Nephrogenic systemic fibrosis from Gadolinium MRI contrast (pathology dermatology dermatopathology)

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Excerpt from my dermatopathology board review video. Full video here: • Metabolism & Depositio... . Enjoy!
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Пікірлер: 3

@yuvrajbhullar7158 20 күн бұрын

What’s the cure to removing the deposition?

@BrianMillsSkills 8 күн бұрын

There's no way to fully remove deposition even in patients with great kidney function. The best currently approved chelator that can be used off label for Gadolinium chelation is DTPA, which is the chelator that was used in some linear Gadolinium agents, urine data shows it increases excretion when used in patients with Gadolinium exposure. If the patient is in a disease state such as Gadolinium Deposition Disease or Nephrogenic Systemic Fibrosis, the chelation may cause an immunological flare though. There's patient urine data that shows that even the reservoirs of gadolinium that IV DTPA can reach, it is very hard to get it to 0, I'm aware of patient data that shows DTPA being used every month for a number of years are still showing gadolinium in their urine data.