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Neuronal Signaling and Sodium-Potassium Pump (from PDB-101)
Рет қаралды 62,902
Күн бұрынOur neurons use electrical impulses and complex molecular machinery to communicate information throughout our bodies. In order to be ready to transfer the signal when it arrives, the neurons need to maintain high concentrations of sodium on the outside of the membrane and potassium ions on the inside. With each signal transmission, sodium enters the neuron followed by potassium exiting the cell.
The sodium potassium pump is a transport protein that regulates and restores the gradients of sodium and potassium ions across the membrane. With each pumping cycle, it transports 2 potassium ions back into the cell, and 3 sodium ions out of the cell.
Using structures from the Protein Data Bank, this animation shows how the essential proteins work together to prepare for and conduct the neuronal signal. The video zooms in on the mechanism sodium-potassium pump to explore the concept of the active membrane transport.
To learn more about the proteins shown in this video, visit PDB-101 (pdb101.rcsb.org/) and read the Molecule of the Month articles on Voltage-gated Sodium Channel (pdb101.rcsb.or..., Potassium Channels (pdb101.rcsb.or..., and Sodium-Potassium Pump (pdb101.rcsb.or....
@RCSBProteinDataBank 3 жыл бұрын
Please use this link if you would like to contribute subtitles in your language: kzfaq.info_video?ref=share&v=ZKE8qK9UCrU Note: KZfaq is removing Community Contributions on September 28. If you would like to translate the content of the video before this day we will be able to publish. After September 28 the above link will not work. Please contact us if you would like to translate the video into your language.
@senemakyurek4145 3 жыл бұрын
Can you add Turkish subtitles please?😊
@Asillean8866 2 жыл бұрын
,55qp
@99.99 3 жыл бұрын
In all the channels that I barely understand, this one is by far my favorite one!
@BasicScienceSeries 3 жыл бұрын
Amazing video! Thank you protein data bank for making bioscience supercool!
@aqueousice3667 2 жыл бұрын
Don't forget that the many of the phospholipids at the cytoplasmic side of the membrane are negatively charged, which contributes greatly to the generation of local membrane potential.
@dguhoshi786 3 жыл бұрын
Thank you so much for this video. That was the best explanation I caould find that was concise and also quite detailed!!!
@timothybolton7852 3 жыл бұрын
I learn so much easier with these graphics it’s awesome 🙏🏻🙌🏻
@ybuntu 3 жыл бұрын
A very wonderful video. Thank! ------- Please translate into Russian and Korean!!! I really love showing my friends your videos - how amazingly life is.
@vblaas246 3 жыл бұрын
I see an mMaya animation, I click like immediately :) I can translate in Dutch.
@vasdgod 3 жыл бұрын
Thanks for making the video
@robbyschwartz 3 жыл бұрын
Amazing!!! great work
@Nick-rv9ek Жыл бұрын
THANK YOU I NOW UNDERSTAND IT
@toaignika16 3 жыл бұрын
Wonderful
@beornottobe8153 3 жыл бұрын
that's amazing 💗😍Thank u from Algeria A final year high school student2021❤️ And a future medical student2022❤️
@aymenbouaoune6597 3 жыл бұрын
يا جدك صحاب الباك راهم هناااا 😍😍 منيش وحدي مالا ❤ ههههه اونفان الواحد فهم دروس الاتصال العصبي
@beornottobe8153 3 жыл бұрын
@@aymenbouaoune6597 في كل بلاصة 😹🤝 بون كوغاج🌸🤗
@aymenbouaoune6597 3 жыл бұрын
@@beornottobe8153 منين نتا؟؟
@mely731 2 жыл бұрын
@@aymenbouaoune6597 nti* Mn mila😂
@kiyanhill1170 3 жыл бұрын
Thank you so much!
@joelinekitenge9683 3 жыл бұрын
Thank you
@whyartlife6202 3 жыл бұрын
This is so beautiful
@Biologywithrasheed 3 жыл бұрын
Good
@KanraveeKik 2 ай бұрын
May I ask about the Sodium - Potassium pump please? It it stop working during the Deporarization to Hyperporalization stage ? Or it still pump all like auto active ?
@jfrjfernando1987 3 жыл бұрын
Very good God Love you
@lakea.6218 2 жыл бұрын
Addressing the health KD this pump changed my life. I was severely potassium deficient. In addition, i removed the toxicological sources of oxidation while Taking a variation of antioxidants + ATP.
@Roman_person_handl 3 жыл бұрын
what happens when we drink coffee or sedative pills?
@cyberbiosecurity 3 жыл бұрын
Yes!
@joeferdin9871 3 жыл бұрын
1:04
@alto5593 3 жыл бұрын
Superb video, but what is that annoying bell at the end ?
3 жыл бұрын
10/10
@LeolisaNicko 3 жыл бұрын
Wow
@lennykoss8777 3 жыл бұрын
💗
@Darkmatter321 Жыл бұрын
Wonder how they figured all this stuff out. I mean they can't possibly see this stuff happening by any kind of Microscope
@dread12059 3 ай бұрын
That's what I'm saying. My curiosity peaks and I ask questions like that.
@user-oj5ed6of4o 3 жыл бұрын
> After the signal is finished, the locations of ions have been reversed. Sodium concentration is high on the inside and potassium concentration is high on the outside Wrong. Influence of one signal on sodium/potassium concentrations is completely negligible. > The sodium-potassium pump restores the sodium and potassium gradients, making the cell ready to send another signal. Again, wrong. It requires many thousands of signals to make cell "not ready" to send another signal. > Because the pump moves these ions against their concentration gradients, it requires the energy of one ATP molecule for each cycle. Not exactly: the energy is required because the pump moves these ions against their ELECTROchemical gradients, not just concentration (i.e. chemical) gradients. And potassium electrochemical gradient actually is low: its chemical and electrical gradients nearly balance each other. P. S. Sorry for my English.
@user-oj5ed6of4o 3 жыл бұрын
@@user-qh4hw2mp6w В первой цитате говорится, что после прохождения сигнала локализация ионов меняется на противоположную: концентрация ионов натрия становится высокой внутри клетки, а ионов калия -- снаружи. Это неверно -- на самом деле прохождение сигнала практически не меняет концентрации ионов натрия и калия, так как перемещается лишь ничтожная их доля. Во второй цитате говорится, что натрий-калиевый насос восстанавливает градиенты ионов натрия и калия, обеспечивая готовность клетки посылать следующий сигнал. Здесь верна лишь первая часть предложения. Клетка и так будет готова посылать следующий сигнал, так как её потенциал покоя восстановлен калиевыми каналами, а концентрации ионов практически не изменились. Натрий-калиевый насос поддерживает необходимые концентрации ионов в фоновом режиме, подавать его работу как завершающую стадию отдельного импульса совершенно неправильно. Тем более электрохимический градиент натрия расходуется не только на проведение импульсов. В третьей цитате говорится, что уже упомянутый насос нуждается в энергии АТФ, так как перемещает ионы против их концентрационных (т.е. химических) градиентов -- это не совсем точное утверждение, так как затраты энергии на перемещение ионов определяются их ЭЛЕКТРОхимическими градиентами. В частности, для перемещения ионов натрия требуется больше энергии, чем можно ожидать исходя из одной лишь разности его концентраций, а для перемещения ионов калия -- наоборот, намного меньше.
@bolademono2563 3 жыл бұрын
nada
@LEANDROTORRESSSS12 3 жыл бұрын
jaja
@LEANDROTORRESSSS12 3 жыл бұрын
capoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo
@ultrainstinctpetah9381 2 жыл бұрын
KRIS GET THE BANANA
@RoProReal 2 жыл бұрын
potassium
@negvey 3 жыл бұрын
and people still argue that free will exists... COPE harder
Friendeez
Рет қаралды 17 МЛН