Milstein & Kohler's 1975 paper in Nature was groundbreaking (we seem to use that word a lot around here) in it's implications and impact. Their discoveries cracked open the practical use of monoclonal antibodies in a host of medicines and therapies and helped them net the Nobel Prize years later as a result.
Referenced paper:
drive.google.com/file/d/1nuV1...
Further reading:
kendallasmith.com/writing/
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