Making an old pain and fever medication
Рет қаралды 2,180,554
7 жыл бұрынToday I will be making acetanilide, which was historically used as a pain reliever. It was discovered in 1886 and sold under the brand name Antifebrin by the company Kalle & Co. It has since been completely replaced by paracetamol/acetaminophen.
Video links:
• NileBlue video: • The Interesting Histor...
• Doug's Lab Acetic anhydride (Part 1): • Acetic Anhydride Part ...
• Doug's Lab Acetic anhydride (Part 2): • Acetic Anhydride Part ...
• Making Aniline: • How to make Aniline
I followed the pathway sodium benzoate - benzene -- nitrobenzene -- aniline. All of those videos are on my channel
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Nile talks about lab safety: • Chemistry is dangerous.
@SimonBoshoff 7 жыл бұрын
Love your work! How about doing an "end of the world"-medicines series. You know.. how to make 5 or so of the most basic medicines.
@NileRed 7 жыл бұрын
Interesting idea. Ill keep it in mind
@benjaminjernfors 7 жыл бұрын
NileRed I would totally subscribe if you did that
@SimonBoshoff 7 жыл бұрын
NileRed maybe the antibiotic Augmentin ?
@bjornlindberg9779 7 жыл бұрын
Yes something like that, medicines you can make at home when everything gone to s**t, the prepper version kind of.
@SimonBoshoff 7 жыл бұрын
how about a local anesthetic from picric acid, which can be synthesised from asprin, H2SO4 and KNO3
@KnolltopFarms 7 жыл бұрын
You know...half of the enjoyment I receive from your videos comes from the thought that you are really enjoying yourself on screen...or more precisely, on mic. You also have a great tone and syllabic tempo, so it adds to the easy enjoyment, thank you. Your average farmer.
@NileRed 7 жыл бұрын
+Knolltop Farms thanks, I really appreciate that!
@NOTZeroBlank 3 жыл бұрын
The other half?
@ShiNoNaiHasu 3 жыл бұрын
@@NOTZeroBlank learning i guess
@madkirk7431 3 жыл бұрын
Well, if he didn't like doing this he wouldn't do this.
@KidPrarchord95 2 жыл бұрын
@@madkirk7431 Is that true, though? It's gotta at least be worth the money.
@kalolord 7 жыл бұрын
Just a heads up for when you make para red: I've made it twice in the lab, and it is a VERY STRONG dye! It stains everything, expect yourself to be scrubbing your equipment for weeks after making it.
@supercool1312 4 жыл бұрын
Dániel Kalocsai Is there not something you can do to stop it staining (maybe covering the glass in some kind of plastic film?) or weaken it
@kalolord 4 жыл бұрын
@@supercool1312 Well, it might work, but I've never done such a thing nor have I've seen anyone do that... Plastic labware exists though, so it might be worth a shot. If you don't use glassware that has joints, the stain is manageable too. Glazed ceramics work decent too in my experience (Büchner funnel). Most important: do not use glass filters, they are immediately ruined.
@nicholashodges201 3 жыл бұрын
What about coating your equipment with water glass? It's actually glass in a solution that forms a fairly impermeable film that can be flaked off later
@kalolord 3 жыл бұрын
@@nicholashodges201 Never tried it or heard about anyone trying it.
@nicholashodges201 3 жыл бұрын
@@kalolord it's old, pretty sure nilered has has a video on it. It's was used to created barriers on cloth leather & other materials until plastic coatings became a thing. You can make it w lye & desiccant GEL (it's gotta be the silica based stuff)
@vanhetgoor 7 жыл бұрын
When I see you explaining and showing us how it is done, I get more respect for the chemists from one hundred years ago, who did all this work without modern equipment. Maybe they had a bunsen-burner, a thermometer and a scale. And a good set of brains of course!
@origamigek 7 жыл бұрын
And the funny part is that after a million hours of work, boiling and roasting a billion gallons of urine, to isolate phosphorus, which is insanely cool, they try to use it to turn base metals into gold.
@CS_Mango 3 жыл бұрын
Well they actually had a lot of stuff that's used nowadays back then.
@karvast5726 3 жыл бұрын
Eh,they probably had quite elaborate lab equipement already just not stuff like hot plates and magnetic stirring
@aayushpaswan2941 2 жыл бұрын
about mpemba effect:- kzfaq.info/get/bejne/j6-jZteZlZeyhmQ.html
@jordanwitte 2 жыл бұрын
@@karvast5726 Minus NMR, MS, hplc, GC, IR, and every other piece of modern instrumentation that is required for modern drug synthesis
@Obi-Wan_Kenobi 2 жыл бұрын
I am very thankful for the modern medicine that exists today being both invented and easy to access. Thanks to them, my life is so much safer compared to the billions of humans who lived before me and I am incredibly grateful.
@polyrhythmnix9723 2 жыл бұрын
It still isn't advanced enough to give Anakin his legs back after you left him to burn on that lava planet, you freakin psychopath.
@TheGlitch93 2 жыл бұрын
Master kenobi...
@joschiringeis9863 2 жыл бұрын
Me to 👍
@Helena-me6mp 2 жыл бұрын
GENERAL KENOBI! *coughs*
@anakinskinwalker1724 2 жыл бұрын
Say that to Anakin who LIVES off of medicine
@BrunoDantasS.5655 2 жыл бұрын
Me before knowing NileRed: "And i HATE Chemistry" Me after knowing NileRed: "And i LOVE Chemistry"
@cbjonsey5785 4 жыл бұрын
when i saw the title i was like “ohhhhh, he’s talking about heroine”
@jonjordan5871 3 жыл бұрын
I wonder if it is possible to synthesize it completely synthetic without the normal precursors because I know its semi synthetic opioid. Not looking for a recipe just curious lol. (Take it easy on me I dont have extensive chemistry knowledge.)
@jonjordan5871 3 жыл бұрын
Also if its not possible to make synthetically made opiates an explanation would be pretty cool.
@baconpantsable 3 жыл бұрын
I thought he was making crack
@mchagnon7 3 жыл бұрын
@@jonjordan5871 Krokadil is basically exactly that.
@jonjordan5871 3 жыл бұрын
@@mchagnon7 that uses codeine in the synthesis if I’m not mistaken?
@erikdimitrov8140 7 жыл бұрын
Finally some complicated organic synthesis again. I started getting a little bit bored from these extractions. Please do more videos like this one.
@Kentainmb 7 жыл бұрын
erik dimitrov helll yeah. His explanation of how he manipulated the equilibrium through the aniline rxn with acetic anhydride was on point
@NileRed 7 жыл бұрын
ha thanks
@K0ester 7 жыл бұрын
Agree, I love these videos.
@FourTwentyMagic 7 жыл бұрын
Hardly a complicated synthesis, but interesting nonetheless!
@aayushpaswan2941 2 жыл бұрын
about mpemba effect:- kzfaq.info/get/bejne/j6-jZteZlZeyhmQ.html
@Lostpanda123 7 жыл бұрын
Great video as always! Love that you take your time and go through the mechanisms!!
@MetallicAGirl14 2 жыл бұрын
Does anyone else have absolutely no knowledge in chemistry but love watching these videos? Nile could just make something that a child could make but I’d be impressed 😂
@carterplasek498 7 жыл бұрын
I love these organic synthesis videos, thank you for the great content!
@vipr1142 2 жыл бұрын
"Kalle and CO" So Swedish name lol
@toxikspeaks689 3 жыл бұрын
Nilered, Thank you for the videos that you make, as someone who started chemistry about a year ago and has been teaching myself as of recent, these videos are very helpful. i find medicines in general to be incredibly interesting and i love how right off the bat i learned something i didnt know. I have some knowledge of old medicines but not near the knowledge it seems you have. Keep up the amazing work, you are an inspiration. don't worry though, im going back to school here soon to finish the degree.
@elitearbor 7 жыл бұрын
Those are absolutely gorgeous crystals. Chemistry can be so aesthetically pleasing at times!
@pacificcoastpiper3949 2 жыл бұрын
Definitely
@renanocsso 7 жыл бұрын
wow, next couple of months? This must be really a lot of work, and lots of studies. Great videos, you really teaches stuff. I can't wait to see the next one. Good work!!
@MLife1000 2 жыл бұрын
This channel is so interesting and the videos and explanations help make it easy to understand. I’m glad I subscribed to this channel a few years ago.
@Hopee667 2 жыл бұрын
you are so amazingly brilliant your videos always blow my mind 🤯 thank you for doing everything safely too ♥️
@gigglysamentz2021 7 жыл бұрын
Waaah, you even rinse the glass rod, that's dedication to yield XD
@ColinRies 7 жыл бұрын
I think that Doug's Lab Acetic Anhydride method is pretty cool, but really dangerous and requires some specialized apparatus. The classic Acetyl Chloride (can be easily bought here) and Sodium Acetate method is much easier to do. Nice video anyway, I always wonder how you (and NurdRage, ChemPlayer, Doug's Lab,...) come up with such projects. Speaking of Para Red, got any plans to make actual Nile Red? I ask because Nile Red is a really cool dye with very interesting properties.
@NileRed 7 жыл бұрын
+Colin Ries I will make it. Both para red and Nile red need 2-naphthol, which I just bought
@ColinRies 7 жыл бұрын
Nice :) Looking forward to the video. Got any literature for me where I could read about the synthesis and maybe try myself? I really want to have some.
@GogiRegion 6 жыл бұрын
(+Colin Ries) Why would you regulate acetic anhydride but not acetyl chloride?! The reason they regulate acetic anhydride is because of heroin, which can be made just as easily with acetyl chloride. The only difference is that acetyl chloride is more dangerous.
@ancient7716 2 жыл бұрын
Awesome! I would love to see more pharmacology related videos like this
@stevetobias4890 3 жыл бұрын
Very cool video. You inspire me to study chemistry and improve my understanding of different substances.
@gavinli1368 2 жыл бұрын
Huh. Acetanilide. I vaguely recognize that from Dr. Stone. It was one of Senku’s intermediary steps into making sulfanilamide to cure pneumonia in a stone age tech world.
@gonzalobertomeu2938 2 жыл бұрын
I came to the coment section only to see if someone have realized too XD, I've used the ctr+f to find stone and here it is
@RockyMountainBlades 2 жыл бұрын
It’s just interesting how the first people to come up with involved reactions like this one were just like “woah i created some crazy chemical looking thing, i wonder if i can use it as a pain medication?”
@TheNerogarden 2 жыл бұрын
"Bob? Are you okay? Damn... This one is also poisonous... oh well, next"
@RockyMountainBlades 2 жыл бұрын
@@TheNerogarden lol
@ger128 5 ай бұрын
I was excited to see you use the "cow adapter" you had previously mentioned in your benzaldehyde from almond oil video
@hs5484 2 жыл бұрын
ive searched so much stuff up after watching nile red videos im definintly on a list
@nicholi8933 7 жыл бұрын
I love precipitate crashes. They are a lot of fun when it works correctly.
@the12nina 5 жыл бұрын
If your reaction is carried out in acidic conditions you could purify your aniline with activated charcoal. I find doing vacuum distillations very boring and time demanding. I love your Channel! Please keep it up!!!
@darkmf666 7 жыл бұрын
Awesome! I didn't know about your other channel, just subscribed :)
@Why-ej7hl 2 жыл бұрын
Your videos are awesome ❤️
@cromowarrior7308 6 жыл бұрын
Hey! FIrst of all, know that I'm going to watch every one of your videos, and have already seen many of them! I love them and thank you for all the nice reaction you show us :D Just wanted to add a little tought here, you could have made a saturated solution with acetanilide and dump in the best looking ones like you made with the lead sugar one :) I wonder how could they look like! p.s.(Lately I've always chosen your videos as my multimedial substrate to relay on when I smoke a good bong it somehow resembles your glassware) Ciao!
@JoseChavez-tu8ne 2 жыл бұрын
Same but w a rig
@Reth_Hard 7 жыл бұрын
Still waiting for this LSD synthesis video...
@AhmetOzdemir-om3bj 4 жыл бұрын
Reth Tard Not really possible in his lab.He would need more specilised equipment.
@humr2346 4 жыл бұрын
Good luck with purchasing lysergic acid :D
@icedawggg 4 жыл бұрын
@@humr2346 it's easy I do it all the time 🤪
@otacon1024 4 жыл бұрын
@@AhmetOzdemir-om3bj Equipment is easy, precursors aren't. Unless you're talking total synthesis, which would be a massive pain in the ass...
@melzkunlod8380 4 жыл бұрын
@@otacon1024 even meth precursor is only a cough medicine.
@faisalhamid1421 2 жыл бұрын
This has brings out my school nostalgia ,we used to go our chemistry lab for preparation of parectamol ...
@karygreene471 2 жыл бұрын
One of the coolest things I have ever watched.
@rogvirstormblade9803 4 жыл бұрын
your videos are what made me want to follow a career in chemistry, just finished my first semester of college on the path to becoming a chemical engineer. thank you
@GreenFanBoy 3 жыл бұрын
How is your path to chemistry doing?
@AnUnknownPlayer. 2 жыл бұрын
@@GreenFanBoy i suspect they’re probably still in college.
@puss404 2 жыл бұрын
How you doing bro? Everything is okay?
@BLODSWIPER 2 жыл бұрын
Would be cool to see you try and make medicine made out of raw herbs / plants.
@Mark_nobody3 2 жыл бұрын
To do that, you have to extract the herbs compound by drying and crushing it into powder then mixing it with other components that gives the effects you need for a medicine, also another option is freeze drying and making it into a pill
@gormless-idiot 2 жыл бұрын
That's alchemy, which is an outdated method of pseudoscience.
@BLODSWIPER 2 жыл бұрын
@@gormless-idiot Yeah but it would be cool to see him extract certain properties from plants and make medicine/vitamin supplement out of it.
@MsPegasus1001 2 жыл бұрын
@@gormless-idiot outdated medicine is still medicine and it is not pseudoscience its original science. Big pharma coined everything they couldn't profit from as pseudo to monopolize on medicine, Dandelions still treat stomach problems, appendicitis, and breast problems, such as inflammation or lack of milk flow, fever, boils, eye problems, diabetes, and diarrhea. Then they demonized dandelions because there was no way to compete with such a versatile plant so they said it was a noxious weed that was useless when in fact it is a wonderful plant to keep. Stop spreading bs about things you have no clue about!
@MsPegasus1001 2 жыл бұрын
You can make your own medicine at home. Elderberry cough syrup 1lb ripe Elderberries washed. Then into a metal saucepan, add 1/4 cup water quick boil, then simmer add 3 to 4 aniseeds, two or three large Apple peels just the peels, 1/4 cup mint leaves and stems and reduce to half. Strain out liquid make sure no Elderberry seeds remain. Return to clean sauce pan and continue to simmer; add 1 cup honey, keep the heat low, and stir. Add honey or sugar until syrup consistency. Put into mason jars and refrigerate will keep for 3 to 4 months in the fridge during the winter. 1 tablespoon for adults 1 teaspoon for children under 5 Elderberries are to never be eaten raw but cooked with no seeds is delicious. The elderberry juice will stain anything it touches, and find a nursery that carries elderberries if you don't know how to identify them. My children prefer this over store-bought, and it kicks the butt of everything from a common cold to the flu.
@josecqneto 7 жыл бұрын
This is so much more efficient than the one that I did in the lab!! Thanks for doing awesome videos!
@krystalgonzales5287 10 ай бұрын
This is so cool!
@MrCat-fy7bz 6 жыл бұрын
I don't understand any chemistry but i still find your videos so interesting
@manyshnooks 3 жыл бұрын
Chloral hydrate would be a good one. I know it's available dirt cheap from Aldrich by the kilogram, but it's an easy and interesting synthesis.
@AddisonPhilips 7 жыл бұрын
Truly Great Video! Beautiful crystals, nimbly recrystallized - bravo! I also appreciated your use of the "cow receiver". I noticed you clamped that receiver, but were able to rotate the various receiving flask's around. So the vacuum would hold everything together, did you clamp it loosely, or what? Very nice job.
@shawnorthrop2009 3 жыл бұрын
Second bullet, second word of Phenacetin's side-effects. Once you see it, you can't unsee it. Love the vids
@StefanNoack 7 жыл бұрын
I am watching this while suffering from pain and fever.
@tyrellrivera 4 жыл бұрын
😂😂😂😂
@fetusenchilada 7 жыл бұрын
can you please do a video of either producing or extracting of Safranal. Safranal is contained in saffron,fig leafs,wolf berry,cumin seed, elderberry and lemon. but i would much the see the synthesis of Safranal.
@Imsorrymamajama 7 жыл бұрын
had to say i lovw your videos. new subscriber. thanks for the sweet anf interesting content.
@MrLorenzo190 3 жыл бұрын
Mmm now supporting my favourite KZfaqr. A proud moment
@cellogirl11rw55 5 жыл бұрын
That's very interesting. I am severely allergic to sulfa drugs, but not to acetaminophen, which is also based on acetaldehyde.
@brittneyknopp2473 3 жыл бұрын
I would love to see a “how fast can I say” or “how to pronounce” video about methemoglobinemia and other long science and chemical names :)
@GreenFanBoy 3 жыл бұрын
*looks at Titin *
@DavidGreybeard 7 жыл бұрын
Thanks for bumping Doug's Lab. He hasn't uploaded in a hot minute.
@manueldeubler1127 7 жыл бұрын
Yout get the like for the crystallization. So satisfying.
@TheLuluTV 4 жыл бұрын
Hey, i know this Video is kinda old but i am currently binge watching all your Videos. And i just found that the Antifebrin canister you showed was produced by kalle & co in biebrich, germany. Which is in my direkt neighborhood and still exists to this Date! When it was produced biebrich was still a separate City but has been integrated as a suburb of Wiesbaden. Best wishes from germany. Keep up your awesome work and stay healthy and safe!
@lukegamerdonkey6663 2 жыл бұрын
what an awesome comment! cant believe he didn't even reply to you 🤷♂️👍
@grimmpotat6911 2 жыл бұрын
Am
@mariogiunta1989 2 жыл бұрын
@@lukegamerdonkey6663 it's a 4 year old video, it wouldn't surprise me if he hasn't opened this video up in years.
@manyshnooks 3 жыл бұрын
Acetic anhydride is restricted as it's the final step in diamorph (aka heroin) manufacture - acetylation. However by restricting the chemical clan chemists switched to using glacial and the MAM produced so called "black tar" heroin, which while less refined, was actually higher potency (and worse for users that didn't use wheel filters or check pH)
@mwc6985 6 жыл бұрын
your channel is great
@gsmeyersaz 5 жыл бұрын
Nice video again!!!
@normalhuman9878 2 жыл бұрын
Honestly I was kinda expecting something illegal
@bjornlindberg9779 7 жыл бұрын
Hello Nile, thanks for another awesome video. I have a question, I see that you use stir bars a lot. I assume that a stir bar must be highly nonreactive with almost everything it comes in contact with. So what are they made of? Could you make some of that stuff? Also, what, if anything, would break it down? Thanks / Björn
@qwertyTRiG 7 жыл бұрын
Björn Lindberg He describes it as a glass rod.
@KallePihlajasaari 6 жыл бұрын
The magnetic stir-bars are usually coated with high grade PTFE (Teflon). The the stirring rods are usually glass rods with flame rounded ends, PTFE rods or sometimes chemically resistant polypropylene (Nalgene) rods.
@DrGreerIsRight 4 жыл бұрын
Hey @Nilered . You're my favorite KZfaq person. Your videos are amazing. Love ya. Bye
@rileylaveck8017 2 жыл бұрын
I thank you for helping me fall asleep
@TheTaylorhorton 4 жыл бұрын
Sulfanilamide from acetanilide? Getting some Doctor Stone vibes.
@gavinli1368 2 жыл бұрын
I was looking for one of these comments. I knew I couldn’t be the only Dr. Stone fan watching this video.
@TheChemicalWorkshop 7 жыл бұрын
we can't get acetic anhydride in Germany...making it is quite dangerous but we will do it... also i'm wondering whatever Dough's Lab ist still alive? we haven't seen videos from hin for a looong time...
@196Stefan2 5 жыл бұрын
I know! But you can either buy acetylchloride and anhydrous sodium acetate, or (for another way), glacial acetic acid and phosphorous tribromide (and sodium acetate). Unfortunately acetylchloride and PBr3 are quite expensive.
@tobinator680 5 жыл бұрын
Another very OTC way albeit a very dangerous one would be a ketene lamp like in Dougs video. Although I would use a second scrubber with acetic acid and would burn the Methane and with the it any leftover ketene.
@bbgallant6257 2 жыл бұрын
Thanks!
@sussybaka4200 2 жыл бұрын
Damn son
@xxwitty_gachaxx8711 2 жыл бұрын
Watching this while tired: I like your funny words, magic man
@lenagaaa 5 жыл бұрын
This is so spooky KZfaq recommended after this was my unknown in Orgo lab 🤔
@holdinmcgroin8639 7 жыл бұрын
What medicine do you suggest for someone who is tired of the pains of life?
@cdawson198600 7 жыл бұрын
Holdin McGroin a dose of get over it works for those willing to take it.
@truephysics2835 7 жыл бұрын
*NaCN*
@flapdrol4771 7 жыл бұрын
C2H5OH
@GraydonTreude 7 жыл бұрын
a 9mm applied directly to the head
@ryderlancewilson760 7 жыл бұрын
Holdin McGroin 1 kg of C17H21NO4
@RAM-jg7ez 2 жыл бұрын
Isn't it just fitting ,that youtube gave me an ad about a medicine against pain and fever, in a video about making a medicine against pain and fever...
@nathanford2943 6 жыл бұрын
Great videos
@SWTH71 7 жыл бұрын
Next video how to isolate THC please?
@liamdertinger5705 7 жыл бұрын
Here is a google mini series idea, try to synthesis all of the main sugars found in human life, (glucose, fructose, lactose, cellulose, ect). Try them and compare their flavours and sweetness levels.
@GoTurbo 5 жыл бұрын
Cellulose is a polysaccharide so will be absolutely tasteless. The other ones would be interesting though.
@realityshotgun 2 жыл бұрын
@@GoTurbo cellulose is actually very slightly sweet. I have tasted it.
@GoTurbo 2 жыл бұрын
Cellulose is completely tasteless, but would be theoretically sweet if in contact with cellulases which hydrolyse glycosidic bonds, releasing the individual monomers. Or, there could be contamination with other sugars.
@klauskarlkraus 2 жыл бұрын
Sugar is sugar. Your body don't care 🤷♂️
@kevinbyrne4538 7 жыл бұрын
Sulfanilamide ! A dream come true ! I've been waiting soooo long for some KZfaqr to make it. P.S. We should collect contributions to buy you one of those gadgets for measuring melting points.
@Adam-wl8wn 4 жыл бұрын
This never got made.
@mhxybeats653 3 ай бұрын
Nile calling back to his college days with the way he was cutting that powder
@poppyrendall847 7 жыл бұрын
I did not know paracetamol can effect asthma, that would have been good to know o_O
@NileRed 7 жыл бұрын
+Poppy Rendall I think it's mostly in kids though.
@poppyrendall847 7 жыл бұрын
Ahh ok, I'm only 19 so that would explain a bit xD
@deltamezzo4598 2 жыл бұрын
Making Minecraft potion in real life
@irnistarfirix 2 жыл бұрын
As part of our pharmacy course we made acetanilide in the lab along with aspirin, benzanilide and a lot of other drugs
@ethelv3 2 жыл бұрын
Finally gonna watch this video after it’s been in my KZfaq suggested for a week
@theramblingbrit4431 7 жыл бұрын
This is probably a stupid question, but if you're adding it to water anyway, why can't you use the Aniline that was distilled with some water?
@NileRed 7 жыл бұрын
+The Rambling Brit I definitely could have. It's more to not taint my aniline supply. I probably should hav just used the wet aniline and then added whatever the difference I was to make it up to 20g. Oh well, I already have more than I'll probably ever use
@thesemenwar5008 7 жыл бұрын
The Rambling Brit If you know the initial concentrations you can calculate the theorical yield more accurately. He dosen't know how much water was in there, so maybe is because of that.
@ryderlancewilson760 7 жыл бұрын
Hi, can you make some menthol crystals? For house perfume
@trychan959 7 жыл бұрын
Uvuvwevwevwe Onyetenyevwe Ugwemubwem Ossas its osas ffs
@dascorncakes1151 7 жыл бұрын
yes please do this, I thought menthol was a dumb name for meth but no, it's actually a cool smelling minty crystal thing that you can buy online easily.
@ryderlancewilson760 7 жыл бұрын
Joshua Sorrenti Yes, i put 2-3 crystals on a hot coal and they makes a lot of smoke, the smoke smells so good and the house smells like mint for hours! :) (sorry for my bad english but i'm italian)
@patuszodi7532 7 жыл бұрын
i just read on wiki the other day that the vast majority of menthol used in our tobacco and foodstuffs is chemically synthesized (rather than extracted from naturally occurring sources). it's cheaper economically and environmentally to just make the stuff. i'd like to watch a video of its synthesis.
@gigglysamentz2021 7 жыл бұрын
Menthol is chiral (as in 8 different forms chiral...), so I assume it would be pretty difficult to make in an amateur lab.
@ameftowriter1319 2 жыл бұрын
You probably don't know, but your experiment reminds me a manga series called Dr. Stone where the main character has actually made that and even Sulfanilimide in its early chapters.
@em-eois3228 2 жыл бұрын
this was pretty interesting even if i couldn't understand a lot of it. im not even in a class or anything, it just was on my fyp
@ashleyferris5749 7 жыл бұрын
hey I love your videos and want to know if in the future you can do a kids friendly chemistry video, like how to grow your own Crystals. I always like doing home science things with my niece and nephew and would like to get them into basic chemistry.
@vidi00 2 жыл бұрын
do you know how to make xans and lsd?
@andrewlorona7360 7 жыл бұрын
Hey NileRed, I wonder if you have ever done any chemistry with ozone? Its a very interesting gas.
@wetbutter6914 2 жыл бұрын
bro idk what your saying but this is satisfying
@kaviaari 7 жыл бұрын
Nice work. There's a missing curved arrow in the 1,2-attack at 8:13
@NileRed 7 жыл бұрын
+kaviaari oh no :(
@LaraSchilling 7 жыл бұрын
NileRed! I got into uni for Medicinal Chemistry, actually going to be an educated drug cook!
@amodernalchemist432 4 жыл бұрын
Lemme know when I can place an order.....hehehehe
@LaraSchilling 4 жыл бұрын
@@amodernalchemist432 oh damn, bad news, yo. I dropped out :(
@saintt9044 4 жыл бұрын
Lara Schilling what a twist lmao. I just happened upon this comment thread
@LaraSchilling 4 жыл бұрын
@@saintt9044 Yeah, it was a hard decision, but I couldn't keep up with the academic rat race. If I had actually stayed enrolled at the start of lockdown, I'd have been able to attend classes from home, but they couldn't offer that when I needed them because nobody cares about disabled students having access until a pandemic hits and affects the ableds. LOL.
@JonathanKayne 2 жыл бұрын
I would love to see you make sulfanilamide since it's referenced in anime like Dr stone.
@Keith-qz9yk 4 жыл бұрын
Your video makes me think of Dr.Stone with the Sulfanilamide.
@goodfeller2 7 жыл бұрын
Where in the hell did you get that acetic anhydride?
@GogiRegion 6 жыл бұрын
(+Mitchell G) Make acetyl chloride if you really want to (it’s more reactive and dangerous, but that also means it works just as well if not better).
@Flor2Easy 7 жыл бұрын
Can you do my exams please?
@NileRed 7 жыл бұрын
Sure. Ill fail anything you want me to
@CAoffRoading 7 жыл бұрын
NileRed nice... totally Savage.
@Flor2Easy 7 жыл бұрын
^_^
@RRQualityRemoteControls 2 жыл бұрын
I like your funny words magic man!
@bouncydachon 2 жыл бұрын
Ah yes a youtube video on making drugs! My favorite!
@Hellcommander245 7 жыл бұрын
Do a video on how to make lysergic acid diethylamide.
@deplorableamerican9451 7 жыл бұрын
Mr. Krabs That's illegal.
@justinpatterson7700 7 жыл бұрын
And? it'll probably get a few views before taken down and nile arrested.
@ballboys607 7 жыл бұрын
Mr. Krabs he's explicitly stated he won't ever do that in his methylamine video... this is just obnoxious.
@BeepingSheep 5 жыл бұрын
Social stigma and legality issues aside, a full synthesis of something as difficult as a lysergamide would be incredibly educational.
@Moritz_X50-4 7 жыл бұрын
Can you do some Uranium chemistry?
@SS-ut6zm 2 жыл бұрын
"Today I am making an old pain and fever medication. Heroin."
@zamasu1056 2 жыл бұрын
that looks bussin i'm a ice lover
@Sauce787 7 жыл бұрын
I wish there was a chemistry channel like this that would focus on the chemistry behind psychoactive molecules, and would do demonstrations making tryptamines and phenethylamines.
@NileRed 7 жыл бұрын
+Sauce Boy i would do it if it weren't illegal
@Sauce787 7 жыл бұрын
NileRed I understand that, and will work use as much research and information as I can get from reliable sources such as PIHKAL, TIHKAL and online forums. Keep up the good work though.
@HidekiShinichi 7 жыл бұрын
NileRed texhnically you could do that as long as your ingridients would be legal. you would need to make it, film it, destroy the results somehow so that you wont have illegal substance, post fil and say that you make it on a boat in a piece of ocean that does not belong to anyone/ is part of country that does not ban those stuff
@Sauce787 7 жыл бұрын
Hideki Shinichi Lol, it's easier just to make legal analogs or pro drugs for the illegal compounds. That way you can demonstrate the general chemistry without breaking the laws. Main problem however is that to do that you would still need to obtain many watched and regulated chemicals and precursors.
@HidekiShinichi 7 жыл бұрын
Sauce Boy yeah but its not the same
@jumpierwolf 4 жыл бұрын
Acetic anhydride is restricted due to its use in converting morphine to heroin
@AsmodeusMictian 4 жыл бұрын
The answer to the question I didn't want to ask! Thank you!
@briancarter3704 3 жыл бұрын
Their both alright as long as they got legs
@ko95lia 7 жыл бұрын
you need to add the NileBlue into your "other channels" on your NileRed channel
@alysergicview4225 7 жыл бұрын
I have heard of some chemical reaction called "The Mitsunobu Reaction" I do not know what it is used for, but I have heard it is very difficult. Would you do this one next?
@FrugalGarden 7 жыл бұрын
Please make caffeine with coffee and carbon dioxide
@AlldaylongRock 7 жыл бұрын
i guess he doesnt have the equipment to do that, he will make it from theobromine maybe( since we have the theobromine extract vid) and he has Me-I on stock, maybe that is a way
@DrakkarCalethiel 7 жыл бұрын
Jorge M I think he even said he will synthesise the caffeine from scratch. (I think it was in the caffeine extraction from greentea) The theobromine and methyl-iodine reaction is the most simple and the good thing is he has everything.
@origamigek 7 жыл бұрын
KZfaq: Applied Science - Extracting caffeine with supercritical CO2
@polyjohn3425 7 жыл бұрын
+ᴠᴧᴨᴛᴧᴃᴌᴧcᴋ Wow, that's a lot simpler than I would've expected.
@silentassassins47 7 жыл бұрын
be careful man, if u start teaching ppl to make medicine free.. ur gonna have a hard time...
@ih8tusernam3s 4 жыл бұрын
I don't know why I find this stuff so fascinating.
@seanwalton6208 7 жыл бұрын
Very nice yield.
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