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Thank you Dr. Ryan you are an effective teacher. All the way from Philippines 🇵🇭 I want to express my gratitude in all of your videos! Thank you Mental Dental 🦷

🎯 Key Takeaways for quick navigation: 00:00 📚 This video covers autonomic nervous system pharmacology, which is divided into the parasympathetic and sympathetic branches. 02:32 🧠 Understanding that both branches control the same organs but have opposing effects (fight-or-flight vs. rest and digest) is crucial. 04:26 🚦 Autonomic receptors include ionotropic (ion channels) and metabotropic (GPCRs) receptors, which play a significant role in drug action. 06:11 💊 Cholinergic receptors (muscarinic and nicotinic) are associated with the parasympathetic nervous system, while adrenergic receptors (alpha and beta) are linked to the sympathetic nervous system. 10:16 📖 The autonomic nervous system has specific drugs, including agonists and antagonists, that target these receptors to modulate their functions. 19:03 ⚙️ The synthesis of catecholamines (epinephrine and norepinephrine) and their receptors' actions on smooth muscle, heart, and more are discussed. 26:06 🔄 Drugs like sympathomimetics and sympatholytics either mimic or block sympathetic responses, affecting blood pressure, heart rate, and more. 27:13 🧠 Alpha 2 receptor agonists like clonidine and methyl dopa block the sympathetic nervous system in the central nervous system, producing antagonistic effects. 28:32 ⚖️ Epinephrine reversal refers to the conversion of its vasoconstrictor effect into a vasodilatory effect in the presence of an alpha blocker, highlighting drug interactions. 30:04 💔 Vasovagal reflex involves a malfunction where baroreceptors, controlled by both the sympathetic and parasympathetic systems, can lead to conditions like sinus bradycardia, demonstrating how the autonomic nervous system doesn't always function as intended. Made with HARPA AI

I understood more during this 32 min video than 6 hours of lecture XD. Thank you for your explanations and visuals!

Great way to explain this heavy topic, great job! Helped a lot.

Best lecture i have ever heard ♥️

Thank you so much, Dr Ryan! 🌸

That was incredibly helpful. Thank you🙂

Great lecture! Concise, well organized and excellent presentation. Thank you!

Thank you so much Rayan! You made dentistry a lot more easier😍

Thank you Dr !!

Excellent video! Easy to understand a very complex content.

THANK YOU THANK YOU THANK YOUUUUU! love, a med student that will actually get to go to sleep at a decent hour because of your concise explanation

Second time watching this video. Much more clear now after going true some practice question from the Mosby’s Book. Likin completing a cicle Thank you

You made it so easy😊😊 Tysm..god bless you

You are the best. Thank you so much

It made pharmacology simple for me Thank you sir 😊😊

Amazing lecture 👍

Very helpful. Thank you so much 🤗🌸

you really made it easy thanks a lot

Thank you brother, this video helped a lot. Greetings from India.

Excellent explenation! Great lecture! I finally understood this topic! Thank you for making this easy!😍

Wonderful presentation

honestly, thankyou❤️

Incredible how to make it easy thanks and big love to you ♥️♥️

Amazing video...ur a good teacher..keep going

thank you for lectures it very helpful, keep it up

Thank you so much, your efforts of making the video was worth it☺👍👍👍

THANKYOU THANKYOU THANKYOU!!!

Thank you 🙏

Really outstanding

this video is really great

This is awesome 👏🏻

Thank you soo much sir very well explanation

Thankyou so much Ryan!❤

Great teacher

Clonidine used to control Bap for people detoxing from opioids makes more sense why it is a drug of choice. I have worked in detox asan acupuncturist. Your videos are helping me understand so much. Thank you. They are clear and very understandable. I am studying fir my FL RDH prometric pt stimulated computer sections of the boards. I have almost no idea how to study. I graduated in 1981 scored 86 n nationals back then. 95 on clinical sun two states. Things h Ave changed. I am “rusty”. Clinical practice is different from academic understanding. Thank you.

I really enjoyed this lecture alot🙌💃💃 thumb up👍

Difficult indeed, but THIS and slowly digesting "Tufts Pharmacology" helped me a LOT

Thank you Doctor... Would you please help us with a lecture on autacoids as well?

4:00 I can say with certainty that when under a fight or flight situation (read: presenting in front of classmates) I can experience involuntary constriction of my bladder rather than relaxation

Thank you Dr Ryan for your videos! Just had a question regarding the preganglionic neuron for SNS. Shouldn’t both SNS and PSNS preganglionic be cholinergic?

Great video! I would have liked to know what each drug is prescribed for, easier for memorizing 😊

I am reading a lot but nothing sinks in and just desert me. And I am here ☺

I followed the video step by step while taking notes and I really understood clearly all of it until the Epinephrine reversal part were it was confusing

Plz make videos on general medicine, physiology

sorry i want to ask about the b2 receptors i did not get why the dont not cause vasoconstriction but cause vasodilation

How can baroreceptor be activated by high high blood pressure caused by one norepinephrine..Plz explain the mechanism

Do you recommend watching these videos in order? Thank you!!

Hello Dr you said M3 relaxes smooth muscle? Should it contract smooth muscle to squeeze out the saliva etc? 12:36

Hey Ryan, I'm a little confused why you have Nicotine as a Nicotinic antagonist. Your reasoning why makes sense, but wouldn't nicotine by definition be an agonist for nicotinic receptors? The Wiki on nicotine is also stating it is an agonist. Could you please clarify this? Thank you.

Hi! I have an assignment given by my lecturer to find out about the types of autonomic nervous system poisoning and I was really confused. Does ANS poisoning depending on the effect (parasympathetic and sympathetic) or is it depending on the mechanism of the toxin? (anticholinergic, cholinergic etc)

do i have to learn each adrenergic antagonist and their MOA....

Hi Rayan thanks for this great video. I just have a question If the synaptic ganglion and medula binds to Nicotine wich is a Acetylcholine rector (AChR) any drug that is Anticholinergic would inhibits both PSNS AND SNS systems???

Why the titles of all videos say PART II, Where are PARTS I?????

Hey Ryan, great vid! I was able to follow through the whole video, but I have a question about the urinary bladder. If it's relaxed during SANS, then why is there a tendency for some people to urinate or defecate a lot when they're stressed or nervous? I'm really confused. Hope you'll be able to answer my question. Thank you so much and more power to your channel!

Hi! If we subscribe do we get access to the powerpoints or notes for these videos? It would save me a lot of time to be able to take notes on there as opposed to retyping the info! thanks!

Is this for NBDE part II or INBDE?? looks like Physiology more than Pharm

Hi Ryan, thank you for your video. I'm just wondering when will the new slides for pharm will be posted? please let me know. Thank you again

17:00

so is it right to say that clonidine is an agonistic drug with a sympatholytic effect?

What do most of these words mean?? I'm so confused but this is kinda cool

So alpha 2 agonist are sympatholytic. Wouldn't that mean vasodilation???

Hi why isn’t there all chapter

Hello Dr. Ryan, I've been following your videos recently Thank you so much for you great efforts! Is this series of Pharmacology breaks down the Tufts file and enough or do I still have to go through Tufts file too after these videos? I hope I don't!

Hello, Dr. Ryan. Do you have more content of all subjects in Patreon? Am I missing a lot of important stuff if I only pay my monthly fee of $5.44/mo.? Would you highly recommend Patreon? Please advise me. Thanks in advance.

Should I memorize all these drugs for the NBDE part 2?

In ur video when u r describing alpha receptors u have written it causes urinary retention isn't that wrong? Alpha receptors are associated with SNS so it should cause increase in urine flow @mentaldental

I want to understand all chap ???

Hey Dr Ryan. Your new subscriber here. Please can u also make videos on mcqs related to the inbde ? It would be a humble request

Hi Dr! Are you still accepting donations in PayPal? Thank you

Hi there! @ Dr Ryan or other watchers. I am currently studying for Integrated Boards, and I'm honestly overwhelmed with allllll the content out there for boards ... for some reason Pharm set me off. Is this all really needed to learn for boards? :( It seems impossible to know so much about literally everything ever. Just let me know someone if i need to learn all this stuff because I am losing motivation

But, there are adrenergic receptors on heart too, aren't them? why is that not mentioned here?

N

Actually I’m mbbs student so want help ??

this is the worst topic