"Blind obedience is the greatest enemy of truth." Einstein

Are we getting closer to putting Sean into some DMT? This has been a goal I’ve been pushing for a while ...

Besides Carhart Harris there are no better guests to talk about consciousness and its altered states than Thomas Metzinger, David Pearce, Andres Gomez Emilsson, Anil Seth, Evan Thompson. Please consider inviting them because the subject triggers a lot of interest and these people have a lot of intriguing things to say about it.

Great, an enjoyable conversation. I personally feel that it brought psychedelics more into the realm of normality after the many years of panic and witchhunt.

Mindscape 82: the best one yet. Sean C. having a 'breakthrough' psychedelic experience would find the horizons to his theoretical physics and cosmological work broadened so much that there wouldn't be enough time to jot down in real-time all the newly gained revelatory deeper understanding -- until perhaps session #2 a month later? :) in my mind, without a doubt, one of the most human things you could ever do is this. most importantly of all, don't forget to come back and report to us about the new perspectives, in a Mindscape episode or in a book!

Nice, just what I was in need while I prepare for a future LSD trip! Sean you are the best.

I write articles about psychedelics: Carhart Harris is my hero. His lectures are EXCELLENT. If you're going to take psychedelics (and you might like to....), do listen to his stuff. D.A., J.D. NYC

I wonder if sean would ever take a high dose of psychedelics and experience an ego death. I think it would open his eyes to another dimension of perceptions.

This is going to be great!

46:43 Well... I would just say that Sean is not being generous to the surely small sample of "advocates" he's probably referring to. Great answer by Carhart-Harris, BTW, although I think it again goes woosh over Sean's head: the problem is the way he puts it: "the nature of reality", which implies a dualism, whether Sean sees it or not. "The nature of nature" is a bit better. If I am part of nature, and I use psychedelics effectively, then I can get insights into a very important part of nature, the part that stitches together my very real experience. For a naturalist who constantly reminds everyone that they themselves are quantum systems, Sean seems unable to do the same with "reality" or "nature". A physicist's mind, i guess. 1:01:21 I hear you, that sounds reasonable. But they are not mutually exclusive. Decriminalize AND roll out regulated therapeutic use, as well as offer information/education campaigns. But let people do it themselves, experiment by themselves. Don't add making people criminal on top of whatever crisis is leading them to psychedelics. My fear is that a big brother attitude will be taken toward psychedelic use and we end up brainwashing people with the institutions and therapists ideologies... IDK. My two cents. I wish they would have been more talk of brain activity... anyways, keep up the research...

Unfortunately this conservation was held with too much mutual reservations, I guess because of their too different mindsets to grapple problems in general (mathematical rigor vs psychological fuzziness)? From ego-dissolving intrapersonal "Archetypes of the Unconscious" to an quantum-mechanically sound "A-Many-Worlds-Theory" ... there are a hell of a lot of unexplored pitfalls in-between, probably the extreme edges of the subjective "inside" and the objective "outside" universe so to speak. It would have been interesting to tackle this dualism of "inner experience" and "outside reality/realities" in a more open-ended and even controversial manner rather than to establish - after 40 years now - that the "War on Drugs" was probably not good for science and halted some serious progress to this day (as with "War on Terror" or anything for that matter which were just fast political excuses to successfully cut on civil liberties. And once in place - after the fear-mongering - are nearly impossible to regain. One must be very constrained in his/her thinking to rationalize prohibiting substances which are abundant in nature or easily derived from when you take a look at the massive amounts of legal chemicals in our environment actively destroying our eco-systems in a cause and effect manner. .... Or to let terrorism being loosely defined by the state so to murder people all around the world without due process. Seeing a pattern here? Sorry for the rant ..) I mean the concept of the Default-Mode-Network which his whole paper "The entropic brain" is heavily based on was not even touched upon. Or his contra-intuitive finding that classic psychedelic do not generally increase brain-activity but in fact decrease activity in brain regions associated with the DMN and thus allowing for a entropy increase overall. His division of primary consciousness and secondary consciousness in terms of criticality and sub-criticality is only touched upon in a short sentence of "striking the balance" C'mon this is - when not elaborated on - just banality. I mean I could go on and on for missed opportunities to dive deeper in exploring those concepts in helping understanding the brain in systemic and holistic terms, one could even argue in old-fashioned cybernetic terms. So for anyone interested please do yourselves a favour and go read his paper from 2014 "The entropic brain".

It's time to take a *TRIP* with Sean!

I feel like most people wont try psychedelics until they are on their death bed and then they will realize that they shouldve explored this realm a longggg time ago. They are the ultimate paradigm-shifter.

Joe Rogan is somewhere listening to this podcast

@sean carroll, do you sense that these conversations you have with all these guests has influenced your professional work?

The show should have had Neil "Smoke" Degras-Tyson

Neuroplasticity should have been mentioned, it was shown in a landmark paper in the summer of 2018.

Thank you for the interesting discussion. Learning, earning and yearning is the name of the game in life. And the very sequence is crucial. Enjoyable episode on psychopharmacology which should be part of the high school lessons all over the world... and much more. Best regards Sir.

Mindscape and psychedelics? Boi this is gonna be a good one!

Do it, Sean. Do the deems.

Wonderful. Great interview. Sean is skeptical yet open minded.

Great topic. Thanks for the podcast!

Joe rogan going to listen to this 10 times

Great episode, maybe because it felt too personal, I had experience with many of the drugs mentioned and having this perspective and scientific knowledge to associate with my own experiences are amazing. When I was around 18 I took this anti inflammatory medicine (super dose of the whole pack) and Jesus I had hallucinations, way more than any psychotropic I had in my life, it’s active ingredient is Benzydamine, is it considered a psychotropic drug? Btw the commercial name was Benflogin

Sean has tried LSD, if I remember correctly from a previous episode (sorry, if that is incorrect). Anyway, this interview could've been a lot longer; I feel like there was a lot more to talk about.

Sean often uses the example of coffee and cream mixing together to explain how entropy and complexity are related. I think it relates to brain function as well.

Nothing about microdosing?

Utterly brilliant.

it seems common sense to me that if a substance can help you, then it can also harm you. obviously decades have been wasted in understanding how to tease out help from harm. put those to things together and it's clear that now is not the time to do LSD or DMT, etc..... there just isn't enough historical data and analysis yet.

I hope psychadelics can help me find purpose, sense and meaning.

This is a very hard subject. Its hard to talk about because of the 'taboo' and the 'woo woo'. Its hard because our language lacks the correct descriptive words to accurately convey what exactly the psychedelic experience is. Let alone what it could implicate about our nature as humans, and about the nature of existence period. I think this was a great podcast. Im a huge huge fan of both these men and have followed them both for years. Its a tough subject and I applaud Mr. Carroll for having the courage and the constitution to talk about these things with an open mind and with an open heart. Thank you for this episode, would love to see more of the Dr. on Mindscape.

I learned several new ideas - thanks, guys. To think, governments have been keeping the treatments for addiction and mental illness illegal for 50 years. That's the stuff revolts are made of.

Big fan here:)

LSD and Shrooms helped turn me into an atheist by opening my previously closed mind. DMT was helpful in getting out of some bad mental health crisis. Would be fascinated to do psychedelics in an fMRI and/or PET scan to see what the brain is doing on them. For SCIENCE!!!

Has either of these two ever even dosed before? Especially the so-called expert? Because it doesn't sound like it to me....

"Drugs are not everyone's cup of tea". Oh the irony 😅

Psychedelics were banned because people started to openly protest war.

Yes yes yes!

Expert has to buy a 10k dollar safe for mushrooms that just grow on Earth and help you live and die peacefully thinks Decriminalization is not the way to go. I`m sorry. but imho he should be put in jail for drugs. Just so he knows what he is advocating. These elites think private jets are ok to fly to climate summits. But god forbid Regular people should eat mushrooms.

David Deutsch please! :)

59:52 "Don't take them for escape". I don't quite understand that statement. For what other reason is there to take them?

LSD is not a tryptamine.

CAVE MAN COFFEE

Ketamine saves.

Psychadelics would show Sean how annoyingly dismissive he is about legitimate possibilities for reality that despite our wishes may not ever be testable. Try a heroic dose of anything and come back with any real certainty of anything at all other than the fact that you are fundamentally, humbly, uncertain and need to be open minded about as much as possible as often as possible and then I’ll be impressed. And to be honest I think it’s pretty clear Sean is just insecure about being categorized as “woo woo” for social capital which I have even less respect for

Big waste of time really.. Lot of talk, nothing of information. Seems more like a coffee table, saying "yeaa,, changes life... you see more clear...", such a deep topic taken so shallow. Sean should invite a new guest to talk about this again, in a scientific way, and please talk about ayahuasca !

Lol did they both just agree that hallucinations were just visual distortions , and you don't actually see things...they obviously didn't take enough lmao

For God's sake, please remove those annoying intermittent ads in your show.. Either put them at the end or at the start, but they are so intruding during the conversation that I'm probably gonna unsubscribe if this continues.. Which is a shame, because your podcasts are awesome!