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Reversible vs Irreversible Inhibition:
In reversible inhibition, the binding is non-covalent, reversible binding. Here removal of the inhibitor restores the enzyme activity. So the duration of action depends on how fast the drug is removed from the body. On the other hand, in irreversible inhibition, the bond is a strong covalent bond, which permanently inactivates the enzyme. Here the restoration of activity depends on the synthesis of new enzymes, which usually takes longer. So generally, the action of irreversible inhibitors lasts longer. In short, reversible inhibition is like trapping an enzyme for a while, whereas reversible inhibition is like killing it.
Chapters:
00:00 Introduction
00:15 Reversible Inhibition
00:56 Irreversible Inhibition
01:53 Importance of the Difference
03:56 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.