Peter Rottier and Angus Lamond discussed the structure, entry, and evolution of coronaviruses. Rottier provided an overview of coronavirus history, evolutionary patterns, and current research areas, highlighting their zoonotic potential and the need for further research on infection cycles and entry mechanisms. Lamond shared insights into the structure and entry of coronaviruses, focusing on the spike protein's role in virus entry and the receptors used by different coronaviruses.
Moderated by:
Angus Lamond, Professor of Biochemistry, University of Dundee
Group Leader at EMBL Heidelberg (1987-1995)
Speaker and presenter:
🎙️ Peter Rottier, Emeritus Professor of Virology, Utrecht University
Visiting Scientist (Warren Group, Meyer Group), Cell Biology and Biophysics, EMBL Heidelberg, 1982-1984
Summary:
0:06 - Coronaviruses: Origins, Hosts, and Infection Cycles
• Peter Rottier discusses coronaviruses, their features, and infection cycle.
• Peter Rottier discusses the history of zoonotic coronaviruses, including OC43 (cattle to humans) and SARS/MERS (bats to civet cats/dromedary camels).
• Peter Rottier explains the classification of coronaviruses into different genera and clades.
6:06 - Coronavirus Structure, Replication Cycle, and Evasion Strategies
• Peter Rottier explains the structure and genome of coronaviruses.
• Peter Rottier explains how viruses replicate within cells.
• Peter Rottier explains how viruses assemble new particles in host cells.
13:22 - Coronavirus Structure, Entry, and Receptors
• Focus on the spike protein and its role in infection.
• Virus budding and production occur rapidly, with hundreds of new particles produced per cell.
• Peter Rottier explains the structure of the spike protein in mouse hepatitis virus.
• Peter Rottier explains how coronaviruses use receptors in the respiratory tract to infect cells.