Prions have been a concern to me for years now. A year ago the state of Arkansas set up check stations for deer hunters to bring in their meat to get tested. At that time it was stated that there was a 40% increase in the number of deer tested being infected. That's scary to me. I have been telling people I know to get their meat tested but they all laugh at me and eat it anyway. I fear that 15 to 20 years from now, we will see a huge number of people with prion disease. I hope I'm wrong

I van tell you exactly how this is happening now. "No creature should ever eat it's own kind." Well... we've been feeding cows, cows! We're putting Tallow on Corn at Feedlots and feeding it to cattle. The cycle continues and continues. The cows are not alive long enough to show signs of the damage. But, as it continues, I suspect we will see more and more of this with people. Eat only grass-fed cows. Best way to avoid this issue. Remember, Tallow is made in the same plant that the cows are slaughtered in. Tallow may contain brain matter from the cows considering the brain contains a lot of fat and would be useful in the production of Tallow for use at Feedlots. This is a disgusting practice that was never meant to happen. The feedlots will defend this practice until the end of time saying it is useful for making the cows bigger for more meat production to feed more people. It's disgusting and is probably killing people. It's very sad.

I was looking for a simple yet informative description of CJD for my surgical nurse interns and your explanation and teaching visuals are perfection! I also developed a better understanding of Prion disease, CJD and vCJD because you presented this material so well. I've never completely grasped how prion disease happens but you made it so much clearer! Thank you very much!

Here in Chile, the ratio of people is very high (3,5 cases in 1 million) compared to other countries, and it has almost nothing to do with animals. According to the neurologist that diagnosed my dad, in Chile is just sporadic or genetic. In this case it might be sporadic, and I could carry it too. My dad is on his 3rd month and is 57 years old. As far as I know, Chile has the highest rate of incidents and even a whole family was affected by this. There is a small group in Facebook that has also shared their experiences and a lot of them had lost at least 3 relatives just because it could be hereditary. I’m truly scared of this, but now, I have to take care of my dad and be the main support for my mom. I hope that more research could be done so future people can have some kind of medicine. This is so quick that seems unreal :/

I love your drawings and cutouts. So much faster (?) and more artistic than computer-generated animations :). Really adds a human touch.

I have a great interest and appreciation for science. I just fell on your videos and love your explanation and drawings. You're a great teacher! I look forward to more of your videos

Great information. You explained really well in a very simple yet detailed way. Thanks

Thank you. Please continue teaching us!!! You are a great educator.

As a 16 years old student doing a research.. that is terrifying to know that the immune system cant do much about it. But it’s interesting to know a lot about the topic prion disease.

My brother just passed from CJD. It's the most horrific way for a person to die.

Knowing about prions make me paranoid asf

Excellent video. I just watched the Australian documentary about the Kuru tribe in Papua New Guinea. The disease can lay dormant for so long!! It’s horrifying. 🥺

Thank you! This has been the best explanation ive seen! Im studying medical laboratory technology and heard about CWD from family members, so naturally, I went down the google/youtube rabbit hole about prions haha. Keep it up, I like the drawings. I thought the BBB would prevent proteins from entering so this was very informative.

This video was well done. Great job!

Quality info. Thanks for the presentation

I have to do a project presentation and I was given PrP as my topic. I have been reading article on top of article and none have explained it remotely near as good as you have. Thanks

Thank you for a very clear description of prion disease.

I wish you could explain ALS in your excellent way. My father had ALS for >20 years and one of my aging cousins also have had ALS for that length of time. I had a former co-worker who died of CJD, sad!

love her drawings, shes put so much effort into making this

She's back! 🥳 Happy New Year!💪🧠

Once more Thank You !! And wishing you a Happy and safe New Year…

This is wonderfully explained; thank you☺

Thanks for this fantastic explanation!

Excellent explanation! I can finally understand why prion dieases are so damaging to the brain and can cause so many neurodegenerative diseases. 1) It seemed to me that the 'mad cow disease' developed pretty fast in the victims. Is that because of the amount of infected prions consumed? Does the amount of infected prions accelerate the process? 2) Just to make it clear, no amount of cooking can prevent someone from "catching infected prions" if the meat is contaminated?

Loved your explanation Even without technology you made it clear and interesting

Excellent, short simple and effective.

Thank you for sharing your knowledge....well done...may you stay safe

Beautifully explained

thank you so much I needed this 💕

Fascinating,educational and Terror inducing. Thank you.

Excellent presentation 👍

thank you for this. great video

Interesting and wonderful to have you back. I wonder if certain types of dementia (non alzheimer's) could be attributable to prion infections?

Such great explanation 💯💯 thanks

Can prion diseases pass through dairy or colostrum? I have read theoretically they can. I have been interested in colostrum supplements and their health benefits and even ordered some, but then read that prions could pass through colostrum and so I haven't taken it yet.

This was so good.

How was it that 3 European science researchers were studying misfolded proteins under a microscope and somehow became contaminated and died shortly after ?

Is there any chance you could do a video on T-cell exhaustion as it seems to be in the news lately?

I'm really glad I stopped eating beef due to a sensitivity. Prion diseases are terrifying and often kick start my health anxiety.

I have booked in for No v a vac and have complex health issues and am concerned still about the spike after a suspected case in early 2020 and a year of hell thst i feel was related from lingering spikes or damage. I hsce read NV may cause prion disease. Can you please help me understand if that is something that can happen from the protein V NV?

Very interesting thank you.

Thanks for this video!

Great video. Thank you.

I'm very genetically likely to be a rare one. I've known this a long time and I'm struggling with memory and sleep now. So, here I am.

thanks I have a microbio exam tomorrow!

Thanks for the explanation?

What are the plans for a possible treatment ? Maybe we should experiment on dendritic cells and make them effective against misfolded prions, then update our dendritic cells or production with CRiSPR. Is it possible? Or is there a better plan already ?

thank you for this

Hie, amazing video! Just a doubt : how do these proteins actually escape being digested by the enzymes of GI tract incase one has eaten infected meat? Thanks in advance.

Are the lysosome and ubiquitin-proteasome processes examples of proteolysis? Wrapping my head around some basic terms 😅

Hi, I loved your video! Everything is clear and well-explained. Thank you so much! I have a question. Is it possible for different proteins to get unfolded by the contact with defective prions? I read something about amyloid beta, but I'm sure I didn't get it. 😢

Thank you…you made this topic very easily understandable. I had been curious because of the wild deer that have been coming down with a Chronic Wasting disease 🦠 (zombie deer disease) that they say is a type of prion disease and how people can potentially catch it from eating this meat

thank you so much

Now where has my favorite youtuber went :((

Theres cases where transplant patients have contracted prion disease. Also patients being infected from contaminated surgical and dental tools. Thats why a lot of sugical and dental tools are disposable.

Ive learned that there are other illnesses that are caused by malfunctioning proteins that attack other parts of the body. For example Amyloidosis.

In Saskatchewan we have a growing problem with Chronic Waisting Disease in whitetail and mule deer as well as in elk (and maybe other animals like moose and antelope). As a result, we can turn in the heads (or some brain matter) to have it tested. But by then our butchering equipment would be contaminated. Can it be decontaminated? We are also told that young animals (of that year) will not be tested; the claim is that they cannot carry and / or cannot infect the person consuming their muscle tissue. What is your opinion on these concerns?

If prions use the immune system to enter nueral tissue, could immunosuppressant therapy be used soon after infection to prevent progression?

Can any protein anywhere in the world (ex. shake) become Prion?

My question is, how could we even know that a person has the disease before they start to show symptoms from neuron loss? I mean if removing the lymph nodes is an option, that would mean that we need to do so BEFORE the misfolded proteins cross the brain-blood barrier and thus start causing the damage which would in turn develop the symptoms. I understand this could still help people with the genetic variant since you can test for that but as stated that is just 10-15% of the cases. My question refers to the acquired type. Could anyone please clarify?

Does the medication bupropion have any side effects similar to prion disease ???

Thanks for the explanation of prion disease. My gf died from this horrible disease.

CJD is the basis for the story in "Knox Goes Away" with Michael Keaton.

I remember reading about how some MD went to a small secluded native society that was particularly riddled with prion disease to do research. He discovered that they essentially had a lot of cannibalistic practices and, in particular, a very prevalent practice was to eat the brains of their dead relatives (due to some religious belief of some sort). So... is this disease something that might be considered living....?

i like this lecture. i’m getting ASMR tingles from it

Can prions be transmitted from working with cadavers. If your handling a cadaver brain and dont perform proper hand washing or precautions?

Herbivores are short lived animals and don't seem to have ways of transmission between themselves Would they be more vulnerable?

By carnism and/or canniblism and/or with cross-contamination of human hands and/or DNA?

No discussion here of scrapie disease in sheep, the earliest known prionic disease which passes as an infection. Sheep are not meat eaters so cannabilism is out. So how does the infaction spread?

So basically, the point of origination for prions in general is unknown right now. Are there any research articles published that discuss theories about how a healthy protein might become a prion without coming into contact with other misfolded proteins?

I’m just beginning to learn about biological topics and this is a great concise but easy to understand video- thanks!

I wonder if some lab is playing with prion. Trying to make an anti ubiquiton Prions. Is it possible we will have a hyper prion attack one day? I pray not.

How do the prions survive digestion?

are dendritic cells the only way that prions are able to cross the blood-brain barrier?

As a Greek individual, I regularly indulge in deep-fried lamb brains. Is there a risk of danger due to prions?

Do prions not aggregate and form these huge fiber-like strands?

There are 7 prion-like domains in the S1 part of the spike protein in the vaccines. The abstract from the paper "A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review" goes into detail.

Hi. Your video is Great. It's easy understanding and very useful for me to better know how people would be affected by this. But one thing I want to know more is how do you find only 500 hundred case during the past years. I'm in China and my father has been diagnosed as CJD last month and he is now dying. Then I talk with the people around me and I found 3 people get this desease and died in recent years. Then I explore in China forums I found a lot of families have same situation. Seems it's not that rare. I really hope I was wrong but if it's true then it would be horrible. My family is in pain and i really don't want to see more families would encounter this.

Luc montagnier said the covid vaccines could make prions if u have a long exposure in ur system Tru ?

Ya but how does it replicate? And what is the mechanism of the folding?

Please tell me, can I eat the brain and spinal chord from other animals? Or is this also dangerous?

Wow thank u

As an immunologist, you should know prions are only more prevalent today because the population is increasing exponentially, and of course the numbers will reflect this.

Is this disease contagious from person to person?

Is it true that the yeast we use for bread is a plant prion?

Are prions present in eye tears? Pls answer me mam i have testet contact lense in stores 🤦🏻‍♀️

Similar to the risk of being struck by lightning, so nothing to be concerned about. Worrying will increase your chances of getting cancer.

can spike protein act similarly to prion protein?

That sounds like a SEVIRE design flaw in the human body Like " death by normal chain reaction "

Moo thanks!

I always thought prion diseases were caused by cannibalism. Is that the case?

I've had consistent bad and vivid dreams every night for over a year now, waking me up each night at least once. Could this be a symptom?

I love your easy to understand presentations and many thanks for those :) Is it true that the Novavax vaccine can cause Prion disease?

Can you ingest misfolded prions from just tasting brain/spinal cord and spitting it out? Just curious lol

Fun fact Tyson foods sells livestock feed with pork brain and spinal tissue that's fed to hogs to this day. It would cost Tyson 17 cents per hog to prevent spinal tissue and brain from entering the inedible feed. But because there's no evidence... It's not a matter of IF but when. The USDA will make no regulation without evidence. I've been concerned about this for over 8 years. Tyson foods - kill floor supervisor, logansport Indiana

I thought a prion was by definition a misfolded protein. I knew someone who died of MSA, which is a prion disease caused by alpha synuclein.

My uncle died last year from this (uk ) c

PrPC is located on cell surface tethered to plasma membrane. If this PrPC is located here and was originally meant as means to withstand temporary low oxygen environments......If you look at these maps where the disease is discovered and you see high altitude environments as a point of origin where cases where found in the 60's...Is hijacking happening through the GPI anchor? Is their also a mechanical explanation for this problem? Are their changes related to chirality, gravitational changes, magnetic spin states, alterations in the plants the deer are consuming in certain areas? Does this disease go past the brain? I am seeing a video of a deer walking around with what appears to be a section of its body missing and the deer seems oblivious to this. Seems strange someone would post automatically saying its CWD as an assumption. Seems like the CWD in deer is concerning. A Tic as a vector of transmission has been brought up. What is causing the Lysosome to not destroy it ? Is it pH alone or is it the type of Hydrogen needed to destroy it, or is it the chirality or spin of the Hydrogen that needs to be adjusted? 3 isotopes of hydrogen exist? What type exists in the Lysosome? Something is very unusual about these prions. Have any sources of Water changed near areas where this disease is occurring? By changes I mean changes related to properties of hydrogen? www.usgs.gov/media/images/distribution-chronic-wasting-disease-north-america-0 There is a very mechanical reason for this disease and the mechanics may more than likely be outside the origin of the host. Something may be mechanically altering the chiral preference of a life form and it may be somehow magnetically or some unusual radiation and the entry point may be the GPI. I believe Buck Institute is researching Mechanoimmunology ...might want to pass this over to them. I am not an immunologist so will not be taken seriously.

I’m sick today

What is Pokemon doing in that picture?