Prader-Willi vs. Angelman Syndrome (Imprinting)

Рет қаралды 178,787

6 жыл бұрын

SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

Пікірлер: 69

@Dr_Shin Жыл бұрын

Clarification that you HAVE TO KNOW In Prader-Willis, Know that the maternal copy of this gene in chromosome 15 involved here is what is NORMALLY imprinted (Inactive) by methylation. ONLY the paternal copy of the this gene is active/utilized NORMALLY. Thus, there can be 3 different causes of Prader-Willis: 1) Loss of the paternal copy of the gene 2) Uniparental maternal disomy (Either Hetero or Iso) because now both of the genes will be imprinted/inactive 3) Translocation that replaces the needed segment of the paternal gene in ch 15 with a different gene. In Angelman, Same mechanism as Prader-Willis. Just opposite. Paternal copy is NORMALLY imprinted. Loss of maternal copy of the gene will lead to this disease.

@themicahg0928 Жыл бұрын

Thank you!!

@arturomauriciobautistaroma5694 Жыл бұрын

I'm agree

@themesaregreat 5 жыл бұрын

Everytime i learn about imprinting i completely forget it two weeks later

@xKiB5 5 жыл бұрын

lmao so true omg

@junaidmushtaq9421 4 жыл бұрын

Easy topic ,

@thebeets6055 3 жыл бұрын

That is incredibly accurate

@skull_bonet1 Жыл бұрын

Watching this an hour before exam. You never know how you're changing the world 🥰

@vanshajchandra307 3 жыл бұрын

In Chandler Bing’s voice “could it beeee any simpler?” Great video

@Kcebab12345 6 жыл бұрын

prader vader made me crack up pretty good lol

@xKiB5 5 жыл бұрын

great work, keep it up!! I love this

@nastiianastiia5763 3 жыл бұрын

Thank You for Your great work

@lee-annechazanga7017 2 жыл бұрын

Just made the clinicals easier, thanks!

@keshvichauhan6804 5 жыл бұрын

you are too good, thank you

@SamAmiri Жыл бұрын

A super quick recap for the exam: Prader-Willis: 1. Mum side inactive. 2. Father side is missing/defective. Angelman: 1. Mum's side is missing/defective. 2. Dad's side is inactive. mnemonic: PIMAMI or PIDADI P = Prader I = Inactive M = missing/defective A = Angelman M = Missing/defective I = Inactive Prader-Willis Special Case: 1. Uniparental maternal disomy = causing both genes to be imprinted/inactive. 2. Translocation = replaces segment of the paternal gene in ch 15 with a different gene.

@cesaraugustoruiz 9 ай бұрын

Very helpful, thanks

@RohitPant04 2 жыл бұрын

Darth Vader Willi looks like Peter Griffin wearing a Darth Vader costume for Halloween! 😳

@StoicScape219 5 ай бұрын

Thank you for this :) Getting ready for my pediatrics exam next week

@kaath08 4 жыл бұрын

LOVED IT! thnx... greetings from MEXICO

@stephanevers3430 6 жыл бұрын

more vids bro!! youre a big help

@yasminyouyuo 2 жыл бұрын

perfect thank you

@Gulshangurban Ай бұрын

Thank you

@sahilbansari5385 Жыл бұрын

Dirty we need more videos on genetics please upload as soon as possible.!!!

@drj2590 4 жыл бұрын

superb very short and productive

@deliamariacoman214 4 жыл бұрын

Could you explain why the deletion in the father's chromosome causes another syndrome than the deletion in the mother's chromosome?

@ast1848 6 жыл бұрын

Can you please make a vid on ABO blood typing and rhesus system? confusing af

@wehatedisneystars 5 жыл бұрын

GOD BLESS YOU!!!!!!!!

@xaaboopinkly 4 жыл бұрын

Thanks sir! ❤️

@dr.mohammedbasheer8672 6 жыл бұрын

Thanks a lot this is really helpful ^_^

@dennybreese Жыл бұрын

Thanks!

@CurlyHeadMed 6 жыл бұрын

Thanks for this. Btw, have some of your videos been deleted? I feel like you had way more videos a month ago. For example, my favorite video on enzyme kinetics (with Km for cock and Vmax for vagina) is missing.

@komaddog 2 жыл бұрын

Dirty little mind lol

@mmafan4701 6 ай бұрын

Very easy to way deliver nice concepts ❤

@Na-hh5yo 5 жыл бұрын

thank you soooo muc forthis

@noornoor-yv8tu 2 жыл бұрын

Thank u.

@amitanandda 6 жыл бұрын

Awesome video you can also remember chromosome no from their name As both names have a and e in them and a is the 1st letter so 1 and e is the 5 th letter so 5 combine them together and u get chromosome 15

@samik3184 5 жыл бұрын

angel-man (a is the 1st letter but e is the 4th letter bro)

@CXY96 4 жыл бұрын

@@samik3184 ABCDE, check your alphabet bro

@srinivasaraosirasapalli5104 5 жыл бұрын

nice explanation

@yes3072 3 жыл бұрын

So how many total of chromosomes and autosomes does angelMan and Prader-Willi have??

@johnspikesii4223 3 жыл бұрын

Absent mommy's llttle angel; Darth Prader seeks his missing father (i know it isn't canon, but it works)

@saadmaqsood9804 4 жыл бұрын

and he has a small willi hypogonaldism

@Be1smaht 2 жыл бұрын

Which is imprinted vs. Methylated

@smol_chilli_pepper 5 жыл бұрын

How do they determine which chromosome came from which parent? Doesn't both autosomal chromatids look exactly the same? So when they were determining the causes of Angelman's and Prader-Villi how did they know that it was the maternal or paternal chromosome that had the deletion?

@AiLuvROCK 5 жыл бұрын

They don't look exactly the same because of the parent-of-origin-specific imprinting. I think that's how they found out.

@smol_chilli_pepper 5 жыл бұрын

@@AiLuvROCK hey thanks for answering. when you say "they don't look the same" are you referring to the autosomal chromotids? because that's what I mean. Do chromotids from a specific parent look a particular way or have hallmark genes? How in a laboratory setting did they realise that it was the mutation on the maternal strand that caused Angelman's when the chromotids essentially look the same?

@AiLuvROCK 5 жыл бұрын

@@smol_chilli_pepper Np. So yes, the chromosome from the mother looks different than from the father because they are imprinted in a different way. This means that some parts are inactivated by DNA methylation. So in the case of Angelman syndrome, a part of maternal chromosome 15 is lost, either by deletion or by inheritance of 2 paternal chromosomes. On the paternal chromosome this part is imprinted (=methylated). So you have no expression of this part of the gene. Does this help?

@eee4048 5 жыл бұрын

X is paternal and y is maternal

@iamthevengeance4766 2 жыл бұрын

@@AiLuvROCK in angelmann is paternal or maternal is imprinted

@JasonVaysberg 3 ай бұрын

Apparently Beckwith-Wiedemann Syndrome can also be an imprinting disorder, in case this comes up.

@Mrhamster114 3 жыл бұрын

God bless you, Dirty

@nanais007 Жыл бұрын

Well this is a cool video. My son FMFX and I assume he has a subtype of PWS.

@AG-en5y 2 ай бұрын

❤❤❤

@Sponge247 5 жыл бұрын

cant see his willi

@prakashrana1404 5 жыл бұрын

🤣😂

@niky9731 3 жыл бұрын

Im literally having the HARDEST time trying to determine a paternally imprinted pedigree from a maternally imprinted pedigree

@drikaprezoto628 3 ай бұрын

MAterNal forms the word MAN, in AngelMAN 😊

@sandrarobbin3019 6 жыл бұрын

WHERE THE HECK IS ALL YOUR VIDEOS AND YOUR FACEBOOK PAGE???????????????????????????????????

@3rdeyeshine94 5 жыл бұрын

Genomic imprinting an Gene changing through psychedelics

@ashumedico12 6 жыл бұрын

can u please video on milestones in pediatrics

@DirtyMedicine 6 жыл бұрын

we already have one

@user-yi7vq5sk6y 2 ай бұрын

Alguien que hable español castellano

@kayallen7603 6 ай бұрын

and nothing can be done, right? Sad. Poor kids.

@alpkaandabanloglu5669 4 жыл бұрын

Vader wili omg 🤣

@fatemehkf5066 Жыл бұрын

Prader willi causes because of maternal copy is turned off.

@Be1smaht 2 жыл бұрын

Sorry dirty this one wasnt good. Everything imprinted is not methylated. There is disomy too.

@Dr_Shin Жыл бұрын

Imprinting by definition is methylation. Of course there are exceptions, but it is true in these two diseases. He did not clarify the imprinting & mechanism of these two diseases very well, but nothing he said was inaccurate. In PW, Maternal copy of the gene is imprinted NORMALLY, and that is why loss of paternal gene causes this disease. In Angelman, Paternal copy of the gene is imprinted NORMALLY, and the loss of maternal gene causes the disease. For example, these are the 3 different mechanisms that can cause loss of paternal gene and cause PW. 1) Loss of function mutation of the paternal copy (~70%) 2) Uniparental maternal disomy (~25%) 3) Translocation of the needed segment of the paternal gene with a different gene. So in a strict sense, Imprinting is the more important factor in these diseases. Disomy is just one of the various mechanisms that can cause these diseases.