Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients
mbio.asm.org/c...
The measles-mumps-rubella (MMR) vaccine
Theorized to provide protection against coronavirus disease
To determine whether any MMR IgG titers are inversely correlated with covid severity
Comparing MMR titers to recent COVID-19 severity levels.
The MMR II group
50 subjects who would primarily have MMR antibodies from the MMR II vaccine
Comparison group
30 subjects consisted of those who would primarily have MMR antibodies from sources other than MMR II
Including prior measles, mumps, and/or rubella illnesses
Results in the MMR group
Significant inverse correlation (rs = −0.71, P less than 0.001)
Between mumps virus titers and COVID-19 severity
Results in the comparison group
There were no significant correlations between mumps IgG titers and severity in the comparison group
Results in both groups
No correlation between between severity and measles or rubella titers in either group
Scale of the observation
Mumps titers of 134 to 300 arbitrary units (AU)/ml (n = 8), functionally immune or asymptomatic
Less than 134, (n=17) all had mild symptoms
Less than 75, (n=11) all had moderate symptoms
Less than 32, all who had been hospitalized and had required oxygen
Our results demonstrate that there is a significant inverse correlation between mumps titers from MMR II and COVID-19 severity
Four important points
Young children are largely spared from severe disease
Second, numerous countries have COVID-19 death rates that are as low as 1% of the death rates of other countries
Many people, despite prolonged close contact with someone who is COVID-19 positive, never test positive themselves
Nearly half of people who test positive for COVID-19 are asymptomatic
Mechanism of action
Sequence homology between both mumps and measles and rubella with SARS-CoV-2
After two doses
97% protected against measles
88% against mumps
97% against rubella
NHS site
www.nhs.uk/con...
Born between 1970 and 1979, as you may have only been vaccinated against measles
Born between 1980 and 1990, as you may not be protected against mumps
Bradford Hill
Strength of association
Consistency
Reproducibility
Specificity
Temporality
Biological gradient, dose response
Plausibility
Coherence with lab findings
Experiment
Reversibility