The US stands unique in having permanent storage solutions for low and intermediate-level nuclear waste but lacks a comprehensive plan for high-level waste-a challenge faced by many countries with nuclear power plants. In this episode, Dr. Kathryn Huff, Assistant Secretary at the Office of Nuclear Energy in the DOE, and Dr. Allison Macfarlane, former Chairman of the Nuclear Regulatory Commission, discuss the complexities and potential solutions for managing high-level nuclear waste.