Methotrexate - Pharmacology (DMARDs, mechanism of action, side effects)

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4 жыл бұрын

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"Methotrexate is a first line treatment for RA and other autoimmune diseases. It is an immunosuppressant meaning it suppresses the immune system. Methotrexate is a folic analog and works by inhibiting dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in the synthesis of nucleotides."
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Пікірлер: 81

@dianekelly3452 Жыл бұрын

Thank you! I’ve been taking methotrexate for 23 years. During that time no doctor told me this or explained anything about side effects or why I should take folic acid. I was never told about problems that might arise if I got pregnant or any adverse reactions that might arise in my body. I’ve had several rheumatologists and now feel that my care was inferior or at least minimized. You’ve enlightened my understanding of methotrexate, which is far beyond of what I’ve read in the information sheets pharmacies have given me during these past 23 years. I really appreciate what you have shared with me in this video.

@aliciamonger2920 5 ай бұрын

Hi there. I’m about to start taking the same medication. Have you felt the med has helped you?

@3aeren 2 күн бұрын

@@aliciamonger2920 it failed for me after 2 years.. my psoriasis and psoriatic arthritis have gone into overdrive... just had my first injection of Tremfya last week :)

@samiadilrus 4 жыл бұрын

Thanks so much for this, Armando. Really loving your pharmacology videos! simple yet effective.

@LesterBrunt 4 жыл бұрын

Very interesting. Would love to see something on adalimumab or other tnf-inhibitors.

@gaganpreetkaur3029 2 жыл бұрын

I Really appreciate to you to make these innovative, simple and short videos. Thanks for your information.

@Chocolettino 4 жыл бұрын

Great video. Really good for revising!

@marastewart5297 10 ай бұрын

This is so much easier to understand than my professor’s explainations, thank you!

@sagarjariya6681 Жыл бұрын

It was so so amazing, the way you explain on white board animation... Thanks alot!

@KK-qk7iv 3 жыл бұрын

Can you create a playlist for your pharmacology videos? would be really useful for pharmacy and pharmacology students!! thank you

@manishkmishra5376 4 жыл бұрын

Awesome as always

@Abcd-nb2fp 3 жыл бұрын

This is so helpful thanks a lot

@irfanbeig4800 3 жыл бұрын

Great explanation.

@ushagowda7202 3 жыл бұрын

very good explanation sir

@barbarian-furu 7 ай бұрын

great explanation, thank you!

@user-xu8pt6uy8h 2 жыл бұрын

You are great and amazing ♥️♥️♥️ thank you from all my heart and for sure we have enjoyed it 😍

@ishfaqmajeed4898 10 ай бұрын

Nice explanation… short to the point ❤

@evelyn_r 4 жыл бұрын

should also put in a side note that it can have negative interactions with aspirin. I've been taking this med since I was about 18 and I only found out now at 32 years of age.

@IreneHeeney 2 ай бұрын

Excellent! Thank you

@gabrielaonate7692 2 жыл бұрын

thanks for your videos pharmacology made understandable

@lizr9894 4 жыл бұрын

Very good explanation. I’m trying to understand this because my Rheumatologist suggested methotrexate for my autoimmune disease(s), but i have MTHFR gene variants. I was told by another doctor that I should take l-methylfolate because I don’t metabolize any folate (is that even possible?) Could I have serious side effects from methotrexate even if I take folate with it?

@nevermind9889 Жыл бұрын

I started watching you about 12 years ago, the things you teach are incredible. Keep up the good work my friend.

@doctornsn3548 4 жыл бұрын

Thank you!!!

@virginiapyeong7812 4 жыл бұрын

Lovely! Thanx

@harishan893 4 жыл бұрын

Great video Armando. What drawing app are you using these days? Looks great.

@Ali-oz3hd 4 жыл бұрын

Thank you

@jhpark544 3 жыл бұрын

always thank you for you great work~~ I have a question. MTX can inhibit 'thymidylate synthase', too? In my text book , 5-FU inhibit that enzyme.

@retrogang6326 5 ай бұрын

Beautiful!

@srikantpanda7993 Жыл бұрын

good one thanks

@soong24 3 жыл бұрын

Thank you sir🤗

@sameenakouser7575 4 жыл бұрын

M happy to see u again sir...😎😎😎

@wendellsebastian1957 4 жыл бұрын

thanks for the great video! looking forward for your explanations on hydroxychloroquine

@Kiran.2020 2 жыл бұрын

You are the best 💖

@ughsirius Жыл бұрын

Thank you so much!!

@mustimakethis Жыл бұрын

Loved the video and explanation. Just one question completely unrelated but what software do you use to draw these diagrams?

@raghumedicalcoaching1808 3 жыл бұрын

God bless you.

@chlenuga 4 жыл бұрын

Cool, make a video about TNF inhibitors if you can

@alext8828 4 жыл бұрын

What was that middle part again?

@thokozanimzwandile4726 2 жыл бұрын

I owe my degrees to you.... Thanks a lot man.

@sthnwatch 4 жыл бұрын

Thanks Armando. Keep these vids coming mate. And know this too, our ClinSc/HlthSc Lecturers at Uni all love these vids and mention them all the time as they (your videos) help them to teach us all these diverse complex topics. Keep 'em coming. Suggestion: Methotrexate Medication and AEs on Vit. B12 uptake. PLEASE!!! !! ! It'll change the world for the better if you do this topic with one of ya unique videos mate!

@MammaCass 4 жыл бұрын

So far it’s almost killed me and then now has been the only drug to reduce my swelling.. hard drug to handle and yet a wonderful drug in treating RA

@Lakeslover1 3 жыл бұрын

Yes I agree. My life has become full of fatigue and it’s been hard to manage that, but the drug has helped me.

@MammaCass 3 жыл бұрын

@@Lakeslover1 yeah I feel the same but the side effects do ease up a bit the longer you take it x

@Lakeslover1 3 жыл бұрын

@@MammaCass Thank you so much for your reply .

@thefenerbahcesk4156 4 жыл бұрын

Can methotrexate mess with other dividing cells we dont want it to mess with? Epithelial cells for example?

@Nix1111 3 жыл бұрын

Yes, it's non-specific in action. It's structure is very similar to dihydrofolate, so it will interact in the same areas as dihydrofolate, making it very non-specific and very toxic.

@Oab1299 4 жыл бұрын

Also i want to add: we sould gave the patient folinat 5 mg/week with uses mtx.

@gerhardbecker3781 4 жыл бұрын

Awesome stuff. Do you also advise your patients not to take folic acid the day they take methotrexate?

@VeroSD 4 жыл бұрын

Every rheumatologist I ever had recommended for ME not to take folic acid on the day(s) I take methotrexate , but I think that recommendation changes depending on the schedule, dosage and/or mode of administration.

@GRIPANDSLIP 2 жыл бұрын

Super interesting, I had to pause a lot and do more research to understand context but it's nice to know what they've put me on.

@fatherted681 3 жыл бұрын

Legend

@laurentgalibert846 4 жыл бұрын

Lots of what is explained here is a compilation of text book theories and arguments that have been put forth to explain the mode of action of methotrexate. The validity of these arguments is actually questionable as anti-inflammatory effects of MTX can be observed for concentrations that are below these needed to achieve the pharmacological effects described here. Also, this video ignores the fact that the mode of action of low-dose MTX (regimen usually used in the treatment of RA) relies upon metabolic transformation of MTX and that its anti-inflammatory effect is at least partly dependent upon release of extracellular adenosine and stimulation of A2AR on immune cells.

@TravelFreeBird 2 ай бұрын

Question. 2:18. "methotrexate reduces levels of methionine and this results in a decrease in methionine synthase activity" 1. A decrease in 5 meythl THF would therefore logically cause an overload in the methionine cycle since more enzymes (methionine sytnthase) would be available. 2. How does methetrexate cause a decrease in methionine levels? By point #1, it should increase the levels of methionine.

@drsomto007 Жыл бұрын

Please help Pharmacy Students by creating a playlist for pharmacology, we also watch your videos

@drpradipjoshi Жыл бұрын

Another side effevt of MTx is pulmonary fibrosis

@dennisunfft Жыл бұрын

My Doc let me have 3 pills of 2,5 mg TWICE a week (3 Monday & 3 Tuesday) is this normal? I am diagnosed with Ra.

@3aeren 2 күн бұрын

yes thats fine

@Ghar-e-Hira768 4 жыл бұрын

Please upload videos on plants specially plant hormones,their structures and functions.Please I humbly request you.And please upload quickly I have to prepare for my exams😊.

@ivojager2143 9 ай бұрын

Yes, yes, indeed. Interesting, hmmm. Facinating, one might say. So I'm going to have to trust my docter, because I didnt get any of this.

@hamzabjaoui9283 3 жыл бұрын

My Dad have acnes in full of his body (Psoriasis) His doctor gave him this. Is it safe? He take half a bottle every 15 days (Sorry for bad eng)

@3aeren 2 күн бұрын

is he having regular blood tests? methotrexate failed for me after 2 years .. im on tremfya now

@MindandQiR1 3 жыл бұрын

If a man is on injection metho, since traces of it can be found in sperms, will this be bad for the female by getting absorbed through the vaginal lining?

@3aeren 2 күн бұрын