I have a request for a future video.

Hey Taylor - you're doing better than me! I need x3 listens..... 😝

Glad to see I'm not alone

Hi Taylor, don’t feel bad. My husband is dumb too. He always says that he could have been a Doctor but his mom drank alcohol when she was pregnant.

Me too. It is simple to make the distinction.

@Ayo if you say soo, i guess i must be

@Ayo why would you call someone you (I assume) don't know creepy? One reason to want to live a long life, that helps us to live long and healthy is good company, something to live for, family and friends etc it makes life worth living in the first place, sadly I've lost hope in the human race with constant conflicts, deception, greed on and on. People need to be good to each other that's the first step in good health from my point of view, love and happiness equals health.

Same here. She is an invaluable resource 💗

And unfortunately the last time she was on he used it as some weird opportunity to litter the interview with "gotcha" questions. I was really disappointed.

@@alkeegan9915 . That were not "gotcha" questions. Perfectly legit as he's asked everything else on the topic. I was disappointed with her answer but that does not detract from what she does; she is tremendous.

The effect has been perfected!

That's a reversal of what I might otherwise expect... Thanks so much for listening, Larry!

*Take Rapamycin, you will extend your life span.*

Yes! Listen to 00:42:15 when we talk about interrupted cellular reprogramming.

@@FoundMyFitness I did see a study where a certain diet and lifestyle change reversed 'epigenetic age' or markers, its interesting but it doesn't necessarily mean that the person will live longer, they may even shorten their lives following such a protocol, the diet for example - participants were allowed to eat I think more than safe levels of Liver (longterm it may damage their livers due to too much vit A) a few servings of red meat, intermittent fasting, exercise etc, now what if a person who has CKD for example decides to follow their example nd starts pounding down red meat, they will progress faster down the rout to end stage kidney disease as the kidneys are already damaged and cant filter as they used to, depending on the exercise this can also tax the kidneys and so following the example of lifestyle and diet changes that showed a reversal of epigenetic age would actually (more than likely) REDUCE their life. This is why these studies have to be taken with a pinch of salt as they may NOT work on us as individuals and could even harm us. I love your interviews by the way. I wondered what you thought about what I said, thank you.

Have you tried adding eggs?

@@DonnaLHaney I ate about 2 eggs a week in both cases. Eggs consumption is associated with an increased all-cause mortality, and in randomized trials with increased Tryglecerides and insulin resistence, so I try to limit their intake.

@@ok373737 thx for replying. I was vegan for 7 years, then had my DNA analysis which showed an extremely high need for choline, so I added eggs (and fish, as well as dairy & some cheese). I understand, as you say, eggs are generally "associated with" higher all cause mortality, but I wonder how else someone like myself should balance that with getting enough choline in their diet.

@@DonnaLHaney what in the DNA analysis suggested that more Choline is needed? How many eggs do you eat a week? Eating nuts, fish, some chicken and red meat should provide some Choline but not as much as eggs. But who know if the RDA is actually optimal for you.

@@ok373737 one related SNP is PEMT rs7946, indicating a lower conversion rate in the liver to acetylcholine (per Dr. Rhonda Patrick genetic analyzer 2019). Later analysis with Chris Masterjohn limited to choline recommended 800+mg dietary choline/day. RDI is about 1/2 that. I've been eating two eggs/day plus fish, cruciferous veggies, nuts, etc and supplement with both choline & TMG. I've always had very low triglycerides, but became insulin resistant as a vegan. I now follow the old ZoneDiet macros, but violate Dr. Sears' advice to avoid egg yolks, trying to balance all of this, but can't really afford to get a lot of repeated tests to see how it's going.

Yeah you need way more. I personally consume 4g of OM3 a day (around 2G DHA / day). AM not a doctor, but I have been doing this for about 7 years, and I notice within a few weeks when I stop in my skin, mood, hair, and cognition (and in blood lipids).

she is

Kane Tanaka underwent pancreatic cancer surgery at the age of 45. She is 119.

Interestingly, alot of very long lived people have had many serious diseases including cancers. I guess the saying is true: "That which does not kill us, makes us stronger". Body has a remarkable way to bounce back from disease. But there are no guarantees.

Your personal anecdotes don't mean anything in the grand scheme of what the information says. Everyone always has that typical personal take "well my grandma drank and smoked her entire life and she lived to 90" ok cool but that doesn't mean anything in regards to the literature and statistics.

@Alfonso Hunt yes, optimism according to some studies also has an impact on wound healing! So a positive mental well-being, along with optimism and reducing stress, are key for health and wellness. This is not merely to be rejected as 'quackery'.

@Alfonso Hunt This is mostly mythology. The Amygdala becomes damaged very late in life, and when it does, you become more happy and carefree. All those cautious mental feelers, prepared for anything, just erode. So when they interview very old people, they sound very upbeat. My grandfather was always quiet and very reserved. But when he got to his high 90s he became the life of the party telling all kinds of jokes, and smiling all the time. The liking of mental activity is probably just a reflection of brain health. There is no evidence that if you slave drive your brain to do more activity, that you will become healthier. In fact, there was a study and mental exercises did not achieve much. The, changing mental outlook thing to extend your life, is just new age mumbo jumbo. Often repeated, but still junk science...with a dose of wishful thinking...and a dose of blame for those not giddy in the midst of their aches and pains. I am not trying to be a downer, there are many things we can do to age better, extend our healthspan and lifespan. Thinking your way to a long life is just unlikely to be one of those. That said, depression does cause harm.

She is 37. instagram.com/p/CcS5_p3L6SL/

Add Rapamycin ànd you will extend your lifespan.

I don't think GrimAge is available anywhere. However, Elysium's is trained "a bit more like" a second generation test like GrimAge. Probably the best consumer option right now.

Wasn't she purely stating her findings based on the biomarkers? Ie evidence based observations? No notions being spouted. Only watched it once so happy to be corrected.

So what's your point about MTOR ? Is this not a factor accelerating aging? And animal protein boosts MTOR more than plant protein... More anabolism, but less longevity.

@@ThierryPianoSolo you are correct, but mtor stimulation seems to only be problematic in metabolically unhealthy individuals. Also, I would argue the benefits of animal based protein with regard to muscle gain and prevention of muscle loss as we age outweigh any negative consequences. My argument isn't that plant based diets aren't effective with regard to longevity, just that they aren't optimal. Of course, the truth is we just don't know enough yet to make definitive claims!

@@ericsevyn5464 Mtor is not bad in itself, but problematic in excess. That's why centenaries people eat not so much animal protein (but are not strictly vegetarians). We have enough data to be certain of that.

3 main things: 1. Higher temperature tends to accelerate aging. This is due to a higher probability of enough heat quanta meeting in proximity to complex molecules where a bond can be broken, made, or arms around a stereo center switched, that is not part of normal function, damaging proteins and other molecules (Said more succinctly, there is higher quantum tunneling damage with higher temperature). 2. Antioxidant activity. Some animals have less effective forms of SOD, fewer forms, and lower concentration, and some other antioxidants that their bodies make. 3. Various species have better or worse DNA repair systems, and different rates of damage. Temperature is pretty big. This likely explains why bowhead whales, naked mole rats, some fish, lobsters, bivalves, and reptiles like tortoises, live so long. And is certainly a factor in why humans live so long. We also live a long time because we have the best SOD levels around. But some other creatures may have better DNA repair than we have. We are the temperature we are, because enzymes only operate well at a range of temperatures, and our enzymes are fairly particular, which is why we die easily if our core temp changes much...too many processes are too slow outside that window. So just dialing it down, at least a lot, is not a viable life extension method. However, having very low inflammation does lower temperature. Same thing with lower blood sugar, and fasting. But clearly there is a point of diminishing returns as we move away from optimal temps for our enzymes. Some super centenarians make a lot more Sirtuin 6, this improves the accuracy of double DNA break repair...which could easily be why they reach an advanced age. There are other factors, of course, for the variability of animal aging. Immune system is one of these. We have a pretty terrific immune system...probably too good, due to recent selection in cities and long exposure to domesticated animals (over the last several thousand years), which we really were not designed for...likely leading to more autoimmune disorders.

@@ChessMasterNate Thanks Nate! If you have any references on the subject, please let me know!

Wrong.

@@ThierryPianoSolo Wright.

I don't think you understand what "metaphysical" actually means....

@@iranjackheelson Who knows, right? I obv think I do, and I have no reason to believe you, a random youtube commenter, more than myself, right? So it's sort of a pointless thing to say. But perhaps you felt the need to say it, and that's okay too. It's the same feeling as caused me to make my comment.

Links to learning resources?

🤣

Oui Oui, Vive la france

L🤣L

Poor diets, alcohol abuse and sun damage just melts years off.

@@RandomNirvanaSXE Sun damage? in the UK? 🤣 , Ethnic brits in Australia then yes maybe..

@@RandomNirvanaSXE more like: a lack of sun, stress, working into the 60s, poor diet, lack of exercise, sugar, alcohol etc. Greetings from England!

All of our videos are transcribed and close captioned.

Indeed! The (otherwise incredible) guest’s glottal fry was just too much for my ears. Ugh. God, I hate that trend. Good to know a transcription is possible for voices such as this one.

Balanced diet, not carnivore... Carnivore diet leads to red face, hoarse voice and poor skin quality as all the carnivore KZfaqrs prove... It's not a healthy diet in the long run.

I had that immediate thought as well!

She "speaks" versus talks..