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Premature ovarian insufficiency also known as #prematuremenopause is a heterogenous disorder of multifactorial origin defined as the occurence of #secondaryamenorrhoea, hypergonadotropism (#FSH above 40mIU/ml) and hypoestrogenism #estradiol below 50 pmol/L in woman below 40 yrs of age.
Number of total follicle count during gestation decreases from 7 million during the 20 th week to 30,000 during puberty. In the climectrium the expected number of follicles is one thousand. A possible mechanism of tne origin of #prematureovarianfailure can be decreased number of primordial follicles due to atresia or altered follicle maturation. The decline in the ability to repair DNA double strand damages by homologus recombinant repair during meiosis, due to decline in repair genes BRCA 1, MRE11, Rad51 and ATM, leads to accumulation of these damages that contribute to the depletion ofvthe ovarian reserve.
Woman with #POI have 5 to15 % chance of spontaneous conceiving at some times after confirming diagnosis.
Source: Frontiers in Gynecological endocrinology, Vol2
#अंडे, #माहवारीबन्द