The happiness on his face is so contagious!

1. Once the mesoderm develops, it is segmented into 3 parts (medial to lateral): paraxial mesoderm, intermediate mesoderm, lateral plate mesoderm (2 layers: somatic layer going with ectoderm, splanchnic layer with endoderm) 2. Folding of the trilaminar disc occurs the intermediate mesoderm starts to condense and invaginates the splanchnic mesoderm. The divot created is called the urogenital ridge. The condensed intermediate mesoderm (in the core of urogenital ridge) is called nephrogenic cord. 3. The nephrogenic cord is located behind the gut tube. At the bottom of the gut tube the cloaca is found which will later become the anal canal, bladder and urethra. 4. During week 4, around the cervical region of nephrogenic cord, the pronephros starts to develop. Which is a Duct with smaller nephrotomes (tubules). But by the end of week 4 it already starts to degenerate. 5. The mesonephros develops off the degenerating pronephros but in the thoracolumbar region. Also made of mesonephric duct and small mesonephric tubules coming out of it. 6. The mesonephros is the primitive urinary system until week 10. 7. The mesonephric tubules grow towards the aorta, and glomeruli grow from the aorta via angiogenesis. The tubules form capsules around glomeruli (bowmans capsule). Primitive urinary system. Week 5-10 8. The mesonephric duct collects the filtrate from the tubules and disposes it into the cloaca. Both hindgut and mesonephric duct empty into cloaca. The allantois empties the cloaca. 9. In the pelvic region, intermediate mesoderm condenses infront of mesonephric duct to form metanephric mesoderm. It releases growth factors to stimulate mesonephric duct to grow ureteric bud out of it. The ureteric bud also releases growth factors to stimulate metanephric mesoderm (blastema) to grow. Reciprocal induction. 10. The ureteric bud grows into the blastema and develops a ureteric stalk (ureter) connected to mesonephric duct. 11. The ureteric bud grows inside the blastema and develops the renal pelvis and major calyces from which the minor calyces develop. Millions of collecting tubules grow from the minor calyces. Collecting system. 12. Each collecting tubule has metanephric mesoderm cap around it, the collecting tubules secretes growth factors making the mesoderm condense and form metanephric vesicle and then forms the metanephric tubule which is connected to the collecting tubule. 13. The metanephric tubule then becomes the DCT and keeps growing to form the PCT and then makes a cup shape structure called bowmans capsule. The common iliac arteries form glomerular capillaries and interact with bowmans capsule. Loop of henle also formed between PCT & DCT. Bowmans capsule from PCT from DCT from collecting tubule from minor calyces… 14. The common iliac artery to the kidney degenerates and the kidney ascends and blood vessels from the top part of aorta develop and invade the kidney (renal arteries). 15. By week 10 the ureter is emptying into mesonephric duct then into cloaca. Distal part of mesonephric duct is absorbed by cloaca and then ureter is emptying directly into it. The mesonephric duct becomes a part of reproductive system. 16. The cloaca develops a urorectal septum that divides it into anterior portion (bladder) and posterior portion (anal canal). The anterior portion is called urogenital sinus which has 3 parts. Proximal part > bladder, middle part > urethra (prostatic & membranous in males), distal part > penile urethra.

Dear Zach: You are a true Ninja. Each year you save millions of students from hard topics! You are the A team of Medicine. I am so Glad to see your channel Grow!

I don't usually write comments on youtube videos but man this guy can teach! I hope that one day I can come back and donate to this channel. Thank you from the bottom of my heart.

Zach, I almost never give comments on youtube but this video just made my life so much easier! I have just finished watching it and now all my study notes make so much sense, the only question I am posing myself is WHY ISN'T IT TAUGHT LIKE THIS IN MY MEDSCHOOL? Keep the good job, I am getting my medcial degree thanks to you :)

I´m a Urology resident and I must say you've done an amazing job explaining this. Right now I'm in my pediatric rotation and this have been very useful. Thank you so much! Greetings from Colombia.

May Allah bless you zach and guide you to the TRUE path ,you are helping millions of med students.Ameen

I am a medical student in Pakistan. Our medical college is probably not equipped with the best of facilities in the world, but your videos really help us in tons of ways. Thank you so much, Zach! 😊

I never have imagined learning embryology would be so interesting! You are amazingly talented and we are so blessed to have you Zach

My med school is asking for donations from alumni. They're not getting anything because it's all going to his patreon once I graduate.

I am out of words, i know that saying " Thank you so much" is not enough, I love your tutorial videos. I always watch your videos before opening my lecture notes. Keep it like that.

this channel is worth more than diamonds!!!!!!

You literally should get an Oscar for teaching medicine like that !

Goosebumps while watching,I was not able to understand this topic for so long . Thank you Zach sir

I just want to say I have watched so many of your videos and you've saved my ass so many times from confusing lectures from undergrad all the way into med school now. You're amazing!!! thank you and please don't stop making videos.

The joy after understanding this is just indescribable. I love you... all the way from Ghana

There are no words that could describe what I feel right now. You are a true savior. My professors compared to you are nothing. Thank you so much!!!!!!!

Zach!! i was struggling with this last night and was wondering when you'd upload this video 😭💕

Words can’t sum up how incredible you and the team of ninja nerd are. God bless you all

I love you. I don't know how I'm just learning about your account now, but you have just SAVED me an entire afternoon trying to understand what my teachers explained. I wish you would be my teacher tbh. My med school is full of people with a giant ego and little to no capabilities of teaching

Watching this from Germany! I got so frustrated with this topic! You made it so easy to grip and understand. Love it! Thank you for your work and dedication to all the videos!

i'm a 19 years old Italian medical student and i have no words to describe what this video means to me. Absolutely brilliant content. Subbed.

how much i thank u still wont be enough but know that u will be on my prayers ,u saved me from sooooooooooooooo many bad situations thank u from bottom of my heart

This man is going to single-handedly get me through this uni degree

Almost seen half video... ماشاءاللّٰه You teach well!

I'm currently studying for my part 1 MRCOG exam and I just want to say what a gift your videos are to us. The level of detail, the clarity with which you teach, and your enthusiasm are what make these videos so wonderful. Thank you so much for all your hard work, you are truly a phenomenal teacher! I wish you nothing but the best.

This is such a great video and comprehensive explanation that makes one feels as an expert! I watched it at 2nd yr & 3rd yr of medicine and it was hugely beneficial!

I never comment on youtube videos but... THANK YOU SO MUCH! God bless you! You are saving millions of students! Us med students love you, keep up the good work and more videos!

I can’t explain my emotion about your video , your more than great , your are inspirational I didn’t even expect understand this But you magically make everything easy and understandable Thank you , really thank you

You are better than any teacher I have ever had. Thank you for this amazing content. I will mention you in my graduation speech!!!!!!!!!

I am a third year medical student from south Sudan.i sincerely wanted to thank you for your hard work and for so much trying to make everyone understand each and every topic that you give,personally I really enjoy your lectures and you are really making our journey more enjoyable and amazing .thank you so much and stay blessed.....ever ninger nerd

Your enthusiasm and passion is contagious!

thanks bro! my kid was born with bilateral renal dysplasia/MDKS. this is super helpful as parent-patient education, since none of her specialists have the time to teach someone like me who's never read an a & p textbook.

Wow!! You explain very complex subjects in a very logical and easy to understand manner! I'm so glad I found your channel

Dear Zach.... I am motivated to learn more looking at the enthusiasm u have in teaching.... I love the way u teach and u make it easy to understand.... I hated embryology till I came across of your teaching.... Thank you so much... And may god bless you always... 🙏

dude, your happiness and excitement stole the show, so many blessings for you

How politely this man teaches! Just awesome ❣️

You're doing a great job, millions of med students are being saved by you sir. Keep up the good work.❤️

I really appreciate this ...... I'd be set for my exams if u guys could do a video on development of the genital system

Such a coincidence,I'm writing Embryology exams tomorrow and you just uploaded ,it in time

This is the best. You totally explained development of urinary system, from the kidney down to the collecting system and then finally the bladder. You are the best👍

Its the very first time in my life to enjoy Embryology! Thank u Zach you are such a great tutor!❤❤❤

Thank you so much!!! Urology registrar in paediatric rotation , you just saved me many hours👏🏾👏🏾🙌🏾 🇿🇦🇿🇦

I just have a request...that, after uploading the video, could you also upload a picture of the complete summary of the topic as written on the white board? Please? 🥺

i love you man i swear to god i'm almost crying thanks dude really thanks

I will say it billion times this man saved our life in medicine we are not injured but he just saved our life he is our real doctor

Hi Zach, I'm in my first year of Vet Medicine and I love your Embryology videos !! You have a way of making the most seamlessly boring and hard subjects, easy to understand and actually really enjoyable. Thank you !!

you are literally a life saver😭💕 thank you for making our medical journey a whole lot easier❤️

Please do a video series on how to read and interpret X-rays and other radiographs

Thank GOD you made this video. I was trying to read the textbook, and it was describing foreign foetal anatomy to me >_< (Not covered in my bachelor's degree for Nursing), and we are expected to learn all of this for our post-graduate studies in paediatrics. Thank you so much! Love the passion you put into the videos too!

All my support for you from Algeria The fact that you uploaded this video when I'm studying the renal unit makes me wanna tear up 🥺🥺, thank you so much

I LOVE YOU OMFG u uploaded this just in time before my exam

Dr. Zach !!!! I wish to see you one day ! I just want to hug you and say Thank you !!!

I cannot thank u enough Some ppl r gifted that they hv good grasping n understanding f the subject n obviously u hv it n on top f it u can relay that to others in way that it feel so easy Thank u thanks a lot

GOAT wearing the GOAT hoodie

Thank you en Thank you soo much It’s really a lot we’ll done It needs to be watched over en over to be understood well

Zachhh! I just walked out of my anatomy semester exam and trust me I only studied your embryology videos and was able to attempt and draw every question omgggg. Thank you so much. ❤️

I have no words to express my heart situation to u sir....sir,u did it very very well..and thank u so much 💖

OMG!!!!! You are literally the best! I love how much you really enjoy while explaining these things and at the same time, get your points delivered so clearly!

To me, you are the best teacher in the universe. Thanks a lot. I'm from sri lanka 🇱🇰

You‘ve excelled yourself - as usual. Thank you Ninja Nerd ❤️

I have never seen someone this happy explaining embryology 😫😭😂🖤🖤

Omg i was literally praying for this vid 🥺🥺🥺🥺 thank you so much for your hard work !!🥺

Hats off to the way the lecture is delivered...👍👍👍 Awesome and Brilliant...💖 One of my most loved and followed channels...☺️ Stay Happy And Blessed Forever...Love From Pakistan 🇵🇰

Thank you so much this is very helpful. the way you talk makes it really easy to understand. I like how you repeat things by speaking and writing too. Thank you.

You are literally a life saviour ❤️🥺..and that smile throughout the lecture 🤧🤧, you made embryology so easy man 😭😭

You are the best anatomy teacher I have eveer seen...I am grateful to you sir

I just wonder that all of these videos are free of cost man,😲 Just keep it up man, u are genious

I have my Ninja Nerd T.shirt made already. Impressed with your work.

Man, you're the best ! Thank you from the bottom of my heart, keep going Zach ❤❤

You are blessed with teaching skills SIR ❤️❤️❤️❤️❤️ A BIG FAN 💖💖💖💖💖

Thank you very much you're really helping me for my exams . Will recommend this channel in the medical school I go

Thank you for your amazing explanation and your happiness in your face is so precious

Zach you’re a life saver, and education saver😂. God bless you🥰

You are a LIFE SAVIOUR maaan ❤️ wish u all the best

Literal life saver. So clear and well explained. Thank you so much.

Zach, thanks to you and your videos i succeded in passing my embryo exam!!

Best Uroembryology Video, I have ever seen...

Hi ninja your classes are very useful to us

Please do not stop making these videos 😢 This channel is seriously my medical school

Couldn't understand better than this. Thank you!!

I already see 1.02 million subscribers in the not so distant future!!

i am preparing for MRCOG .. and OMG this video was awesumm .

you are so amazing .. i usually cant watch long videos but yours makes me feel so curious about everything and its so exciting .. thanks a lot

you’re such a genius! thanks for saving our a** out of bloody tough exams

Im from Brazil and I love your classes!!!!!!

As always, perfectly explained and you even make us happy with your lectures! I cannot thank you enough for all the help. You really make this hard topics understandable. Greetings from Spain!

What a teacher, and what a lecture! Amazing!, one day l will meet that's my dream dr.

One more word: you are a great teacher and thank you very much for your amazing videos

14:30 he looks so enthusiastic when he says bowman's capsule, it makes me happy too :)

Seriously I don't think anyone can stay atheist after watching this video! I keep stoping the video and being amazed by how this whole process is going on inside someone's belly and how it's happening so perfectly without any little mistake in most times, subhanalah!

Thanks a bunch,,one of de best channels for medicos so far

I love your channel very much. Love from Thai medical student❤

perfect explanation and clarification with the simplest way everrr !!!!!!

You are amazing Keep saving medical students life

Truly it's an amazing lecture ever

thank you from all my heart 🌻

This channel is getting me through med school so thank you so much Zach! ☺

As usual, he's the man that saves the day.... Thanks so much man for this, I really had a several superman punches and claymore kicks from this topic 😩😩😩😩, but now I can tell someone about it 😇😇 thanks to you.

You are an amaaaazing teacher!!! Your energy is infectious!