Michael Hall (University of Basel): The Story of TOR (Target of Rapamycin)

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iBiology Science Stories

iBiology Science Stories

Күн бұрын

www.ibiology.org/cell-biology...
Michael Hall describes the discovery of TOR (Target of Rapamycin) protein, the key controller of the size of both individual cells and entire organisms.
Talk Overview:
TOR, the Target of Rapamycin, is now known to be a central controller of cell, tissue and organism growth and an important molecule in many human diseases including cancer, cardiac hypertrophy, diabetes and obesity. Michael Hall explains how the fortuitous decision, in 1991, to investigate the action of rapamycin in yeast, led to the discovery of TOR.
Speaker Biography:
Dr. Michael Hall received his PhD from Harvard and was a post-doctoral fellow at the Institut Pasteur and the University of California, San Francisco. He joined the Biozentrum of the University of Basel in 1987 and where he is currently a Professor of Biochemistry. Hall’s lab continues to study TOR and its role in development, aging and disease.
Hall has received numerous awards in recognition of his pioneering work. Recent honors include the Louis-Jeantet Prize for Medicine (2009), the Marcel Benoist Prize (2012), the Breakthrough Prize (2014), the Canada Gairdner Award (2015), and the Albert Lasker Basic Medical Research Award (2017). Hall is also a member of the US National Academy of Sciences.
Learn more about Dr. Hall’s research here:
www.biozentrum.unibas.ch/rese...

Пікірлер: 19
@Monica-dj7ee
@Monica-dj7ee 5 жыл бұрын
I am glad that Dr. Hall always remembers to credit his team members John and Ray before starting the topic description, though he could just I-centralize it. I got the opportunity to attend his lecture on Rockefeller university. The prospect of mTOR though reservedly complex, is optimistically expanding.
@Krath1988
@Krath1988 6 жыл бұрын
This channel and these videos are amazing and absolutely essential to bringing science into public view. Thank you!
@gokhanakman9785
@gokhanakman9785 2 жыл бұрын
Inspiring....I really enjoy listening the historical perspective
@skeeterskater5884
@skeeterskater5884 2 жыл бұрын
Dr Hall- one of the finest videos I have watched on YT! Would be glued to my seat if you would do an update from 2004 to the present time as there seems to be an explosion of work in this field. Thanks, again!! Colin, MD
@ProfFeinman
@ProfFeinman Жыл бұрын
Great presentation. Not only metformin interacts with TOR pathways but ketone bodies are TOR deactylase inhibitors which likely plays a role in the highly effective use of ketogenic diets in treating and presumably preventing type 2 diabetes. (Prevention in that ketogenic diets ameliorate metabolic syndrome).
@martins_kreicis
@martins_kreicis 4 жыл бұрын
Fabulous science and fabulous explanation. Human mind at its best. Thank you.
@juanmarcos3073
@juanmarcos3073 2 ай бұрын
Excellent explanation, thank you!
@Anitalazt
@Anitalazt 2 жыл бұрын
A great video, very interesting and easy to understand...I hope the TOR can be a good element to use against some diseases.
@user-uj8og9cm9d
@user-uj8og9cm9d 10 ай бұрын
Excellent video though I would have enjoyed more detail about the role of phosphorylation as a signalling agent in the TOR signalling cascade. Especially as I think many of the enzymes in the TOR pathways are kinases.
@violettelongo7055
@violettelongo7055 4 жыл бұрын
Can you do the season 2 please? from 2004 to 2020.
@ashutoshdhebe8476
@ashutoshdhebe8476 6 жыл бұрын
Is there any way i can contact Sir Micheal N Hall.wanted to know about HLPP anticancer treatment.
@tajmenn
@tajmenn 6 жыл бұрын
just google him and send him an e-mail
@flaviosonanini6585
@flaviosonanini6585 Жыл бұрын
he looks like robert deniro
@miimchatv3862
@miimchatv3862 5 ай бұрын
I wish you provided a translation to Arabic Language for this video
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