5:17 panspermia to me is so freaking awesome and scary. Loot crates full of organic compounds from who knows where, just waiting to land in an ocean

To sum it up, *mitochondria is the powerhouse of the cell*

That was an excellent talk. Congratulations Joe LaManna.

Thoroughly enjoyable exposition, well done.

That was so informative! Fantastic! Thank you!

Great talk. Thank you.

I must confess, this Joe LaManna brought in a broad multi-disciplinary gathering of info to make his points and did so quite effectively.

one of the best lecture i have heard with so much science

Whoa, this is the best illustration and explanation of the electron transport chain...41:53...I've ever seen or heard.

Interestingly, archaea are probably growing inside your water heater. The water heater's steel tank is protected from corrosion by an anode rod made from magnesium (or aluminum). It gives off small amounts of hydrogen in the process. This "food" coupled with high temps (120 F) allows archaea to thrive. In some cases, these organisms can cause a phenom known as "smelly water" in which the hot water has a sulfury smell. This is due to archaea metabolism. The cure used to be removing the anode rod, but that causes tank corrosion to accelerate which causes the water heater tank to leak prematurely. The best fix is to raise the tank temperature to 140 F which kills the archaea. (If that is done, a thermostatic mixing valve is recommended to prevent scalding). So you've got hydrogen, iron (from the tank), sulfur, etc. plus archaea living usually unnoticed inside a water heater....

Cool. Thanks for sharing.

there is often severe muscle wasting in people with cancer. one theory is called: Nuclear Meltdown, and it concerns mitochondria degradation. Michael Wiggs and his crew made a mouse model with implanted cancer cells and monitored the health of the mouse and many indications for four weeks, which is when the mice would be euthanized so they didn't die from the cancer. many of the indicators they monitored did NOT show a steady degradation, but instead would show minor degradation for the first three weeks, and then a LOT of degradation in the fourth week, and the mouse would be near death. But, when they monitored mitochondrial function, they noticed it degraded in a stepping stone fashion. this indicates that mitochondria show early changes we can investigate to see if we can intervene in the degradation process before severe muscle loss becomes deadly.

Brilliant

muito obrigado pela postagem !! reassistindo...

This is a helpful presentation. I would like to suggest when considering life on earth, that early earth was likely near or in the gas cluster that created our solar system. It is highly likely nova's and other astronomical events beyond meteor strikes were occurring proximal to nascent earth. Lack of tectonic plate development, waters arrival via heavy meteor bombardment, a moon forming then exerting extreme tidal forces and general instability of the sidereal area proximal to earth due to cosmic events as the solar system was forming likely forced life to begin not only in vents under the ocean, but inside deep vents where early ocean plates were forming. The nature of the interstellar cloud earth was formed in may have itself had life. Meteors from that cloud, may have delivered many things, including various putative forms of life, at least one of which may have been suitable for evolution on earth. Thus a chemical and heat energy system for early life on earth is likely as is a higher probability of an extra terrestrial origin of life than one would normally consider based on earth's current condition due to a very different solar system than we know today.

Spectacular presentation! Thank you Dr. Joe LaManna! And thank you all those who helped create this video recording for KZfaq. I am thrilled by everything that was said and my understanding of life's fundamental energy evolution is definitely enhanced. Well done!

Amazing to see the advancing Frontier of knowledge and how much we are getting closer to know our beginnings. Hats off to all the great scientists

Lehninger's Principles was one of my favorite texts.

That’s my face too (5:54). A face of ‘Yes, this is good stuff.’

Eukaryote = nucleus mitochondria converts ADP to ATP? Ah, it's all explained after 41 minutes, a hydrogen concentration gradient (between outer/inner membrane space and the matrix) creates the conversion. Amazing.

Interesting content. i love this origins stuff. Also, the production of the video is very good. The audio is clear and constant. the lecturer is recorded head on, which I prefer. And MOST THRILLING, the graphics are presented head on with enough time for the viewer to actually read them. These criteria are logical and seem basic, but so many lectures are record that violate ALL these points. >_

I'd love to see a count of how many times we hear " we assume, we believe, we postulate, we hope" etc.

soo good

Thank you. Very interesting.

Lots of prestigiistation in this presentation.

some great fanfic

The Fungus Penicillium uses oxygen just as we do, and just as other multicellular Fungi do, and as far as I know, they cannot ferment sugars. Yeasts, unicellular Fungi, can ferment sugars in absence of oxygen, and some of them van form ethanol through fermentation.

With the precise complexity of how the mitochodria functions at the molecular level, you cannot just miss to be in awe and realize that there must be the intelligent designer creator who must have created all these amazing processes to happen.

2:48 from all we know, energy can only be manipulated but not generated.

But doesn't the ultimate question concern the information encoded in the DNA sequence?

I had thought that this lecture would cover the kendling of the spark of life. But he seems to go from organic chemicals in comets straight to cyanobacteria. I am really curious how the ADP/ATP path came to dominate (almost m) all life. Was/is there no alternative to this pathway of generating and using energy in cells? Are there any organisms remaining today who use an alternative pathway to the ADP/ATP pathway?

How we Reflect our Mitochondria Functions at the Molecular Level, You know ,your gut. The Undiscovered Front Line.

Did it come from space randomly or was it put here..

Recommendation to pan the audience once with the camera at the beginning or end, if at all, but don't keep cutting away to them. It just adds cognitive load (it's distracting) and adds nothing of value for your viewers.

36:46 nice!

Please stop those unnecessary shots of the audience watching... Adds nothing to story and subtracts feom time we can see the presentation.

This was way more interesting than the trash I usually watch on KZfaq.

We need Terahertz wave.

So, at the end of Part 1, If the Oxygen level in the atmosphere was 0.2%, then assuming no change in Nitrogen, then Carbon Dioxide must have been about 20%, and now they are switched with Oxygen at 20% and Carbon Dioxide at 0.2% or thereabouts...

Survival must be about the mitochondrial sheath? Maybe it’s hiding in the cell? Maybe it’s speaking in some way?

What determines the mitochondrial density of a cell? Why would a protobacterium have existed that produces a bunch of ATP all by itself to then go into a symbiotic union with an Archaea?

If all cells need energy, what was the thing that consumed the mitochondria and for what purpose? It didn't have energy without the mitochondria, so it wasn't a cell, so it wasn't metabolizing, so why did it eat anything at all?

Light sculpts life

I love a cartoon..... it all started a long long long time ago.........

But what is the chemical reaction or process that produced FIRST lifeform, whatever that may be? How does something go from non-life to life?

so, all we are just bacterias- that is sound great !

Who is the girl in the opening photo?

Interesting, albeit a bit clumsy that the speaker would say out loud that there are 18 leading hypotheses for the origin of life (=18 "we don't knows") Yet if one should dare suggest a 19th hypothesis that is not materialist in nature, some people head straight to the fainting couch.

Thank you , This reminds me of all the late night studying. And hours of classes . That over many years need a upgrade. My study of meteorites has shown me that your exactly correct as to how , perfectly the seeding of life in space is automatically performed. That is we are silly to think we have to take plants and have planetary development . When the best conditions are available. The faster meteorites that form the planets . Are all set up to develop life with the planets core and the formation of a balanced heated chemical reaction , that is so exactly balanced. That it had to of been thought of before it was made to happen . As well as it’s in balance with planets with cores . That have sun systems to hold orbits to allow critical time to allow chemical and heat and pressure to release the bacteria . That is also occurring in the universe on those green zone planets . In fact life in its many forms . Must in fact be replicated as exactly or near exactly . By the laws of sciences by a very perfect creator who knows before he started what he his reaction would bring . That had to be very important to have had such a wide range of actions become perfectly balanced.

If this had cartoons showing what they were talking about we would all be smart and this video would have ten million views

at 7:05 he said that NH3 and CH4 were "metabolized" to...How can this be? I thought it was PRIMORDIAL...!!

I don't know how I really got here either

Great content. Woeful presentation.

51:23 not sure this analogy makes sense. A predating cell doesn’t get 10% of 10%, it gets 10% from the energy substrate in the bacteria, just like the bacteria did. Probably just doesn’t make sense to specialize eating other bacteria, which would limit yourself to wherever the other bacteria are growing, and since bacteria divide that fast, they would run out of the other bacteria end of story.

No number 5, but great talk

So, after all that, we still don't know.

It would be better to have longer shots of the charts instead of audience head shots. We really don't need to see those.

I love these videos, but it bothers me that you zoom in on single people in the audience.

I like the lecture and I agree with the angry birds commenting on the luck of preparation for this lecture.

I'm hearing a lot of "evolution of the gaps" ideas in this presentation..

There is an electrical voltage that exists at least on the surface of the earth. With the recent discoveries of the importance of bio electricity, it might be found that these that run through the ground on our planet might be an important ingrediant in the formation of life from the begining.

Evidence? From 14 billion years ago?

42:27 It's a Trap

So how come with all this information, the population as a whole have not been educated generally, but let religion to pollute and also run far too many institutions and get to influence the secular, to where now have the political current situation, so acidic to knowledge and progress? Progress to develop, but to deal with the real problems that are affecting badly, life on this planet. Tolerance to it?

if mitochondria came from bacteria then why it is not infectious,what if it goes out of control and start replicating.

mitochondria evolves into midichlorians, sometimes mistaken for the x-gene, giving humans superhuman powers.

I didn't hear you say that *most* of the many proteins needed to construct mitochondria are coded in the *nucleus,* _not_ in the mitochondrial DNA. If it started as a separate life form, how did the genes transition to the nucleus? How plausible is that?

lets then take a more advanced look at photosynthesis so that we may understand weather life without design is likely: How many people realise today that we cant reproduce the process of photosynthesis today, despite all our computers and labouratories? We cant reproduce it, thats how complex the biochemistry is. Why and how would evolution go about trying to produce a protein for binding pigment molecules before pigment molecules existed? If chlorophyll evolved before the antenna proteins that bind it, it would in all likelihood destroy the cell, so the proteins had to evolve first. But natural selection could not favour a ‘newly evolved’ protein which could bind chlorophyll and other pigment molecules before those crucial pigments had themselves come into existence! Each binding site must be engineered to bind chlorophyll a or chlorophyll b only or carotene only. The carotene molecules must be present in just the right places for quenching triplet states in the chlorophylls. Even if the pigment molecules were already around, producing just the right protein would be an extremely difficult task. It would not only have to bind pigment molecules only, but it would need to bind just the right pigments in just the right places in just the right orientation so that energy could be transferred perfectly between them, with a little lower energy at each step. Anything else would do nothing, or would transfer energy at random, and the complex would accomplish nothing at best and burn up the cell at worst. And there is another problem for evolution. The insertion of the pigment molecules changes the conformation of the apoprotein from about 20% to about 60% α-helical content.45 So evolution would have to produce a protein with a wrong shape that would assume just the right shape by the insertion of pigment molecules in just the right positions and orientations when those pigment molecules had not yet evolved. The energy transfer timeframe between pigment molecules in the antenna complex is between 10-15 and 10-9 seconds. The system that God engineered captures 95-99% of the photon energy for photochemistry, even though there are four other ways the energy can be lost during the slightly less than a billionth of a second the system has for capturing it.46 Humans certainly cannot begin to design systems with such efficiency, but the evolutionists are determined that chance, what Cairns-Smith47 calls ‘old fumble fingers’, can. Our understanding of the assembly of apoproteins with their pigments is very poor, but we do know that the chloroplast encoded chlorophyll a binding proteins of PSI and PSII core complexes are inserted cotranslationally into the thylakoid. Protein intermediates of the D1 protein have been observed due to ribosome pausing. It may be that this ribosome pausing permits cotranslational binding of chlorophyll a to the protein. This kind of controlled insertion, with synthesis of otherwise phototoxic material, is precisely what we would expect from intelligent planning and forethought, but how might ‘old fumble fingers’47 hit on such a scheme? All of the parts must be shipped to the right location, and all must be the right size and shape, down to the very tiniest detail. ATP synthase is an irreducibly complex motor-a proton-driven motor divided into rotor and stator portions as described and illustrated earlier in this paper. Protons can flow freely through the CF0 complex without the CF1 complex, so that if it evolved first, a pH gradient could not have been established within the thylakoids. The δ and critical χ protein subunits of the CF1 complex are synthesized in the cytosol and imported into the chloroplast in everything from Chlorella to Eugenia in the plant kingdom. All of the parts must be shipped to the right location, and all must be the right size and shape, down to the very tiniest detail. Using a factory assembly line as an analogy, after all the otherwise useless and meaningless parts have been manufactured in different locations and shipped in to a central location, they are then assembled, and, if all goes as intended, they fit together perfectly to produce something useful. But the whole process has been carefully designed to function in that way. The whole complex must be manufactured and assembled in just one certain way, or nothing works at all. Since nothing works until everything works, there is no series of intermediates that natural selection could have followed gently up the back slope of mount impossible. The little proton-driven motor known as ATP synthase consists of eight different subunits, totalling more than 20 polypeptide* chains, and is an order of magnitude smaller than the bacterial flagellar motor, which is equally impossible for evolutionists to explain. Evolution cannot account for the assembly and activation of rubisco. All attempts to reconstitute a 16-unit rubisco from any source have failed, so the assembly of rubisco must be studied in the chloroplast extracts. The eight large (L) subunits of rubisco are coded by the chloroplast DNA, and the eight small (S) subunits by nuclear DNA. The S subunit of rubisco is synthesized on free cytosolic polyribosomes* and maintained even during synthesis in an unfolded state by chaperones* of the Hsp70 class and their protein partners. When the small unit is brought to the import complex of the chloroplast, the fourteen-polypeptide chloroplast Cpn60 chaperonin protein associates with IAP100 (protein) of the import complex and can also associate with mature imported small subunits. The chloroplast Cpn60 chaperone is similar to the E. coli GroEl protein. After the unfolded precursor protein enters the stromal space, it binds briefly to a stromal Hsp70 chaperone protein and the N terminal targeting sequence is cleaved. The large subunits of the rubisco enzyme are produced by the DNA and machinery of the chloroplast itself and stored complexed to a Cpn60 chaperonin.This chaperone protein keeps the large subunit protein from folding incorrectly, and therefore becoming useless, and is also necessary for the proper binding of the eight large subunits; without it they will form a useless clump. In many plants, the large subunits are chemically modified by specialized enzymes before they bind to the chaperonin protein. There is strong evidence that chloroplast Cpn60, Cpn21 and Hsp70 also participate in the assembly of the sixteen-unit rubisco complex. After a soluble L8 core is formed with the assistance of the chaperonin proteins, tetramers (four-part complexes) of small subunits bind to the top and bottom of the complex to form the complete enzyme. There are almost certainly other chaperones and chaperone-like polypeptides or lipo-proteins involved that are not yet characterized but i cant write a textbook here. How do evolutionists explain how natural selection would have favoured a protein complex the function of which was to prevent a still-useless rubisco small subunit from folding outside the chloroplast? Before it evolved a way to get the protein inside, there would be no benefit from keeping it unfolded outside. How could blind chance ‘know’ it needed to cause large subunit polypeptides to fold ‘correctly’ and to keep them from clumping? It could not ‘anticipate’ the ‘correct’ conformation before the protein became useful. And evolution would need to be clever indeed to chemically modify something not yet useful so that it could be folded ‘correctly’ when even the ‘correctly’ folded polypeptide would not yet become useful.

He shows how energy is produced from sugar, and ignores that mitochondria also produce energy from fat, but even more efficiently. WTF? Unless i missed something that's a hugely misleading presentation that suggests mashmallows are necessary for life. :o

Whoops! I thought this video was about midichlorians. My bad.

You didn't even touch on the most fundamental problem with the "origin of mitochondria". The *proteins.* There are a *lot* of proteins that have to be constructed just so to make it work at all. So how could they have been coded in less than a trillion trillion trillion years? If not random chance, then what mechanism? Natural selection can't work until there's an advantage. But there would be no advantage until it was almost complete.

Life was from the spoken word, rest assured you will expire as a mere PHD.

Wow! and here was me thinking that Americans were all science deniers and creationists ! How fabulous to (yet again) be reminded of the incredible advances of scientific knowledge as well as the comforting realisation of the link each of us has with every other living thing past and present. 56:39

3:27 What about INFORMATION?

Mitochondria are not a separate organism, they are produced by the formation of a cell and do not undergo mitosis!

Is it impossible to get these folks with this knowledge to get better at presenting? I’ve head nothing but pounding from his hand waving. Important stuff which one has to pay attention to understand and they’re throwing in distractions. I know , I know, it’s “ get off my lawn stuff but please

I don't want to sound mean but this speaker would benefit from some public speaking training. He has a maddening speaking style that alternates between halting, half sentences filled with lots of ums and ahs, followed by bursts of technical jargon, followed by more half sentences. There's often just too much detail when a simpler explanation would suffice. It often felt like the proverbial guy explaining how a watch is constructed in response to the question "what time is it?". I was able to follow along only because I'm already familiar with most of the subjects discussed here.

16:35 This claim IS not prove at all?

36:00 We need a lot of "faith" to belive that this is really possible!!

"...chemically, L and D forms are exactly the same." Thalidomide laughs at this statement.

His start about water coming from meteorites is badly wrong. The Earth build from near absolute zero meteorites. There was not heat and volcanism at the beginning. The atmosphere is the result of the mass of the Earth, so it was there from the beginning. But it is true that there was not much Oxygen, nearly all Nitrogen.

23:11 Ironically, it was her husband who wrote, "extraordinary claims require extraordinary evidence".

All in all, this lecture doesnt say anything new. I learned all this 50 years ago. Its basic cell biology.

Here's something that makes this factual......Sorry you're tube will not let the average person learn. So sad 😞

There are FIVE information codes in every cell, aside from blood cells. The five are the DNA code, the mtDNA code, the epigenome code, the 'sugar' code that lines the surface of every cell, and the lipid code making up cell membranes. All these had to work in unison. The makeup of these for life are mathematical impossibilities-by-chance. To say the ribosome sums up evolution is ludicrous. That is defined as a 10^50 or more. It's far too complex without outside intelligence to make it happen. On top of this, the Intelligent Designer is a master chemist with 65 different hormones in the human body. We are a creation.. Not an evolution. All classic and written-about adaptations in peer review papers are epigenome-derived. The actions of the epigenome is called epigenetics. The metamorphosis of the butterfly from a caterpillar is done by epigenetics. The Darwin Finch got its beak adaptations epigenetically...not by the theorized evolution means is by the same means...just without the metamorphosis. Found to be a fact by Dr. Michael Skinner in 2014. Evolution is a theory. Epigenetic-derived adaptations is a materially found fact instead. Theory vs. fact? Go with the facts! All of these epigenetic-derived adaptations had an ASSUMPTION of evolving DNA mutations. This assumption is a false precept. This false precept was called wrongly 'microevolution'. Then this false building block was used to say 'macroevolution' came from these little steps. The absurd claim of genome degeneration causing evolutionary generation is comic book science. We are from an intelligent design. The intelligent designer? Jesus Christ! Call upon his name in faith to receive the free gift of eternal life right now! Mis-expression of the genes or the sequence of the mtDNA causes diseases. In healthy people it is finely tuned. This fits the intelligent design paradigm.

nice story as per usual always glossing over the important stuff. That chirality question is a killer why all sugars are used by life always righted handed and the amino acids left-handed. as usual the answer is aliens did it

Why can't we recreate it in a test tube then, should be easy

This is called a fairy tale folks.

#AwarenessConsciousness

Lol.

Can someone talk to the bald guy with the blue shirt and tell him to listen to the lecture. His questions are distracting and non-relevant. And.... he keeps coming to all these lectures.

terriblle presentation

Give me a break make rna in the lab and ill understand how mitrochondria was made 70 yrs after miller eury and nothing first stuff made first explain how rna is made or membrane not mitrochondria is the master piece of life its perfect in design how did lipids carbohydrates and nucleotides combine what is the mechanism we dont know good point on nitrogen

hahahaha

Anyone can try anything like, for instance, trying to find out how a mouse trap would appear on the Moon's surface? How can I capitalize on a donkey's intelligence? Time is a God-given gift, capitalize it by investigating evidence whether it's according to your opinion or not. First, accept the fact that we are here without having asked. we are free-will individuals with personality and a moral sense; therefore we are accountable for it. The essence of living together lies in who am I regarding my neighbor. Ask and you will find it, knock and it will open. Why has anybody in the universe ever approached us on Earth, except for Jesus Christ, who resurrected at least three real people with friends and family to witness such an important event? Jesus while on earth among mankind, eating and drinking said that he would resurrect too and he did after three days, being under Roman guard, after he was found dead and pierced his heart by a spike.

"Old rats turn into bats". This Brazilian old saying perfectly summarizes the Evolutionary fairy tale, which alleges that one species can transform into another species. Go figure.

The Greys inserted mitochondria into a cell to start the process. The process led to us. It's called seeding, and they've done it across the galaxy. Even the greys can't move among galaxies, but no doubt someone else is doing the same thind elsewhere.

this presentation shows various theories on the origin of life but ignores the most obvious one: God. Such presentations are often presented as being objective, but they fall squarely into a faith system that denies or ignores God as a valid hypothesis.

Who cares ?

8:49 How about Inteligent Design? ID is prety much what we see in the astonishing complexity of Mithocondria, Ribosoms, DNA, and Life in general...Most of the "leading" hypotesis are only Garbage, Lies, Errors, Why mention them as "leading" in the first place?