Testosterone replacement therapy: compelling use cases, side effects, and optimal dosing schedules

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Testosterone replacement therapy: compelling use cases, side effects, and optimal dosing schedules

Рет қаралды 200,212

Күн бұрын

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Watch the full episode: • 274 - Performance-enha...
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This clip is from episode 274 - Performance-enhancing drugs and hormones-risks, rewards, & broader implications for the public. Derek is the entrepreneur behind @MorePlatesMoreDates and an expert in molecules commonly used and misused by bodybuilders and athletes.
In this clip, we discuss:
- Total testosterone versus free testosterone
- What do we know about the amount of total testosterone over time in a man's life?
- Optimizing the dosing schedule for testosterone
- And more
--------
About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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@lomotil3370 2 ай бұрын

🎯 Key points for quick navigation: 00:12 *📊 Data on normal free testosterone levels stratified by age is limited compared to total testosterone data.* 01:07 *🧪 Free testosterone is typically estimated, not directly measured, introducing potential for error.* 02:15 *📉 Men experience about 1% drop in total testosterone and 2-3% drop in free testosterone annually after age 30-35.* 04:18 *💉 Primary hypogonadism (high LH/FSH, low testosterone) is the most justified use case for testosterone replacement therapy (TRT).* 06:52 *💊 A typical starting dose for TRT is 100-120mg per week, adjusted based on individual response and factors like SHBG levels.* 09:38 *⏱️ Injecting testosterone twice weekly is considered minimum for optimal hormone stability, with more frequent injections potentially beneficial.* 11:26 *📈 Less frequent injections can cause hormone spikes, leading to increased side effects and conversion to estradiol and DHT.* 14:43 *🔄 More frequent dosing better mimics natural hormone rhythms, potentially reducing side effects like gynecomastia.* 17:35 *💉 Testosterone cypionate has a longer half-life than enanthate, but injection frequency is more important than ester type for stability.* 19:41 *💪 Subcutaneous injections may provide a more sustained release compared to intramuscular, but the difference becomes less significant with frequent dosing.* Made with HARPA AI

@mkinvincible Ай бұрын

Excellent!

@ADayInTheLifeOfJames Ай бұрын

Thanks mate

@229glock Ай бұрын

Two things stand out. Derek is super knowledgeable for someone who’s not an MD, and Peter is super humble for being a practicing MD with what appears to be a true quest for knowledge from someone who has useful info to share.

@nokungfuforyou323 Ай бұрын

I am sure the kid knows a lot of s*** but both of these guys are reinforcing their grift.

@nukedpancakes3_863 Ай бұрын

Peter most definitely has an air of doctor arrogance around him.

@mussersbowsboatsandscience6610 Ай бұрын

Despite public perception MDs are particularly knowledgeable about their specialty, not everything health related or will often talk like the know something like TRT when they may have just looked up the guidelines before you talked to them in their office

@kennethwickey3661 Ай бұрын

*a non practicing MD who dropped out of his residency

@terminator2348 Ай бұрын

@@kennethwickey3661 He is a practicing MD. Look it up

@HIM2PODCAST Ай бұрын

I was 33 when I got tested and my levels where the same as a 83 year old man. I couldn't play sports or get it up. I was fat. Now I do 1cc a week for last 3 years and I play 5 hockey games a week and gym 4 days a week, dropped 50 pounds, and play with girls 3 days a week. I feel unreal. Thx trt

@jackkollman9683 Ай бұрын

Should have just started with the will power....thanks weakness and the drive through mentality of health...

@floorpizza8074 Ай бұрын

@@jackkollman9683 Proper hormonal function is as important to mental and physical well being as insulin is to controlling blood sugar. What you are saying is equivalent to saying "just power through your diabetes, no need to take insulin." Take a few weeks and get some basic education in how hormones work before posting such things.

@GemLeo0679 Ай бұрын

@@floorpizza8074100 my friend. That was an extremely ignorant comment of jack

@jeffreyfurtado44 Ай бұрын

When you say 1 cc, how many mg is that and what type of test. Thanks

@RobertofDetroit Ай бұрын

Dude, same, same!!! I’m like yeah there are risks but if I’m feeling 80 in my 30’s don’t think I wanna make it to my 80’s

@Photoshop729 Ай бұрын

Spent my entire 40s feeling like I was under water despite forcing myself to work out, eat right, etc. Tried treatments for depression and ADHD since my symptoms mimicked those issues, but only got side effects. Finally, got TRT and it is life changing. Was always an athlete who thought it was an illegal drug, wish I woulda started ten years ago wouldn’t have lost a decade to misery. I don’t think you can judge people without knowing their story. I’ve literally gone from hating life and barely surviving to thriving and driving. And my biceps look pretty good too.

@HMuny55 Ай бұрын

No matter where you are on the spectrum before TRT makes you feel amazing

@MadsNattyOfNorway Ай бұрын

Fookin awesome. Good your health&wealth is back✌️

@gregevans1502 Ай бұрын

Interesting experience. The effect on your psychology/attitude sounds surprisingly strong. Thx for this.

@jasonriley5438 Ай бұрын

Went through this same exact thing in my 20s and early 30s. Been on TRT for 3 years and it’s amazing how good I feel on a consistent basis now.

@juanrojas6596 Ай бұрын

So you're talking about these clinics that I really don't know what they're doing.. Where do you suggest we go what?Type of doctor do we see..I'm 53.. I work out try to live A healthy lifestyle but dam i'm still tired.. any input Would be helpful

@nateh6441 2 ай бұрын

I've been on HRT since 2018 for PGF started at 1 ml per week switched to twice a week at half dose. My first year I switched to subq from IM and the twice a week schedule with life changing results. Age 45- 6 years in - I've switched back to once a week injections and found no adverse effects. I did think that it would help me be more muscular but primarily the differences I'm experiencing are lower fatigue, lower joint pain, better function, improved mood. I cant imagine going back to the way I felt at 39.

@coachjsu Ай бұрын

Are you saying you felt better with once a week or twice a week injections (IM Or Subq), kind of confused reading this.

@sandeephunjan Ай бұрын

39 seems extremely young to start TRT. Are you in the States?

@jordixboy Ай бұрын

I started at 28, there is no minimum age to need testosterone...

@scottparks95 Ай бұрын

@sandeephunjan some people have other issues leading to hypogonadism. At 29yr old my total testosterone was 42. Trt changed and possibly saved my life.

@nateh6441 Ай бұрын

@coachjsu I felt better my first few years with 2 shots per week. 6 months ago I switched to weekly shots and feel no difference. I still feel great. My doc said that with longer term HRT that my body would more efficiently use the T

@therehastobesomethingmoore Ай бұрын

Started TRT at 59, 3 years ago, and it has really helped. I have worked HARD in the gym and take just enough to keep me st normal levels. I still have a way to go but my body and energy level has changed dramatically. I look forward to exercising daily rather than feeling like a tired slug.

@deca10 16 күн бұрын

What was your T prior to start TRT? I am 60 with 601 level and on the fence about starting TRT. Sleep well but some bedroom issues and mid-section looseness is an issue. Push pull legs w/out one cycle/week.

@deca10 16 күн бұрын

6’5 and 222.

@therehastobesomethingmoore 14 күн бұрын

@@deca10 Every year during my physical the level kept going down....finally when it hit 300 and my Doc would not get me started, I switched doctors. Very happy with the results. At 601....not sure...that is not really low....

@deca10 14 күн бұрын

Appreciate the response. I will continue to monitor level. Best of luck with your TRT.

@alexedens1 Ай бұрын

I started TRT at 51 doing weekly injections of Cypionate through a local clinic. Great results. Within the last year I switched to pellets. A bit more expensive but extremely convenient, especially as a frequent traveler. Plus no highs and lows. Overall I think it’s worth the extra expense.

@keiththomson9628 Ай бұрын

I think you have it backwards. You can control your levels much better with injections.

@alexedens1 Ай бұрын

@@keiththomson9628 Gotta respectfully disagree. The pellets last between 5-6 months, depending on activity level. I’ve done labs at various points during each stretch and every time the numbers are spot on. The T leeches out at a constant rate that even a shot per day can’t match. The trick is in the initial dosing. The proper number of pellets need to be inserted. If that’s done correctly you are locked and loaded for the duration. No thoughts or worries for 1/2 a year. I won’t be going back to injections.

@carlosSillas14 Ай бұрын

@@keiththomson9628he said convenient cause he is on the go and doesn't have to mess with injections.

@successsystem2468 Ай бұрын

Alex what are pellets?

@DanielFlores-ru4ij Ай бұрын

I've been on TRT for about 8mon now and I can say at least for me it's changed my life. So many physical and emotional issues that this has changed. I want to say it's helped. Plus changing my whole life style. Diet and exercise. I was 285. Now I'm 235. I feel amazing. Get blood work and see what you can get started

@miguelcisneros5654 Ай бұрын

Glad to hear that. I’m overweight and all I keep hearing is TRT is just gonna make you bloat and be even fatter you need to get fit before T. But i don’t have any damn energy after work cause low T…

@DanielFlores-ru4ij Ай бұрын

@@miguelcisneros5654 my doctor automatically told me trt will make you feel 25 again. I was very skeptical of what I've researched and for me my biggest concern was my hair. I know it sounds crazy but I decided hair or my health. So I went with it. Best decision i made. Find a doctor that specializes in it. Get blood work done. Everything you said i had the same issue. Work all day and too lazy to do anything now..10 or 12 hr shift is nothing. After that i workout eat and it's changed my life. It doesn't bloat you or anything like that. Only thing I've noticed is extra body hair i never had before but that's it. Go for it. Hope to hear from you if you decide to.

@Leo6933 21 күн бұрын

Do you feel you would have felt the same if you lost the weight first?

@DanielFlores-ru4ij 20 күн бұрын

@@Leo6933 honestly i dont know because I couldn't loose the weight. It's difficult to explain. Like I was in a daze i was at a point where I was lazy didn't want to do anything. Always tired. I didn't even want to go outside with my kids and play. Go on vacations I literally would go to work and then home. Lay around all day and do absolutely nothing. So to answer your question I feel like since i first started taking trt. It's like my eyes were open. Wide open. Everything was clear. I was focused. I was excited I was motivated. It was amazing. My back knees none of that bothers me anymore. It's pretty remarkable.

@Leo6933 20 күн бұрын

@@DanielFlores-ru4ij Well I’m happy your doing better. For me when I took it I realized I didn’t really need it after I got my nutrition and exercise regimen on point.

@Risingabovechaos Ай бұрын

I'm 48 and was hypogonadal. Now I'm at 586ng/DL. This book goes into real detail and gives insight to things others don't mention. Complete Guide to Testosterone by James Francis.

@BiHuSrcu Ай бұрын

u on trt?

@Risingabovechaos Ай бұрын

@@BiHuSrcu No. None.

@joeblow2183 2 күн бұрын

I’m 68 I’m on it. I had levels around 400 but I didn’t have explosive power in the gym anymore. I got on trt but I needed boron to help free test up. If you love hitting the weights, you want to hold on to your muscles, you want to train for and perform better in your chosen sport then I say go. I love training.

@psycold Ай бұрын

I'm 41 and I've been on TRT for about 9 months. For the first 6 months I couldn't get above around 500 nanograms per deciliter, they kept cranking up the dose. I started doing a split dose of twice a week and now I'm over 900. Only side effects have been acne which is not terrible on my back, but weirdly I got pretty severe acne between my pecs, and it's very stubborn stuff that won't go away. I've had it for like 3 months now. It is weird being my age and waking up with morning wood every day, but I'm not complaining. I honestly haven't noticed much of a difference in terms of gym performance and muscle growth, but the biggest thing for me is that it works as like an anti-depressant. I am always in a good mood now.

@Taylor2424 Ай бұрын

Same here on the acne...I'll get one on the shoulder every once in a while....but mostly chest area

@GemLeo0679 Ай бұрын

All it’s going to do is make you solid and in good shape. You’re not juicing

@Over-v1w Ай бұрын

In Sweden, if (IF) you make it past the narrowsighted doctors that stares blindly at the reference range with complete disregard for symptoms, the only injectable option for trt is 1 gram every 8-12 weeks (6 weeks first injection). NO hcg under any circumstances.

@adamshiffer9963 9 күн бұрын

One gram at once?

@cheetahwolf8978 17 күн бұрын

I was in a motorcycle incident and had some trauma to my balls, went from being active and healthy to feeling lethargic and unmotivated in about the timespan of a year. Got my test levels checked and found out they were low. Never had symptoms of low test prior to the accident, so can only assume it was from the trauma. Anyways, been on TRT for the past 4 years after thorough testing from an endo and continuous monitoring every couple months, and I've been feeling great and back to working out regularly and feeling renewed motivation

@quantumfx2677 2 ай бұрын

A good friend of mine living in Colorado has had a hematocrit over 50 for over 20 years and says its common where they live and pregnant women have to leave from the higher altitudes and even as a child is still growing until they become much older but its zero health problems for adults and many live a healthy long life and take the hematocrit fear over 50 with a grain of salt.

@thatcarlifeR8 Ай бұрын

I’m one of the OG’s. I have been on TRT for. 16 years. I started when I was 32. I’m 48 years old now. I would probably make an interesting case study. My has always been 200 mg per week split into two doses self administered. I think it’s had a pretty dramatic positive impact on my overall health in that my calcium score is still zero and my cholesterol has always been high I do not take drugs. In fact, I refuse to. my triglycerides are also high yet. I had my first calcium test five years ago and it was zero then and it is still zero now. 200 mg of testosterone for me puts me around 750. And it will put my free testosterone around 50. Over the years I have gone on and off for as long as six months because quite honestly, I just gets tired of sticking a needle in myself

@marken816 23 күн бұрын

Negative side effects?

@thatcarlifeR8 23 күн бұрын

@@marken816 not 100% sure tbh. In the beginning, it was quite the delicate balance finding the right dosage along with the right amount of anti-estrogen. It took about a year to get everything correct. My calcium score is zero and I’ve had it tested twice in the last five years so clearly there’s been no ill results from not taking statins in my case. Only other real side effects are a little bit of water retention, and overall body hair growth and I don’t know if that’s because of the testosterone or just getting old.

@marken816 23 күн бұрын

@@thatcarlifeR8 Okay, great to hear. I'm just 23yo, tests in the normal range (if bit lower at 300), purely curious about people's experiences.

@Rkz-rv7ys 17 күн бұрын

I'm 36 thinking of getting on TRT too . Good to hear your experience Ty

@thatcarlifeR8 17 күн бұрын

@@Rkz-rv7ys it was all based on bloodwork. At 32 my level was in the 250 range. I didn’t just decide I wanted it, doctor advised and prescribed.

@deadlyalliance8281 Ай бұрын

35 yr old male. 5' 2" inches 146 lbs. 100mg/0.5ml a week. Peak was 926 total, 194 free. Estradiol on a peak was 31. Trough 6.5 days later, 540 total and 101 free. I'm super happy with these numbers. Pin every Friday like it's my birthday!! 🎉🎂 Only thing is my ferritin bottomed out, like bottom-bottom, bottomed out. 4 ferritin, 40 iron. Iron binding capacity is slightly over 100% 428/425. Im on an every other day iron, lactoferrin and copper regimine and to try and get these numbers higher. Just started this. September 9th is my next ferritin and iron check. As far as the test levels are concerned, they are $$$ at 100 mg a week. Definitely don't need to go higher, but to focus on my iron and ferritin.

@Kstephens07 Ай бұрын

Your free T even at peak is kinda low imo. Hell even at trough most guys feel their best if it’s above 200. You may feel good now because of how bad you felt with low T but I don’t believe you are fully optimized. Optimized free t would be between 200 and 300 regardless of peak or trough.

@deadlyalliance8281 Ай бұрын

@@Kstephens07 I was on 200mg every 10 days before this. Had a total of 1250, free of 255, estradiol of 48 and that I beleive was on a trough lmao. This 100mg a week is working out perfect for me. I dont wanna be in enhanced ranges, just higher than what I was, which clearly I am. I was at a total of 227 with a free of 34 before starting all this. My bodys androgen receptors work very well.

@BiHuSrcu Ай бұрын

At what age did u start?

@deadlyalliance8281 Ай бұрын

@@BiHuSrcu one year ago actually, so my body has most likely stopped making it's own. These levels I obtain on peaks and troughs should be the ones I obtain for life at this dosage. Only thing I need to do is get my iron and ferritin up and my labs will be *chefs kiss*. Not only that but this was 3 days after injection, which could be SLIGHTLY lower than an actual peak. Usual peak via IM test cyp happens after 10 hours up to 2 days so... We can probably assume, but can't prove I'm right at 1000 ng/dc total and slightly above 200 free and im 110% happy with that. Anything above that and I'll be pushing into enhanced ranges and that's not what trt is for. That's called testosterone sports therapy or testosterone enhanced therapy in the realm of going above normal high levels. My energy levels are already through the roof and (SOMEHOW) I'm suppose to feel even more like super man when I get my ferritin and iron up.

@BiHuSrcu Ай бұрын

Honestly peak 926 sounds optimal to me, i like how they said that injecting twice a week at least might help decrease those super abnormal peaks…what made you get on trt?

@eddiegardner8232 2 күн бұрын

As a post prostate cancer patient on TRT, I administer testosterone cypionate daily, to minimize aromatization into estrogen and conversion to DHT. I have an unproven suspicion that estrogen “may” be involved in initiation of prostate cancer, as it is in breast cancer, and DHT is more active in binding to androgen receptors than testosterone, so I feel that there is no good reason to “kick the sleeping bear” any more than necessary to get normal testosterone related body functions working again. A year into TRT, PSA remains undetectable and I feel normal again. PS Derek knows more about hormones than any endocrinologist I have ever spoken to, and most don’t have a clue about how to do TRT properly. He should have gone to med school.

@rockroll7649 Ай бұрын

I started out with 300mg cypionate. I went to 200mg every 2 weeks and still had hypogonadal symptoms. Then went to 150mg every week. My test runs at 600 ng/dl and am doing great.

@TheBigUsualSuspect Ай бұрын

I've been using TRT for a year now. My levels were at 200. I'm over 40 years old and work out almost six times per week. I started working virtually, and by the end of the day, I was done, sore, lethargic, etc. After three months on it, my level shot up to over 2000 using 100 ml per week. I lowered it to 25 ml per week, drew blood again, and it dropped to 900. So, I've been using 25 ml per week. I feel it mostly in my daily lifestyle, work, workout, recovery, etc. I also eat lots of protein, fat, and few carbs. I haven't seen any gains in my strength on any of my lifts, but that's okay-that's not the purpose of this TRT.

@donmerrigan2362 Ай бұрын

I'm really hoping you're mixing up your terminology here. People are generally prescribed .5-1ml of test c/wk in the US. You aren't using anywhere from 50-100 times the common dosing. Maybe you meant to say mg per week. But even then your numbers would be considered absolutely off the charts for those doses.

@TheBigUsualSuspect Ай бұрын

@@donmerrigan2362 Yes, each bottle is 100 mg, so I'm breaking it into 4 shots. I'm taking 0.25 ml per week; that's what I meant. Apologies for the confusion.

@hanskazan7403 Ай бұрын

@@TheBigUsualSuspect why lowering it man 2000 is good

@TheBigUsualSuspect Ай бұрын

@@hanskazan7403 2000 is way too high IMO, its not TRT anymore.

@markd4768 12 күн бұрын

That’s not a TRT dose 😂your on a cycle of steroids my friend!

@MartyGrass-e2v 9 күн бұрын

My doctor told me that between the ages of 25 and 75, free testosterone decreases by 50-60%, from 430 ± 100 pmol/l to 220 ± 80 pmol/l. The testosterone concentration decreases by about 100 ng/dl per decade. The most important thing to do before starting TRT is to understand the cause of the low free testosterone level, as it could be a symptom of another important disease. I had hypogonadism and my level was 63 pmol /l at the age of 47. I started TRT 100 mg per week. Now I am on 250 mg per week but it is my decision to increase it this way. (I don't think my doctor would approve of this) TRT is very addictive and completely changes a person's life. I'm not sure what my reaction would be if someone told me I should stop taking testosterone. I'll probably deny the situation and continue using.

@mschafer89 12 күн бұрын

Splitting doses also minimizes impact on H/H and BP. In our clinic, I've noticed men on at least twice a week injections have a much lower frequency of erythrocytosis and have much smaller increase in blood pressure. Interestingly, I also see much lower H/H levels and less BP fluctuations with subcutaneous injections, whether once a week or more frequently.

@JRRod-yc8em Ай бұрын

I tried sub q for 4 weeks to see if I would get those benefits they talked about. I did not, in fact I felt worse. I switched back to IM, felt way better, more focused and energized and motivated.

@fivebooks8498 Ай бұрын

How often did you pin and what was the ester? I’m wondering if I pinned propionate daily sub q if that would get those benefits. Seems like it would mimic closer to how it happens naturally.

@robertworton2394 Ай бұрын

You guys didn’t mention the scrotal cream that’s working for a lot of guys that’s strange because I would think that would be something more important to talk about other than that Dom nasal spray

@Zoet50 Ай бұрын

I get all my medical advice from the liver king

@mr.chilll5179 Ай бұрын

Can't go wrong there...

@ScottyLo Ай бұрын

I’m glad I don’t see him anymore

@ADayInTheLifeOfJames Ай бұрын

😂

@alexandereisen3486 Ай бұрын

I use his stack 😂😂

@fivebooks8498 Ай бұрын

@@alexandereisen3486 I saw the list of what he was on and the doses. It really wasn’t that much.

@kimd2094 Ай бұрын

A video on trt, let's see the comments of 60 yr olds woth 700+ test levels who say it's all about good sleep and nutrition..

@Slickone-wk9mc Ай бұрын

Cope 🤷‍♂️

@jackkollman9683 Ай бұрын

Legal steriods are a big business, and weak men need an excuse...

@fitbjj Ай бұрын

I think you're in the wrong community. 60 year olds here with 700 test admit to taking trt. Go to one of the actors that gain 40 pounds of muscle in 4 months and post this

@scottfalcon Ай бұрын

lol, because you don't need to workout or eat properly to gain muscle.

@jeffreyfurtado44 Ай бұрын

Grow up.

@TILLEYJS 3 күн бұрын

Here's a question for anyone on TRT. I've been on it for 5 years. If I don't work out for 3-4 weeks, I get crazy cramping(spontaneous). Anyone else get weird cramping in general? Dose(test cyp) is 90mg/week. Potassium and magnesium is normal levels. 43 years old.

@fdsm9211 Ай бұрын

I started TRT at 37 (45 now) My total T was in the 200s but I was fat and unhealthy. I might have jumped the gun yes I admit. Thankfuly I did it after having children. I have to say that I feel very strong in the gym and I don't lose muscles easily with lower body fat. I actually look better than when I was in my 20s and training. I take my shots every other day and no side effects ( I have high BP but that's genetic and controlled now). To me, I have no regrets what so ever. One serious negative is that libido is very high. It's not always fun when you have to work.

@MrCites1 Ай бұрын

Have you considered doing a bukkake party?

@fdsm9211 Ай бұрын

@@MrCites1 I am too much of a boring person to do that.

@guessmyname1104 Ай бұрын

I already had most of the negative side effects from TRT as pre-existing conditions. None of them got worse after I started. In fact, some of them, like sex drive, improved after I started.

@mortengabrielsen6923 2 ай бұрын

Great work people, so interesting, keep it coming!!

@MontezumasViper 8 күн бұрын

I ran subQ cypionate 3x 100mg per week and was able to move my hematocrit down to 50 from 56 vs once a week IM. No more blood donations... Also, check your blood profiles (CBC) and ferritin levels. You might see that frequent donations stress those values. Its best to avoid doing it if you can

@corismsyn Ай бұрын

Derek, I have varicocele. I had no idea this could affect my T levels. I've always been a hard gainer. What should I do to get this checked out?

@user-co2db1ql3u Ай бұрын

Oh thank God it's under an hour. I feel KZfaq vids should be 30 mins max

@Mark-ks9jj 9 күн бұрын

Primoteston Depot (Testosterone enathate) has a recommended dosing protocol of 1ml (250mg) every 10 days. Dosed as sub-doses of 50mg (0.2mls) M-W-F IM gives a slow build up to stable levels within the therapeutic window & virtually zero side effects. There is no good reason to suffer the huge spikes & troughs of side effects by following the recommended dosing, its archaic.

@tealshift2090 2 күн бұрын

Exactly, anyone that doses it once every 10 days is insane. even once a week is insane, at minimum it should be twice a week, if the person doesnt want 3x a week.

@marcus_ohreallyus Ай бұрын

I've been doing 0.3 at three times per week and it keeps me in the 900 to 1000 range. I had hypogonadism from a varicocele, so my natural baseline without TRT was around 150. I load insulin syringes once per week, so they're ready to go on injection day. I use a 29g insulin needle into the upper vastus lateralis and the thick liquid has no problem going through the small syringe

@JosephAbdo-t9n Ай бұрын

I’ve been on TRT for 5 years and I found that my sides near diminished splitting my dose twice per week also I had to get realistic on the fact that I didn’t need the max TRT dose of typically 200 mg week, for me my sweet spot is 60 mg twice weekly. I would recommend to go by labs and how you feel not ego💯💪

@RedOakCrow Ай бұрын

A Bulgarian doctor I follow says that most men with Low Test do need TRT, but it's Thyroid Replacement Therapy that's actually needed.

@thedamon221 2 ай бұрын

I didn't understand a dang bit of this video. I went to one of those men's clinics and they told me I needed to take t shots. I saw my doctor and he said he didn't recommend it. I think my test level was 190. I don't know what to do or who to see who knows about this.

@brettarsenault6573 Ай бұрын

Same. Did it anyway. Got my life back. You choose your own path. low t will make you not take chances. Consider that influence in your decision.

@jdl2180 Ай бұрын

That should be a very easy decision when your numbers are that low!

@innocentbystander8038 Ай бұрын

190 is way low. General medical practitioners usually have no clue about this stuff. If I was you, I would run with the T clinic. But your choice, obviously.

@allthecommonsense Ай бұрын

Drs are idiots.

@mattarndt4452 Ай бұрын

It’s mainly about whether you have symptoms of hypothyroidism. Symptoms like low libido, low energy, inability to burn fat and difficulty building muscle, to name a few. 190 is very low for total testosterone. I would be surprised if you aren’t experiencing symptoms.

@8Rider6 Ай бұрын

Has Derek done any videos on Enclomiphene? Curious on its effectiveness compared to straight test.

@pwcoon Ай бұрын

I’ve been dosing daily subq for 12 months no ups and downs, acne or other side effects. My hematocrit prior to the switch from weekly to daily was 53 to 55 which required monthly donation now with daily 50 to 52 still high but steady. Prior to TRT it was in the 47 to 48 very steady. I’m very fortunate that my hospital has a program that tracks all my blood test over the years. Therefore easy to compare trends. I transfer 200mg vial into 10 syringes a pain because it’s so thick and a very small dose but it works.

@StelioKontoss Ай бұрын

A little tip, use bigger needle to draw, smaller to inject. And warm up the vial or the syringes under hot water it helps liquify the oil and goes in easier!

@bearclaw5115 Ай бұрын

@@StelioKontoss Good advice on the needles, 21g for drawing 25g for injecting. I'd skip the water warming for hygiene purposes.

@pwcoon Ай бұрын

Outstanding I use a larger needle to draw but I will try the warm water method next time

@tzahi12370 Ай бұрын

No bumps from subq injections ? How much do you inject every day 0.2 ml? Did you had acne before from once or twice a week shots?

@pwcoon Ай бұрын

Yes on the daily. Yes on the acne once a week inter muscle. It stopped within one week of subq. A small amount once in a while now. SMALL amount on my nose!

@joebeta1837 10 күн бұрын

Have you guys noticed that KZfaqrs like Peter Attia tend to interview only other KZfaqrs who have their channels already?

@tealshift2090 2 күн бұрын

They are trying to gain the other youtuber's audience, (both of them). common thing for youtubers to do.

@allibouloum6577 2 ай бұрын

how do you determine if the low testosterone is a testes problem versus a CNS problem? How do you solve it when its a CNS problem? What is the long term plan if you want to maintain your own level, and only topping up to achieve benefits? Will you always destroy your own testosterone production if you take trt?

@quantumfx2677 2 ай бұрын

You will have to look at age, physical activity, and nutrition then if you are under stress constantly or have other mental problems there goes your CNS, and overtraining can also cause a problem. If you remove much of the stress or at least manage it your T levels should go up. Remember a certain amount of stress is necessary but being the right kind! Hopefully, you're not under constant stress as it will take you down and set you up for health problems and crush your testosterone but jumping on TRT is not the answer right away unless everything else is in check first and if it is and you are not too low you will want a reputable TRT clinic to try other routes first and if only then if you still can't get to point of good levels where you are feeling good then TRT will come into play. Depending on your age going on TRT at a young age you can recover or at least you should back to good levels but not everyone can after going on TRT and ending up on it for life. I no longer believe this will be the case shortly as we have made improvements and in fact, TRT will also fall by the wayside as LH TRT is here and will cheaper and covered by insurance with only needing one injection every 2 years as well as being cardio protective.

@hardmtnbiker Ай бұрын

Work on maximizing your body’s ability to function efficiently, naturally. I think too many men think that they will go on TRT and it will remedy all the decades of neglecting their body’s own abilities to increase athletic performance. It’s not just about being less stressful but how about a clean diet, daily exercise, proper hydration, proper supplements, sleep hygiene. Improving endurance and evaluation of max watts or increasing your VO2 max and HRV. Perhaps the path of most resistance that few men will ever take since they can solve their problems with a testosterone replacement therapy the rest of thier lives and will feel amazing doing it that way.

@Lucas_Jeffrey Ай бұрын

enclomiphene and blood work would be a simple test. if it raises your T level significantly, it's a pituitary issue. If it doesn't affect your T at all, it could be gonads, but could also be that your pituitary won't produce LH even with reduced estrogen activity

@marshallsaltzman9924 Ай бұрын

See how you respond to clomid or hcg

@bearclaw5115 Ай бұрын

Exogenous testosterone given in a therapeutically active dose will always shut down your natural production. Which is fine if you are dependent on taking T and will do so for life. Way too many guys think "Well I'll try it for a while" and dabble with it here and there. Much better to see where your at, take action to improve your health and try to raise it naturally. If that doesn't work then go ahead and got on T knowing it's for the long haul.

@gulfcoastfitcation816 12 күн бұрын

Great information. Thank you. Enjoyed listening and learning.

@XARIER39 Ай бұрын

I don't like when two experts talk to each other about this. It's like they don't consider the audience's relative knowledge. I do like when Derek talks about it to his own audience on his channel because he understands how to word or phrase information so that the average gym goer can understand.

@fivebooks8498 Ай бұрын

So for example they were talking about FSH and LH being low versus the testicles just not working. So your body puts out a signal called FSH and LH and that tells your testicles to make testosterone. Sometimes your body is putting the signal out good but the testicles aren’t working. In that case they were saying it’s best to just get on exogenous testosterone. But if your testicles work fine but you’re just not putting off the FSH and LH signals for them to make it then sometimes it’s better to figure out why those signals are low. It could be diet or lack of sleep. Also they were talking about the half life’s of the different types of test. There’s an ester attached to the testosterone that basically acts as a timed release mechanism. Whatever kind of ester used will determine how often you need to inject. However they were saying that regardless of that if you divide the dose up and inject every day or every other day helps keep estrogen low.

@1888CHAD8881 Ай бұрын

Anyone above 30 should get levels checked. Literally as important as blood pressure. Low T causes a ton of health issues.

@cannabros Ай бұрын

absolutely! especially with all the processed food that have invaded our food supply!

@tealshift2090 2 күн бұрын

It should be any age every so many years. There are plenty of 20 year olds that find out they have very low levels.

@travissmith-wz5nc Ай бұрын

37 with 170 total t. Went on test endosate levels completely went away. Dr switched to test cypinate. 30 ml 2x a week. 800 total t now.

@mkinvincible Ай бұрын

What is your lifestyle ? Weight ? Any medical problems?

@travissmith-wz5nc Ай бұрын

@mkinvincible 5'11 200. 33 waist. Had a ultrasound on the boys one is only getting 40% blood flow

@mkinvincible Ай бұрын

@@travissmith-wz5nc⁠damn! Sorry to hear that. Do you have an arterial malformation that decreases the blood flow to the boys? I am 6 feet and was 205 pounds. I went to low 180's and feel great. I think the 20 pounds more were screwing me up plus high stress levels. Now I am sleeping more. You should try to cut 25 pounds and optimize your sleep. It should help.

@travissmith-wz5nc Ай бұрын

@@mkinvincible old wrestling injury

@mkinvincible Ай бұрын

@@travissmith-wz5ncgot you. It's what it's then. It sounds like you should talk to your primary care doc and he/she should consider the replacement for you. Best of luck.

@HD-Tech 3 күн бұрын

Peter Im 53 an had a testosterone level of 123 (felt horrible). Im prescribed test cypionate 200mg inj. every 10 days. I don't feel life changing results as many talk about. Should I talk to my DR about 1/2 the dose every 5 days for a more consistent result?

@TILLEYJS 3 күн бұрын

No real answers to your question. You probably start with 100mg every week.

@nicoc7024 Ай бұрын

What is considered Supra physiologic for free and total test?

@Irish_Goodbye_Guy Ай бұрын

I’m 54 year old and feel horrible. I just got tested and I’m at 70 ng/dl. My doc prescribed 200mg once per month. I hope it helps.

@mrcmdjd57 2 ай бұрын

I use 15 mg T-cyp sub Q q AM as I feel this gets as close as possible to the system designed by nature.

@davidbennemann Ай бұрын

have to disagree - desinged by nature means you have ups and downs. but with daily injections and the half life of 4,5 days, you dont have downs. only with cream you could mimic nature.

@StelioKontoss Ай бұрын

Before or after coffe?🤣🤭

@Pieter_Lion Ай бұрын

Where do you inject? I take it thats a daily dose? Are you not running into issues like scar tissue buildup and lumps?

@cshan159 Ай бұрын

@@Pieter_LionI got same question

@slimturnpike Ай бұрын

@@Pieter_Lion I stopped subQ for this very reason, lumps. Back on IM

@JK-vb6ju Ай бұрын

Did blood work and low test doc prescribed me test amd i do half cc a week no side effects at 44yrs if needed i will do half cc my whole life

@israelh.2259 Ай бұрын

I’m 27 5’11 175. Looking to get on trt, been feeling the symptoms low energy, fatigue etc. thought it was relating back to depression but don’t wanna get in the medication. Will be getting my blood work next couple weeks.

@israelh.2259 Ай бұрын

@user-ec9hb3bo7m thanks!!

@mrtee3477 Ай бұрын

@user-ec9hb3bo7mSTOP!. You do not require scientists for this; this has been around for decades.

@SixFive8 Ай бұрын

@user-ec9hb3bo7m its easy to plan workouts in your head on low T its is depressingly difficult to do it no matter how much will power.

@maodanz1672 Ай бұрын

Try shilajit ,nor tongat ,try icing boys o sugar or alch. No cannabis legs heavy day per week you want to be on trt forever ?

@mattb7406 2 ай бұрын

Plz interview Dr Gil T for TRT. He is awesome!

@bearclaw5115 Ай бұрын

He is awesome but his expertise is more on the nutritional side of things. If you want to talk T, Derek is at the top of a short list.

@Reutzel507 2 ай бұрын

Propionate daily for me. Estrogen response is much less compared to injecting 1-2x of Cypionate.

@bearclaw5115 Ай бұрын

Propionate is a very irritating ester to inject (kind of feels like you got stung). You could use cyp daily and get the same effect.

@BB2001. Ай бұрын

i get crazy post injection pain with propionate even with the best carrier oils.

@Reutzel507 Ай бұрын

@@BB2001. I did right away. I am only pinning 3/10th cc a day. I use an insulin syringe. 30 units.

@HappyWolverine Ай бұрын

Twice a week with insulin pin in delt. Couldn't be easier Thank me later

@tzahi12370 Ай бұрын

Do you think high estrogen on TRT can cause acne?

@Josephv3848 Ай бұрын

Why aren’t they discussing the T gel? I’m 58 and been on gel for 18 years daily. Amazing. Now Hemaocrit over 50 for first time. 🤔

@johncasper8193 Ай бұрын

I like the T gel also, works great for me. What I’ve heard there are absorption problems for some people. Some people it doesn’t work.

@JimmyRickards Ай бұрын

Im 52 my total testosterone is at 894 & my free testosterone is 281.8. On trt 1cc of test cypionate a week

@BiHuSrcu Ай бұрын

dang those r great levels

@projectmayhem2330 Ай бұрын

I’m 40, loved TRT, have genuine low test, never touched PEDS. Had to stop, was killing my hair, even on finasteride. I’m too vein lol I’ll feel sluggish and skinny and keep my thick head of hair

@MrAndy9188 Ай бұрын

I would rather lose the hair than feel terrible. I believe low test also has a cascade effect in other areas of metabolic health.

@PianoJMM85 Ай бұрын

I second that.

@jaytpmc Ай бұрын

Gonna lose your hair no matter what 🤷

@Kstephens07 Ай бұрын

Get on fin and min and spread dose more frequently to prevent DHT spikes

@BiHuSrcu Ай бұрын

f the hair

@lennardtoma6803 Ай бұрын

I get TRT (because of testicular cancer) in a dose and frequency I haven't heard you talk about (also in other episodes): 1000mg of undecanoate. The first prescribed frequency was once every 12 weeks. In my case they brought it down to 8. So a pretty long half-life with a relatively low spike once injected. I'm from the Netherlands here, so maybe a European thing. But curious about your thoughts, considering that other forms with 2 week half life you guys kind of dismiss (if I understood correctly). What do you think about undecanoate with a half life of 8-12 weeks then?

@bearclaw5115 Ай бұрын

Undecanoate would be the superior choice for long term administration, maintaining even levels for approximately 4 times longer than other esters. Although mg to mg it is slightly less potent than cypionate or enanthate because a higher portion of the drug is comprised of the ester (at least how it is measured in the U.S.). The problem with your protocol is that 8 weeks is still way too long of an interval even for undecanoate. They push this protocol for marketing reasons (only once every 3 mos? Cool!) and because the long interval makes it possible to go to a doctor for administration ($$$). An injection of undecanoate every 4 weeks cut in half would be much better. And if I was in your shoes I'd take a 1/4 dose every two weeks. Here in the U.S. this is not practical because T. undecanoate injections are only available through your doctor (Aveed) and your physician needs their 'special' training as well. Senseless but that is what it is. In the U.S., the most practical protocol is T. cyp twice a week done at home.

@user-og8kb4yk6k Ай бұрын

I do microdosing daily injectjons wherever the needle will go. Testosterone cypionate 160mg a week. So about .12ml per day. I have minimal side effects estrogen and prolactin stay in check. Zero issues with hematocrit and hemoglobin. Free test around 278. And total test 750ng/dl 24 hours after my injection. Ive tried every protcol known. This works best for me

@Slickone-wk9mc Ай бұрын

Im 50 yrs old. 185 lbs. I bench and squat twice my body weight.. 5’8” with a 32” waist… im on 150 mills a week of Test Cyp amd life couldn’t be better.. i make it threw the work day now, my wife is happier, im happier and more confident. I was a thin hardgainer with low test at 200 nanos per deciliter.. 165 pounds weak no energy… pecker didnt work that well and life was just a struggle daily.. My wife and I work out together. Eat one ingredient foods, pound the water, sleep well and the rest works its self out. These gatekeepers in the fitness world need to get over themselves.. just cause you dont fuck with dont mean others shouldn’t.

@matthewherren 26 күн бұрын

Two questions from a watch guy: 1. What watch are you wearing? 2. What watch poster is on the wall?

@johnthicks8568 Ай бұрын

LH and FSH can also be heavily lowered by concussions.

@bulldogblvd Ай бұрын

I have been doing cypionate sub Q once per week for the past four years and I don’t notice any difference in my body throughout that week. So, I have not felt the need to have to split up my dosages.

@Getlost55 Ай бұрын

@12:20 you hit it right on the head. It only took me 20 years to figure this out lol.

@MrYusha 6 күн бұрын

I had a botched hernia operation when I was 9 and I'm 42 now. But the operation wrecked one of my nuts and I was put on test cyp 250mg weekly when I was in my late 20s and had my T checked. It was 298 at the time. I also take half a mg of anastrozole every 2 weeks... Haven't felt great from it, ie it's not a magic bullet. But it's got more benefits than just a morning wood which I have a problem with. I think that's neurological. Like my private parts aren't getting the message from my brain...

@ronkay1573 2 күн бұрын

Test cyp half life is 8 days not 10. Once a week is all you need (100-200mg).

@entropicdoom8018 Ай бұрын

At age 43 last year, I got my test measured. I was at 290ng/dl for total and 72ng/dl free test. My urologist said I needed TRT. It sounds like from this video and comments that while my total test is low, my free test is decent. I started TRT at 50 mg every 2 weeks. Blood work showed no change in test levels. Did 100mg every week, test was at 700-800. Noticed improved mood, mental clarity, and labido. Increased to 150-200 every week and test was at 1200ng/dl. At this level i saw further improvement in focus, mood, and libido. Moreover, I saw dropped 10% body fat. Muscle retention when sick and not eating is much better. I would lose 20 lbs of muscle during a bought of food poisoning. Now i lose less than half that. However, I get acne on muscle groups areas that I am particularly focusig on that week. Definitely needed to stay on top of more frequent showers an showering immediately after sweating a lot. I will be staying at 150-200mg per week.

@cupidxon Ай бұрын

I received my testosterone bloodtest yesterday ( I am 100% natural) , they are totally normal, but i have some questions. Results : - Total Testosterone : •839 ng/dl - Free Testosterone : •16,3 ng/dl (I did the conversion to ng/dl to make it more understandable, lab result was showing 0,163 ng/ml) - Bioavalaible testosterone : •450 ng/dl, which is about 53,7 % of my Total T. SHBG : 37,7 nmol/l (Lab reference range : 17 - 77 nmol/l ) My questions are : 1. If i reduce my SHBG levels to the strict healthy minimum , (Let’s say 20 nmol/l ) can my Free Testosterone levels potentially double ? And reach the optimal range which goes from 18 to 25 ng/dl ? 2. Is my bioavalaible testosterone slightly high ? (Because in most people Test results i see , bioavalaible testosterone rarely exceed 50% of Total T) Is it good/bad to have more than 50% of your testosterone bioavalaible ? What are the benefits/side effects ? 3. I did a first testosterone test 2 months ago and my Total Testosterone was 737 ng/dl but my SHBG levels were EXACTLY the SAME (37,7 nmol/l) Considering the fact that my total testosterone increased from 737 ng/dl to 839 ng/dl in a 2 months scale whitout ANY CHANGE in SHBG levels, can it indicate a good body endocrine function ? Or is it something else ? Thank you a lot if you respond to those questions, i always reach to professionals like you.

@fitchmultz 2 ай бұрын

Great conversation. Thank you.

@dustinb2258 25 күн бұрын

So the 200mg I’m prescribed is leaving me with ups and downs and I’d be better off doing a shot once a week at the very least?

@JAYBOLA1 Күн бұрын

Try splitting 70 every 3 days bro

@bbb345sddf Ай бұрын

I’m 56, 6’1” and 230lbs at water tank tested 8% bodyfat. I have a natural testosterone level of almost 800. I also travel 75% for work and head on the family. I train at 4am on the morning to get in my workout before work and family obligations and eat healthy even when traveling (grocery stores instead of restaurants etc.). I don’t care what anyone says it absolutely your lifestyle that affects your testosterone levels so if they are low then change the poor choices you are making. These TRT clinics give it to anyone and it will screw you up.

@whatthefunction9140 Ай бұрын

Same. I stopped exercising and was earing shitt. For years. Got my t tested and it was 180. I was told my testosterone woukd never go much higher naturally. I started eating well and lifting daily. Now I'm at 750 and feel better than when I was 20. 25 years ago. Do the work.

@bobwilliams9061 Ай бұрын

@@whatthefunction9140 Thank you. I have no idea whatmine is but I lift hard but at 64 the results are less than inspiring. I’m tempted but probably wont make the jump.

@whatthefunction9140 Ай бұрын

@bobwilliams9061 yeah sorry didn't mean to sound like it has no place. I want to start around 60 if I can't keep my numbers where they are.

@RunningWithSauce Ай бұрын

I was absolutely ripped and run a half marathon weekly zone 2, two fast interval runs a week, lift 3x full body heavy per week, macro nutrient compliant with a coach. I dropped a ton of muscle and strength and my vo2 plummeted. I had no idea what was going on, super sick 24/7. A doc finally diagnosed me with systemic mastocytosis and eosinophillic leukemia. I started taking targeted chemotherapy and my blood work for anemia and a lot of other messed up stuff normalized but I still felt like crap and couldn’t get my strength back. My bench had plummeted from working sets at 225 lbs to 135 in 6 months. I had my T tested and total T was 180. I’m at 500 now and am finally symptom free at 50 years old two years later. My work ethic has been far above most I know as I served in special operations until 24 years old and never ever stopped taking care of fitness. Some people DO have real medical issues and your own testimony doesn’t negate others experience. Yes there’s shady clinics out there.

@jordixboy Ай бұрын

That's genetics, I was foing everything alright and my test was still low at 28, needed trt, before hopping on I tried 2-3 years to fix it , no success, you can't extrapolate your story to others as there are many factors such as genetics. In your case you seem to have good genetics for high t, but your life style led you to low t. In my case I had low T even doing everything allrigjt, sleep training, nutrition, low body fat...

@mparente2 Ай бұрын

If possible, why not just take a SERM? Clomiphene works well.

@DoctorHemi Ай бұрын

I'm surprised they didn't discuss the new daily oral TRT options (sold under the brand names Kyzatrex, Jatenzo and Tlando). Because it's pill form, it's more convenient than pinning daily and it's only twice/day instead of 3-times/day of Natesto.

@StelioKontoss Ай бұрын

Because its new, injections have been studied and done for a long time, they are safe and effective. Pinning > any other method.

@bogrunberger Ай бұрын

Afaik oral testosterone is hard on your liver and often not preferred.

@HappyWolverine Ай бұрын

Omg stop You don't need to pin daily on trt Twice a week for me with insulin pin on delt. Couldn't be easier

@DoctorHemi Ай бұрын

@@HappyWolverine, agreed, but they discuss people who want to pin daily. My only point was that the oral TRT options would (somewhat) mimic that.

@ryanroseevans Ай бұрын

Problem you have with any oral version is bioavailbilty and your guts optimisation to break it all down and utilise it efficiently. Pinning is a lot more accurate

@Austin-uq9ms Ай бұрын

28 year old police officer with 10 years in. got my test check and total was 301 doc prescribed 100mg once a week, 4 weeks later it only went up 348. Explain

@vitaly6312 Ай бұрын

Are you on 3rd shift? How’s your sleep?

@JosephAbdo-t9n Ай бұрын

For me I was 38 got my labs done for normal health check my dock added metabolic panel and hormones. I was 163 total testosterone. She told me to go exercise, eat better loose weight and sleep come back and we test again. I did that for a few months, came back I was 201, weeks tested 90 days later I was 178. I started TRT that week and it changed my life I sit at 750-800 and have taken years to dial it in and I’m still learning. It’s a choice and a lifestyle you will have to live with once you start there really is no going back if you are truly suffering from male hypogonadism.

@strongjaymusicgroup Ай бұрын

TRT is life

@jamesbunnett1694 Ай бұрын

I don't really care what is natural per say. Is it safe to do trt at a reasonable level, continuously? At 175mg a week pinned twice weekly, I had never felt so good...... i don't think we live 'natural' lives these days. As a tradesman I am physically on the tools and running a company so I have physical and mental stress at least 10 hours a day. I love my job, just want the energy I need to do it effectively

@brettwilhide1042 14 күн бұрын

Hello I'm nervous after hearing this video. I just saw my urologist and have testicular failure with a T level of 58. I'm a 38yo man who was on T over 10 years ago. I have severe symptoms and the dr prescribed me 200 every 2 weeks. I've never done the injection but I need testosterone. I'm waiting for the pharmacy to get it now. Any suggestions? Maybe ask the urologist to do 100 every week?

@charlesterrizzi8311 12 күн бұрын

Test cypionate? It has an 8 day half life so twice a week seems ideal, not once every two weeks. Anyone can learn to self administer

@tzahi12370 Ай бұрын

Do you think that high estrogen on TRT can cause acne ? Dht is blocked almost completely with dutasteride so its not from Dht , someone knows what can cause it ? I had acne since the beggining on TRT

@johncasper8193 Ай бұрын

Give yourself more time, 4 weeks is not enough time. Check your T again in 2 months. After 2 months, if your T does not come up, You might need to increase your dose.

@tzahi12370 Ай бұрын

@@johncasper8193 what??? Are you talking to me??

@johncasper8193 Ай бұрын

@@tzahi12370 yes

@tzahi12370 Ай бұрын

@@johncasper8193 Im on TRT for 4 years!..my problem is acne nothing else

@scottonanski4173 8 күн бұрын

@13:10 "Nice" 😂

@jessielr13 8 күн бұрын

What are your thoughts on Aveed every 10 weeks?

@obcane3072 Ай бұрын

Injecting SQ has been shown to hit steady state in 6 hours and then begin a slow taper but will be still be in therapeutic range. Study used 100mg and it showed wide variance testosteronw levels: ranged from 600 to 1100. I have my patients take q5-7 depending on patient preference and have them check test level in 3 days. Danger in females is that the pharmacist prescribes the 1mL vial per week and some patients don't want to waste it so they inject the full 200 mg. Have had some patients with free test of 30. Never prescribe IM.

@TheSuperEsari Ай бұрын

Also interested to hear about TRT protocol in Europe, i hear the pinning frequency is much lower, 6-10wks?

@markolehtonen6640 Ай бұрын

TRT protocol in Finland: Either Sustanon (7-12 days typically ), or Nebido (typically 6-10 weeks)

@marken816 23 күн бұрын

@@markolehtonen6640 Eikö näin pitkät injektiovälit aiheuta tasojen heittelyä?

@markolehtonen6640 23 күн бұрын

@@marken816 Tarkoitat nebidoa? On pitkävaikutteinen, ja tuo on sille oikea väli. Toki annosta voi puolittaa/jakaa.

@astroskyofficial 29 күн бұрын

What about TEST u? Considering its ultra long half life wouldnt it be ideal to get a very good level maybe once every 4 weeks. It means less injections, but also it become just as frequent as test c twice a week.? Iv done some calculations. Seems pretty good no? You front load to get the levels you need fast then switch into the 4 week protocol.

@Mr.majic_cracker 15 күн бұрын

How would i get on TRT in canada? Seems impossible

@GlobalNewsfromPompeyTown 7 күн бұрын

I am in Ontario, gontonyour Dr. get a blood test for available and free testosterone. If the results are low, you can ask for a prescription. In Ontario, they prescribe Delestryl ml every 4 weeks, and if no improvement, they can prescribe 1ml every 2 weeks.

@Pieter_Lion Ай бұрын

Anyone knows if its always needed to donate blood? Like say if you inject more frequently can you avoid having your hematocrit rise to dangerous levels? It seems like a pain in the *ss to have to donate blood every few months and I would like to know if there’s a way around it

@nateh6441 Ай бұрын

I've been on 6 years never had dangerous Hematocrit

@Pieter_Lion Ай бұрын

@@nateh6441 whats your protocol then?

@hardmtnbiker 2 ай бұрын

Obviously TRT/HRT is becoming more popular but I’m curious about how many men that prescribed to this therapy are risking other problems.

@Lucas_Jeffrey Ай бұрын

there is certainly unavoidable consequences. but there are serious consequences to living with chronically low testosterone. Low T increases the excess mortality risk for men. it's a risk equation different for everyone.

@bearclaw5115 Ай бұрын

It's riskier to have low T than T in the proper therapeutic range. The only exception to this is if a man has had low T for many decades and then suddenly boosts it. There is an increased chance of stroke in those individuals for one year after which risk goes back to baseline. In other words addressing the problem earlier than later is safer.

@hardmtnbiker Ай бұрын

@@Lucas_Jeffrey there are serious consequences to have a low GFR or having HTN or Diabetes from years of abuse and neglect of consistent exercise, just saying.

@ryanroseevans Ай бұрын

Id rather live to 65 optimal and thriving that 90 like a pile of dog crap.

@hardmtnbiker Ай бұрын

I seriously don’t think these practices that promote “Men’s Health” actually address the collateral damage of possibly renal failure possible stroke and other serious complications from stressing a broken done cardiovascular system with weak organs.

@user-sy3wd5jn4n Ай бұрын

So many great questions asked. Yet none of them really answered.

@michaelclementi727 3 күн бұрын

Hi Doctor Attia, Thank you for the video very informative. love my doctor down here in SC but would love to be treated by you. I also subscribe to Dr. Pete, my urologist put me on 100mg / week but I thought I should have it twice a week. What I was on made me a little stronger but not much weight loss and I watch my diet. My you could give me some more info Thank you for taking the time to read this

@thejeffbosley Ай бұрын

Would a Dutch test help show uptake etc?

@winstonbrown347 16 күн бұрын

the more frequent you inject or use with lower dose, the safer it is for your liver. That high dose at once can shock the liver too much.

@AaRoNaNtHoNy80 Ай бұрын

I am 44, I was diagnosed with hypogonadism at 43. My insurance won't help because they label it as a "lifestyle choice". I don't know what to do at this point.

@user-xh1if2hi2u 24 күн бұрын

Viking alternative.

@fredduggin Ай бұрын

Im 6’1” 170lbs 68 years old Been on cyp for 4 years on recommendation from doctor 150 mg week 7% bf Bench 225 DL 310 Squat 350 2r on each Feel good with good energy no sides

@tommyjoe4310 16 күн бұрын

where is a reliable to test in Canada....family doctors dont even want to test for it

@fatnesstofitnessthereandback Ай бұрын

Loved this

@TheOfficialLavish 28 күн бұрын

Can testosterone enhance anxiety or panic attacks, or create?

@BigJackCreeper 3 күн бұрын

Tried testosterone replacement therapy. Great at first. The effects tapered off. I got acne, my hair fell out, my testicles shrunk to peanuts. I stopped. Never again.

@EvanZamir Ай бұрын

Obesity is causing the bulk of the decline in male testosterone over the last few decades. Stay lean and your testosterone will likely be fine.

@KonfusedDude Ай бұрын

Low trt may driving the obesity

@kcheng3594 Ай бұрын

thank you for the comment. I found it very inspiring.

@spacetime3 18 күн бұрын

Does anyone have information on GEL vs Injections, wouldn't gels enable you to mimick the morning boost in T more easily?

@Mark-ks9jj 9 күн бұрын

The problems with any transdermal dosing forms are inconsistent dosing amounts due to variable absorption, plus there is a small risk with spouses/kids etc if they happen to come in contact with the topical off your hands etc.

@MontezumasViper 8 күн бұрын

Gels reach steady state. So, no not really. However, testosterone pills like Kyzatrex rise and fall during the day. They are also almost completely free of side effects based on the studies.