An #osmotic #diuretic prevents the reabsorption of water and sodium and hence increases urine production or causes diuresis. They are intravenously administered, pharmacologically inactive compounds. They make the blood and renal filtrate more osmolar. Isosorbide and #mannitol are two examples of osmotic diuretics.
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chapters-
0:00 | start
0:10 | what is osmosis?
0:40 | types of use of osmotic diuretics
1:42 | Mannitol
2:00 | Mechanism of action
3:54 | indications for use
4:17 | Adverse effect
4:45 | Drug dosages
5:30 | monitoring
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Osmotic diuretics act on the water-permeable parts of the nephron in the kidney. These substances have the ability to affect different body parts. They can be used, for instance, to lower intracranial and intraocular pressure. Osmotic diuretics boost plasma volume without affecting the neurological system since they do not penetrate the blood-brain barrier. In actuality, this is what causes them to behave in a way that reduces the local plasma volume in the nervous system.
An osmotic diuretic is an osmotically active drug that is filtered into the renal tubules but not reabsorbed. Diuresis occurs as a result of this substance's ability to hold water in the renal tubules.
Mannitol is the sole important osmotic diuretic used in medicine.