aapko ki jo back becher hote hai wo sabse aage jaate hai
@anusuade5098
@anusuade5098 Жыл бұрын
thanks
@RohitSharma-Rj09
@RohitSharma-Rj09 3 жыл бұрын
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@fatimanoor2199
@fatimanoor2199 4 жыл бұрын
Maa Shaa Allah very good videos
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you so much
@manaligautam1105
@manaligautam1105 4 жыл бұрын
Thankyou so much sir..This really helped me out😊
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Manali Gautam thank you fir your feedback.
@cricketfans1977
@cricketfans1977 5 жыл бұрын
Please continue post the video related to pharmacology
@vishalkaushal5097
@vishalkaushal5097 4 жыл бұрын
Thank you sir It is very helpful
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Most welcome
@anshujjeniya8230
@anshujjeniya8230 4 жыл бұрын
Seriouly sir very nice video in the time of lockdown study jo ruk gai thi wpas start ho gai h bahot ache se smjte h aap concepts clear ho jate h
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Ansh Ujjeniya Thank you so much. All the best and TC
@MANU28PHARMACY
@MANU28PHARMACY 4 жыл бұрын
Thank you sir. Your video is very informative And very easy to understand. Once again thank you sir.
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you sir
@aakashkumar3634
@aakashkumar3634 4 жыл бұрын
Tq sir
@RxDharmendra22
@RxDharmendra22 4 жыл бұрын
Thanks Sir 🙏🙏🙏, I Salute You
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Most welcome
@vk-yd7kg
@vk-yd7kg 4 жыл бұрын
thanks a lot sir 😊😊....kash hamarale clg teachers bhi aapjaise hote 😓....but anyways ur video are very useful and helpful for we students ....you are great 😃....keep it up 😊
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thanks alot
@shubham12364
@shubham12364 4 жыл бұрын
Thank u, so much sir, & your video is very helpful
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thanks alot
@PK-yk9gy
@PK-yk9gy 5 жыл бұрын
Very well explained in easy way ..... thanks
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Thank you
@debasishtripathy2703
@debasishtripathy2703 4 жыл бұрын
You are doing a great job sir it's very helpful
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank youb
@Doctor-sh9yv
@Doctor-sh9yv 4 жыл бұрын
Sir you are amazing😊😍 Thanku so much
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Most welcome
@cricketfans1977
@cricketfans1977 5 жыл бұрын
Sir, your video is very helpful for students
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Thank you so much
@HusniBuner
@HusniBuner 3 жыл бұрын
Good to learn from you sir.respect from Pakistan🇵🇰🇵🇰🇵🇰
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much
@mailkakhan2314
@mailkakhan2314 3 жыл бұрын
Most helpful vedios
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
@somitnabiyal2899
@somitnabiyal2899 4 жыл бұрын
धन्यवाद सर जी
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Welcome
@sajidanoor4994
@sajidanoor4994 3 жыл бұрын
Thank u so much sir for such a good information ......
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure. Thank you
@shahsaba123
@shahsaba123 3 жыл бұрын
Asalamualikum.. Sir ur way of teaching is very good... I have read this topic 3 times on book but l cnt understand as much, but after listen ur lecture l understand very well, and also help me alot wt l read from the book....
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Great. Thank you
@suchitapatil2697
@suchitapatil2697 4 жыл бұрын
Nice lecturer sir tx u so much
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you so much
@vickysultan8702
@vickysultan8702 4 жыл бұрын
Shukriya sr
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Welcome
@finallad6912
@finallad6912 4 жыл бұрын
Thanks sir . Very easy understanding
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you
@atiqullah3534
@atiqullah3534 4 жыл бұрын
wow love you sir that was really interested i am going to see your all lectures
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thank you
@stub_born
@stub_born 3 жыл бұрын
Can we study it for MBbs also?
@rehanaahmad5419
@rehanaahmad5419 3 жыл бұрын
Thanku sooo soooo much SR
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure
@j.sbhandari8813
@j.sbhandari8813 3 жыл бұрын
U are awesome sir, God bless you 😇
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much
@vickybhawsar6482
@vickybhawsar6482 3 жыл бұрын
Thanku so much sir❤️
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure
@yadavkarina8076
@yadavkarina8076 3 жыл бұрын
Easlyunderstable💯💯💯🎊🎉👍
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
@adarshraghuwanshi1505
@adarshraghuwanshi1505 4 жыл бұрын
Thank u sir, approx all concepts are cover in your videos.
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Thanks alot
@tauqueerahmad44
@tauqueerahmad44 5 жыл бұрын
Sir mn to aapka Fan ho gya, bhot mja aagya padhne m
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Tauqueer Ahmad Thank you so much for your valuable feedback and support.
@THESHIV2.O
@THESHIV2.O 2 жыл бұрын
Very nice sir
@anuranjankumar4642
@anuranjankumar4642 2 жыл бұрын
Excellent video 👌🇮🇳
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you
@manansahu1501
@manansahu1501 3 жыл бұрын
🙌🙌 thankyou sir
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure
@Durganair147
@Durganair147 2 жыл бұрын
Sir thanku somuch🙏
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
My pleasure
@pabitrabiswas6466
@pabitrabiswas6466 4 жыл бұрын
Very helpful sir.hope for more videos on next chapter....
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Pabitra biswas thank you. I have uploaded many videos.
@tasnimulhasan8594
@tasnimulhasan8594 2 жыл бұрын
i am an mbbs student.. and this is going to be the part of my daily life to see your lectures, sir! ❤❤❤❤ for you...
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you so much for your love
@drfarokhmaster10
@drfarokhmaster10 3 жыл бұрын
superb excellent
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
@tararmueez
@tararmueez 3 жыл бұрын
What a awesome channel😍 excatly what i want
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much
@nishat987
@nishat987 5 жыл бұрын
Sir aap bohat accha padhate hoo Concept clear karne ke liye very very thank you sir .
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Minz vlogs My pleasure. Thanks for such a nice compliment. Plz share with your friends.
@dr.iswarprasannapegu560
@dr.iswarprasannapegu560 4 жыл бұрын
Thank u sir
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Welcome
@mehrunnisa3130
@mehrunnisa3130 2 жыл бұрын
Great sir
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you
@siddharthsoam7751
@siddharthsoam7751 5 жыл бұрын
Thkuuuu sir g you are the best
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Thank you so much
@durgeshsingh6447
@durgeshsingh6447 3 жыл бұрын
Thanks 😊 sir
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure
@vijaykant7726
@vijaykant7726 3 жыл бұрын
Thanku so much sir you bless me
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
My pleasure.
@alimuhammad-yx3yu
@alimuhammad-yx3yu 5 жыл бұрын
Wow so easy lectures method
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
ali muhammad Thank you
@shuguftaparveen8695
@shuguftaparveen8695 2 жыл бұрын
I will miss my pharmacolgy online class and listen to your videos which are more useful
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you so much for your support and feedback
@hardikdahima2499
@hardikdahima2499 3 жыл бұрын
You are great sir ,i love you😀
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you so much
@girishyt8207
@girishyt8207 3 жыл бұрын
Cristal clear metabolism thanks sir ji 👍👍👍👍🤗🤗🤗❤️❤️🌹🌹🌹🌹🌹
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
@ankitavishwakarma7966
@ankitavishwakarma7966 4 жыл бұрын
Thank you so much it was very helpful I really can't understand whole pharmacology and medicinal chemistry but after watching your videos I can say that I understand All these concept easily
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
Great. I am glad that my lecture is helping you. Wish you all the best
@rrjaved3599
@rrjaved3599 2 жыл бұрын
Good work
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you
@adnanjamil9429
@adnanjamil9429 2 жыл бұрын
Best Ever
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you.
@shaikhhusain4136
@shaikhhusain4136 5 жыл бұрын
Thank you sir very good video
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Thank you
@jashanpreetkaur4336
@jashanpreetkaur4336 3 жыл бұрын
Thank u so much sir. Entero hepatic circulation ki video upload ki hai u tube pe
@drxpratap5057
@drxpratap5057 5 жыл бұрын
Good video sir thanks 👍
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
My pleasure.
@tribikrambarai4988
@tribikrambarai4988 5 жыл бұрын
Great video sir
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Tribikram Barai thank you
@sharineskaria1171
@sharineskaria1171 3 жыл бұрын
Great
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
@drpawanyadavvlogs7887
@drpawanyadavvlogs7887 5 жыл бұрын
Nice sir thank you so much
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Welcome
@neelchoudhary-q8
@neelchoudhary-q8 Жыл бұрын
Nice
@drrashidhasani3588
@drrashidhasani3588 4 жыл бұрын
Nice lecture sir
@solutionpharmacy
@solutionpharmacy 4 жыл бұрын
sayyed Rashid Sultanpuri Thank you
@abidmehmood2038
@abidmehmood2038 5 жыл бұрын
Excellent sir
@solutionpharmacy
@solutionpharmacy 5 жыл бұрын
Thank you sir
@sszabirashma7657
@sszabirashma7657 2 жыл бұрын
Thnkqq sir for this video☺ sir plzzzz upload the pharmacodynamics
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Already uploaded
@rajahuzaifa4846
@rajahuzaifa4846 3 жыл бұрын
Great sir. Love and respect from Pakistan
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Raja Huzaifa thank you
@zaffarkhan3864
@zaffarkhan3864 2 жыл бұрын
@@solutionpharmacy Sir, You deserve much respect 👍👍👍👍 Sir what is the need of taking drug if it alter in its form from active to inactive .... Kindly elobrate it us for better understanding... I m not questioning . Always regards
@solutionpharmacy
@solutionpharmacy 2 жыл бұрын
Thank you for your love. See when we take drugs then it goes for metabolism and as per the chemical nature of drug it produce action either directly or by converting in its metabolites. Few drugs get inactivated but by oral route and not by parenteral. Thats why we study about such drugs.
@medicalcodingexamcpc356
@medicalcodingexamcpc356 3 жыл бұрын
Mashallah👌👍
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Shukriya
@riyaali7982
@riyaali7982 3 жыл бұрын
U r best teacher really 😍😍🍸🍹🍷🍺
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thanks alot
@funwithhaniya8926
@funwithhaniya8926 3 жыл бұрын
Nice video 👍
@solutionpharmacy
@solutionpharmacy 3 жыл бұрын
Thank you
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