Molecular Biology #1 2020

  Рет қаралды 177,079

OLLI UCSC

3 жыл бұрын

A typical animal cell contains more than 40,000 different kinds of molecules. In the past 20 years, great progress has been made in understanding how these molecules combine and interact to form a living creature.
Prof. Emeritus Barry Bowman organizes the course and offers two lectures. Two other professors from the Molecular, Cell and Developmental Biology Department at UCSC present lectures covering topics related to their research programs.
These talks are intended for a general audience. A scientific background or knowledge of biology is not expected. Barry Bowman, the course coordinator, will begin with a basic review of genes, proteins and cells.
Lecture #1. Prof. Emeritus Barry Bowman: An introduction to the basics of molecular biology
Lecture #2. Assistant Prof Josh Arribere: How quality control protects our cells
Lecture #3. Prof. Martha Zuniga: SARS Wars: Immune defenses against SARS-CoV-2 and COVID-19 pathology
Lecture #4. Prof. Emeritus Barry Bowman: Digging deeper into DNA
Barry Bowman is Professor Emeritus of Molecular, Cell and Developmental Biology at UCSC.

Пікірлер: 76
@wackymontederamos
@wackymontederamos 3 жыл бұрын
This lecture made my life so much less boring. I worked as a household helper here in Singapore, all the house chores is choking me to death until I become interested into biology. Now i can cook, clean and iron so much better while listening to this lecture.
@birhon
@birhon 2 жыл бұрын
If you fly me out to Singapore I will help you cook, clean, and iron
@asdfafafdasfasdfs
@asdfafafdasfasdfs Жыл бұрын
@moonlightgamers1436 by using the internet! lots of excellent materials like this video also certificates etc. often better than what you can get in person.
@asdfafafdasfasdfs
@asdfafafdasfasdfs Жыл бұрын
@moonlightgamers1436 you can self-teach everything, given enough motivation. Aside of some physical experiments, of course - if relevant to what you're doing. You also need to be very good at organizing yourself so it's not for everyone.
@asdfafafdasfasdfs
@asdfafafdasfasdfs Жыл бұрын
@moonlightgamers1436 note that I'm not saying necessarily that degrees shouldn't exist, but the internet offers vastly increased personalization (a problem that traditional education has always struggled with, as people have very different needs and physical educational resources are very limited) and could certify skill in an entirely different, more focused and optimized way. Traditional education at least until thesis / PHD is designed basically for mass consumption, which was the best that could be done historically but doesn't really hold anymore with the new technologies and tools available. Recently, also AI, e.g. ChatGPT is existentially threatening traditional education models (which includes too if those models are replicated online of course), so the whole system is ready for a fundamental overhaul.
@asdfafafdasfasdfs
@asdfafafdasfasdfs Жыл бұрын
@moonlightgamers1436 you're clearly biased and wrong. Since you bring up personal anecdotes, let me bring up mine as well: I always had trouble staying focused in university classes, I don't like much being crammed in small rooms with lots of people, so I ended learning mostly at home anyway (huge waste of time, since I had to attend classes too). I wrote good grades out of pressure but generally university was very discouraging and it prevented me from truly connecting to the content. Now moving from the anecdotes back to the general: physical universities are also extremely exclusionary, and not in the good way, many exclude based on economic status and geographic location, and even if it was completely fair there would be just not enough capacity to give education to everyone that's adequate to skill / talent. Online education is not only youtube (though there's PRETTY GOOD content here, including video recordings of full courses at top universities or online-first classes like what we're watching here, detailed step by steps, if you happen to not understand one you can try another, etc) and Coursera, but buying the big detailed books used at University in Amazon (or subscribing to a library). And interacting with other people and asking questions can be done in communities (can't find one? you can create it). For example in Khan Academy the discussion is excellent. And there are more niche communities. Next question is how do I prove myself, and that's where you have to get more creative, e.g. writing, figuring out something new, open source, etc. that also pushes you to invest your time wisely and have concrete goals from the start instead of learning semi-robotically. Yes currently especially in science there's extreme gate-keeping where people obsess over traditional credentials, so indeed you will have difficulties without a degree (not impossible though), but that needs to change.
@jessefranklin-peiper7366
@jessefranklin-peiper7366 2 жыл бұрын
glad that there are professors like this out there, not just pumping out information, but rather taking their time to be sure their students understand the material. So patient!
@XM1679
@XM1679 Жыл бұрын
Sometimes they forget how to teach and just turn into textbooks
@TheDavidlloydjones
@TheDavidlloydjones 10 ай бұрын
That's inane, Jesse. To "be sure their students understand the material" needs a feedback loop. If you missed something, how do you think they'll know?
@yanag3246
@yanag3246 3 жыл бұрын
Best lecture ever!
@Jordan-hu6hd
@Jordan-hu6hd 2 жыл бұрын
The question answered at 14:18 is excellent. It’s cool that you can find lectures and talks like this on the Tube
@tylermarshall7894
@tylermarshall7894 3 жыл бұрын
What a badass lecture. Great work, cheers and be well!
@alanlee5541
@alanlee5541 3 жыл бұрын
Excellent presentation which explains complex problems in a simple way. The coherence of the whole talk is so good that I enjoyed every second of the talk. Thank you!
@robertad5623
@robertad5623 3 жыл бұрын
Thank you so much for sharing!
@Not-ip1hn
@Not-ip1hn Жыл бұрын
A profound lesson on the introductory of Molecular biology, the fundamentals are truly astonishing you made a rather complex lesson turn into a simple explanation of the functions of cells to a whole new level.
@markoconnell804
@markoconnell804 Жыл бұрын
So the code to make the protein which it binds to on the DNA to start is from the DNA to begin with. This is why the topoisomerase so important so a factor can get to the binding spot it is programmed for on a molecular level. Brilliant method. Thank you to whomever discovered this.
@rodneyspence7441
@rodneyspence7441 Жыл бұрын
I’ve been watching the Ken Burns documentary called “Cancer - The Emperor of All Maladies” in which they say most types of cancer involve mutations on 50-100 different genes whereas at first they thought it only involved a few. And even for those types that do just involve a few genes the cancer will keep mutating to resist the drugs. I hope some of the young people here keep learning about the cell biology so that this nightmare of a disease can be defeated. Thanks for teaching this important information in an understandable way!
@LarsLarsen77
@LarsLarsen77 Жыл бұрын
My friend discovered a single SNP that causes cancer in humans.
@glendaoliveira5342
@glendaoliveira5342 2 жыл бұрын
Thank you for the awesome lecture! I'm a Ph.D. student, with chemistry as a background, adventuring myself in the biochemistry field. This lecture literally changed my way of understanding the basic concepts!
@clarissegirishya2752
@clarissegirishya2752 2 жыл бұрын
Absolutely 👌
@marksilver1573
@marksilver1573 Жыл бұрын
Such a complicated structure couldn't just happen by chance, nature itself is pure intelligence, and it boggles the mind!
@maharlikawarrior6625
@maharlikawarrior6625 Жыл бұрын
Topic is well-explained...thank you this video
@zaidgamer2794
@zaidgamer2794 2 жыл бұрын
You are amazing what a very informative lecture
@RollingTree2
@RollingTree2 Жыл бұрын
Excellent! Explanations laying out in orderly, contextually thorough fashion what physically/visually happens, and why, via layman descriptions, before adding terminology. Rare. So often, teaching begins with, and emphasizes, terminology and abstractions, and fails to clearly link processes. Thank you!
@gerardochavez8238
@gerardochavez8238 9 ай бұрын
THIS
@N3Rd32
@N3Rd32 Жыл бұрын
Very informative right off the bat. The slides really helped along with the presentation. Thank you for taking the time to create these videos and inform the public on such interesting and important subjects.
@lugus9261
@lugus9261 Жыл бұрын
1:22:35 this is an interesting question because "purpose" and "function" are words we see all the time in biology in explanations for why something is the way it is, but you don't see that in other sciences as often. A geologist isn't going to tell you purpose or function of why a rock exists, just how
@antpoo
@antpoo 2 жыл бұрын
How do we get a ‘c’ spike the protein to fold if we don’t know the cause?
@user-yx1xg8sf4v
@user-yx1xg8sf4v 2 жыл бұрын
whats the relationship in Biochemistry, Molecular Biology and Genetics
@mikoplays
@mikoplays Жыл бұрын
Some of the questions from the audience are interesting.
@amosochiengowenda5466
@amosochiengowenda5466 Ай бұрын
Great
@markoconnell804
@markoconnell804 Жыл бұрын
How does the binding factor know the correct spot to bind to the DNA? Why that spot versus any and every other spot on the DNA of the bacteria trying to get the sugar molecule?
@ezzovonachalm9815
@ezzovonachalm9815 9 ай бұрын
could I have had the opportunity to see this very presentation as I was a medicine student .....!!!
@Affan_Alam
@Affan_Alam 2 жыл бұрын
Can anyone suggest me the first very book for molecular biology ( I am in class 10 )
@_neophyte
@_neophyte Жыл бұрын
33:00 this is so fascinating. it looks like machine code, like binary code (obiously it's not truly "binary" but you get the point). Our bodies are truly just machines, the most marvellous machines to ever exist. I'm going to start my degree in biomedical engineering soon because of the fascination i have for nature and the desire to contribute to people's health using technology.
@michasosnowski5918
@michasosnowski5918 Жыл бұрын
Cathalythic reactions are fascinating to me. Mln per second? It blows my mind. Its like a spider waiting on his web, so that fly would hit the web, and then its an instant hit with poison. Inside the cell, there are billions of flies propably, and the spider is much faster. Boom, and the next one. Boom, next one. On and on.
@Ronald-xp7ry
@Ronald-xp7ry 2 ай бұрын
It seems to me that there are forces that are determinated by the structutrees of the cell. All the forces that make molecles moves are determinating tho the objective of the celular organels objective.
@lindatimoritahamzah5647
@lindatimoritahamzah5647 2 жыл бұрын
Hallo im come from Indonesia, i'm from biologi education of Tidar University
@markoconnell804
@markoconnell804 Жыл бұрын
That extra code on the end I would guess is for the purpose of repair the code should it be degraded enough. I could be wrong certainly. Hopefully we will discover what it does later on.
@ShellsPink
@ShellsPink Жыл бұрын
Here's a question: How do Fluoroquinolones work and how do they affect/damage DNA??
@TariqAziz-sg9fl
@TariqAziz-sg9fl 3 жыл бұрын
I need vedeo lecture on molecular biology for ecologist
@markoconnell804
@markoconnell804 Жыл бұрын
The DNA also reads backwards too.
@kainajones9393
@kainajones9393 Жыл бұрын
Great lesson. Would be good if your cursor were a bit more prominent . Hard to know where your pointing sometimes
@ShellsPink
@ShellsPink Жыл бұрын
Mmm this put me to sleep!! Thank You!!
@ShellsPink
@ShellsPink Жыл бұрын
Actually very enlightening, fascinating ....and seals the deal for my belief in a designer, Creator, the whole shebang... but I really did fall asleep while watching!!
@julioequinones
@julioequinones 2 жыл бұрын
1:15:51 two questions where asked, the first of which was answered as if for both. The spirit of the question layed with the second, which was not interpreted by the Lecturer. Q1 answer. 90% DNA noncoding Q2 answer ~15% viral artifacts according to the lecture @ 27:50 So the answer is no, she did not get that number correct vs the Lecturer saying yes.
@maebyvalentinamontesmillan9249
@maebyvalentinamontesmillan9249 Жыл бұрын
40:59 / 1:30:27
@markoconnell804
@markoconnell804 Жыл бұрын
God is so amazing.
@LarsLarsen77
@LarsLarsen77 Жыл бұрын
Who is older? The students? Or the professor? I watched this at 1.75x and it was still too slow.
@instruments3366
@instruments3366 Жыл бұрын
3:00
@Saylor3561
@Saylor3561 2 жыл бұрын
18:22
@SpiritualLifeAdvisor
@SpiritualLifeAdvisor 2 жыл бұрын
Viral genes, bacterial, and fungal genes make up the complex organism called the human being. Plants are more advanced because they have incorporated MORE viral/bacterial/fungal genes into their genome sequencing than mammals. Meaning they have more ways to morph, adapt, and create defenses against its environment for survival. Plants will always survive past the mammals and always will regulate the ecosystem because they have nearly 100% of the ecosystems genes incorporated within its own genome.
@SpiritualLifeAdvisor
@SpiritualLifeAdvisor 2 жыл бұрын
This is why and how plants CURE us lowly evolved mammals.
@SpiritualLifeAdvisor
@SpiritualLifeAdvisor 2 жыл бұрын
THe one gentleman asked how and why each persons genome sequencing has its own unique qualities. Depending on your ancestors exposure to viral/bacterial/fungal within their environment throughout their lives at a chronic long term exposure rate, those organisms incorporate THEMSELVES aka their own genome DNA into YOUR original DNA genome sequences, called deletions of your own pattern of genes. This is how a genetic disorder or aka, genetic evolution, becomes part of the persons own DNA pattern/sequence, and then that there is replicated as a constant and passed onto your offspring. This is how DNA is created or the multi-organism. An multi organism is multiple organisms co-existing symbiotically with each other. When biochemists map the pattern of each persons unique DNA sequencing, its the differences of the viral/bacterial/fungal patterns, that naturally map back against the parents because the parents give half of their own DNA to their children.
@rodneyspence7441
@rodneyspence7441 Жыл бұрын
Hello, I’m a retired NASA aerospace engineer with no real background in cell biology, but I’m just dumbfounded by the apparent design I see here with all these intricate chemical mechanisms at work. I was thinking about the origin of the first living cell on earth. If you need a large macromolecule like a ribosome to build other protein molecules, it raises the question of the origin of the first ribosome and the origin of the DNA assembly instructions to build that first ribosome. You run into a chicken and egg dilemma - seems like you would first need a ribosome to build the first ribosome. Not only that, seems like you would first need a living cell to build the first living cell! I may have to rethink my evolutionary assumptions on this issue. I honestly have a difficult time believing this whole transcription, translation, protein synthesis process in the first living organism came about through random natural processes - even over millions of years.
@jeffkaze7
@jeffkaze7 Жыл бұрын
hey hi could you help teach me some basic high school physics. It would be a huge help to me
@user-pl2tl4yc5o
@user-pl2tl4yc5o Жыл бұрын
مين دا
@patrickcasey1664
@patrickcasey1664 2 жыл бұрын
I’m here from meow wolf. Anyone else?
@ktl4539
@ktl4539 Жыл бұрын
Poor articulation of the material. TRNA? Come on, man. Transfer RNA.
@chesthairs
@chesthairs Жыл бұрын
same thing
@jameshopkins3541
@jameshopkins3541 Жыл бұрын
don't speak like a teacher please use loquendo do not take air by the mouth